Kathy Pritchard-Jones

Kathy Pritchard-Jones

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Kathy Pritchard-Jones

Kathy Pritchard-Jones

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WARNING: G-401 and SK-NEP-1 cell lines are not Wilms tumor cell lines.

Pediatr Blood Cancer 2019 Jul 29;66(7):e27741. Epub 2019 Mar 29.

Molecular Bases of Genetic Risk and Genetic Testing Unit, Department of Research, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

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http://dx.doi.org/10.1002/pbc.27741DOI Listing
July 2019

Comment on: "Indications and results of diagnostic biopsy in pediatric renal tumors: A retrospective analysis of 317 patients with critical review of SIOP guidelines".

Pediatr Blood Cancer 2019 Jul 2;66(7):e27746. Epub 2019 Apr 2.

University College London Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1002/pbc.27746DOI Listing
July 2019

Reply to the Letter to the Editor: Renal tumors in children older than 10 years-Should we be doing upfront nephrectomy?

Pediatr Blood Cancer 2019 Jul 15;66(7):e27760. Epub 2019 Apr 15.

University College London Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1002/pbc.27760DOI Listing
July 2019

Evaluation of needle biopsy as a potential risk factor for local recurrence of Wilms tumour in the SIOP WT 2001 trial.

Eur J Cancer 2019 Jul 1;116:13-20. Epub 2019 Jun 1.

Cancer Section, Developmental Biology & Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.04.027DOI Listing
July 2019

The genetic changes of Wilms tumour.

Nat Rev Nephrol 2019 Apr;15(4):240-251

Wellcome Sanger Institute, Cambridge, UK.

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http://dx.doi.org/10.1038/s41581-019-0112-0DOI Listing
April 2019

Stage at diagnosis for childhood solid cancers in Australia: A population-based study.

Cancer Epidemiol 2019 04 1;59:208-214. Epub 2019 Mar 1.

Cancer Council Queensland, Brisbane, Australia; Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia; Institute for Resilient Regions, University of Southern Queensland, Brisbane, Australia; School of Public Health, University of Queensland, Brisbane, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.canep.2019.02.013DOI Listing
April 2019

Science and health for all children with cancer.

Science 2019 Mar;363(6432):1182-1186

Board, International Society of Paediatric Oncology (SIOP), Zug, Switzerland.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aaw4892
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http://dx.doi.org/10.1126/science.aaw4892DOI Listing
March 2019

Pharmacotherapeutic Management of Wilms Tumor: An Update.

Paediatr Drugs 2019 Feb;21(1):1-13

UCL Great Ormond Street Hospital Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1007/s40272-018-0323-zDOI Listing
February 2019

Outcomes of non-anaplastic stage III and 'inoperable' Wilms tumour treated in the UKW3 trial.

Radiother Oncol 2019 02 15;131:1-7. Epub 2018 Dec 15.

Cancer Section, Developmental Biology & Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2018.10.026DOI Listing
February 2019

Somatic TP53 Mutations Are Detectable in Circulating Tumor DNA from Children with Anaplastic Wilms Tumors.

Transl Oncol 2018 Dec 29;11(6):1301-1306. Epub 2018 Aug 29.

UCL Great Ormond Street Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121832PMC
December 2018

Follow-up surveillance of Wilm's tumour - Authors' reply.

Lancet Oncol 2018 10 1;19(10):e503. Epub 2018 Oct 1.

Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1016/S1470-2045(18)30691-0DOI Listing
October 2018

The Care and Outcomes of Older Persons with Lung Cancer in England and the United States, 2008-2012.

J Thorac Oncol 2018 07 1;13(7):904-914. Epub 2018 May 1.

Department of Internal Medicine, Section of General Internal Medicine, Cancer Outcomes, Public Policy, and Effectiveness Research Center, Yale School of Medicine, New Haven, Connecticut. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.04.022DOI Listing
July 2018

WT1 Mutation in Childhood Cancer.

Methods Mol Biol 2016 ;1467:1-14

UCL Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1007/978-1-4939-4023-3_1DOI Listing
January 2018

Paediatrics: Integrating genomics to dig deeper into Wilms tumour biology.

Nat Rev Urol 2017 12 25;14(12):703-704. Epub 2017 Oct 25.

Department of Oncology, Great Ormond Street Hospital for Children, NHS Foundation Trust, Great Ormond Street, London WC1N 3JH, UK and the UCL Great Ormond Street Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.

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http://www.nature.com/doifinder/10.1038/nrurol.2017.178
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http://dx.doi.org/10.1038/nrurol.2017.178DOI Listing
December 2017

Nephrogenic rests in Wilms tumors treated with preoperative chemotherapy: The UK SIOP Wilms Tumor 2001 Trial experience.

Pediatr Blood Cancer 2017 Nov 6;64(11). Epub 2017 Apr 6.

Molecular Haematology and Cancer Biology Unit, Institute of Child Health, University College London, London, United Kingdom.

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http://dx.doi.org/10.1002/pbc.26547DOI Listing
November 2017

Review of phase I and II trials for Wilms' tumour - Can we optimise the search for novel agents?

Eur J Cancer 2017 07 15;79:205-213. Epub 2017 May 15.

Department of Hematology and Pediatric Onco-Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1016/j.ejca.2017.04.005DOI Listing
July 2017

Bilateral Wilms tumour: a review of clinical and molecular features.

Expert Rev Mol Med 2017 07 18;19:e8. Epub 2017 Jul 18.

UCL Institute of Child Health,University College London,London,UK.

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http://dx.doi.org/10.1017/erm.2017.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687181PMC
July 2017

Role of CD56 in Normal Kidney Development and Wilms Tumorigenesis.

Fetal Pediatr Pathol 2017 Feb 9;36(1):62-75. Epub 2016 Dec 9.

b University College London Institute of Child Health, Cancer Section , London , UK.

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http://dx.doi.org/10.1080/15513815.2016.1256358DOI Listing
February 2017

Diagnosis of cancer as an emergency: a critical review of current evidence.

Nat Rev Clin Oncol 2017 Jan 11;14(1):45-56. Epub 2016 Oct 11.

The Primary Care Unit, Department of Public Health and Primary Care, Institute of Public Health, Forvie Site, Robinson Way, University of Cambridge, Cambridge CB2 0SR, UK.

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http://dx.doi.org/10.1038/nrclinonc.2016.155DOI Listing
January 2017

Wilms tumor: "State-of-the-art" update, 2016.

Semin Pediatr Surg 2016 Oct 4;25(5):250-256. Epub 2016 Sep 4.

Cancer Section, Developmental Biology & Cancer Programme, Institute of Child Health, University College London, 30 Guilford St, London WC1N 1EH, UK. Electronic address:

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http://dx.doi.org/10.1053/j.sempedsurg.2016.09.003DOI Listing
October 2016

Biology and treatment of renal tumours in childhood.

Eur J Cancer 2016 Oct 28;68:179-195. Epub 2016 Oct 28.

Cancer Section, University College London, Institute of Child Health, UK.

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http://dx.doi.org/10.1016/j.ejca.2016.09.005DOI Listing
October 2016

Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study.

J Clin Oncol 2016 09 18;34(26):3195-203. Epub 2016 Jul 18.

Tasnim Chagtai, William Mifsud, Neil Sebire, Richard Dafydd Williams, and Kathy Pritchard-Jones, University College London Institute of Child Health, London; Sergey Popov, University Hospital of Wales; Gordan Vujanić, Cardiff University School of Medicine, Cardiff, United Kingdom; Christina Zill, Jenny Wegert, and Manfred Gessler, Wuerzburg University, Wuerzburg; Marcel Kool, German Cancer Research Center, Heidelberg; Norbert Graf, Saarland University Hospital, Homburg, Germany; Linda Dainese, Yves Le Bouc, Annick Blaise, and Aurore Coulomb, Sorbonne Universités; Linda Dainese, Yves Le Bouc, and Aurore Coulomb, Assistance Publique Hôpitaux de Paris-Hôpital Armand Trousseau, Paris; Christophe Bergeron, Centre Léon Bérard, Lyon, France; Suvi Savola, MRC-Holland; Harm van Tinteren, Netherlands Cancer Institute, Amsterdam; Godelieve A.M. Tytgat and Marry M. van den Heuvel-Eibrink, Princess Maxima Center for Pediatric Oncology/Hematology, Utrecht, the Netherlands; Peter F. Ambros and Leo Kager, Children's Cancer Research Institute; Leo Kager, St Anna Children's Hospital, Vienna, Austria; Maureen J. O'Sullivan, Our Lady's Children's Hospital, Dublin, Ireland; and Linda Holmquist Mengelbier and David Gisselsson, Lund University, Lund, Sweden.

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http://dx.doi.org/10.1200/JCO.2015.66.0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505170PMC
September 2016

European Survey on Standards of Care in paediatric oncology centres.

Eur J Cancer 2016 07 28;61:11-9. Epub 2016 Apr 28.

Direction of Clinical Research, The Gustave Roussy and Universite Paris-Sud, 114 Rue Edouard Vaillant, Villejuif 94805, France.

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http://dx.doi.org/10.1016/j.ejca.2016.03.073DOI Listing
July 2016

Intra-Tumor Genetic Heterogeneity in Wilms Tumor: Clonal Evolution and Clinical Implications.

EBioMedicine 2016 Jul 27;9:120-129. Epub 2016 May 27.

UCL Institute of Child Health, London, United Kingdom; Department of Histopathology, Great Ormond Street Hospital, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.05.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972528PMC
July 2016

Evidence for a delay in diagnosis of Wilms' tumour in the UK compared with Germany: implications for primary care for children.

Arch Dis Child 2016 May 6;101(5):417-20. Epub 2016 Mar 6.

Department of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/archdischild-2015-309212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862069PMC
May 2016

Ethical issues of clinical trials in paediatric oncology from 2003 to 2013: a systematic review.

Lancet Oncol 2016 05 27;17(5):e187-97. Epub 2016 Apr 27.

Department of Paediatric, Adolescents and Young adults Oncology, Institut Curie and School of Medicine, University Paris Descartes, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1016/S1470-2045(16)00142-XDOI Listing
May 2016

Biomarkers to detect Wilms tumors in pediatric patients: where are we now?

Future Oncol 2015 ;11(15):2221-34

UCL Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.2217/fon.15.136DOI Listing
April 2016

Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration.

J Clin Oncol 2015 Sep 24;33(27):2999-3007. Epub 2015 Aug 24.

Jeffrey S. Dome, Children's National Health System, Washington, DC; James I. Geller, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Elizabeth A. Mullen, Dana-Farber Cancer Institute, Boston, MA; Norbert Graf, Saarland University, Homburg, Germany; Conrad V. Fernandez, IWK Health Centre, Halifax, Nova Scotia, Canada; Filippo Spreafico, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Milan, Italy; Marry Van den Heuvel-Eibrink, Princess Màxima Center for Pediatric Oncology, Utrecht, the Netherlands; and Kathy Pritchard-Jones, University College London Institute of Child Health, London, United Kingdom.

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http://dx.doi.org/10.1200/JCO.2015.62.1888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567702PMC
September 2015

A multi-Gaussian model for apparent diffusion coefficient histogram analysis of Wilms' tumour subtype and response to chemotherapy.

NMR Biomed 2015 Aug 9;28(8):948-57. Epub 2015 Jun 9.

Developmental Imaging and Biophysics Section, Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1002/nbm.3337DOI Listing
August 2015

Paediatrics: Long-term effects of Wilms tumour therapy on renal function.

Nat Rev Urol 2015 Aug 14;12(8):423-4. Epub 2015 Jul 14.

Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.

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http://www.nature.com/articles/nrurol.2015.167
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http://dx.doi.org/10.1038/nrurol.2015.167DOI Listing
August 2015

The yin and yang of kidney development and Wilms' tumors.

Genes Dev 2015 Mar;29(5):467-82

UCL Institute of Child Health, University College London, London WC1N 1EH, United Kingdom.

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http://dx.doi.org/10.1101/gad.256396.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358399PMC
March 2015

Drug discovery in paediatric oncology: roadblocks to progress.

Nat Rev Clin Oncol 2014 12 16;11(12):732-9. Epub 2014 Sep 16.

Institute of Child Health, Cancer Section, University College London, 30 Guilford Street, London WC1N 1EH, UK.

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http://www.nature.com/articles/nrclinonc.2014.149
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http://dx.doi.org/10.1038/nrclinonc.2014.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637819PMC
December 2014

Declining childhood and adolescent cancer mortality: great progress but still much to be done.

Cancer 2014 Aug 22;120(16):2388-91. Epub 2014 May 22.

University College London Institute of Child Health, London, United Kingdom.

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http://doi.wiley.com/10.1002/cncr.28745
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http://dx.doi.org/10.1002/cncr.28745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232044PMC
August 2014

Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour.

Nat Commun 2014 Aug 7;5:4398. Epub 2014 Aug 7.

1] Division of Genetics and Epidemiology, Institute of Cancer Research, London SM2 5NG, UK [2] Cancer Genetics Unit, Royal Marsden Hospital NHS Foundation Trust, London SM2 5PT, UK.

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http://dx.doi.org/10.1038/ncomms5398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143912PMC
August 2014

Toxicity and outcome of children and adolescents participating in phase I/II trials of novel anticancer drugs: the Royal Marsden experience.

J Pediatr Hematol Oncol 2014 Apr;36(3):218-23

*Pediatric Drug Development Unit, Children and Young People's Unit, The Royal Marsden NHS Foundation Trust §Pediatric Drug Development Team, Divisions of Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, Sutton †Pediatric Oncology Department, Great Ormond Street Hospital ‡Institute of Child Health, University College London, London, UK.

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http://dx.doi.org/10.1097/MPH.0000000000000003DOI Listing
April 2014

Why should survivors of childhood renal tumor and others with only one kidney be denied the chance to play contact sports?

Expert Rev Anticancer Ther 2014 Apr 9;14(4):363-6. Epub 2014 Feb 9.

Hematology and Pediatric Onco-Hematology Department, Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

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http://www.tandfonline.com/doi/full/10.1586/14737140.2014.88
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http://dx.doi.org/10.1586/14737140.2014.882234DOI Listing
April 2014

Towards reducing inequalities: European Standards of Care for Children with Cancer.

Eur J Cancer 2014 Feb 30;50(3):481-5. Epub 2013 Nov 30.

Institute of Child Health, University College London, UK.

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http://dx.doi.org/10.1016/j.ejca.2013.11.004DOI Listing
February 2014

Wilms' tumor: biology, diagnosis and treatment.

Transl Pediatr 2014 Jan;3(1):12-24

1 Haematology and Oncology Department, Great Ormond Street Hospital For Children NHS Foundation Trust, London, UK ; 2 Molecular Haematology and Cancer Biology Unit, University College London, Institute of Child Health, London, UK.

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http://dx.doi.org/10.3978/j.issn.2224-4336.2014.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728859PMC
January 2014

Is Wilms tumor a candidate neoplasia for treatment with WNT/β-catenin pathway modulators?--A report from the renal tumors biology-driven drug development workshop.

Mol Cancer Ther 2013 Dec 20;12(12):2619-27. Epub 2013 Nov 20.

Corresponding Author: Kathy Pritchard-Jones, Hugh and Catherine Stevenson Professor of Pediatric Oncology, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858246PMC
December 2013

Bilateral wilms tumor with TP53-related anaplasia.

Pediatr Dev Pathol 2013 May-Jun;16(3):217-23. Epub 2013 Feb 6.

Divisions of Molecular Pathology and Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, United Kingdom.

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http://dx.doi.org/10.2350/12-08-1245-CR.1DOI Listing
August 2013

Commissioning: aiming for a gold standard of care.

Health Serv J 2013 May;123(6353):22-3

London Cancer.

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May 2013

Children with cancer: driving the global agenda.

Lancet Oncol 2013 Mar 20;14(3):189-91. Epub 2013 Feb 20.

Institute of Child Health, University College London, London WC1N 1EH, UK.

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http://dx.doi.org/10.1016/S1470-2045(13)70043-3DOI Listing
March 2013

An international strategy to determine the role of high dose therapy in recurrent Wilms' tumour.

Eur J Cancer 2013 Jan 4;49(1):194-210. Epub 2012 Sep 4.

Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1016/j.ejca.2012.07.010DOI Listing
January 2013

SIOP PODC: clinical guidelines for the management of children with Wilms tumour in a low income setting.

Pediatr Blood Cancer 2013 Jan 26;60(1):5-11. Epub 2012 Sep 26.

Department of Paediatric Oncology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/pbc.24321DOI Listing
January 2013

Consent to tissue banking for research: qualitative study and recommendations.

Arch Dis Child 2012 Jul 18;97(7):632-6. Epub 2012 May 18.

Department of Infection, Immunity and Infl ammation, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1136/archdischild-2011-301165DOI Listing
July 2012

The contribution of chest CT-scan at diagnosis in children with unilateral Wilms' tumour. Results of the SIOP 2001 study.

Eur J Cancer 2012 May 22;48(7):1060-5. Epub 2011 Jun 22.

Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ejca.2011.05.025DOI Listing
May 2012

Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in Wilms tumor.

Genes Chromosomes Cancer 2011 Dec 31;50(12):982-95. Epub 2011 Aug 31.

Molecular Haematology and Cancer Biology Unit, University College London, Institute of Child Health, London, UK.

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http://dx.doi.org/10.1002/gcc.20907DOI Listing
December 2011

Renal tumors in children aged 10-16 Years: a report from the United Kingdom Children's Cancer and Leukaemia Group.

Pediatr Dev Pathol 2011 May-Jun;14(3):189-93. Epub 2010 Nov 5.

Department Paediatric Oncology, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.2350/10-06-0855-OA.1DOI Listing
October 2011

Mesoblastic nephroma: a report of the United Kingdom Children's Cancer and Leukaemia Group (CCLG).

Pediatr Blood Cancer 2011 May 16;56(5):744-8. Epub 2011 Jan 16.

Paediatric Surgery Unit, Sheffield Children's Hospital, Sheffield, UK.

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http://dx.doi.org/10.1002/pbc.22871DOI Listing
May 2011

Pilot study of F(18)-Fluorodeoxyglucose Positron Emission Tomography/computerised tomography in Wilms' tumour: correlation with conventional imaging, pathology and immunohistochemistry.

Eur J Cancer 2011 Feb 10;47(3):389-96. Epub 2010 Nov 10.

Department of Paediatrics and Adolescents, University College Hospitals NHS Foundation Trust, 250 Euston Road, London NW1 2PQ, United Kingdom.

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http://dx.doi.org/10.1016/j.ejca.2010.09.039DOI Listing
February 2011

Stromal and epithelial predominant Wilms tumours have an excellent outcome: the SIOP 93 01 experience.

Pediatr Blood Cancer 2010 Aug;55(2):233-8

Department of Paediatric Oncology, Academic Medical Centre, University of Amsterdam, Emma Children's Hospital AMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/pbc.22496DOI Listing
August 2010

Nephrectomy-only for Wilms tumour: negotiating the tangled web requires multi-professional input.

Pediatr Blood Cancer 2010 Jul;54(7):865-6

Section of Paediatric Oncology, The Institute of Cancer Research & Royal Marsden Hospital, Downs Road, Sutton, Surrey, United Kingdom.

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http://doi.wiley.com/10.1002/pbc.22505
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http://dx.doi.org/10.1002/pbc.22505DOI Listing
July 2010

Hereditary leiomyomatosis and renal cell carcinoma: very early diagnosis of renal cancer in a paediatric patient.

Fam Cancer 2010 Jun;9(2):239-43

Department of Medical Genetics, St George's Hospital Medical School, Cranmer Terrace, SW17 0RE, London, UK.

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http://dx.doi.org/10.1007/s10689-009-9306-0DOI Listing
June 2010