Kathlynn C Brown

Kathlynn C Brown

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Kathlynn C Brown

Kathlynn C Brown

Publications by authors named "Kathlynn C Brown"

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Modular Three-component Delivery System Facilitates HLA Class I Antigen Presentation and CD8(+) T-cell Activation Against Tumors.

Mol Ther 2015 Jun 19;23(6):1092-1102. Epub 2015 Mar 19.

SRI International, Bioscience Division, Macromolecular Sciences, Harrisonburg, Virginia, USA. Electronic address:

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http://dx.doi.org/10.1038/mt.2015.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817760PMC
June 2015

Introduction of plasmid encoding for rare tRNAs reduces amplification bias in phage display biopanning.

Biotechniques 2015 Feb 1;58(2):81-4. Epub 2015 Feb 1.

SRI International, Center for Chemical Biology, Harrisonburg, VA.

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https://www.future-science.com/doi/10.2144/000114256
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http://dx.doi.org/10.2144/000114256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810453PMC
February 2015

Dimerization of a phage-display selected peptide for imaging of αvβ6- integrin: two approaches to the multivalent effect.

Theranostics 2014 15;4(7):745-60. Epub 2014 May 15.

2. Department of Internal Medicine, ; 4. The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.7150/thno.7811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038756PMC
January 2015

Identification of a novel lysosomal trafficking peptide using phage display biopanning coupled with endocytic selection pressure.

Bioconjug Chem 2014 Oct 15;25(10):1829-37. Epub 2014 Sep 15.

SRI International, Center for Chemical Biology , 140 Research Drive, Harrisonburg, Virginia 22802, United States.

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http://dx.doi.org/10.1021/bc500326xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198098PMC
October 2014

Identification and characterization of a suite of tumor targeting peptides for non-small cell lung cancer.

Sci Rep 2014 Mar 27;4:4480. Epub 2014 Mar 27.

1] Departments of Internal Medicine, University of Texas Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, TX 75390-8807, USA [2] The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, TX 75390-8807, USA.

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http://dx.doi.org/10.1038/srep04480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967199PMC
March 2014

Combinatorial peptide libraries: mining for cell-binding peptides.

Chem Rev 2014 Jan 3;114(2):1020-81. Epub 2013 Dec 3.

Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center , 5323 Harry Hines Boulevard, Dallas, Texas 75390-8807, United States.

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http://dx.doi.org/10.1021/cr400166nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053476PMC
January 2014

From phage display to nanoparticle delivery: functionalizing liposomes with multivalent peptides improves targeting to a cancer biomarker.

Bioconjug Chem 2013 Jan 7;24(1):85-96. Epub 2013 Jan 7.

Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8807, USA.

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http://dx.doi.org/10.1021/bc300498dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561762PMC
January 2013

Synthesis and biological evaluation of a peptide-paclitaxel conjugate which targets the integrin αvβ₆.

Bioorg Med Chem 2011 Sep 4;19(18):5480-9. Epub 2011 Aug 4.

Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8852, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896110059
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http://dx.doi.org/10.1016/j.bmc.2011.07.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195361PMC
September 2011

Peptidic tumor targeting agents: the road from phage display peptide selections to clinical applications.

Authors:
Kathlynn C Brown

Curr Pharm Des 2010 ;16(9):1040-54

Division of Translational Medicine Departments of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126568PMC
http://dx.doi.org/10.2174/138161210790963788DOI Listing
June 2010

MRI-visible micellar nanomedicine for targeted drug delivery to lung cancer cells.

Mol Pharm 2010 Feb;7(1):32-40

Department of Pharmacology, Simmons Comprehensive Cancer Center, Department of Internal Medicine, Division of Translational Research, and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1021/mp9001393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891983PMC
February 2010

Synthesis and characterization of a high-affinity {alpha}v{beta}6-specific ligand for in vitro and in vivo applications.

Mol Cancer Ther 2009 May 12;8(5):1239-49. Epub 2009 May 12.

Division of Translational Research, Department of Internal Medicine, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9185, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-1098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053473PMC
May 2009

Biopanning of phage displayed peptide libraries for the isolation of cell-specific ligands.

Methods Mol Biol 2009 ;504:291-321

Division of Translational Research, Department of Internal Medicine and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1007/978-1-60327-569-9_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053471PMC
March 2009

A Novel Strategy for Surface Modification of Superparamagnetic Iron Oxide Nanoparticles for Lung Cancer Imaging.

J Mater Chem 2009 ;19:6367-6372

Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd. Dallas, Texas 75390, USA ; Tel: +1 214 645 6370.

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http://dx.doi.org/10.1039/b902358eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875791PMC
January 2009

Peptide-targeted polyglutamic acid doxorubicin conjugates for the treatment of alpha(v)beta(6)-positive cancers.

Bioconjug Chem 2008 Sep 19;19(9):1813-21. Epub 2008 Aug 19.

Division of Translational Research, Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1021/bc800154fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053474PMC
September 2008

Advances in molecular imaging of pancreatic beta cells.

Front Biosci 2008 May 1;13:4558-75. Epub 2008 May 1.

Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas 75390, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790725PMC
May 2008

A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer.

Cancer Res 2007 Jun;67(12):5889-95

Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0245DOI Listing
June 2007

Isolation of multiple cell-binding ligands from different phage displayed-peptide libraries.

Biosens Bioelectron 2006 Apr 18;21(10):1867-75. Epub 2006 Jan 18.

Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Building, Dallas, TX 75390-9185, USA.

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http://dx.doi.org/10.1016/j.bios.2005.11.016DOI Listing
April 2006

Novel ligands for cancer diagnosis: selection of peptide ligands for identification and isolation of B-cell lymphomas.

Exp Hematol 2006 Apr;34(4):443-52

Division of Translational Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, 75390, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0301472X0500583
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http://dx.doi.org/10.1016/j.exphem.2005.12.013DOI Listing
April 2006

Peptide-mediated targeting of the islets of Langerhans.

Diabetes 2005 Jul;54(7):2103-8

Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA.

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http://dx.doi.org/10.2337/diabetes.54.7.2103DOI Listing
July 2005

Isolation of a mycoplasma-specific binding peptide from an unbiased phage-displayed peptide library.

Mol Biosyst 2005 Jul 24;1(2):149-57. Epub 2005 Jun 24.

Center for Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9185, USA.

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http://dx.doi.org/10.1039/b504572jDOI Listing
July 2005

Cell-specific delivery of a chemotherapeutic to lung cancer cells.

J Am Chem Soc 2004 Dec;126(48):15656-7

Center for Biomedical Inventions and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9185, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja0446496
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http://dx.doi.org/10.1021/ja0446496DOI Listing
December 2004

A library-selected, Langerhans cell-targeting peptide enhances an immune response.

DNA Cell Biol 2004 Nov;23(11):742-52

Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1089/dna.2004.23.742DOI Listing
November 2004

In vitro selection of a peptide with high selectivity for cardiomyocytes in vivo.

J Mol Biol 2004 Sep;342(1):171-82

Department of Internal Medicine, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas 75390-9185, USA.

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http://dx.doi.org/10.1016/j.jmb.2004.06.029DOI Listing
September 2004

Hitting the target with bifunctional phage.

Authors:
Kathlynn C Brown

Chem Biol 2004 Aug;11(8):1033-5

Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1016/j.chembiol.2004.08.004DOI Listing
August 2004

Patterning adhesion of mammalian cells with visible light, tris(bipyridyl)ruthenium(II) chloride, and a digital micromirror array.

J Biomed Mater Res A 2004 Mar;68(4):696-703

Center for Biomedical Inventions, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9185, USA.

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http://doi.wiley.com/10.1002/jbm.a.20090
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http://dx.doi.org/10.1002/jbm.a.20090DOI Listing
March 2004

Isolation of lung tumor specific peptides from a random peptide library: generation of diagnostic and cell-targeting reagents.

Cancer Lett 2003 Dec;202(2):219-30

Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9185, USA.

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http://dx.doi.org/10.1016/j.canlet.2003.08.011DOI Listing
December 2003

Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction.

Biochemistry 2002 Feb;41(8):2805-13

Departments of Chemistry and Biology, University of Virginia, Charlottesville, Virginia 22901, USA.

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http://dx.doi.org/10.1021/bi011762pDOI Listing
February 2002

Protein affinity labeling mediated by genetically encoded peptide tags.

Angew Chem Int Ed Engl 2002 Jan;41(2):356-9

Department of Internal Medicine, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas 75390-9185, USA.

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http://dx.doi.org/10.1002/1521-3773(20020118)41:2<356::aid-anie356>3.0.co;2-mDOI Listing
January 2002