Dr. Kathleen M Kokolus, PhD - Roswell Park Cancer Institute

Schweinfurthin natural products induce regression of murine melanoma and pair with anti-PD-1 therapy to facilitate durable tumor immunity.

Authors:

Kathleen M Kokolus Jeremy S Haley Emily J Koubek Raghavendra Gowda Saketh S Dinavahi Arati Sharma David F Claxton Klaus F Helm Joseph J Drabick Gavin P Robertson Jeffrey D Neighbors Raymond J Hohl Todd D Schell

Oncoimmunology 2019 11;8(2):e1539614. Epub 2018 Nov 11.

Department of Microbiology & Immunology, Penn State College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.1080/2162402X.2018.1539614	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343772	PMC

November 2018

2 Reads

6.283 Impact Factor

Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors.

Authors:

Lindsay K Ward-Kavanagh Kathleen M Kokolus Timothy K Cooper Aron E Lukacher Todd D Schell

Cancer Immunol Immunother 2018 Apr 13;67(4):639-652. Epub 2018 Jan 13.

Department of Microbiology and Immunology, Penn State College of Medicine, 500 University Drive, H107, Hershey, PA, 17033, USA.

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http://dx.doi.org/10.1007/s00262-018-2115-2	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862761	PMC

April 2018

8 Reads

1 Citation

3.941 Impact Factor

Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice.

Authors:

Kathleen M Kokolus Ying Zhang Jeffrey M Sivik Carla Schmeck Junjia Zhu Elizabeth A Repasky Joseph J Drabick Todd D Schell

Oncoimmunology 2018 21;7(3):e1405205. Epub 2017 Dec 21.

Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.1080/2162402X.2017.1405205	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790362	PMC

December 2017

27 Reads

1 Citation

6.283 Impact Factor

β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8 T Cells and Undermines Checkpoint Inhibitor Therapy.

Authors:

Mark J Bucsek Guanxi Qiao Cameron R MacDonald Thejaswini Giridharan Lauren Evans Brian Niedzwecki Haichao Liu Kathleen M Kokolus Jason W-L Eng Michelle N Messmer Kristopher Attwood Scott I Abrams Bonnie L Hylander Elizabeth A Repasky

Cancer Res 2017 10 17;77(20):5639-5651. Epub 2017 Aug 17.

Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0546	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645237	PMC

October 2017

79 Reads

5 Citations

9.330 Impact Factor

Improved survival and complete response rates in patients with advanced melanoma treated with concurrent ipilimumab and radiotherapy versus ipilimumab alone.

Authors:

Kristian M Koller Heath B Mackley Jason Liu Henry Wagner Giampaolo Talamo Todd D Schell Colette Pameijer Rogerio I Neves Bryan Anderson Kathleen M Kokolus Carol A Mallon Joseph J Drabick

Cancer Biol Ther 2017 01 1;18(1):36-42. Epub 2016 Dec 1.

a The Division of Hematology Oncology, Penn State Milton S. Hershey Medical Center , Hershey , PA , USA.

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http://dx.doi.org/10.1080/15384047.2016.1264543	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323007	PMC

January 2017

10 Reads

11 Citations

3.072 Impact Factor

Malignant melanoma-The cradle of anti-neoplastic immunotherapy.

Authors:

Kristian M Koller Wenge Wang Todd D Schell Eugene M Cozza Kathleen M Kokolus Rogerio I Neves Heath B Mackley Colette Pameijer Anna Leung Bryan Anderson Carol A Mallon Gavin Robertson Joseph J Drabick

Crit Rev Oncol Hematol 2016 Oct 7;106:25-54. Epub 2016 May 7.

Penn State University, Milton S Hershey Medical Center, Division of Hematology Oncology, United States. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2016.04.010	DOI Listing

October 2016

14 Reads

5 Citations

4.030 Impact Factor

Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells.

Authors:

Benjamin J Povinelli Kathleen M Kokolus Jason W-L Eng Christopher W Dougher Leslie Curtin Maegan L Capitano Christi T Sailsbury-Ruf Elizabeth A Repasky Michael J Nemeth

PLoS One 2015 20;10(3):e0120078. Epub 2015 Mar 20.

Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, United States of America; Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120078	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368554	PMC

February 2016

5 Reads

1 Citation

3.234 Impact Factor

Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis.

Authors:

Chen-Ting Lee Kathleen M Kokolus Nicholas D Leigh Maegan Capitano Bonnie L Hylander Elizabeth A Repasky

PLoS One 2015 20;10(3):e0120327. Epub 2015 Mar 20.

Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120327	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368208	PMC

February 2016

4 Reads

2 Citations

3.234 Impact Factor

Housing Temperature-Induced Stress Is Suppressing Murine Graft-versus-Host Disease through β2-Adrenergic Receptor Signaling.

Authors:

Nicholas D Leigh Kathleen M Kokolus Rachel E O'Neill Wei Du Jason W-L Eng Jingxin Qiu George L Chen Philip L McCarthy J David Farrar Xuefang Cao Elizabeth A Repasky

J Immunol 2015 Nov 12;195(10):5045-54. Epub 2015 Oct 12.

Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263;

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http://dx.doi.org/10.4049/jimmunol.1500700	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637222	PMC

November 2015

13 Reads

6 Citations

4.922 Impact Factor

Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation.

Authors:

Jason W-L Eng Chelsey B Reed Kathleen M Kokolus Rosemarie Pitoniak Adam Utley Mark J Bucsek Wen Wee Ma Elizabeth A Repasky Bonnie L Hylander

Nat Commun 2015 Mar 10;6:6426. Epub 2015 Mar 10.

Department of Immunology, Roswell Park Cancer Institute, Center for Genetics and Pharmacology, Elm and Carlton Streets, Buffalo, New York 14263, USA.

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http://dx.doi.org/10.1038/ncomms7426	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471870	PMC

March 2015

5 Reads

23 Citations

10.742 Impact Factor

Housing temperature influences the pattern of heat shock protein induction in mice following mild whole body hyperthermia.

Authors:

Jason W-L Eng Chelsey B Reed Kathleen M Kokolus Elizabeth A Repasky

Int J Hyperthermia 2014 Dec;30(8):540-6

Department of Immunology, Roswell Park Cancer Institute , Buffalo, New York , USA.

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http://dx.doi.org/10.3109/02656736.2014.981300	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340593	PMC

December 2014

10 Reads

5 Citations

2.645 Impact Factor

A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response.

Authors:

Jason W-L Eng Kathleen M Kokolus Chelsey B Reed Bonnie L Hylander Wen W Ma Elizabeth A Repasky

Cancer Immunol Immunother 2014 Nov 12;63(11):1115-28. Epub 2014 Oct 12.

Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA.

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http://dx.doi.org/10.1007/s00262-014-1617-9	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325998	PMC

November 2014

6 Reads

19 Citations

3.941 Impact Factor

Mild cold-stress depresses immune responses: Implications for cancer models involving laboratory mice.

Authors:

Michelle N Messmer Kathleen M Kokolus Jason W-L Eng Scott I Abrams Elizabeth A Repasky

Bioessays 2014 Sep 25;36(9):884-91. Epub 2014 Jul 25.

Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://dx.doi.org/10.1002/bies.201400066	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230712	PMC

September 2014

22 Reads

6 Citations

4.730 Impact Factor

Behaviorally mediated, warm adaptation: a physiological strategy when mice behaviorally thermoregulate.

Authors:

Christopher J Gordon Cenk Aydin Elizabeth A Repasky Kathleen M Kokolus Geoffrey Dheyongera Andrew F M Johnstone

J Therm Biol 2014 Aug 2;44:41-6. Epub 2014 Jul 2.

Toxicity Assessment Division, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1016/j.jtherbio.2014.06.006	DOI Listing

August 2014

2 Reads

7 Citations

1.505 Impact Factor

Stressful presentations: mild cold stress in laboratory mice influences phenotype of dendritic cells in naïve and tumor-bearing mice.

Authors:

Kathleen M Kokolus Haley M Spangler Benjamin J Povinelli Matthew R Farren Kelvin P Lee Elizabeth A Repasky

Front Immunol 2014 10;5:23. Epub 2014 Feb 10.

Department of Immunology, Roswell Park Cancer Institute , Buffalo, NY , USA.

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http://dx.doi.org/10.3389/fimmu.2014.00023	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918933	PMC

February 2014

2 Reads

14 Citations

Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature.

Authors:

Kathleen M Kokolus Maegan L Capitano Chen-Ting Lee Jason W-L Eng Jeremy D Waight Bonnie L Hylander Sandra Sexton Chi-Chen Hong Christopher J Gordon Scott I Abrams Elizabeth A Repasky

Proc Natl Acad Sci U S A 2013 Dec 18;110(50):20176-81. Epub 2013 Nov 18.

Department of Immunology, Department of Animal Resources, and Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263.

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http://dx.doi.org/10.1073/pnas.1304291110	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864348	PMC

December 2013

3 Reads

72 Citations

9.810 Impact Factor

Effector CD8+ T cell IFN-γ production and cytotoxicity are enhanced by mild hyperthermia.

Authors:

Thomas A Mace Lingwen Zhong Kathleen M Kokolus Elizabeth A Repasky

Int J Hyperthermia 2012 ;28(1):9-18

Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, USA.

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http://dx.doi.org/10.3109/02656736.2011.616182	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293214	PMC

May 2012

6 Reads

11 Citations

2.645 Impact Factor

Feeling too hot or cold after breast cancer: is it just a nuisance or a potentially important prognostic factor?

Authors:

Kathleen M Kokolus Chi-Chen Hong Elizabeth A Repasky

Int J Hyperthermia 2010 ;26(7):662-80

Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

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http://dx.doi.org/10.3109/02656736.2010.507235	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012377	PMC

December 2010

4 Reads

13 Citations

2.645 Impact Factor

Dr. Kathleen M Kokolus