Katunuma Nobuhiko

Katunuma Nobuhiko

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Katunuma Nobuhiko

Publications by authors named "Katunuma Nobuhiko"

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Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway.

Glia 2014 Jun 24;62(6):855-80. Epub 2014 Feb 24.

Department of Pharmacology and Laboratory of Cerebrovascular Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou, 215123, China.

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http://dx.doi.org/10.1002/glia.22645DOI Listing
June 2014

Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model.

Acta Pharmacol Sin 2013 Aug;34(8):1007-12

Department of Pharmacology and Laboratory of Cerebrovascular Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China.

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http://dx.doi.org/10.1038/aps.2013.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003021PMC
August 2013

Processing of human protryptase in mast cells involves cathepsins L, B, and C.

J Immunol 2011 Aug 8;187(4):1912-8. Epub 2011 Jul 8.

Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.4049/jimmunol.1001806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150348PMC
August 2011

Posttranslational processing and modification of cathepsins and cystatins.

J Signal Transduct 2010 16;2010:375345. Epub 2010 Dec 16.

Institute for Health Sciences, Tokushima Bunri University, 180 Nishihamabouji, Yamashiro-cho, Tokushima City, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1155/2010/375345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100116PMC
July 2011

Structure-based development of specific inhibitors for individual cathepsins and their medical applications.

Proc Jpn Acad Ser B Phys Biol Sci 2011 ;87(2):29-39

Institute for Health Sciences, Tokushima Bunri University, Tokushima, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043741PMC
http://dx.doi.org/10.2183/pjab.87.29DOI Listing
June 2011

Promiscuous processing of human alphabeta-protryptases by cathepsins L, B, and C.

J Immunol 2011 Jun 11;186(12):7136-43. Epub 2011 May 11.

Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.4049/jimmunol.1001804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339195PMC
June 2011

Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity.

PLoS One 2010 Sep 22;5(9):e12894. Epub 2010 Sep 22.

Department of Oral Molecular Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012894PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943924PMC
September 2010

Quinolinate phosphoribosyl transferase, a key enzyme in de novo NAD(+) synthesis, suppresses spontaneous cell death by inhibiting overproduction of active-caspase-3.

Biochim Biophys Acta 2010 May 3;1803(5):527-33. Epub 2010 Mar 3.

Division of Molecular Biology, Institute for Health Sciences, Tokushima Bunri University, Tokushima, Japan.

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http://dx.doi.org/10.1016/j.bbamcr.2010.02.007DOI Listing
May 2010

Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.

Virology 2009 Nov 24;394(2):227-34. Epub 2009 Sep 24.

Department of AIDS Research, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.

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http://dx.doi.org/10.1016/j.virol.2009.08.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111982PMC
November 2009

Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis.

J Clin Invest 2009 Nov 1;119(11):3340-55. Epub 2009 Oct 1.

Veterans Affairs Greater Los Angeles Healthcare System and University of California at Los Angeles, Los Angeles, California 90073, USA.

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http://dx.doi.org/10.1172/JCI38674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769194PMC
November 2009

[Structure-based drug development and medical/biological application of cathepsin specific inhibitors].

Seikagaku 2009 Nov;81(11):952-61

Institute for Health Sciences, Tokushima Bumi University, 180 Nishihamabouji, Yamashiro-cho, Tokushima City, Tokushima 770-8514, Japan.

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November 2009

Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis.

J Virol 2009 Oct 29;83(19):9630-40. Epub 2009 Jul 29.

Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1128/JVI.01095-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748054PMC
October 2009

Structural basis for the kexin-like serine protease from Aeromonas sobria as sepsis-causing factor.

J Biol Chem 2009 Oct 4;284(40):27655-63. Epub 2009 Aug 4.

Laboratory of Molecular Microbiological Science, Faculty of Pharmaceutical Sciences, Hiroshima International University, Hiro-Koshingai, Kure, Hiroshima 737-0112, Japan.

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http://www.jbc.org/content/284/40/27655.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M109.006114
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http://dx.doi.org/10.1074/jbc.M109.006114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785694PMC
October 2009

Inhibition of collagenolytic cathepsins by beta-lactoglobulin in milk and its suppressive effect on bone resorption.

J Nutr Sci Vitaminol (Tokyo) 2009 Jun;55(3):264-70

Faculty of Life Science, Tokushima Bunri University, Tokushima, Japan.

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http://dx.doi.org/10.3177/jnsv.55.264DOI Listing
June 2009

Reciprocal relationship between the apoptosis pathway mediated by executioner caspases and the physiological NAD synthesis pathway.

Adv Enzyme Regul 2008 22;48:19-30. Epub 2007 Nov 22.

Institute for Health Sciences, Tokushima Bunri University, 180 Nishihamabouji, Yamashiro-cho, Tokushima City, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1016/j.advenzreg.2007.11.007DOI Listing
December 2008

Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells.

J Immunol 2008 Dec;181(11):7525-36

Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.4049/jimmunol.181.11.7525DOI Listing
December 2008

Structure of an archaeal alanine:glyoxylate aminotransferase.

Acta Crystallogr D Biol Crystallogr 2008 Jun 14;64(Pt 6):696-9. Epub 2008 May 14.

Department of Life System, Institute of Technology and Science, The University of Tokushima, 2-1 Minamijosanjima-cho, Tokushima 770-8506, Japan.

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http://dx.doi.org/10.1107/S0907444908006732DOI Listing
June 2008

Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens iota-toxin.

Proc Natl Acad Sci U S A 2008 May 19;105(21):7399-404. Epub 2008 May 19.

Institute for Health Sciences and Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Yamashiro-cho, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1073/pnas.0801215105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387182PMC
May 2008

Structure of l-aspartate oxidase from the hyperthermophilic archaeon Sulfolobus tokodaii.

Biochim Biophys Acta 2008 Mar 8;1784(3):563-71. Epub 2008 Jan 8.

Department of Life System, Institute of Technology and Science, The University of Tokushima, 2-1 Minamijosanjima-cho, Tokushima 770-8506, Japan.

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http://dx.doi.org/10.1016/j.bbapap.2007.12.012DOI Listing
March 2008

Cathepsin L activity controls adipogenesis and glucose tolerance.

Nat Cell Biol 2007 Aug 22;9(8):970-7. Epub 2007 Jul 22.

Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncb1623DOI Listing
August 2007

Crystal structure of archaeal highly thermostable L-aspartate dehydrogenase/NAD/citrate ternary complex.

FEBS J 2007 Aug 25;274(16):4315-25. Epub 2007 Jul 25.

Institute of Genetic Resources, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1111/j.1742-4658.2007.05961.xDOI Listing
August 2007

Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus.

J Biol Chem 2006 Jun 4;281(23):16157-67. Epub 2006 Apr 4.

Structural Biophysics Laboratory, RIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto, Sayo, Hyogo 679-5148, Japan.

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http://dx.doi.org/10.1074/jbc.M601089200DOI Listing
June 2006

A novel apoptosis cascade mediated by lysosomal lactoferrin and its participation in hepatocyte apoptosis induced by D-galactosamine.

FEBS Lett 2006 Jun 5;580(15):3699-705. Epub 2006 Jun 5.

Institute for Health Sciences, Tokushima Bunri University, 180 Nishihamabouji, Yamashiro-cho, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1016/j.febslet.2006.05.057DOI Listing
June 2006

Significance of 32-kDa cathepsin L secreted from cancer cells.

Cancer Biother Radiopharm 2006 Jun;21(3):217-24

Department of Biochemistry, School of Dentistry, Aichi-Gakuin University, Chikusa-ku, Nagoya, Japan.

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http://dx.doi.org/10.1089/cbr.2006.21.217DOI Listing
June 2006

Catechin derivatives: specific inhibitor for caspases-3, 7 and 2, and the prevention of apoptosis at the cell and animal levels.

FEBS Lett 2006 Feb 6;580(3):741-6. Epub 2006 Jan 6.

Tokushima Bunri University, Institute for Health Sciences, 180 Nishihamabouji, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1016/j.febslet.2005.12.087DOI Listing
February 2006

Changes of glucose metabolism and skin-collagen neogenesis in vitamin B6 deficiency.

Biofactors 2005 ;23(2):59-67

Tokushima Bunri University, Faculty of Life Science, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1002/biof.5520230201DOI Listing
November 2005

IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells.

Immunity 2005 Nov;23(5):491-502

Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama 230-0045, Japan.

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http://dx.doi.org/10.1016/j.immuni.2005.09.010DOI Listing
November 2005

Crystal structure of a novel FAD-, FMN-, and ATP-containing L-proline dehydrogenase complex from Pyrococcus horikoshii.

J Biol Chem 2005 Sep 15;280(35):31045-9. Epub 2005 Jul 15.

Institute for Health Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1074/jbc.C500234200DOI Listing
September 2005

A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3.

FEBS J 2005 Aug;272(16):4044-54

Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, Japan.

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http://dx.doi.org/10.1111/j.1742-4658.2005.04810.xDOI Listing
August 2005

Crystal structure of the NAD biosynthetic enzyme quinolinate synthase.

J Biol Chem 2005 Jul 3;280(29):26645-8. Epub 2005 Jun 3.

Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minamijosanjima-cho, Tokushima 770-8506.

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http://dx.doi.org/10.1074/jbc.C500192200DOI Listing
July 2005

The first crystal structure of an archaeal helical repeat protein.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Jul 30;61(Pt 7):636-9. Epub 2005 Jun 30.

Department of Biological Science and Technology, Faculty of Engineering, University of Tokushima, Tokushima 770-8506, Japan.

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http://dx.doi.org/10.1107/S1744309105019263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952456PMC
July 2005

New apoptosis cascade mediated by lysosomal enzyme and its protection by epigallo-catechin gallate.

Adv Enzyme Regul 2004 ;44:1-10

Institute for Health Sciences, Tokushima Bunri University, 180 Bouji, Nishihama, Yamashiro-cho, Tokushima-shi, Tokushima-ken 770-8514, Japan.

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http://dx.doi.org/10.1016/j.advenzreg.2003.11.016DOI Listing
March 2005

Critical role of cathepsin-inhibitors for autoantigen processing and autoimmunity.

Adv Enzyme Regul 2004 ;44:309-20

Department of Pathology, School of Dentistry, Tokushima University, 3 Kuramoto-cho, Tokushima 770-8504, Japan.

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http://dx.doi.org/10.1016/j.advenzreg.2003.11.004DOI Listing
March 2005

Reverse zymography using fluorogenic substrates for protease inhibitor detection.

Electrophoresis 2005 Mar;26(6):1038-45

Tokushima Bunri University, Institute for Health Sciences, 180 Nishihamabouji, Yamashiro-cho, Tokushima City, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1002/elps.200306142DOI Listing
March 2005

Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells.

J Med Invest 2005 Feb;52(1-2):1-9

Takeda Pharmaceutical Company, Ltd., Pharmacology Research Laboratories I, Osaka, Japan.

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http://dx.doi.org/10.2152/jmi.52.1DOI Listing
February 2005

The first crystal structure of hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum.

J Mol Biol 2005 Jan;345(2):325-37

Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minamijosanjimacho, Tokushima 770-8506, Japan.

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http://dx.doi.org/10.1016/j.jmb.2004.10.063DOI Listing
January 2005

Crystallization and preliminary X-ray diffraction analysis of homing endonuclease I-Tsp061I.

Acta Crystallogr D Biol Crystallogr 2004 Nov 20;60(Pt 11):2006-8. Epub 2004 Oct 20.

Institute for Health Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1107/S0907444904020232DOI Listing
November 2004

Crystallization and preliminary X-ray diffraction analysis of the hyperthermostable NAD-dependent glutamate dehydrogenase from Pyrobaculum islandicum.

Acta Crystallogr D Biol Crystallogr 2004 Apr 23;60(Pt 4):715-7. Epub 2004 Mar 23.

Department of Biological Science and Technology, Faculty of Engineering,The University of Tokushima, 2-1 Minamijosanjima-cho, Tokushima 770-8506, Japan.

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http://dx.doi.org/10.1107/S0907444904001854DOI Listing
April 2004

Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.

Microbes Infect 2004 Apr;6(5):468-74

Department Microbiology and Immunology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.micinf.2004.01.008DOI Listing
April 2004

Significant accumulations of cathepsin B and prolylendopeptidase in inflammatory focus of delayed-type hypersensitivity induced by Mycobacterium tuberculosis in mice.

Biochem Biophys Res Commun 2004 Mar;316(1):78-84

Department of Materials Systems Engineering, Kagawa University, 2217-20 Hayashi-cho, Takamatsu 761-0396, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2004.01.176DOI Listing
March 2004

Clostridium perfringens iota-toxin, ADP-ribosyltransferase: structure and mechanism of action.

Adv Enzyme Regul 2003 ;43:361-77

Faculty of Pharmaceutical Sciences, Department of Microbiology, Tokushima Bunri University, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1016/s0065-2571(02)00044-4DOI Listing
January 2004

Medical significance of cysteine protease inhibitors in mammalian secretory fluids.

J Med Invest 2003 Aug;50(3-4):154-61

Tokushima Bunri University, Institute for Health Sciences, Tokushima, Japan.

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August 2003

Insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors.

Biol Chem 2003 Jun;384(6):883-90

Tokushima Bunri University, Institute for Health Sciences, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1515/BC.2003.099DOI Listing
June 2003

Isolation and characterization of a novel and potent inhibitor of Arg-gingipain from Streptomyces sp. strain FA-70.

Biol Chem 2003 Jun;384(6):911-20

Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1515/BC.2003.102DOI Listing
June 2003

Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors.

Biol Chem 2003 Mar;384(3):447-55

Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Vecna pot 111, SI-1000 Ljubljana, Slovenia.

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http://dx.doi.org/10.1515/BC.2003.050DOI Listing
March 2003

Crystal structure and site-directed mutagenesis of enzymatic components from Clostridium perfringens iota-toxin.

J Mol Biol 2003 Jan;325(3):471-83

Institute for Health Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.

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http://dx.doi.org/10.1016/s0022-2836(02)01247-0DOI Listing
January 2003

Chondroitin sulfate proteoglycan is a potent enhancer in the processing of procathepsin L.

Biol Chem 2002 Dec;383(12):1925-9

Faculty of Health and Living Science, Naruto University of Education, Naruto 772-8502, Japan.

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http://dx.doi.org/10.1515/BC.2002.216DOI Listing
December 2002

Crystallization and preliminary X-ray diffraction analysis of glutamate dehydrogenase from an aerobic hyperthermophilic archaeon, Aeropyrum pernix K1.

Acta Crystallogr D Biol Crystallogr 2002 Aug 20;58(Pt 8):1338-9. Epub 2002 Jul 20.

Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, 2-1 Minamijosanjimacho, Tokushima 770-8506, Japan.

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http://dx.doi.org/10.1107/s0907444902008478DOI Listing
August 2002

Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity.

J Clin Invest 2002 Aug;110(3):361-9

Department of Pathology, Tokushima University School of Dentistry, Tokushima, Japan.

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http://dx.doi.org/10.1172/JCI14682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151084PMC
August 2002

Crystallization and preliminary X-ray crystallographic studies of monoacylglycerol lipase of the moderately thermophilic Bacillus sp. H-257.

Acta Crystallogr D Biol Crystallogr 2002 Jul 20;58(Pt 7):1232-3. Epub 2002 Jun 20.

Institute for Health Sciences, Tokushima Bunri University, Yamashiro-cho, Japan.

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http://dx.doi.org/10.1107/s0907444902006169DOI Listing
July 2002

Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia.

J Biol Chem 2002 Feb 21;277(7):4816-22. Epub 2001 Nov 21.

Department of Pharmacology, Graduate School of Dental Science, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1074/jbc.M108382200DOI Listing
February 2002

A cysteine protease inhibitor prevents suspension-induced declines in bone weight and strength in rats.

J Physiol Anthropol Appl Human Sci 2002 Jan;21(1):51-7

Department of Nutrition, School of Medicine, University of Tokushima.

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http://dx.doi.org/10.2114/jpa.21.51DOI Listing
January 2002