Kathryn E Carlson

Kathryn E Carlson

UNVERIFIED PROFILE

Are you Kathryn E Carlson?   Register this Author

Register author
Kathryn E Carlson

Kathryn E Carlson

Publications by authors named "Kathryn E Carlson"

Are you Kathryn E Carlson?   Register this Author

72Publications

1291Reads

11Profile Views

New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons.

ACS Med Chem Lett 2018 Aug 5;9(8):803-808. Epub 2018 Jul 5.

Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, New Jersey 07601 United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsmedchemlett.8b00106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088359PMC
August 2018

Selenophenes: Introducing a New Element into the Core of Non-Steroidal Estrogen Receptor Ligands.

ChemMedChem 2017 02 9;12(3):235-249. Epub 2017 Jan 9.

State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, 185 East Lake Road, Wuhan, 430071, P.R. China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201600593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405701PMC
February 2017

Exploring the Structural Compliancy versus Specificity of the Estrogen Receptor Using Isomeric Three-Dimensional Ligands.

ACS Chem Biol 2017 02 29;12(2):494-503. Epub 2016 Dec 29.

Department of Chemistry, University of Illinois at Urbana-Champaign , 600 South Mathews Avenue, Urbana, Illinois 61801, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.6b00918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315646PMC
February 2017

Neural-Network Scoring Functions Identify Structurally Novel Estrogen-Receptor Ligands.

J Chem Inf Model 2015 Sep 4;55(9):1953-61. Epub 2015 Sep 4.

Department of Chemistry & Biochemistry and the National Biomedical Computation Resource, University of California, San Diego , La Jolla, California 92093, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jcim.5b00241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780411PMC
September 2015

Synthesis and receptor binding in trans-CD ring-fused A-CD estrogens: comparison with the cis-fused isomers.

Bioorg Med Chem Lett 2014 Aug 27;24(16):3841-4. Epub 2014 Jun 27.

Department of Chemistry, University of Ottawa, D'Iorio Hall, 10 Marie Curie St., Ottawa K1N 6N5, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2014.06.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249688PMC
August 2014

Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor.

J Med Chem 2014 Apr 7;57(8):3532-45. Epub 2014 Apr 7.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, State Key Laboratory of Virology, Wuhan University School of Pharmaceutical Sciences , Wuhan 430071, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm500268jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002130PMC
April 2014

Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor.

ACS Chem Biol 2013 Apr 30;8(4):707-15. Epub 2013 Jan 30.

Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/cb3006243
Publisher Site
http://dx.doi.org/10.1021/cb3006243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631453PMC
April 2013

Thiophene-core estrogen receptor ligands having superagonist activity.

J Med Chem 2013 Apr 15;56(8):3346-66. Epub 2013 Apr 15.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, State Key Laboratory of Virology, Wuhan University School of Pharmaceutical Sciences, Wuhan 430072, China.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1186%2Fs13071-016-16
Web Search
http://pubs.acs.org/doi/abs/10.1021/jm400157e
Publisher Site
http://dx.doi.org/10.1021/jm400157eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666579PMC
April 2013

Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands.

ChemMedChem 2012 Jun 19;7(6):1094-100. Epub 2012 Apr 19.

State Key Laboratory of Virology, Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, 185 East Lake Road, Wuhan, 430071, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201200048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301955PMC
June 2012

BC-spiro-estradiols. Synthesis and estrogen receptor binding affinity of four new estradiol isomers.

Bioorg Med Chem Lett 2012 Jun 11;22(11):3713-7. Epub 2012 Apr 11.

Department of Chemistry, University of Ottawa, Ottawa, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2012.04.022DOI Listing
June 2012

Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide.

J Med Chem 2012 Mar 21;55(5):2324-41. Epub 2012 Feb 21.

State Key Laboratory of Virology, Wuhan University, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430072, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm201556rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297713PMC
March 2012

Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands.

J Med Chem 2012 Jan 14;55(1):528-37. Epub 2011 Dec 14.

Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/jm201436k
Publisher Site
http://dx.doi.org/10.1021/jm201436kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381613PMC
January 2012

Exploration of dimensions of estrogen potency: parsing ligand binding and coactivator binding affinities.

J Biol Chem 2011 Apr 14;286(15):12971-82. Epub 2011 Feb 14.

Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.205112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075970PMC
April 2011

Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs).

J Med Chem 2010 Apr;53(8):3320-9

Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm100047kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916745PMC
April 2010

Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.

Eur J Med Chem 2009 Sep 20;44(9):3412-24. Epub 2009 Feb 20.

Department of Chemistry, University of Illinois, 600 South Matthews Avenue, Urbana, IL 61801, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2009.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175689PMC
September 2009

Phenethyl pyridines with non-polar internal substituents as selective ligands for estrogen receptor beta.

Eur J Med Chem 2009 Sep 24;44(9):3560-70. Epub 2009 Mar 24.

Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2009.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176332PMC
September 2009

Synthesis and evaluation of aryl-substituted diarylpropionitriles, selective ligands for estrogen receptor beta, as positron-emission tomographic imaging agents.

Bioorg Med Chem 2009 May 9;17(9):3479-88. Epub 2009 Mar 9.

Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2009.02.064DOI Listing
May 2009

Steroidal bivalent ligands for the estrogen receptor: design, synthesis, characterization and binding affinities.

Bioorg Med Chem 2009 May 12;17(10):3528-35. Epub 2009 Apr 12.

Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave., Urbana, IL 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2009.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178464PMC
May 2009

Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity.

Bioorg Med Chem Lett 2009 Jan 6;19(1):108-10. Epub 2008 Nov 6.

Department of Chemistry, University of Illinois, Urbana, IL 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2008.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711511PMC
January 2009

Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor.

Bioorg Med Chem 2008 Dec 7;16(23):10075-84. Epub 2008 Oct 7.

Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2008.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613833PMC
December 2008

Expeditious synthesis of steroids containing a 2-methylsulfanyl-acetyl side chain as potential glucocorticoid receptor imaging agents.

Steroids 2008 Jan 7;73(1):69-76. Epub 2007 Sep 7.

Institut für Radiopharmazie, Forschungszentrum Dresden-Rossendorf e.V., Postfach 510119, 01314 Dresden, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.steroids.2007.08.013DOI Listing
January 2008

Chiral dimethylamine flutamide derivatives--modeling, synthesis, androgen receptor affinities and carbon-11 labeling.

Nucl Med Biol 2006 Aug;33(6):695-704

Department of Medical Biophysics and Nuclear Medicine, The Hebrew University of Jerusalem, Hadassah Hospital, Jerusalem 91120, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nucmedbio.2006.05.010DOI Listing
August 2006

Bromine- and iodine-substituted 16alpha,17alpha-dioxolane progestins for breast tumor imaging and radiotherapy: synthesis and receptor binding affinity.

J Med Chem 2006 Jul;49(15):4737-44

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm060348qDOI Listing
July 2006

Coactivator proteins as determinants of estrogen receptor structure and function: spectroscopic evidence for a novel coactivator-stabilized receptor conformation.

Mol Endocrinol 2005 Jun 20;19(6):1516-28. Epub 2005 Jan 20.

Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2004-0458DOI Listing
June 2005

A proteomic microarray approach for exploring ligand-initiated nuclear hormone receptor pharmacology, receptor selectivity, and heterodimer functionality.

Mol Cell Proteomics 2005 Mar 20;4(3):267-77. Epub 2004 Dec 20.

Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.M400192-MCP200DOI Listing
March 2005

Pyrazolo[1,5-a]pyrimidines as estrogen receptor ligands: defining the orientation of a novel heterocyclic core.

Bioorg Med Chem Lett 2004 Nov;14(22):5681-4

Department of Chemistry, University of Illinois, 600 S. Matthews Avenue, Urbana, IL 61801-3731, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2004.08.046DOI Listing
November 2004

Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity.

J Med Chem 2004 Nov;47(24):5872-93

Department of Chemistry and Department of Molecular and Integrative Physiology, University of Illinois, 600 South Matthews Avenue, Urbana, Illinois 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm049631kDOI Listing
November 2004

Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands.

Farmaco 2004 Aug;59(8):601-7

Dipartimento di Scienze Farmaceutiche, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.farmac.2004.01.007DOI Listing
August 2004

Estrogen receptor microarrays: subtype-selective ligand binding.

J Am Chem Soc 2004 Apr;126(15):4754-5

Department of Chemistry, University of Illinois, 600 South Matthews Avenue, Urbana, Illinois 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja039586qDOI Listing
April 2004

Ligand-induced changes in estrogen receptor conformation as measured by site-directed spin labeling.

Biochemistry 2004 Feb;43(7):1891-907

Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi035566pDOI Listing
February 2004

Molecular sensors of estrogen receptor conformations and dynamics.

Mol Endocrinol 2003 Dec 28;17(12):2593-602. Epub 2003 Aug 28.

Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2003-0239DOI Listing
December 2003

Exploration of the bicyclo[3.3.1]nonane system as a template for the development of new ligands for the estrogen receptor.

Bioorg Med Chem Lett 2003 Dec;13(24):4485-8

Department of Chemistry, University of Illinois, 600 S Mathews Avenue, Urbana, IL 61801, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2003.08.061DOI Listing
December 2003

Synthesis of 17-alpha-substituted estradiol-pyridin-2-yl hydrazine conjugates as effective ligands for labeling with Alberto's complex fac-[Re(OH2)3(CO)3]+ in water.

J Org Chem 2003 Sep;68(18):7063-70

Department of Chemistry and Biochemistry MSC 3C, New Mexico State University, P.O. Box 30001, Las Cruces, New Mexico 88003, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo034780gDOI Listing
September 2003

Synthesis of novel arylpyrazolo corticosteroids as potential ligands for imaging brain glucocorticoid receptors.

Steroids 2003 Feb;68(2):177-91

Institut für Bioanorganische und Radiopharmazeutische Chemie, FZ-Rossendorf e.V., Postfach 510119, Dresden 01314, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0039-128x(02)00171-xDOI Listing
February 2003

Estrogen receptor dimerization: ligand binding regulates dimer affinity and dimer dissociation rate.

Mol Endocrinol 2002 Dec;16(12):2706-19

Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/mend/article-lookup/doi/10.1210/me.
Publisher Site
http://dx.doi.org/10.1210/me.2002-0250DOI Listing
December 2002