Publications by authors named "Katsuya Tsuchihara"

94Publications

Potentiality of multiple modalities for single-cell analyses to evaluate the tumor microenvironment in clinical specimens.

Authors:
Yukie Kashima Yosuke Togashi Shota Fukuoka Takahiro Kamada Takuma Irie Ayako Suzuki Yoshiaki Nakamura Kohei Shitara Tatsunori Minamide Taku Yoshida Naofumi Taoka Tatsuya Kawase Teiji Wada Koichiro Inaki Masataka Chihara Yukihiko Ebisuno Sakiyo Tsukamoto Ryo Fujii Akihiro Ohashi Yutaka Suzuki Katsuya Tsuchihara Hiroyoshi Nishikawa Toshihiko Doi

Sci Rep 2021 Jan 11;11(1):341. Epub 2021 Jan 11.

Experimental Therapeutics, National Cancer Center Hospital East, Chiba, Japan.

View Article and Find Full Text PDF
January 2021

Simultaneous quantification of arctigenin and its glucuronide conjugate in mouse plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry.

Authors:
Yosuke Suzuki Michiko Sato Takuya Awazuhara Yusuke Nukui Airi Yoshida Tomoka Terashima Keita Watanabe Rumi Fujioka Katsuya Tsuchihara Satoshi Kishino Keiko Ohno

J Sep Sci 2021 Jan 2. Epub 2021 Jan 2.

Department of Medication Use Analysis and Clinical Research, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan.

View Article and Find Full Text PDF
January 2021

The initial assessment of expert panel performance in core hospitals for cancer genomic medicine in Japan.

Authors:
Kuniko Sunami Yoichi Naito Eriko Aimono Toraji Amano Daisuke Ennishi Hidenori Kage Masashi Kanai Keigo Komine Takafumi Koyama Takahiro Maeda Sachi Morita Daisuke Sakai Shinji Kohsaka Katsuya Tsuchihara Takayuki Yoshino

Int J Clin Oncol 2021 Jan 1. Epub 2021 Jan 1.

Department of Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa-shi, Chiba, 277-8577, Japan.

View Article and Find Full Text PDF
January 2021

Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1).

Authors:
Yoichi Naito Hiroyuki Aburatani Toraji Amano Eishi Baba Toru Furukawa Tetsu Hayashida Eiso Hiyama Sadakatsu Ikeda Masashi Kanai Motohiro Kato Ichiro Kinoshita Naomi Kiyota Takashi Kohno Shinji Kohsaka Keigo Komine Itaru Matsumura Yuji Miura Yoshiaki Nakamura Atsushi Natsume Kazuto Nishio Katsutoshi Oda Naoyuki Oda Natsuko Okita Kumiko Oseto Kuniko Sunami Hideaki Takahashi Masayuki Takeda Shimon Tashiro Shinichi Toyooka Hideki Ueno Shinichi Yachida Takayuki Yoshino Katsuya Tsuchihara

Int J Clin Oncol 2020 Nov 29. Epub 2020 Nov 29.

Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

View Article and Find Full Text PDF
November 2020

Identification of the mutation signature of the cancer genome caused by irradiation.

Authors:
Shun-Ichiro Kageyama Junyan Du Syuzo Kaneko Ryuji Hamamoto Shigeo Yamaguchi Riu Yamashita Masayuki Okumura Atsushi Motegi Hidehiro Hojo Masaki Nakamura Katsuya Tsuchihara Tetsuo Akimoto

Radiother Oncol 2020 Oct 17;155:10-16. Epub 2020 Oct 17.

Division of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, Japan; Department of Radiation Oncology, National Cancer Center Hospital East, , Japan.

View Article and Find Full Text PDF
October 2020

Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies.

Authors:
Yoshiaki Nakamura Hiroya Taniguchi Masafumi Ikeda Hideaki Bando Ken Kato Chigusa Morizane Taito Esaki Yoshito Komatsu Yasuyuki Kawamoto Naoki Takahashi Makoto Ueno Yoshinori Kagawa Tomohiro Nishina Takeshi Kato Yoshiyuki Yamamoto Junji Furuse Tadamichi Denda Hisato Kawakami Eiji Oki Takako Nakajima Naohiro Nishida Kensei Yamaguchi Hisateru Yasui Masahiro Goto Nobuhisa Matsuhashi Koushiro Ohtsubo Kentaro Yamazaki Akihito Tsuji Wataru Okamoto Katsuya Tsuchihara Takeharu Yamanaka Izumi Miki Yasutoshi Sakamoto Hiroko Ichiki Masayuki Hata Riu Yamashita Atsushi Ohtsu Justin I Odegaard Takayuki Yoshino

Nat Med 2020 12 5;26(12):1859-1864. Epub 2020 Oct 5.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

View Article and Find Full Text PDF
December 2020

Long-read sequencing for non-small-cell lung cancer genomes.

Authors:
Yoshitaka Sakamoto Liu Xu Masahide Seki Toshiyuki T Yokoyama Masahiro Kasahara Yukie Kashima Akihiro Ohashi Yoko Shimada Noriko Motoi Katsuya Tsuchihara Susumu S Kobayashi Takashi Kohno Yuichi Shiraishi Ayako Suzuki Yutaka Suzuki

Genome Res 2020 Sep 4;30(9):1243-1257. Epub 2020 Sep 4.

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8562, Japan.

View Article and Find Full Text PDF
September 2020

Association between the mutational smoking signature and the immune microenvironment in lung adenocarcinoma.

Authors:
Kei Sato Sachiyo Mimaki Riu Yamashita Yosuke Togashi Tomoyuki Naito Hibiki Udagawa Shinya Katsumata Shoko Nakasone Tomohiro Miyoshi Kenta Tane Keiju Aokage Masato Sugano Motohiro Kojima Satoshi Fujii Takeshi Kuwata Atsushi Ochiai Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Genichiro Ishii

Lung Cancer 2020 09 1;147:12-20. Epub 2020 Jul 1.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan. Electronic address:

View Article and Find Full Text PDF
September 2020

PARP inhibitor olaparib sensitizes esophageal carcinoma cells to fractionated proton irradiation.

Authors:
Shun-Ichiro Kageyama Du Junyan Hidehiro Hojo Atsushi Motegi Masaki Nakamura Katsuya Tsuchihara Tetsuo Akimoto

J Radiat Res 2020 Mar;61(2):177-186

National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
March 2020

Japan society of clinical oncology/Japanese society of medical oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors, cooperated by the Japanese society of pediatric hematology/oncology.

Authors:
Yoichi Naito Saori Mishima Kiwamu Akagi Ataru Igarashi Masafumi Ikeda Susumu Okano Shunsuke Kato Tadao Takano Katsuya Tsuchihara Keita Terashima Hiroshi Nishihara Hiroyki Nishiyama Eiso Hiyama Akira Hirasawa Hajime Hosoi Osamu Maeda Yasushi Yatabe Wataru Okamoto Shigeru Ono Hiroaki Kajiyama Fumio Nagashima Yutaka Hatanaka Mitsuru Miyachi Yasuhiro Kodera Takayuki Yoshino Hiroya Taniguchi

Int J Clin Oncol 2020 Mar 24;25(3):403-417. Epub 2020 Jan 24.

Department of Breast and Medical Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

View Article and Find Full Text PDF
March 2020

Characterization of cancer omics and drug perturbations in panels of lung cancer cells.

Authors:
Ayako Suzuki Keiichi Onodera Ken Matsui Masahide Seki Hiroyasu Esumi Tomoyoshi Soga Sumio Sugano Takashi Kohno Yutaka Suzuki Katsuya Tsuchihara

Sci Rep 2019 12 20;9(1):19529. Epub 2019 Dec 20.

Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.

View Article and Find Full Text PDF
December 2019

Histopathological factors affecting the extraction of high quality genomic DNA from tissue sections for next-generation sequencing.

Authors:
Satoshi Fujii Takayuki Yoshino Kentaro Yamazaki Kei Muro Kensei Yamaguchi Tomohiro Nishina Satoshi Yuki Eiji Shinozaki Kohei Shitara Hideaki Bando Sachiyo Mimaki Chikako Nakai Koutatsu Matsushima Yutaka Suzuki Kiwamu Akagi Takeharu Yamanaka Shogo Nomura Hiroyasu Esumi Masaya Sugiyama Nao Nishida Masashi Mizokami Yasuhiro Koh Yukiko Abe Atsushi Ohtsu Katsuya Tsuchihara

Biomed Rep 2019 Oct 21;11(4):171-180. Epub 2019 Aug 21.

Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
October 2019

Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition.

Authors:
Saori Mishima Hiroya Taniguchi Kiwamu Akagi Eishi Baba Yutaka Fujiwara Akira Hirasawa Masafumi Ikeda Osamu Maeda Kei Muro Hiroshi Nishihara Hiroyki Nishiyama Tadao Takano Katsuya Tsuchihara Yasushi Yatabe Yasuhiro Kodera Takayuki Yoshino

Int J Clin Oncol 2020 Feb 8;25(2):217-239. Epub 2019 Jul 8.

Department of Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

View Article and Find Full Text PDF
February 2020

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry.

Authors:
Ami Maruyama Kenjiro Kami Kazunori Sasaki Hajime Sato Yuzo Sato Katsuya Tsuchihara Hideki Makinoshima

J Vis Exp 2019 06 9(148). Epub 2019 Jun 9.

Shonai Regional Industry Promotion Center; Tsuruoka Metabolomics Laboratory, National Cancer Center; Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center;

View Article and Find Full Text PDF
June 2019

Multifocal origin of occupational cholangiocarcinoma revealed by comparison of multilesion mutational profiles.

Authors:
Sachiyo Mimaki Masahiko Watanabe Masahiko Kinoshita Riu Yamashita Hiroshi Haeno Shigekazu Takemura Shogo Tanaka Shigeru Marubashi Yukari Totsuka Tatsuhiro Shibata Hitoshi Nakagama Atsushi Ochiai Shoji Nakamori Shoji Kubo Katsuya Tsuchihara

Carcinogenesis 2020 05;41(3):368-376

Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwanoha, Kashiwa, Chiba, Japan.

View Article and Find Full Text PDF
May 2020

Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare mutations.

Authors:
Shinnosuke Ikemura Hiroyuki Yasuda Shingo Matsumoto Mayumi Kamada Junko Hamamoto Keita Masuzawa Keigo Kobayashi Tadashi Manabe Daisuke Arai Ichiro Nakachi Ichiro Kawada Kota Ishioka Morio Nakamura Ho Namkoong Katsuhiko Naoki Fumie Ono Mitsugu Araki Ryo Kanada Biao Ma Yuichiro Hayashi Sachiyo Mimaki Kiyotaka Yoh Susumu S Kobayashi Takashi Kohno Yasushi Okuno Koichi Goto Katsuya Tsuchihara Kenzo Soejima

Proc Natl Acad Sci U S A 2019 05 1;116(20):10025-10030. Epub 2019 May 1.

Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Shinjuku-ku, 160-8582 Tokyo, Japan.

View Article and Find Full Text PDF
May 2019

Comparative sequence analysis of patient-matched primary colorectal cancer, metastatic, and recurrent metastatic tumors after adjuvant FOLFOX chemotherapy.

Authors:
Kazuaki Harada Wataru Okamoto Sachiyo Mimaki Yasuyuki Kawamoto Hideaki Bando Riu Yamashita Satoshi Yuki Takayuki Yoshino Yoshito Komatsu Atsushi Ohtsu Naoya Sakamoto Katsuya Tsuchihara

BMC Cancer 2019 Mar 21;19(1):255. Epub 2019 Mar 21.

Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

View Article and Find Full Text PDF
March 2019

Effect of 5-fluorouracil on cellular response to proton beam in esophageal cancer cell lines according to the position of spread-out Bragg peak.

Authors:
Hidehiro Hojo Takeshi Dohmae Kenji Hotta Shun-Ichiro Kageyama Hiromi Baba Ryosuke Kohno Atsushi Motegi Katsuya Tsuchihara Tetsuo Akimoto

Acta Oncol 2019 Apr 11;58(4):475-482. Epub 2019 Jan 11.

a Division of Radiation Oncology and Particle Therapy , National Cancer Center Hospital East, Kashiwa , Chiba , Japan.

View Article and Find Full Text PDF
April 2019

Genetic profiling-based prognostic prediction of patients with advanced small-cell lung cancer in large scale analysis.

Authors:
Hibiki Udagawa Shigeki Umemura Isao Murakami Sachiyo Mimaki Hideki Makinoshima Genichiro Ishii Tomohiro Miyoshi Keisuke Kirita Shingo Matsumoto Kiyotaka Yoh Seiji Niho Katsuya Tsuchihara Koichi Goto

Lung Cancer 2018 12 12;126:182-188. Epub 2018 Nov 12.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

View Article and Find Full Text PDF
December 2018

Characterization of the tumor immune-microenvironment of lung adenocarcinoma associated with usual interstitial pneumonia.

Authors:
Takuya Ueda Keiju Aokage Sachiyo Mimaki Kenta Tane Tomohiro Miyoshi Masato Sugano Motohiro Kojima Satoshi Fujii Takeshi Kuwata Atsushi Ochiai Masahiko Kusumoto Kenji Suzuki Katsuya Tsuchihara Hiroyoshi Nishikawa Koichi Goto Masahiro Tsuboi Genichiro Ishii

Lung Cancer 2018 12 6;126:162-169. Epub 2018 Nov 6.

Division of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan. Electronic address:

View Article and Find Full Text PDF
December 2018

Evaluation and application of RNA-Seq by MinION.

Authors:
Masahide Seki Eri Katsumata Ayako Suzuki Sarun Sereewattanawoot Yoshitaka Sakamoto Junko Mizushima-Sugano Sumio Sugano Takashi Kohno Martin C Frith Katsuya Tsuchihara Yutaka Suzuki

DNA Res 2019 Feb;26(1):55-65

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.

View Article and Find Full Text PDF
February 2019

Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells.

Authors:
Yuzo Sato Shiori Matsuda Ami Maruyama Joji Nakayama Tomoyuki Miyashita Hibiki Udagawa Shigeki Umemura Kazuyoshi Yanagihara Atsushi Ochiai Masaru Tomita Tomoyoshi Soga Katsuya Tsuchihara Hideki Makinoshima

Front Pharmacol 2018 12;9:1129. Epub 2018 Oct 12.

Tsuruoka Metabolomics Laboratory, National Cancer Center, Tsuruoka, Japan.

View Article and Find Full Text PDF
October 2018

Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (Edition 1.0).

Authors:
Kuniko Sunami Hideaki Takahashi Katsuya Tsuchihara Masayuki Takeda Tatsuya Suzuki Yoichi Naito Kazuko Sakai Hirotoshi Dosaka-Akita Chikashi Ishioka Yasuhiro Kodera Manabu Muto Toshifumi Wakai Kentaro Yamazaki Wataru Yasui Hideaki Bando Yumi Fujimoto Shota Fukuoka Kenichi Harano Akihito Kawazoe Gen Kimura Shigehiro Koganemaru Takahiro Kogawa Daisuke Kotani Yasutoshi Kuboki Hiroshi Matsumoto Shingo Matsumoto Saori Mishima Yoshiaki Nakamura Kentaro Sawada Sumito Shingaki Kohei Shitara Kumiko Umemoto Shigeki Umemura Kayo Yasuda Takayuki Yoshino Noboru Yamamoto Kazuto Nishio

Cancer Sci 2018 Sep;109(9):2980-2985

Department of Genome Biology, Kindai University, Faculty of Medicine, Osaka, Japan.

View Article and Find Full Text PDF
September 2018

A computational tool to detect DNA alterations tailored to formalin-fixed paraffin-embedded samples in cancer clinical sequencing.

Authors:
Mamoru Kato Hiromi Nakamura Momoko Nagai Takashi Kubo Asmaa Elzawahry Yasushi Totoki Yuko Tanabe Eisaku Furukawa Joe Miyamoto Hiromi Sakamoto Shingo Matsumoto Kuniko Sunami Yasuhito Arai Yutaka Suzuki Teruhiko Yoshida Katsuya Tsuchihara Kenji Tamura Noboru Yamamoto Hitoshi Ichikawa Takashi Kohno Tatsuhiro Shibata

Genome Med 2018 06 7;10(1):44. Epub 2018 Jun 7.

Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan.

View Article and Find Full Text PDF
June 2018

Japanese Society of Medical Oncology Clinical Guidelines: Molecular Testing for Colorectal Cancer Treatment, Third Edition.

Authors:
Kentaro Yamazaki Hiroya Taniguchi Takayuki Yoshino Kiwamu Akagi Hideyuki Ishida Hiromichi Ebi Kaname Nakatani Kei Muro Yasushi Yatabe Kensei Yamaguchi Katsuya Tsuchihara

Cancer Sci 2018 Jun;109(6):2074-2079

Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.

View Article and Find Full Text PDF
June 2018

Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer.

Authors:
Rumi Fujioka Nobuo Mochizuki Masafumi Ikeda Akihiro Sato Shogo Nomura Satoshi Owada Satoshi Yomoda Katsuya Tsuchihara Satoshi Kishino Hiroyasu Esumi

PLoS One 2018 1;13(6):e0198219. Epub 2018 Jun 1.

Research Institute for Biomedical Sciences, Tokyo University of Science, Noda, Japan.

View Article and Find Full Text PDF
December 2018

Correction: Radiotherapy increases plasma levels of tumoral cell-free DNA in non-small cell lung cancer patients.

Authors:
Shun-Ichiro Kageyama Keiji Nihei Katsuyuki Karasawa Takeshi Sawada Fumiaki Koizumi Shigeo Yamaguchi Shunsuke Kato Hidehiro Hojo Atsushi Motegi Katsuya Tsuchihara Tetsuo Akimoto

Oncotarget 2018 05 4;9(34):23844. Epub 2018 May 4.

National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
May 2018

Radiotherapy increases plasma levels of tumoral cell-free DNA in non-small cell lung cancer patients.

Authors:
Shun-Ichiro Kageyama Keiji Nihei Katsuyuki Karasawa Takeshi Sawada Fumiaki Koizumi Shigeo Yamaguchi Shunsuke Kato Hidehiro Hojo Atsuhi Motegi Katsuya Tsuchihara Tetsuo Akimoto

Oncotarget 2018 Apr 10;9(27):19368-19378. Epub 2018 Apr 10.

National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
April 2018

Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells by mTOR activation through Akt-independent pathway.

Authors:
Shota Yamazaki Youichi Higuchi Masayuki Ishibashi Hiroko Hashimoto Masahiro Yasunaga Yasuhiro Matsumura Katsuya Tsuchihara Masahiro Tsuboi Koichi Goto Atsushi Ochiai Genichiro Ishii

Cancer Sci 2018 Jun;109(6):2063-2073

Laboratory of Cancer Biology, Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.

View Article and Find Full Text PDF
June 2018

Reply to `Comment on `Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehensive Cancer genomics (BREAC) study''.

Authors:
Eiji Shinozaki Takayuki Yoshino Katsuya Tsuchihara

Br J Cancer 2018 05 22;118(9):1278-1279. Epub 2018 Mar 22.

Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.

View Article and Find Full Text PDF
May 2018

Identification of potential regulatory mutations using multi-omics analysis and haplotyping of lung adenocarcinoma cell lines.

Authors:
Sarun Sereewattanawoot Ayako Suzuki Masahide Seki Yoshitaka Sakamoto Takashi Kohno Sumio Sugano Katsuya Tsuchihara Yutaka Suzuki

Sci Rep 2018 03 21;8(1):4926. Epub 2018 Mar 21.

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Chiba, Japan.

View Article and Find Full Text PDF
March 2018

Podoplanin-positive cancer-associated fibroblast recruitment within cancer stroma is associated with a higher number of single nucleotide variants in cancer cells in lung adenocarcinoma.

Authors:
Shoko Nakasone Sachiyo Mimaki Tomohiro Ichikawa Keiju Aokage Tomohiro Miyoshi Masato Sugano Motohiro Kojima Satoshi Fujii Takeshi Kuwata Atsushi Ochiai Masahiro Tsuboi Koichi Goto Katsuya Tsuchihara Genichiro Ishii

J Cancer Res Clin Oncol 2018 May 6;144(5):893-900. Epub 2018 Mar 6.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

View Article and Find Full Text PDF
May 2018

Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.

Authors:
Hideki Makinoshima Shigeki Umemura Ayako Suzuki Hiroki Nakanishi Ami Maruyama Hibiki Udagawa Sachiyo Mimaki Shingo Matsumoto Seiji Niho Genichiro Ishii Masahiro Tsuboi Atsushi Ochiai Hiroyasu Esumi Takehiko Sasaki Koichi Goto Katsuya Tsuchihara

Cancer Res 2018 05 28;78(9):2179-2190. Epub 2018 Feb 28.

Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan.

View Article and Find Full Text PDF
May 2018

Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response.

Authors:
Yukie Kashima Ayako Suzuki Ying Liu Masahito Hosokawa Hiroko Matsunaga Masataka Shirai Kohji Arikawa Sumio Sugano Takashi Kohno Haruko Takeyama Katsuya Tsuchihara Yutaka Suzuki

Sci Rep 2018 02 22;8(1):3482. Epub 2018 Feb 22.

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, 277-8562, Japan.

View Article and Find Full Text PDF
February 2018

A secondary RET mutation in the activation loop conferring resistance to vandetanib.

Authors:
Takashi Nakaoku Takashi Kohno Mitsugu Araki Seiji Niho Rakhee Chauhan Phillip P Knowles Katsuya Tsuchihara Shingo Matsumoto Yoko Shimada Sachiyo Mimaki Genichiro Ishii Hitoshi Ichikawa Satoru Nagatoishi Kouhei Tsumoto Yasushi Okuno Kiyotaka Yoh Neil Q McDonald Koichi Goto

Nat Commun 2018 02 12;9(1):625. Epub 2018 Feb 12.

Department of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa-city, Chiba, 2778577, Japan.

View Article and Find Full Text PDF
February 2018

DBTSS/DBKERO for integrated analysis of transcriptional regulation.

Authors:
Ayako Suzuki Shin Kawano Toutai Mitsuyama Mikita Suyama Yae Kanai Katsuhiko Shirahige Hiroyuki Sasaki Katsushi Tokunaga Katsuya Tsuchihara Sumio Sugano Kenta Nakai Yutaka Suzuki

Nucleic Acids Res 2018 01;46(D1):D229-D238

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Chiba, Japan.

View Article and Find Full Text PDF
January 2018

Sequencing and phasing cancer mutations in lung cancers using a long-read portable sequencer.

Authors:
Ayako Suzuki Mizuto Suzuki Junko Mizushima-Sugano Martin C Frith Wojciech Makalowski Takashi Kohno Sumio Sugano Katsuya Tsuchihara Yutaka Suzuki

DNA Res 2017 Dec;24(6):585-596

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan.

View Article and Find Full Text PDF
December 2017

Immunohistochemical and genetic characteristics of lung cancer mimicking organizing pneumonia.

Authors:
Tomohiro Ichikawa Koichi Saruwatari Sachiyo Mimaki Masato Sugano Keiju Aokage Motohiro Kojima Tomoyuki Hishida Satoshi Fujii Junji Yoshida Takeshi Kuwata Atsushi Ochiai Kenji Suzuki Masahiro Tsuboi Koichi Goto Katsuya Tsuchihara Genichiro Ishii

Lung Cancer 2017 11 5;113:134-139. Epub 2017 Oct 5.

Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center Hospital East, Japan. Electronic address:

View Article and Find Full Text PDF
November 2017

Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehensive Cancer genomics (BREAC) study.

Authors:
Eiji Shinozaki Takayuki Yoshino Kentaro Yamazaki Kei Muro Kensei Yamaguchi Tomohiro Nishina Satoshi Yuki Kohei Shitara Hideaki Bando Sachiyo Mimaki Chikako Nakai Koutatsu Matsushima Yutaka Suzuki Kiwamu Akagi Takeharu Yamanaka Shogo Nomura Satoshi Fujii Hiroyasu Esumi Masaya Sugiyama Nao Nishida Masashi Mizokami Yasuhiro Koh Yukiko Abe Atsushi Ohtsu Katsuya Tsuchihara

Br J Cancer 2017 Nov 3;117(10):1450-1458. Epub 2017 Oct 3.

Division of Translational Genomics, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
November 2017

[Current Status and Future Perspectives of SCRUM-Japan].

Authors:
Atsushi Ohtsu Koichi Goto Takayuki Yoshino Wataru Okamoto Katsuya Tsuchihara

Gan To Kagaku Ryoho 2017 Aug;44(8):621-626

National Cancer Center Hospital East.

View Article and Find Full Text PDF
August 2017

Difference in the relative biological effectiveness and DNA damage repair processes in response to proton beam therapy according to the positions of the spread out Bragg peak.

Authors:
Hidehiro Hojo Takeshi Dohmae Kenji Hotta Ryosuke Kohno Atsushi Motegi Atsushi Yagishita Hideki Makinoshima Katsuya Tsuchihara Tetsuo Akimoto

Radiat Oncol 2017 Jul 3;12(1):111. Epub 2017 Jul 3.

Division of Radiation Oncology and Particle Therapy, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

View Article and Find Full Text PDF
July 2017

Rationale for and Design of the PARADIGM Study: Randomized Phase III Study of mFOLFOX6 Plus Bevacizumab or Panitumumab in Chemotherapy-naïve Patients With RAS (KRAS/NRAS) Wild-type, Metastatic Colorectal Cancer.

Authors:
Takayuki Yoshino Hiroyuki Uetake Katsuya Tsuchihara Kohei Shitara Kentaro Yamazaki Eiji Oki Takeo Sato Takeshi Naitoh Yoshito Komatsu Takeshi Kato Kazunori Yamanaka Kouji Iwasaki Jumpei Soeda Masamitsu Hihara Takeharu Yamanaka Atsushi Ochiai Kei Muro

Clin Colorectal Cancer 2017 06 24;16(2):158-163. Epub 2017 Jan 24.

Department of Clinical Oncology and Outpatient Treatment Center, Aichi Cancer Center Hospital, Nagoya, Japan.

View Article and Find Full Text PDF
June 2017

Amplification of EGFR Wild-Type Alleles in Non-Small Cell Lung Cancer Cells Confers Acquired Resistance to Mutation-Selective EGFR Tyrosine Kinase Inhibitors.

Authors:
Shigenari Nukaga Hiroyuki Yasuda Katsuya Tsuchihara Junko Hamamoto Keita Masuzawa Ichiro Kawada Katsuhiko Naoki Shingo Matsumoto Sachiyo Mimaki Shinnosuke Ikemura Koichi Goto Tomoko Betsuyaku Kenzo Soejima

Cancer Res 2017 04 15;77(8):2078-2089. Epub 2017 Feb 15.

Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.

View Article and Find Full Text PDF
April 2017

Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.

Authors:
Tsuyoshi Takahashi Asmaa Elzawahry Sachiyo Mimaki Eisaku Furukawa Rie Nakatsuka Hiromi Nakamura Takahiko Nishigaki Satoshi Serada Tetsuji Naka Seiichi Hirota Tatsuhiro Shibata Katsuya Tsuchihara Toshirou Nishida Mamoru Kato

Genes Chromosomes Cancer 2017 04 23;56(4):303-313. Epub 2017 Jan 23.

Department of Bioinformatics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

View Article and Find Full Text PDF
April 2017

Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells.

Authors:
Atsushi Yagishita Tasuku Ueno Hiroyasu Esumi Hideyuki Saya Kazuhiro Kaneko Katsuya Tsuchihara Yasuteru Urano

Bioconjug Chem 2017 02 15;28(2):302-306. Epub 2016 Dec 15.

CREST, Japan Science and Technology Agency , 7 Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan.

View Article and Find Full Text PDF
February 2017

Vandetanib in patients with previously treated RET-rearranged advanced non-small-cell lung cancer (LURET): an open-label, multicentre phase 2 trial.

Authors:
Kiyotaka Yoh Takashi Seto Miyako Satouchi Makoto Nishio Noboru Yamamoto Haruyasu Murakami Naoyuki Nogami Shingo Matsumoto Takashi Kohno Koji Tsuta Katsuya Tsuchihara Genichiro Ishii Shogo Nomura Akihiro Sato Atsushi Ohtsu Yuichiro Ohe Koichi Goto

Lancet Respir Med 2017 01 4;5(1):42-50. Epub 2016 Nov 4.

Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

View Article and Find Full Text PDF
January 2017

Phase I trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine.

Authors:
Masafumi Ikeda Akihiro Sato Nobuo Mochizuki Kayo Toyosaki Chika Miyoshi Rumi Fujioka Shuichi Mitsunaga Izumi Ohno Yusuke Hashimoto Hideaki Takahashi Hiromi Hasegawa Shogo Nomura Ryuji Takahashi Satoshi Yomoda Katsuya Tsuchihara Satoshi Kishino Hiroyasu Esumi

Cancer Sci 2016 Dec 19;107(12):1818-1824. Epub 2016 Dec 19.

Division of Translational Research, Exploratory Oncology and Clinical Trial Center, National Cancer Center, Kashiwa, Japan.

View Article and Find Full Text PDF
December 2016

Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung.

Authors:
Tomohiro Miyoshi Shigeki Umemura Yuki Matsumura Sachiyo Mimaki Satoshi Tada Hideki Makinoshima Genichiro Ishii Hibiki Udagawa Shingo Matsumoto Kiyotaka Yoh Seiji Niho Hironobu Ohmatsu Keiju Aokage Tomoyuki Hishida Junji Yoshida Kanji Nagai Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara

Clin Cancer Res 2017 Feb 9;23(3):757-765. Epub 2016 Aug 9.

Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.

View Article and Find Full Text PDF
February 2017

Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.

Authors:
Kouya Shiraishi Yukinori Okada Atsushi Takahashi Yoichiro Kamatani Yukihide Momozawa Kyota Ashikawa Hideo Kunitoh Shingo Matsumoto Atsushi Takano Kimihiro Shimizu Akiteru Goto Koji Tsuta Shun-Ichi Watanabe Yuichiro Ohe Yukio Watanabe Yasushi Goto Hiroshi Nokihara Koh Furuta Akihiko Yoshida Koichi Goto Tomoyuki Hishida Masahiro Tsuboi Katsuya Tsuchihara Yohei Miyagi Haruhiko Nakayama Tomoyuki Yokose Kazumi Tanaka Toshiteru Nagashima Yoichi Ohtaki Daichi Maeda Kazuhiro Imai Yoshihiro Minamiya Hiromi Sakamoto Akira Saito Yoko Shimada Kuniko Sunami Motonobu Saito Johji Inazawa Yusuke Nakamura Teruhiko Yoshida Jun Yokota Fumihiko Matsuda Keitaro Matsuo Yataro Daigo Michiaki Kubo Takashi Kohno

Nat Commun 2016 08 9;7:12451. Epub 2016 Aug 9.

Division of Genome Biology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

View Article and Find Full Text PDF
August 2016

Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes.

Authors:
Sachiyo Mimaki Yukari Totsuka Yutaka Suzuki Chikako Nakai Masanori Goto Motohiro Kojima Hirofumi Arakawa Shigekazu Takemura Shogo Tanaka Shigeru Marubashi Masahiko Kinoshita Tomonari Matsuda Tatsuhiro Shibata Hitoshi Nakagama Atsushi Ochiai Shoji Kubo Shoji Nakamori Hiroyasu Esumi Katsuya Tsuchihara

Carcinogenesis 2016 08 7;37(8):817-826. Epub 2016 Jun 7.

Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
August 2016

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.

Authors:
Hideki Makinoshima Masahiro Takita Koichi Saruwatari Shigeki Umemura Yuuki Obata Genichiro Ishii Shingo Matsumoto Eri Sugiyama Atsushi Ochiai Ryo Abe Koichi Goto Hiroyasu Esumi Katsuya Tsuchihara

J Biol Chem 2015 Jul 28;290(28):17495-504. Epub 2015 May 28.

From the Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba 277-8577, Japan, the Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561.

View Article and Find Full Text PDF
July 2015

Expression profiling of receptor tyrosine kinases in high-grade neuroendocrine carcinoma of the lung: a comparative analysis with adenocarcinoma and squamous cell carcinoma.

Authors:
Yuki Matsumura Shigeki Umemura Genichiro Ishii Koji Tsuta Shingo Matsumoto Keiju Aokage Tomoyuki Hishida Junji Yoshida Yuichiro Ohe Hiroyuki Suzuki Atsushi Ochiai Koichi Goto Kanji Nagai Katsuya Tsuchihara

J Cancer Res Clin Oncol 2015 Dec 20;141(12):2159-70. Epub 2015 May 20.

Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan.

View Article and Find Full Text PDF
December 2015

Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment.

Authors:
Ayako Suzuki Koutatsu Matsushima Hideki Makinoshima Sumio Sugano Takashi Kohno Katsuya Tsuchihara Yutaka Suzuki

Genome Biol 2015 Apr 3;16:66. Epub 2015 Apr 3.

Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, 277-8562, Japan.

View Article and Find Full Text PDF
April 2015

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer.

Authors:
Takashi Kohno Takashi Nakaoku Koji Tsuta Katsuya Tsuchihara Shingo Matsumoto Kiyotaka Yoh Koichi Goto

Transl Lung Cancer Res 2015 Apr;4(2):156-64

1 Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan ; 2 Division of Translational Research, Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo and Chiba, Japan ; 3 Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba, Japan ; 4 Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan.

View Article and Find Full Text PDF
April 2015

Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing.

Authors:
Reika Iwakawa Takashi Kohno Yasushi Totoki Tatsuhiro Shibata Katsuya Tsuchihara Sachiyo Mimaki Koji Tsuta Yoshitaka Narita Ryo Nishikawa Masayuki Noguchi Curtis C Harris Ana I Robles Rui Yamaguchi Seiya Imoto Satoru Miyano Hirohiko Totsuka Teruhiko Yoshida Jun Yokota

Carcinogenesis 2015 Jun 11;36(6):616-21. Epub 2015 Apr 11.

Division of Genome Biology, National Cancer Center Research Institute, Tokyo 104-0045, Japan, Cancer Genome Biology Group, Institute of Predictive and Personalized Medicine of Cancer, 08916 Barcelona, Spain

View Article and Find Full Text PDF
June 2015

Japanese Society of Medical Oncology Clinical Guidelines: RAS (KRAS/NRAS) mutation testing in colorectal cancer patients.

Authors:
Hiroya Taniguchi Kentaro Yamazaki Takayuki Yoshino Kei Muro Yasushi Yatabe Toshiaki Watanabe Hiromichi Ebi Atsushi Ochiai Eishi Baba Katsuya Tsuchihara

Cancer Sci 2015 Mar;106(3):324-7

Department of Clinical Oncology, Aichi Cancer Center Hospital, Aichi, Japan.

View Article and Find Full Text PDF
March 2015

Genomic profiling of small-cell lung cancer: the era of targeted therapies.

Authors:
Shigeki Umemura Katsuya Tsuchihara Koichi Goto

Jpn J Clin Oncol 2015 Jun 10;45(6):513-9. Epub 2015 Feb 10.

Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa.

View Article and Find Full Text PDF
June 2015

Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines.

Authors:
Ayako Suzuki Hideki Makinoshima Hiroyuki Wakaguri Hiroyasu Esumi Sumio Sugano Takashi Kohno Katsuya Tsuchihara Yutaka Suzuki

Nucleic Acids Res 2014 Dec 6;42(22):13557-72. Epub 2014 Nov 6.

Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan

View Article and Find Full Text PDF
December 2014

DBTSS as an integrative platform for transcriptome, epigenome and genome sequence variation data.

Authors:
Ayako Suzuki Hiroyuki Wakaguri Riu Yamashita Shin Kawano Katsuya Tsuchihara Sumio Sugano Yutaka Suzuki Kenta Nakai

Nucleic Acids Res 2015 Jan 5;43(Database issue):D87-91. Epub 2014 Nov 5.

Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

View Article and Find Full Text PDF
January 2015

Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells.

Authors:
Oleksandr H Minchenko Katsuya Tsuchihara Dmytro O Minchenko Andreas Bikfalvi Hiroyasu Esumi

World J Gastroenterol 2014 Oct;20(38):13705-17

Oleksandr H Minchenko, Dmytro O Minchenko, Department of Molecular Biology, Palladin Institute of Biochemistry, Kiev 01601, Ukraine.

View Article and Find Full Text PDF
October 2014

Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis.

Authors:
Shigeki Umemura Sachiyo Mimaki Hideki Makinoshima Satoshi Tada Genichiro Ishii Hironobu Ohmatsu Seiji Niho Kiyotaka Yoh Shingo Matsumoto Akiko Takahashi Masahiro Morise Yuka Nakamura Atsushi Ochiai Kanji Nagai Reika Iwakawa Takashi Kohno Jun Yokota Yuichiro Ohe Hiroyasu Esumi Katsuya Tsuchihara Koichi Goto

J Thorac Oncol 2014 Sep;9(9):1324-31

*Division of Thoracic Oncology, National Cancer Center Hospital East; †Exploratory Oncology Research and Clinical Trial Center, National Cancer Center; ‡Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East; §Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Japan; and ‖Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan.

View Article and Find Full Text PDF
September 2014

Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma.

Authors:
Hideki Makinoshima Masahiro Takita Shingo Matsumoto Atsushi Yagishita Satoshi Owada Hiroyasu Esumi Katsuya Tsuchihara

J Biol Chem 2014 Jul;289(30):20813-23

View Article and Find Full Text PDF
July 2014

[Clinical application of next-generation sequencing technologies to achieve cancer precision medicine].

Authors:
Katsuya Tsuchihara

Gan To Kagaku Ryoho 2014 Jan;41(1):1-6

Division of Translational Research and Clinical Trial Center, National Cancer Center.

View Article and Find Full Text PDF
January 2014

RET-targeting molecular stratified non-small-cell lung cancers.

Authors:
Katsuya Tsuchihara

Transl Lung Cancer Res 2013 Dec;2(6):463-5

Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
December 2013

Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines.

Authors:
Tomomitsu Nasuno Sachiyo Mimaki Makito Okamoto Hiroyasu Esumi Katsuya Tsuchihara

Cancer Sci 2014 Feb 5;105(2):202-10. Epub 2013 Dec 5.

Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan; Department of Otorhinolaryngology, University of Kitasato Hospital, Minami-ku, Sagamihara, Kanagawa, Japan.

View Article and Find Full Text PDF
February 2014

Distinct clinicopathologic characteristics of lung mucinous adenocarcinoma with KRAS mutation.

Authors:
Hideomi Ichinokawa Genichiro Ishii Kanji Nagai Akikazu Kawase Junji Yoshida Mitsuyo Nishimura Tomoyuki Hishida Naomi Ogasawara Katsuya Tsuchihara Atsushi Ochiai

Hum Pathol 2013 Dec 10;44(12):2636-42. Epub 2013 Oct 10.

Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577 Chiba, Japan; Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577 Chiba, Japan; Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, 277-8577 Chiba, Japan.

View Article and Find Full Text PDF
December 2013

Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterparts.

Authors:
Ayako Suzuki Sachiyo Mimaki Yuki Yamane Akikazu Kawase Koutatsu Matsushima Makito Suzuki Koichi Goto Sumio Sugano Hiroyasu Esumi Yutaka Suzuki Katsuya Tsuchihara

PLoS One 2013 12;8(9):e73484. Epub 2013 Sep 12.

Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan.

View Article and Find Full Text PDF
April 2014

Simultaneous identification of 36 mutations in KRAS codons 61 and 146, BRAF, NRAS, and PIK3CA in a single reaction by multiplex assay kit.

Authors:
Hideaki Bando Takayuki Yoshino Eiji Shinozaki Tomohiro Nishina Kentaro Yamazaki Kensei Yamaguchi Satoshi Yuki Shinya Kajiura Satoshi Fujii Takeharu Yamanaka Katsuya Tsuchihara Atsushi Ohtsu

BMC Cancer 2013 Sep 3;13:405. Epub 2013 Sep 3.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
September 2013

RET fusion gene: translation to personalized lung cancer therapy.

Authors:
Takashi Kohno Koji Tsuta Katsuya Tsuchihara Takashi Nakaoku Kiyotaka Yoh Koichi Goto

Cancer Sci 2013 Nov 1;104(11):1396-400. Epub 2013 Oct 1.

Division of Translational Research, Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo, Japan; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.

View Article and Find Full Text PDF
November 2013

Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.

Authors:
Makito Suzuki Hideki Makinoshima Shingo Matsumoto Ayako Suzuki Sachiyo Mimaki Koutatsu Matsushima Kiyotaka Yoh Koichi Goto Yutaka Suzuki Genichiro Ishii Atsushi Ochiai Koji Tsuta Tatsuhiro Shibata Takashi Kohno Hiroyasu Esumi Katsuya Tsuchihara

Cancer Sci 2013 Jul 12;104(7):896-903. Epub 2013 May 12.

Division of Translational Research, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

View Article and Find Full Text PDF
July 2013

Critical role of H2O2 generated by NOX4 during cellular response under glucose deprivation.

Authors:
Satoshi Owada Yuko Shimoda Katsuya Tsuchihara Hiroyasu Esumi

PLoS One 2013 21;8(3):e56628. Epub 2013 Mar 21.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.

View Article and Find Full Text PDF
September 2013

Clinicopathological characteristics of EGFR mutated adenosquamous carcinoma of the lung.

Authors:
Toshihiro Shiozawa Genichiro Ishii Koichi Goto Kanji Nagai Sachiyo Mimaki Shotaro Ono Seiji Niho Satoshi Fujii Yuichiro Ohe Katsuya Tsuchihara Atsushi Ochiai

Pathol Int 2013 Feb 21;63(2):77-84. Epub 2013 Feb 21.

Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

View Article and Find Full Text PDF
February 2013

Clinical outcome of Japanese metastatic colorectal cancer patients harbouring the KRAS p.G13D mutation treated with cetuximab + irinotecan.

Authors:
Hideaki Bando Takayuki Yoshino Satoshi Yuki Eiji Shinozaki Tomohiro Nishina Shigenori Kadowaki Kentaro Yamazaki Shinya Kajiura Katsuya Tsuchihara Satoshi Fujii Takeharu Yamanaka Atsushi Ohtsu

Jpn J Clin Oncol 2012 Dec 15;42(12):1146-51. Epub 2012 Oct 15.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
December 2012

Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing.

Authors:
Kousuke Tanimoto Katsuya Tsuchihara Akinori Kanai Takako Arauchi Hiroyasu Esumi Yutaka Suzuki Sumio Sugano

Hugo J 2010 Dec 19;4(1-4):35-48. Epub 2011 Feb 19.

View Article and Find Full Text PDF
December 2010

ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.

Authors:
Wissam Assaily Daniel A Rubinger Keith Wheaton Yunping Lin Weili Ma Wanli Xuan Lauren Brown-Endres Katsuya Tsuchihara Tak W Mak Samuel Benchimol

Mol Cell 2011 Nov;44(3):491-501

Department of Biology, York University, Toronto, ON M3J 1P3, Canada.

View Article and Find Full Text PDF
November 2011

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress.

Authors:
Kathrin Zaugg Yi Yao Patrick T Reilly Karuppiah Kannan Reza Kiarash Jacqueline Mason Ping Huang Suzanne K Sawyer Benjamin Fuerth Brandon Faubert Tuula Kalliomäki Andrew Elia Xunyi Luo Vincent Nadeem David Bungard Sireesha Yalavarthi Joseph D Growney Andrew Wakeham Yasmin Moolani Jennifer Silvester Annick You Ten Walbert Bakker Katsuya Tsuchihara Shelley L Berger Richard P Hill Russell G Jones Ming Tsao Murray O Robinson Craig B Thompson Guohua Pan Tak W Mak

Genes Dev 2011 May;25(10):1041-51

The Campbell Family Institute for Breast Cancer Research, University of Toronto, Toronto, Ontario, Canada.

View Article and Find Full Text PDF
May 2011

Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs.

Authors:
Hiroko Onozuka Katsuya Tsuchihara Hiroyasu Esumi

Cancer Sci 2011 May 7;102(5):975-82. Epub 2011 Mar 7.

Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

View Article and Find Full Text PDF
May 2011

Biased discordance of KRAS mutation detection in archived colorectal cancer specimens between the ARMS-Scorpion method and direct sequencing.

Authors:
Hideaki Bando Katsuya Tsuchihara Takayuki Yoshino Motohiro Kojima Naomi Ogasawara Hiraku Fukushima Atsushi Ochiai Atsushi Ohtsu Hiroyasu Esumi

Jpn J Clin Oncol 2011 Feb 26;41(2):239-44. Epub 2010 Nov 26.

Cancer Physiology Project, National Cancer Center Hospital East, Kashiwa, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
February 2011

Apparent absence of a proton beam dose rate effect and possible differences in RBE between Bragg peak and plateau.

Authors:
Taeko Matsuura Yusuke Egashira Teiji Nishio Yoshitaka Matsumoto Mami Wada Sachiko Koike Yoshiya Furusawa Ryosuke Kohno Shie Nishioka Satoru Kameoka Katsuya Tsuchihara Mitsuhiko Kawashima Takashi Ogino

Med Phys 2010 Oct;37(10):5376-81

National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
October 2010

Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.

Authors:
Ho-Jin Koh Taro Toyoda Nobuharu Fujii Michelle M Jung Amee Rathod R Jan-Willem Middelbeek Sarah J Lessard Jonas T Treebak Katsuya Tsuchihara Hiroyasu Esumi Erik A Richter Jørgen F P Wojtaszewski Michael F Hirshman Laurie J Goodyear

Proc Natl Acad Sci U S A 2010 Aug 16;107(35):15541-6. Epub 2010 Aug 16.

Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

View Article and Find Full Text PDF
August 2010

Feasibility and robustness of amplification refractory mutation system (ARMS)-based KRAS testing using clinically available formalin-fixed, paraffin-embedded samples of colorectal cancers.

Authors:
Naomi Ogasawara Hideaki Bando Yasuyuki Kawamoto Takayuki Yoshino Katsuya Tsuchihara Atsushi Ohtsu Hiroyasu Esumi

Jpn J Clin Oncol 2011 Jan 9;41(1):52-6. Epub 2010 Aug 9.

Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

View Article and Find Full Text PDF
January 2011

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.

Authors:
Margareta T Wilhelm Alessandro Rufini Monica K Wetzel Katsuya Tsuchihara Satoshi Inoue Richard Tomasini Annick Itie-Youten Andrew Wakeham Marie Arsenian-Henriksson Gerry Melino David R Kaplan Freda D Miller Tak W Mak

Genes Dev 2010 Mar 1;24(6):549-60. Epub 2010 Mar 1.

The Campbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, Toronto, Ontario, Canada.

View Article and Find Full Text PDF
March 2010

[Transcriptome analyses using massively paralleled sequencers].

Authors:
Yutaka Suzuki Katsuya Tsuchihara

Tanpakushitsu Kakusan Koso 2009 Aug;54(10):1256-63

View Article and Find Full Text PDF
August 2009

Provision of a voluntary exercise environment enhances running activity and prevents obesity in Snark-deficient mice.

Authors:
Noriko Ichinoseki-Sekine Hisashi Naito Katsuya Tsuchihara Ikumi Kobayashi Yuji Ogura Ryo Kakigi Mitsutoshi Kurosaka Rumi Fujioka Hiroyasu Esumi

Am J Physiol Endocrinol Metab 2009 May 10;296(5):E1013-21. Epub 2009 Mar 10.

Graduate School of Health and Sports Science, Juntendo University, Inba, Chiba 270-1695, Japan.

View Article and Find Full Text PDF
May 2009

Massive transcriptional start site analysis of human genes in hypoxia cells.

Authors:
Katsuya Tsuchihara Yutaka Suzuki Hiroyuki Wakaguri Takuma Irie Kousuke Tanimoto Shin-ichi Hashimoto Kouji Matsushima Junko Mizushima-Sugano Riu Yamashita Kenta Nakai David Bentley Hiroyasu Esumi Sumio Sugano

Nucleic Acids Res 2009 Apr 22;37(7):2249-63. Epub 2009 Feb 22.

Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

View Article and Find Full Text PDF
April 2009

TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity.

Authors:
Richard Tomasini Katsuya Tsuchihara Chiharu Tsuda Suzanne K Lau Margareta Wilhelm Alessandro Rufini Ming-sound Tsao Juan L Iovanna Andrea Jurisicova Gerry Melino Tak W Mak

Proc Natl Acad Sci U S A 2009 01 12;106(3):797-802. Epub 2009 Jan 12.

The Campbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, Toronto, Ontario, Canada M5G 2C1.

View Article and Find Full Text PDF
January 2009

Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues.

Authors:
Katsuya Tsuchihara Satoshi Fujii Hiroyasu Esumi

Cancer Lett 2009 Jun 11;278(2):130-138. Epub 2008 Nov 11.

Cancer Physiology Project, Research Center for Innovative oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan. Electronic address:

View Article and Find Full Text PDF
June 2009

Nuclear localization of SNARK; its impact on gene expression.

Authors:
Wataru Kuga Katsuya Tsuchihara Tsutomu Ogura Sakyo Kanehara Marie Saito Atsushi Suzuki Hiroyasu Esumi

Biochem Biophys Res Commun 2008 Dec 6;377(4):1062-6. Epub 2008 Nov 6.

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba 277-8561, Japan.

View Article and Find Full Text PDF
December 2008

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.

Authors:
Richard Tomasini Katsuya Tsuchihara Margareta Wilhelm Masashi Fujitani Alessandro Rufini Carol C Cheung Fatima Khan Annick Itie-Youten Andrew Wakeham Ming-Sound Tsao Juan L Iovanna Jeremy Squire Igor Jurisica David Kaplan Gerry Melino Andrea Jurisicova Tak W Mak

Genes Dev 2008 Oct 19;22(19):2677-91. Epub 2008 Sep 19.

The Campbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, Toronto, Ontario M5G 2C1, Canada.

View Article and Find Full Text PDF
October 2008

Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci.

Authors:
Katsuya Tsuchihara Tsutomu Ogura Rumi Fujioka Satoshi Fujii Wataru Kuga Marie Saito Takahiro Ochiya Atsushi Ochiai Hiroyasu Esumi

Cancer Sci 2008 Apr 27;99(4):677-82. Epub 2007 Feb 27.

Cancer Physiology Project, Research Center for Innovative Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

View Article and Find Full Text PDF
April 2008

Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation.

Authors:
Kazunori Sato Katsuya Tsuchihara Satoshi Fujii Masanori Sugiyama Tomoyuki Goya Yutaka Atomi Takashi Ueno Atsushi Ochiai Hiroyasu Esumi

Cancer Res 2007 Oct;67(20):9677-84

Cancer Physiology Project and Pathology Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, and Department of Surgery, Kyorin University School of Medicine, Tokyo, Japan.

View Article and Find Full Text PDF
October 2007

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.

Authors:
Han You Marc Pellegrini Katsuya Tsuchihara Kazuo Yamamoto Georg Hacker Miriam Erlacher Andreas Villunger Tak W Mak

J Exp Med 2006 Jul 26;203(7):1657-63. Epub 2006 Jun 26.

The Campbell family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario M5G 2C1, Canada.

View Article and Find Full Text PDF
July 2006

Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.

Authors:
Katsuya Tsuchihara Valentina Lapin Christopher Bakal Hitoshi Okada Lauren Brown Masami Hirota-Tsuchihara Kathrin Zaugg Alexandra Ho Annick Itie-Youten Marees Harris-Brandts Robert Rottapel Christopher D Richardson Samuel Benchimol Tak Wah Mak

Cancer Res 2005 Aug;65(15):6685-91

The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Ontario, Canada.

View Article and Find Full Text PDF
August 2005

Hepatitis C virus and its roles in cell proliferation.

Authors:
Kunitada Shimotohno Koichi Watashi Katsuya Tsuchihara Katsuhiko Fukuda Hiroyuki Marusawa Makoto Hijikata

J Gastroenterol 2002 ;37 Suppl 13:50-4

Department of Viral Oncology, Institute for Virus Research, Kyoto University, Japan.

View Article and Find Full Text PDF
January 2003