Katja Zirlik

Katja Zirlik

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Katja Zirlik

Publications by authors named "Katja Zirlik"

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42Publications

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Anti-Angiogenics: Current Situation and Future Perspectives.

Authors:
Katja Zirlik Justus Duyster

Oncol Res Treat 2018 23;41(4):166-171. Epub 2018 Mar 23.

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https://www.karger.com/Article/FullText/488087
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http://dx.doi.org/10.1159/000488087DOI Listing
August 2019

Idelalisib.

Authors:
Katja Zirlik Hendrik Veelken

Recent Results Cancer Res 2018;212:243-264

Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.

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http://link.springer.com/10.1007/978-3-319-91439-8_12
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http://dx.doi.org/10.1007/978-3-319-91439-8_12DOI Listing
May 2019

Validation of a biological score to predict response in chronic lymphocytic leukemia patients treated front-line with bendamustine and rituximab.

Authors:
Massimo Gentile Tait D Shanafelt Gianluigi Reda Francesca Romana Mauro Katja Zirlik Stefania Ciolli Luca Laurenti Maria Ilaria Del Principe Davide Rossi Nicola Di Renzo Stefano Molica Francesco Angrilli Marta Coscia Annalisa Chiarenza Annamaria Giordano Giovanna Cutrona Kari G Chaffee Sameer A Parikh Giuseppina Uccello Idanna Innocenti Giovanni Tripepi Graziella D'Arrigo Ernesto Vigna Anna Grazia Recchia Yair Herishanu Lev Shvidel Tamar Tadmor Agostino Cortelezzi Giovanni Del Poeta Gianluca Gaidano Francesco Di Raimondo Antonino Neri Manlio Ferrarini Robin Foà Aaron Polliack Fortunato Morabito

Leukemia 2018 08 20;32(8):1869-1873. Epub 2018 Mar 20.

Consiglio Nazionale delle Ricerche, Instituto di Biomedicina ed Immunologia Molecolare, Reggio Calabria, Italy.

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http://www.nature.com/articles/s41375-018-0100-6
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http://dx.doi.org/10.1038/s41375-018-0100-6DOI Listing
August 2018

Predictive value of the CLL-IPI in CLL patients receiving chemo-immunotherapy as first-line treatment.

Authors:
Massimo Gentile Tait D Shanafelt Francesca Romana Mauro Gianluigi Reda Davide Rossi Luca Laurenti Maria Ilaria Del Principe Giovanna Cutrona Ilaria Angeletti Marta Coscia Yair Herishanu Annalisa Chiarenza Stefano Molica Stefania Ciolli Neta Goldschmidt Francesco Angrilli Annamaria Giordano Angela Rago Osnat Bairey Giovanni Tripepi Kari G Chaffee Parikh A Sameer Ernesto Vigna Katja Zirlik Lev Shvidel Idanna Innocenti Anna Grazia Recchia Francesco Di Raimondo Giovanni Del Poeta Agostino Cortelezzi Antonino Neri Manlio Ferrarini Gianluca Gaidano Neil E Kay Aaron Polliack Robin Foà Fortunato Morabito

Eur J Haematol 2018 Jul 24. Epub 2018 Jul 24.

Unità di Ricerca Biotecnologica, Azienda Sanitaria Provinciale di Cosenza, Aprigliano (CS), Italy.

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http://dx.doi.org/10.1111/ejh.13149DOI Listing
July 2018

Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia.

Authors:
Carl Philipp Simon-Gabriel Katharina Foerster Shifa Saleem Dorothee Bleckmann Marco Benkisser-Petersen Nicolas Thornton Kazuo Umezawa Sarah Decker Meike Burger Hendrik Veelken Rainer Claus Christine Dierks Justus Duyster Katja Zirlik

Haematologica 2018 01 9;103(1):136-147. Epub 2017 Nov 9.

Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center, Faculty of Medicine, University of Freiburg, Germany

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http://dx.doi.org/10.3324/haematol.2017.165381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777201PMC
January 2018

Drug-perturbation-based stratification of blood cancer.

Authors:
Sascha Dietrich Małgorzata Oleś Junyan Lu Leopold Sellner Simon Anders Britta Velten Bian Wu Jennifer Hüllein Michelle da Silva Liberio Tatjana Walther Lena Wagner Sophie Rabe Sonja Ghidelli-Disse Marcus Bantscheff Andrzej K Oleś Mikołaj Słabicki Andreas Mock Christopher C Oakes Shihui Wang Sina Oppermann Marina Lukas Vladislav Kim Martin Sill Axel Benner Anna Jauch Lesley Ann Sutton Emma Young Richard Rosenquist Xiyang Liu Alexander Jethwa Kwang Seok Lee Joe Lewis Kerstin Putzker Christoph Lutz Davide Rossi Andriy Mokhir Thomas Oellerich Katja Zirlik Marco Herling Florence Nguyen-Khac Christoph Plass Emma Andersson Satu Mustjoki Christof von Kalle Anthony D Ho Manfred Hensel Jan Dürig Ingo Ringshausen Marc Zapatka Wolfgang Huber Thorsten Zenz

J Clin Invest 2018 01 11;128(1):427-445. Epub 2017 Dec 11.

Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1172/JCI93801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749541PMC
January 2018

Spleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia.

Authors:
Marco Benkisser-Petersen Maike Buchner Arlette Dörffel Marcus Dühren-von-Minden Rainer Claus Kathrin Kläsener Kerstin Leberecht Meike Burger Christine Dierks Hassan Jumaa Fabio Malavasi Michael Reth Hendrik Veelken Justus Duyster Katja Zirlik

PLoS One 2016 30;11(12):e0169159. Epub 2016 Dec 30.

Department of Hematology, Oncology and Stem cell transplantation, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169159PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201248PMC
July 2017

Selection patterns of B-cell receptors and the natural history of follicular lymphoma.

Authors:
Florian Scherer Marlon van der Burgt Szymon M Kiełbasa Cristina Bertinetti-Lapatki Marcus Dühren von Minden Kristina Mikesch Katja Zirlik Liesbeth de Wreede Hendrik Veelken Marcelo A Navarrete

Br J Haematol 2016 12 21;175(5):972-975. Epub 2015 Dec 21.

Department of Haematology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/bjh.13901DOI Listing
December 2016

Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial.

Authors:
Salah-Eddin Al-Batran Ralf D Hofheinz Claudia Pauligk Hans-Georg Kopp Georg Martin Haag Kim Barbara Luley Johannes Meiler Nils Homann Sylvie Lorenzen Harald Schmalenberg Stephan Probst Michael Koenigsmann Matthias Egger Nicole Prasnikar Karel Caca Jörg Trojan Uwe M Martens Andreas Block Wolfgang Fischbach Rolf Mahlberg Michael Clemens Gerald Illerhaus Katja Zirlik Dirk M Behringer Wolff Schmiegel Michael Pohl Michael Heike Ulrich Ronellenfitsch Martin Schuler Wolf O Bechstein Alfred Königsrainer Timo Gaiser Peter Schirmacher Wael Hozaeel Alexander Reichart Thorsten O Goetze Mark Sievert Elke Jäger Stefan Mönig Andrea Tannapfel

Lancet Oncol 2016 Dec 22;17(12):1697-1708. Epub 2016 Oct 22.

Institute for Pathology, Ruhr-University Bochum, Bochum, Germany.

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http://dx.doi.org/10.1016/S1470-2045(16)30531-9DOI Listing
December 2016

BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia.

Authors:
Andrea Haerzschel Julie Catusse Evelyn Hutterer Manuela Paunovic Katja Zirlik Hermann Eibel Peter W Krenn Tanja N Hartmann Meike Burger

Ann Hematol 2016 Dec 20;95(12):1979-1988. Epub 2016 Aug 20.

Freiburg University Medical Center, Department of Hematology and Oncology, Albert-Ludwigs-University Freiburg, Breisgau, Germany.

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http://dx.doi.org/10.1007/s00277-016-2788-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093209PMC
December 2016

From CLL to Multiple Myeloma - Spleen Tyrosine Kinase (SYK) influences multiple myeloma cell survival and migration.

Authors:
Joschka Lorenz Johannes Waldschmidt Dagmar Wider Marie Follo Gabriele Ihorst Manik Chatterjee Annette M May Justus Duyster Andreas Rosenwald Ralph Wäsch Katja Zirlik Monika Engelhardt

Br J Haematol 2016 09 22;174(6):985-9. Epub 2015 Oct 22.

Department of Haematology, Oncology and Stem Cell Transplantation, University Medical Centre Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1111/bjh.13825DOI Listing
September 2016

Combination of bendamustine and rituximab as front-line therapy for patients with chronic lymphocytic leukaemia: multicenter, retrospective clinical practice experience with 279 cases outside of controlled clinical trials.

Authors:
Massimo Gentile Katja Zirlik Stefania Ciolli Francesca R Mauro Nicola Di Renzo Lucia Mastrullo Francesco Angrilli Stefano Molica Giovanni Tripepi Annamaria Giordano Francesco Di Raimondo Carmine Selleri Marta Coscia Maurizio Musso Lorella Orsucci Donato Mannina Angela Rago Angela Giannotta Felicetto Ferrara Yair Herishanu Lev Shvidel Tamar Tadmor Ilaria Scortechini Fiorella Ilariucci Roberta Murru Attilio Guarini Gerardo Musuraca Giuseppe Mineo Iolanda Vincelli Annalisa Arcari Giuseppe Tarantini Giuseppe Caparrotti Annalisa Chiarenza Luciano Levato Maria Rosaria Villa Maria Rosaria De Paolis Pier Luigi Zinzani Aaron Polliack Fortunato Morabito

Eur J Cancer 2016 06 27;60:154-65. Epub 2016 Apr 27.

UOC Ematologia, Ospedale Annunziata, Cosenza, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.03.069DOI Listing
June 2016

Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma.

Authors:
Dunja Schneider Marcus Dühren-von Minden Alabbas Alkhatib Corinna Setz Cornelis A M van Bergen Marco Benkißer-Petersen Isabel Wilhelm Sarah Villringer Sergey Krysov Graham Packham Katja Zirlik Winfried Römer Christian Buske Freda K Stevenson Hendrik Veelken Hassan Jumaa

Blood 2015 May 17;125(21):3287-96. Epub 2015 Mar 17.

Department of Molecular Immunology, Faculty of Biology, Albert-Ludwigs University of Freiburg and Max-Planck-Institute of Immunobiology and Epigenetics, Freiburg, Germany; Institute of Immunology, Ulm University Medical Center, Ulm, Germany;

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http://dx.doi.org/10.1182/blood-2014-11-609404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482265PMC
May 2015

Evidence for idiotype-directed immunosurveillance is restricted to follicular lymphoma and attributable to somatic hypermutation.

Authors:
Dimitrios Papaioannou Anna-Maria Strothmeyer Marcus Dühren-von Minden Andrea Keppler-Hafkemeyer Katja Zirlik Kristina Mikesch Cornelis A M van Bergen Marcelo A Navarrete Hendrik Veelken

Haematologica 2015 Apr 23;100(4):e143-6. Epub 2015 Jan 23.

Department of Hematology, Leiden University Medical Center, The Netherlands

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http://dx.doi.org/10.3324/haematol.2014.111252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380737PMC
April 2015

Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia.

Authors:
Anne Rissiek Christian Schulze Ulrike Bacher Aneta Schieferdecker Benjamin Thiele Anita Jacholkowski Anna Flammiger Christiane Horn Friedrich Haag Gisa Tiegs Katja Zirlik Martin Trepel Eva Tolosa Mascha Binder

Int J Cancer 2014 Nov 18;135(10):2370-9. Epub 2014 Apr 18.

Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1002/ijc.28884DOI Listing
November 2014

BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia.

Authors:
Niuscha Yaktapour Frank Meiss Justin Mastroianni Thorsten Zenz Hana Andrlova Nimitha R Mathew Rainer Claus Barbara Hutter Stefan Fröhling Benedikt Brors Dietmar Pfeifer Milena Pantic Ingrid Bartsch Timo S Spehl Philipp T Meyer Justus Duyster Katja Zirlik Tilman Brummer Robert Zeiser

J Clin Invest 2014 Nov 20;124(11):5074-84. Epub 2014 Oct 20.

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http://dx.doi.org/10.1172/JCI76539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347247PMC
November 2014

Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis.

Authors:
Heiko Sic Helene Kraus Josef Madl Karl-Andreas Flittner Audrey Lilly von Münchow Kathrin Pieper Marta Rizzi Anne-Kathrin Kienzler Korcan Ayata Sebastian Rauer Burkhard Kleuser Ulrich Salzer Meike Burger Katja Zirlik Vassilios Lougaris Alessandro Plebani Winfried Römer Christoph Loeffler Samantha Scaramuzza Anna Villa Emiko Noguchi Bodo Grimbacher Hermann Eibel

J Allergy Clin Immunol 2014 Aug 26;134(2):420-8. Epub 2014 Mar 26.

Center of Chronic Immunodeficiency, University Medical Center, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.01.037DOI Listing
August 2014

MDSCs: the final frontier of the microenvironment in CLL?

Authors:
Katja Zirlik

Blood 2014 Jul;124(5):666-8

UNIVERSITY MEDICAL CENTER FREIBURG.

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http://dx.doi.org/10.1182/blood-2014-06-578880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118477PMC
July 2014

PIM kinases are essential for chronic lymphocytic leukemia cell survival (PIM2/3) and CXCR4-mediated microenvironmental interactions (PIM1).

Authors:
Sarah Decker Johannes Finter Aaron James Forde Sandra Kissel Juerg Schwaller Thomas Sebastian Mack Anabel Kuhn Nathanael Gray Marie Follo Hassan Jumaa Meike Burger Katja Zirlik Dietmar Pfeifer Chandrasekhar V Miduturu Hermann Eibel Hendrik Veelken Christine Dierks

Mol Cancer Ther 2014 May 21;13(5):1231-45. Epub 2014 Mar 21.

Authors' Affiliations: Department of Hematology/Oncology; Centre of Chronic Immunodeficiency, University Medical Centre Freiburg; Faculty of Biology; BIOSS Centre for Biological Signaling Studies, University of Freiburg, Freiburg, Germany; Department of Biomedicine, University Hospital Basel, Basel, Switzerland; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School; Department of Cancer Biology, Dana-Faber Cancer Institute, Boston, Massachusetts; and Department of Hematology, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0575-TDOI Listing
May 2014

Multimodal treatment of locally advanced esophageal adenocarcinoma: which regimen should we choose? Outcome analysis of perioperative chemotherapy versus neoadjuvant chemoradiation in 105 patients.

Authors:
Jens Hoeppner Katja Zirlik Thomas Brunner Peter Bronsert Birte Kulemann Olivia Sick Goran Marjanovic Ulrich Theodor Hopt Frank Makowiec

J Surg Oncol 2014 Mar 26;109(3):287-93. Epub 2013 Nov 26.

Department of Surgery, University of Freiburg, Freiburg, Germany.

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http://doi.wiley.com/10.1002/jso.23498
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http://dx.doi.org/10.1002/jso.23498DOI Listing
March 2014

Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk.

Authors:
Martina P Bach Eva Hug Markus Werner Julian Holch Clara Sprissler Konstanze Pechloff Katja Zirlik Robert Zeiser Christine Dierks Jürgen Ruland Hassan Jumaa

J Immunol 2014 Feb 27;192(3):1024-33. Epub 2013 Dec 27.

Institute of Immunology, University Clinics Ulm, 89081 Ulm, Germany;

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http://dx.doi.org/10.4049/jimmunol.1300420DOI Listing
February 2014

Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia.

Authors:
Niuscha Yaktapour Rudolf Übelhart Julia Schüler Konrad Aumann Christine Dierks Meike Burger Dietmar Pfeifer Hassan Jumaa Hendrik Veelken Tilman Brummer Katja Zirlik

Blood 2013 Aug 17;122(9):1621-33. Epub 2013 Jul 17.

Department of Hematology/Oncology, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2013-02-484386DOI Listing
August 2013

Improved long-term survival after esophagectomy for esophageal cancer: influence of epidemiologic shift and neoadjuvant therapy.

Authors:
Frank Makowiec Peter Baier Birte Kulemann Goran Marjanovic Peter Bronsert Katja Zirlik Michael Henke Ulrich Theodor Hopt Jens Hoeppner

J Gastrointest Surg 2013 Jul 2;17(7):1193-201. Epub 2013 May 2.

Department of Surgery, University of Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s11605-013-2212-7DOI Listing
July 2013

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling.

Authors:
Marcus Dühren-von Minden Rudolf Übelhart Dunja Schneider Thomas Wossning Martina P Bach Maike Buchner Daniel Hofmann Elena Surova Marie Follo Fabian Köhler Hedda Wardemann Katja Zirlik Hendrik Veelken Hassan Jumaa

Nature 2012 Sep;489(7415):309-12

Centre for Biological Signaling Studies (BIOSS), Albert-Ludwigs Universität Freiburg, 79104 Freiburg, Germany.

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http://dx.doi.org/10.1038/nature11309DOI Listing
September 2012

Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL.

Authors:
Sarah Decker Katja Zirlik Lauritte Djebatchie David Hartmann Gabriele Ihorst Annette Schmitt-Graeff Dieter Herchenbach Hassan Jumaa Markus Warmuth Hendrik Veelken Christine Dierks

Blood 2012 Jan 30;119(4):997-1007. Epub 2011 Nov 30.

Department of Hematology/Oncology, University Medical Center Freiburg, Hugstetter Strasse 55, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2011-06-359075DOI Listing
January 2012

The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia.

Authors:
Fortunato Morabito Rosaria De Filippi Luca Laurenti Katja Zirlik Anna Grazia Recchia Massimo Gentile Emanuela Morelli Ernesto Vigna Vincenzo Gigliotti Rosa Calemma Barbara Amoroso Antonino Neri Giovanna Cutrona Manlio Ferrarini Stefano Molica Giovanni Del Poeta Claudio Tripodo Antonio Pinto

Blood 2011 Dec 13;118(24):6353-61. Epub 2011 Oct 13.

Onco-Hematology Unit, Azienda Ospedaliera Annunziata, Cosenza, Italy.

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http://www.bloodjournal.org/content/118/24/6353.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-04-34
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http://dx.doi.org/10.1182/blood-2011-04-345587DOI Listing
December 2011

The oral spleen tyrosine kinase inhibitor fostamatinib attenuates inflammation and atherogenesis in low-density lipoprotein receptor-deficient mice.

Authors:
Ingo Hilgendorf Sara Eisele Imke Remer Jochen Schmitz Katharina Zeschky Christian Colberg Peter Stachon Dennis Wolf Florian Willecke Maike Buchner Katja Zirlik Alexandra Ortiz-Rodriguez Andrey Lozhkin Natalie Hoppe Constantin von zur Muhlen Axel zur Hausen Christoph Bode Andreas Zirlik

Arterioscler Thromb Vasc Biol 2011 Sep 23;31(9):1991-9. Epub 2011 Jun 23.

Department of Cardiology, University Hospital Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1161/ATVBAHA.111.230847DOI Listing
September 2011

Role of the atypical chemoattractant receptor CRAM in regulating CCL19 induced CCR7 responses in B-cell chronic lymphocytic leukemia.

Authors:
Julie Catusse Marion Leick Mareike Groch David J Clark Maike V Buchner Katja Zirlik Meike Burger

Mol Cancer 2010 Nov 22;9:297. Epub 2010 Nov 22.

University Clinic of Freiburg, Department of Hematology and Oncology, Hugstetterstr, 55, 79106, Freiburg, Germany.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1476-4598-9-297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998479PMC
November 2010

The microenvironment differentially impairs passive and active immunotherapy in chronic lymphocytic leukaemia - CXCR4 antagonists as potential adjuvants for monoclonal antibodies.

Authors:
Maike Buchner Philipp Brantner Natalie Stickel Gabriele Prinz Meike Burger Constance Bär Christine Dierks Dietmar Pfeifer Ariane Ott Roland Mertelsmann John G Gribben Hendrik Veelken Katja Zirlik

Br J Haematol 2010 Oct 25;151(2):167-78. Epub 2010 Aug 25.

Department of Haematology and Oncology, University Medical Centre Freiburg, Freiburg, Germany.

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http://doi.wiley.com/10.1111/j.1365-2141.2010.08316.x
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http://dx.doi.org/10.1111/j.1365-2141.2010.08316.xDOI Listing
October 2010

Comparative analysis of predicted HLA binding of immunoglobulin idiotype sequences indicates T cell-mediated immunosurveillance in follicular lymphoma.

Authors:
Anna-Maria Strothmeyer Dimitrios Papaioannou Marcus Dühren-von Minden Marcelo Navarrete Katja Zirlik Kristina Heining-Mikesch Hendrik Veelken

Blood 2010 Sep 3;116(10):1734-6. Epub 2010 Jun 3.

Department of Hematology/Oncology, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2010-02-270199DOI Listing
September 2010

The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease.

Authors:
Christine Dierks Francisco Adrian Paul Fisch Hong Ma Helga Maurer Dieter Herchenbach Christine Ulrike Forster Clara Sprissler Guoxun Liu Sabine Rottmann Gui-Rong Guo Zirlik Katja Hendrik Veelken Markus Warmuth

Cancer Res 2010 Aug;70(15):6193-204

Hematology/Oncology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3719DOI Listing
August 2010

Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans.

Authors:
Peter Stachon Anna Missiou Carina Walter Nerea Varo Christian Colberg Dennis Wolf Maike Buchner Constantin von Zur Mühlen Katja Zirlik Christoph Bode Andreas Zirlik

PLoS One 2010 Jul 14;5(7):e11589. Epub 2010 Jul 14.

Department of Cardiology, University of Freiburg, Freiburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011589PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904388PMC
July 2010

Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia.

Authors:
Maike Buchner Constance Baer Gabriele Prinz Christine Dierks Meike Burger Thorsten Zenz Stephan Stilgenbauer Hassan Jumaa Hendrik Veelken Katja Zirlik

Blood 2010 Jun 24;115(22):4497-506. Epub 2010 Mar 24.

Department of Hematology and Oncology, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1182/blood-2009-07-233692DOI Listing
June 2010

Tumor necrosis factor receptor-associated factor 1 (TRAF1) deficiency attenuates atherosclerosis in mice by impairing monocyte recruitment to the vessel wall.

Authors:
Anna Missiou Natascha Köstlin Nerea Varo Philipp Rudolf Peter Aichele Sandra Ernst Christian Münkel Carina Walter Peter Stachon Benjamin Sommer Dietmar Pfeifer Katja Zirlik Lindsey MacFarlane Dennis Wolf Erdyni Tsitsikov Christoph Bode Peter Libby Andreas Zirlik

Circulation 2010 May 26;121(18):2033-44. Epub 2010 Apr 26.

Department of Cardiology, University of Freiburg, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.895037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995263PMC
May 2010

[Vorinostat in the treatment of cutaneous T-cell lymphomas. Treatment with histone deacetylases inhibitors].

Authors:
Katja Zirlik Dorothée Nashan Hendrik Veelken

Pharm Unserer Zeit 2010 May;39(3):190-6

Abteilung Innere Medizin I, Medizinische Universitätsklinik, Hugstetter Strasse 55, D-79106 Freiburg i.Br.

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http://dx.doi.org/10.1002/pauz.201000365DOI Listing
May 2010

CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease.

Authors:
Anna Missiou Dennis Wolf Isabel Platzer Sandra Ernst Carina Walter Philipp Rudolf Katja Zirlik Natascha Köstlin Florian K Willecke Christian Münkel Uwe Schönbeck Peter Libby Christoph Bode Nerea Varo Andreas Zirlik

Thromb Haemost 2010 Apr 19;103(4):788-96. Epub 2010 Feb 19.

Department of Cardiology, University of Freiburg, Freiburg, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1160/TH09-07-0463
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http://dx.doi.org/10.1160/TH09-07-0463DOI Listing
April 2010

Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia.

Authors:
Maike Buchner Simon Fuchs Gabriele Prinz Dietmar Pfeifer Kilian Bartholomé Meike Burger Nina Chevalier Laurent Vallat Jens Timmer John G Gribben Hassan Jumaa Hendrik Veelken Christine Dierks Katja Zirlik

Cancer Res 2009 Jul 23;69(13):5424-32. Epub 2009 Jun 23.

University Medical Center Freiburg, Department of Hematology and Oncology, Germany.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-08-4252DOI Listing
July 2009

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.

Authors:
Christine Dierks Ronak Beigi Gui-Rong Guo Katja Zirlik Mario R Stegert Paul Manley Christopher Trussell Annette Schmitt-Graeff Klemens Landwerlin Hendrik Veelken Markus Warmuth

Cancer Cell 2008 Sep;14(3):238-49

Department of Hematology/Oncology, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1016/j.ccr.2008.08.003DOI Listing
September 2008

Essential role of stromally induced hedgehog signaling in B-cell malignancies.

Authors:
Christine Dierks Jovana Grbic Katja Zirlik Ronak Beigi Nathan P Englund Gui-Rong Guo Hendrik Veelken Monika Engelhardt Roland Mertelsmann Joseph F Kelleher Peter Schultz Markus Warmuth

Nat Med 2007 Aug 15;13(8):944-51. Epub 2007 Jul 15.

Kinase Biology/In-vivo Oncology, Department of Pharmacology, Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA.

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http://www.nature.com/articles/nm1614
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http://dx.doi.org/10.1038/nm1614DOI Listing
August 2007

Cytotoxic T cells generated against heteroclitic peptides kill primary tumor cells independent of the binding affinity of the native tumor antigen peptide.

Authors:
Katja Mauerer Zirlik David Zahrieh Donna Neuberg John G Gribben

Blood 2006 Dec 10;108(12):3865-70. Epub 2006 Aug 10.

Institute of Cancer, Barts and The London School of Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom.

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http://dx.doi.org/10.1182/blood-2006-04-014415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895467PMC
December 2006

Cloning of idiotype immunoglobulin genes in B cell lymphomas by anchored PCR and production of individual recombinant idiotype vaccines in Escherichia coli.

Authors:
Cristina Bertinetti Frederic Simon Katja Zirlik Kristina Heining-Mikesch Dietmar Pfeifer Frank Osterroth Felicia M Rosenthal Hendrik Veelken

Eur J Haematol 2006 Nov 27;77(5):395-402. Epub 2006 Jul 27.

Department of Haematology/Oncology, Freiburg University Medical Center, Freiburg, Germany.

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http://dx.doi.org/10.1111/j.1600-0609.2006.00740.xDOI Listing
November 2006

Phase I trial of a novel intradermal idiotype vaccine in patients with advanced B-cell lymphoma: specific immune responses despite profound immunosuppression.

Authors:
Cristina Bertinetti Katja Zirlik Kristina Heining-Mikesch Gabriele Ihorst Heide Dierbach Cornelius F Waller Hendrik Veelken

Cancer Res 2006 Apr;66(8):4496-502

Department of Hematology/Oncology, Freiburg University Medical Center, Freiburg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-4233DOI Listing
April 2006