Publications by authors named "Katy M Soapi"

3 Publications

  • Page 1 of 1

Investigations of the marine flora and fauna of the Fiji Islands.

Nat Prod Rep 2012 Dec 14;29(12):1424-62. Epub 2012 Sep 14.

Centre for Drug Discovery and Conservation, Institute of Applied Sciences, The University of the South Pacific, Suva, Fiji.

Over the past 30 years, approximately 140 papers have been published on marine natural products chemistry and related research from the Fiji Islands. These came about from studies starting in the early 1980s by the research groups of Crews at the University of California Santa Cruz, Ireland at the University of Utah, Gerwick from the Scripps Institution of Oceanography, the University of California at San Diego and the more recent groups of Hay at the Georgia Institute of Technology (GIT) and Jaspars from the University of Aberdeen. This review covers both known and novel marine-derived natural products and their biological activities. The marine organisms reviewed include invertebrates, plants and microorganisms, highlighting the vast structural diversity of compounds isolated from these organisms. Increasingly during this period, natural products chemists at the University of the South Pacific have been partners in this research, leading in 2006 to the development of a Centre for Drug Discovery and Conservation (CDDC).
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http://dx.doi.org/10.1039/c2np20055dDOI Listing
December 2012

Stereoselective synthesis of N-alkylaziridines from N-chloroamines.

Chem Commun (Camb) 2006 Nov 5(41):4338-40. Epub 2006 Sep 5.

School of Chemical Sciences & Pharmacy, UEA, Norwich, UK NR4 7TJ.

We report the first racemic and stereoselective synthesis of cis- and trans-N-alkylaziridines viaN-chloroamines; using this methodology an N-3,4,5-trimethoxybenzylaziridine was synthesised and efficiently cleaved, affording the corresponding NH aziridine in high yield.
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http://dx.doi.org/10.1039/b608504kDOI Listing
November 2006

Expedient synthesis of substituted (S)-N-(alpha-methylbenzyl)aziridines.

Chem Commun (Camb) 2006 Sep 11(33):3513-5. Epub 2006 Jul 11.

School of Chemical Sciences & Pharmacy, University of East Anglia, Norwich, Norfolk, UK.

We report for the first time that after O-acylation the conjugate addition products of (S)-N-(alpha-methylbenzyl)hydroxylamine undergo an efficient diastereoselective 3-exo-tet ring-closure reaction affording 2- and 2,3-disubstituted-N-alkylaziridines in good to excellent yields.
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http://dx.doi.org/10.1039/b606033aDOI Listing
September 2006
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