Publications by authors named "Katsuhiko Shirahige"

100Publications

Age-dependent ribosomal DNA variations in mice.

Mol Cell Biol 2020 Sep 8. Epub 2020 Sep 8.

Institute for Quantitative Biosciences (IQB), University of Tokyo 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, JAPAN

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http://dx.doi.org/10.1128/MCB.00368-20DOI Listing
September 2020

Bioinformatical dissection of fission yeast DNA replication origins.

Open Biol 2020 Jul 22;10(7):200052. Epub 2020 Jul 22.

Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

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http://dx.doi.org/10.1098/rsob.200052DOI Listing
July 2020

Tex19.1 inhibits the N-end rule pathway and maintains acetylated SMC3 cohesin and sister chromatid cohesion in oocytes.

J Cell Biol 2020 May;219(5)

Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UK.

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http://dx.doi.org/10.1083/jcb.201702123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199850PMC
May 2020

ATF7-Dependent Epigenetic Changes Are Required for the Intergenerational Effect of a Paternal Low-Protein Diet.

Mol Cell 2020 05 19;78(3):445-458.e6. Epub 2020 Mar 19.

RIKEN Cluster for Pioneering Research, Tsukuba, Ibaraki 305-0074, Japan; Department of Functional Genomics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.02.028DOI Listing
May 2020

The Phosphatase PP1 Promotes Mitotic Slippage through Mad3 Dephosphorylation.

Curr Biol 2020 01 9;30(2):335-343.e5. Epub 2020 Jan 9.

CRBM, University of Montpellier, CNRS, 1919 Route de Mende, 34293 Montpellier, France. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2019.11.054DOI Listing
January 2020

Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe.

Nat Commun 2019 12 6;10(1):5598. Epub 2019 Dec 6.

Advanced ICT Research Institute Kobe, National Institute of Information and Communications Technology, Kobe, 651-2492, Japan.

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http://dx.doi.org/10.1038/s41467-019-13609-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898681PMC
December 2019

Missense Mutations in NKAP Cause a Disorder of Transcriptional Regulation Characterized by Marfanoid Habitus and Cognitive Impairment.

Am J Hum Genet 2019 11 3;105(5):987-995. Epub 2019 Oct 3.

Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Laboratory of Rare Disease Research, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo 113-8657, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848994PMC
November 2019

Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation.

Proc Natl Acad Sci U S A 2019 08 29;116(33):16404-16409. Epub 2019 Jul 29.

Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, 606-8501 Kyoto, Japan;

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http://dx.doi.org/10.1073/pnas.1904980116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697785PMC
August 2019

The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis.

EMBO Rep 2019 08 29;20(8):e47052. Epub 2019 Jul 29.

Laboratory of Molecular and Genetic Information, Institute for Quantitative Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.15252/embr.201847052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6680119PMC
August 2019

Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression.

Sci Rep 2019 04 15;9(1):6063. Epub 2019 Apr 15.

Laboratory of Pathology and Development, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.

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http://dx.doi.org/10.1038/s41598-019-42578-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465314PMC
April 2019

Cux2 refines the forelimb field by controlling expression of and genes.

Biol Open 2019 Feb 1;8(2). Epub 2019 Feb 1.

Department of Life Science and Technology, Tokyo Institute of Technology, Midori-ku, Yokohama, 226-8501, Japan

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http://bio.biologists.org/lookup/doi/10.1242/bio.040584
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http://dx.doi.org/10.1242/bio.040584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398465PMC
February 2019

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion.

Neuron 2019 02 9;101(3):472-485.e7. Epub 2019 Jan 9.

Department of Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.12.010DOI Listing
February 2019

A chromatin integration labelling method enables epigenomic profiling with lower input.

Nat Cell Biol 2019 02 10;21(2):287-296. Epub 2018 Dec 10.

Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1038/s41556-018-0248-3DOI Listing
February 2019

Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation.

PLoS Genet 2018 11 12;14(11):e1007783. Epub 2018 Nov 12.

Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, United Kingdom.

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http://dx.plos.org/10.1371/journal.pgen.1007783
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http://dx.doi.org/10.1371/journal.pgen.1007783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258251PMC
November 2018

Maternal Protein Restriction Alters the Renal DNA Methylation State in SHRSP Offspring.

Nutrients 2018 Oct 5;10(10). Epub 2018 Oct 5.

Health Nutrition, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 1138657, Japan.

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http://www.mdpi.com/2072-6643/10/10/1436
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http://dx.doi.org/10.3390/nu10101436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213780PMC
October 2018

Mapping of histone-binding sites in histone replacement-completed spermatozoa.

Nat Commun 2018 09 24;9(1):3885. Epub 2018 Sep 24.

Cluster for Pioneering Research, CREST Research Project of JST (Japan Science and Technology Agency), RIKEN Tsukuba Institute, Tsukuba, Ibaraki, 305-0074, Japan.

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http://dx.doi.org/10.1038/s41467-018-06243-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155156PMC
September 2018

Temporal Regulation of ESCO2 Degradation by the MCM Complex, the CUL4-DDB1-VPRBP Complex, and the Anaphase-Promoting Complex.

Curr Biol 2018 08 9;28(16):2665-2672.e5. Epub 2018 Aug 9.

Laboratory of Genome Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2018.06.037DOI Listing
August 2018

Re-evaluating the Localization of Sperm-Retained Histones Revealed the Modification-Dependent Accumulation in Specific Genome Regions.

Cell Rep 2018 06;23(13):3920-3932

Laboratory of Pathology and Development, the Institute for Quantitative Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-0032, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183087
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http://dx.doi.org/10.1016/j.celrep.2018.05.094DOI Listing
June 2018

Somatic copy number alterations have prognostic impact in patients with ovarian clear cell carcinoma.

Oncol Rep 2018 Jul 8;40(1):309-318. Epub 2018 May 8.

Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113‑0032, Japan.

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http://dx.doi.org/10.3892/or.2018.6419DOI Listing
July 2018

Sensitive and robust assessment of ChIP-seq read distribution using a strand-shift profile.

Bioinformatics 2018 07;34(14):2356-2363

Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, Japan.

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http://dx.doi.org/10.1093/bioinformatics/bty137DOI Listing
July 2018

Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis.

Stem Cell Reports 2018 04 8;10(4):1340-1354. Epub 2018 Mar 8.

Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan; Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoin, Kawara-cho, Sakyo-ku, Kyoto 606-8597, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998703PMC
April 2018

The HSF1-PARP13-PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis.

Nat Commun 2017 11 21;8(1):1638. Epub 2017 Nov 21.

Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami-Kogushi 1-1-1, Ube, 755-8505, Japan.

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http://dx.doi.org/10.1038/s41467-017-01807-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696371PMC
November 2017

Cohesin Ubiquitylation and Mobilization Facilitate Stalled Replication Fork Dynamics.

Mol Cell 2017 Nov 9;68(4):758-772.e4. Epub 2017 Nov 9.

Instituto de Biología Funcional y Genómica (IBFG-CSIC), Universidad de Salamanca, Calle Zacarías González 2, 37007 Salamanca, Spain; Centro de Investigaciones Biológicas (CIB-CSIC), Calle Ramiro de Maeztu 9, 28040 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.10.012DOI Listing
November 2017

DBTSS/DBKERO for integrated analysis of transcriptional regulation.

Nucleic Acids Res 2018 01;46(D1):D229-D238

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Chiba, Japan.

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http://dx.doi.org/10.1093/nar/gkx1001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753362PMC
January 2018

Hot debate in hot springs: Report on the second international meeting on SMC proteins.

Genes Cells 2017 Nov 25;22(11):934-938. Epub 2017 Oct 25.

Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/gtc.12539DOI Listing
November 2017

Statistical Analysis and Quality Assessment of ChIP-seq Data with DROMPA.

Methods Mol Biol 2018 ;1672:631-643

Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1007/978-1-4939-7306-4_41DOI Listing
June 2018

interleukin-11 induces and maintains progenitors of different cell lineages during Xenopus tadpole tail regeneration.

Nat Commun 2017 09 8;8(1):495. Epub 2017 Sep 8.

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1038/s41467-017-00594-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591189PMC
September 2017

An In Vitro Human Liver Model by iPSC-Derived Parenchymal and Non-parenchymal Cells.

Stem Cell Reports 2017 08 27;9(2):490-498. Epub 2017 Jul 27.

Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-0032, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549957PMC
August 2017

Genome-Wide Target Analyses of Otx2 Homeoprotein in Postnatal Cortex.

Front Neurosci 2017 31;11:307. Epub 2017 May 31.

Laboratory of Neuronal Development, Graduate School of Medical and Dental Sciences, Niigata UniversityNiigata, Japan.

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http://dx.doi.org/10.3389/fnins.2017.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450002PMC
May 2017

Rtt101-Mms1-Mms22 coordinates replication-coupled sister chromatid cohesion and nucleosome assembly.

EMBO Rep 2017 08 14;18(8):1294-1305. Epub 2017 Jun 14.

Beijing Advanced Innovation Center for Food Nutrition and Human Health, State Key Laboratory of Agro-Biotechnology, College of Biological Sciences, China Agricultural University, Beijing, China

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http://embor.embopress.org/lookup/doi/10.15252/embr.20164380
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http://dx.doi.org/10.15252/embr.201643807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538422PMC
August 2017

Two Components of Aversive Memory in , Anesthesia-Sensitive and Anesthesia-Resistant Memory, Require Distinct Domains Within the Rgk1 Small GTPase.

J Neurosci 2017 05 17;37(22):5496-5510. Epub 2017 Apr 17.

Laboratory of Neuroscience, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032, Japan, and

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http://dx.doi.org/10.1523/JNEUROSCI.3648-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596527PMC
May 2017

Identification of a variant-specific phosphorylation of TH2A during spermiogenesis.

Sci Rep 2017 04 7;7:46228. Epub 2017 Apr 7.

Laboratory of Pathology and Development, Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-0032, Japan.

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http://dx.doi.org/10.1038/srep46228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384234PMC
April 2017

ChIP-seq Analysis of Condensin Complex in Cultured Mammalian Cells.

Methods Mol Biol 2017 ;1515:257-271

Laboratory of Genome Structure and Function, Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.

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http://dx.doi.org/10.1007/978-1-4939-6545-8_16DOI Listing
January 2018

-TCF3 complex is required for the tumorigenicity of colorectal cancer cells.

Proc Natl Acad Sci U S A 2016 Nov 21;113(45):12739-12744. Epub 2016 Oct 21.

Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1605938113
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http://dx.doi.org/10.1073/pnas.1605938113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111701PMC
November 2016

MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression.

Cell Rep 2016 09 25;16(10):2554-2564. Epub 2016 Aug 25.

Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.015DOI Listing
September 2016

Exome sequencing-based identification of mutations in non-syndromic genes among individuals with apparently syndromic features.

Am J Med Genet A 2016 11 26;170(11):2889-2894. Epub 2016 Aug 26.

Division of Medical Genetics, Nagano Children's Hospital, Azumino, Japan.

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http://dx.doi.org/10.1002/ajmg.a.37826DOI Listing
November 2016

Attaching Accessory Devices to the Replisome.

Mol Cell 2016 08;63(3):347-8

Research Center for Epigenetic Diseases, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-0032, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.07.017DOI Listing
August 2016

ARCN1 Mutations Cause a Recognizable Craniofacial Syndrome Due to COPI-Mediated Transport Defects.

Am J Hum Genet 2016 Aug 28;99(2):451-9. Epub 2016 Jul 28.

Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-0032, Japan; CREST, Japan Science and Technology Agency, Kawaguchi, 332-0012, Japan.

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http://dx.doi.org/10.1016/j.ajhg.2016.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974084PMC
August 2016

Physical Association of Saccharomyces cerevisiae Polo-like Kinase Cdc5 with Chromosomal Cohesin Facilitates DNA Damage Response.

J Biol Chem 2016 08 20;291(33):17228-46. Epub 2016 Jun 20.

From the Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032 and

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http://dx.doi.org/10.1074/jbc.M116.727438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016123PMC
August 2016

Mosaic ratio quantification of isochromosome 12p in Pallister-Killian syndrome using droplet digital PCR.

Mol Genet Genomic Med 2016 May 20;4(3):257-61. Epub 2016 Jan 20.

Research Center for Epigenetic Disease, Institute for Molecular and Cellular Biosciences The University of Tokyo Tokyo Japan.

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http://dx.doi.org/10.1002/mgg3.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867559PMC
May 2016

DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation.

Nat Commun 2016 Mar 24;7:10924. Epub 2016 Mar 24.

Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, bunkyo-ku, Tokyo 113-8655, Japan.

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http://dx.doi.org/10.1038/ncomms10924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820786PMC
March 2016

Microarray expression analysis of genes involved in innate immune memory in peritoneal macrophages.

Genom Data 2016 Mar 1;7:90-1. Epub 2015 Dec 1.

Laboratory of Molecular Genetics, CREST Research Project of JST (Japan Science and Technology Agency), RIKEN Tsukuba institute, Tsukuba 305-0074, Japan.

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http://dx.doi.org/10.1016/j.gdata.2015.11.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778626PMC
March 2016

Recent advances in ChIP-seq analysis: from quality management to whole-genome annotation.

Brief Bioinform 2017 03;18(2):279-290

Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1093/bib/bbw023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444249PMC
March 2017

Condensin Relocalization from Centromeres to Chromosome Arms Promotes Top2 Recruitment during Anaphase.

Cell Rep 2015 Dec 10;13(11):2336-2344. Epub 2015 Dec 10.

Cell Cycle Group, Medical Research Council (MRC), Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695335PMC
December 2015

Rif1 binds to G quadruplexes and suppresses replication over long distances.

Nat Struct Mol Biol 2015 Nov 5;22(11):889-97. Epub 2015 Oct 5.

Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.1038/nsmb.3102DOI Listing
November 2015

The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.

Nat Immunol 2015 Oct 31;16(10):1034-43. Epub 2015 Aug 31.

Laboratory of Molecular Genetics, CREST Research Project of the Japan Science and Technology Agency, RIKEN Tsukuba Institute, Tsukuba, Japan.

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http://dx.doi.org/10.1038/ni.3257DOI Listing
October 2015

Exome Sequencing Identification of EP300 Mutation in a Proband with Coloboma and Imperforate Anus: Possible Expansion of the Phenotypic Spectrum of Rubinstein-Taybi Syndrome.

Mol Syndromol 2015 Jul 3;6(2):99-103. Epub 2015 Mar 3.

Institute for Molecular and Cellular Biosciences, Research Center for Epigenetic Disease, The University of Tokyo, Tokyo, Japan ; Division of Medical Genetics, Nagano Children's Hospital, Azumino, Japan.

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http://dx.doi.org/10.1159/000375542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521068PMC
July 2015

Replication-Coupled PCNA Unloading by the Elg1 Complex Occurs Genome-wide and Requires Okazaki Fragment Ligation.

Cell Rep 2015 Aug 23;12(5):774-87. Epub 2015 Jul 23.

Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S22111247150070
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http://dx.doi.org/10.1016/j.celrep.2015.06.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534484PMC
August 2015

Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation.

Nat Commun 2015 Jul 23;6:7815. Epub 2015 Jul 23.

Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-0032, Japan.

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http://www.nature.com/articles/ncomms8815
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http://dx.doi.org/10.1038/ncomms8815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525155PMC
July 2015

The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity by Modulating Its Binding to Chromatin.

J Biol Chem 2015 Aug 14;290(35):21713-23. Epub 2015 Jul 14.

From the Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032 and

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http://dx.doi.org/10.1074/jbc.M114.628255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571893PMC
August 2015

Assembly of Slx4 signaling complexes behind DNA replication forks.

EMBO J 2015 Aug 25;34(16):2182-97. Epub 2015 Jun 25.

Department of Biochemistry, University of Toronto, Toronto, ON, Canada Donnelly Centre, University of Toronto, Toronto, ON, Canada

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http://dx.doi.org/10.15252/embj.201591190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557669PMC
August 2015

Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2.

Curr Biol 2015 Jun 4;25(13):1694-706. Epub 2015 Jun 4.

Laboratory of Genome Structure and Function, Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi Bunkyo-Ku, Tokyo 113-0032, Japan; Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi Bunkyo-Ku, Tokyo 113-0032, Japan; CREST, JST, K's Gobancho, 7, Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2015.05.017DOI Listing
June 2015

Sphingolipids regulate telomere clustering by affecting the transcription of genes involved in telomere homeostasis.

J Cell Sci 2015 Jul 4;128(14):2454-67. Epub 2015 Jun 4.

Department of Biofunctional Science and Technology, Graduate School of Biosphere Science, Hiroshima University, Hiroshima 739-8528, Japan

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http://dx.doi.org/10.1242/jcs.164160DOI Listing
July 2015

Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells.

Cell Stem Cell 2015 May 19;16(5):517-32. Epub 2015 Mar 19.

Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin Yoshida, Sakyo-ku, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.03.002DOI Listing
May 2015

Unique gene expression profile of the proliferating Xenopus tadpole tail blastema cells deciphered by RNA-sequencing analysis.

PLoS One 2015 16;10(3):e0111655. Epub 2015 Mar 16.

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111655PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361676PMC
January 2016

DBTMEE: a database of transcriptome in mouse early embryos.

Nucleic Acids Res 2015 Jan 21;43(Database issue):D771-6. Epub 2014 Oct 21.

Human Genome Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

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http://dx.doi.org/10.1093/nar/gku1001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383872PMC
January 2015

ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex.

Mol Cell Biol 2015 Jan 13;35(1):11-25. Epub 2014 Oct 13.

Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami-Kogushi, Ube, Japan

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http://dx.doi.org/10.1128/MCB.00754-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295370PMC
January 2015

5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.

Cell Rep 2014 Oct 2;9(1):48-60. Epub 2014 Oct 2.

Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.071DOI Listing
October 2014

The maintenance of chromosome structure: positioning and functioning of SMC complexes.

Nat Rev Mol Cell Biol 2014 Sep;15(9):601-14

Karolinska Institutet, Department of Cell and Molecular Biology, von Eulers väg 3, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrm3857DOI Listing
September 2014

Dimeric combinations of MafB, cFos and cJun control the apoptosis-survival balance in limb morphogenesis.

Development 2014 Jul;141(14):2885-94

Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, B-17, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan

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http://dx.doi.org/10.1242/dev.099150DOI Listing
July 2014

Chromatin immunoprecipitation protocol for mammalian cells.

Methods Mol Biol 2014 ;1164:33-8

Laboratory of Genome Structure and Function, Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.

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http://dx.doi.org/10.1007/978-1-4939-0805-9_4DOI Listing
January 2015

BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability.

Cell Rep 2014 Jun 15;7(5):1547-1559. Epub 2014 May 15.

The Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062933PMC
June 2014

Temporal and spatial regulation of eukaryotic DNA replication: from regulated initiation to genome-scale timing program.

Semin Cell Dev Biol 2014 Jun 13;30:110-20. Epub 2014 Apr 13.

Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2014.04.014DOI Listing
June 2014

Dissecting the first and the second meiotic divisions using a marker-less drug-hypersensitive fission yeast.

Cell Cycle 2014 3;13(8):1327-34. Epub 2014 Mar 3.

Graduate School of Pharmaceutical Sciences; The University of Tokyo; Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.4161/cc.28294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049969PMC
August 2015

Histone variants enriched in oocytes enhance reprogramming to induced pluripotent stem cells.

Cell Stem Cell 2014 Feb;14(2):217-27

Laboratory of Molecular Genetics, CREST Research Project of JST (Japan Science and Technology Agency), RIKEN Tsukuba Institute, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan; Department of Functional Genomics, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2013.12.015DOI Listing
February 2014

Genome-wide analysis of murine renal distal convoluted tubular cells for the target genes of mineralocorticoid receptor.

Biochem Biophys Res Commun 2014 Feb 1;445(1):132-7. Epub 2014 Feb 1.

Department of Nephrology and Endocrinology, The University of Tokyo, Tokyo, Japan; Department of Anatomy and Life Structure, School of Medicine Juntendo University, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.01.125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488251PMC
February 2014

Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors.

ChemMedChem 2014 Mar 8;9(3):657-64. Epub 2014 Jan 8.

Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 13 Taishogun, Nishitakatsukasa-cho, Kita-ku, Kyoto 603-8334 (Japan); PRESTO (Japan) Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012 (Japan).

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http://doi.wiley.com/10.1002/cmdc.201300414
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http://dx.doi.org/10.1002/cmdc.201300414DOI Listing
March 2014

Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance.

Hum Mol Genet 2014 Jun 8;23(11):2888-900. Epub 2014 Jan 8.

Sektion für Funktionelle Genetik am Institut für Humangenetik, Universität zu Lübeck, Lübeck 23538, Germany.

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http://dx.doi.org/10.1093/hmg/ddu002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014191PMC
June 2014

Inferring the choreography of parental genomes during fertilization from ultralarge-scale whole-transcriptome analysis.

Genes Dev 2013 Dec;27(24):2736-48

Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo 108-8639, Japan;

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http://dx.doi.org/10.1101/gad.227926.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877761PMC
December 2013

A mesodermal factor, T, specifies mouse germ cell fate by directly activating germline determinants.

Dev Cell 2013 Dec;27(5):516-29

Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin Yoshida, Sakyo-ku, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2013.11.001DOI Listing
December 2013

Sensory-neuron subtype-specific transcriptional programs controlling dendrite morphogenesis: genome-wide analysis of Abrupt and Knot/Collier.

Dev Cell 2013 Dec 27;27(5):530-44. Epub 2013 Nov 27.

Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2013.10.024DOI Listing
December 2013

Smc5/6-mediated regulation of replication progression contributes to chromosome assembly during mitosis in human cells.

Mol Biol Cell 2014 Jan 20;25(2):302-17. Epub 2013 Nov 20.

Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113-0032, Japan Department of Biological Sciences, Tokyo Institute of Technology, Yokohama 226-8501, Japan Bio-Frontier Research Center, Tokyo Institute of Technology, Yokohama 226-8501, Japan Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo 102-0076, Japan.

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http://dx.doi.org/10.1091/mbc.E13-01-0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890350PMC
January 2014

The dynamics of genome replication using deep sequencing.

Nucleic Acids Res 2014 Jan 1;42(1):e3. Epub 2013 Oct 1.

School of Life Sciences, The University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK, Deep Seq, The University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK, Research Center for Epigenetic Disease, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, 113-0032, Japan and Institute for Complex Systems and Mathematical Biology, The University of Aberdeen, Aberdeen, AB24 3UE UK.

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http://dx.doi.org/10.1093/nar/gkt878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874191PMC
January 2014