Publications by authors named "Kathleen M Giacomini"

100Publications

Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.

J Pharm Sci 2020 Sep 7. Epub 2020 Sep 7.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xphs.2020.09.004DOI Listing
September 2020

Neural production of kynurenic acid in requires the AAT-1 transporter.

Genes Dev 2020 Aug 16;34(15-16):1033-1038. Epub 2020 Jul 16.

Department of Physiology, University of California at San Francisco, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.339119.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397858PMC
August 2020

Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives.

Proc Natl Acad Sci U S A 2020 07 22;117(27):16009-16018. Epub 2020 Jun 22.

Department of Microbiology and Immunology, G.W. Hooper Research Foundation, University of California, San Francisco, CA 94143;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1920483117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7355017PMC
July 2020

Oral Anticoagulants and Precision Medicine: Something Old, Something New.

Clin Pharmacol Ther 2020 Jun;107(6):1273-1277

University of California, San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1839DOI Listing
June 2020

COVID-19: A Defining Moment for Clinical Pharmacology?

Clin Pharmacol Ther 2020 07;108(1):11-15

University of California San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1876DOI Listing
July 2020

Novel Technologies Enable Mechanistic Understanding and Modeling of Drug Exposure and Response.

Clin Pharmacol Ther 2020 May;107(5):1045-1047

Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1822DOI Listing
May 2020

Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP.

Mol Pharm 2020 03 10;17(3):748-756. Epub 2020 Feb 10.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, California 94158, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.9b00658DOI Listing
March 2020

Clinical Pharmacology & Therapeutics 2030.

Clin Pharmacol Ther 2020 01;107(1):13-16

University of California San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1705DOI Listing
January 2020

Expanding Precompetitive Multisector Collaborations to Advance Drug Development and Pharmacogenomics.

Clin Pharmacol Ther 2020 01 27;107(1):96-101. Epub 2019 Nov 27.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1691DOI Listing
January 2020

Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3).

Am J Clin Nutr 2020 01;111(1):110-121

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ajcn/nqz255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944527PMC
January 2020

Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.

Clin Pharmacol Ther 2020 01 6;107(1):57-61. Epub 2019 Nov 6.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077926PMC
January 2020

l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan.

Bioorg Med Chem Lett 2019 08 20;29(16):2254-2258. Epub 2019 Jun 20.

Department of Chemistry, University of Nebraska at Kearney, Kearney, NE 69949, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2019.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690782PMC
August 2019

Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits.

Hum Mutat 2019 07 25;40(7):983-995. Epub 2019 Apr 25.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.23758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137536PMC
July 2019

Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.

Clin Pharmacol Ther 2019 09 23;106(3):623-631. Epub 2019 May 23.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941886PMC
September 2019

Research Projects Supported by the University of California, San Francisco-Stanford Center of Excellence in Regulatory Science and Innovation.

Clin Pharmacol Ther 2019 04 17;105(4):815-818. Epub 2019 Feb 17.

Department of Genetics, Stanford University, Stanford, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1308DOI Listing
April 2019

Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters.

Clin Pharmacol Ther 2019 02 20;105(2):323-325. Epub 2019 Jan 20.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1292DOI Listing
February 2019

The International Transporter Consortium: Summarizing Advances in the Role of Transporters in Drug Development.

Clin Pharmacol Ther 2018 11;104(5):766-771

Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1224DOI Listing
November 2018

Pharmacogenetics of Antidiabetic Drugs.

Adv Pharmacol 2018 14;83:361-389. Epub 2018 May 14.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10543589183002
Publisher Site
http://dx.doi.org/10.1016/bs.apha.2018.04.005DOI Listing
July 2019

ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision.

Clin Pharmacol Ther 2018 11 15;104(5):781-784. Epub 2018 May 15.

Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1082DOI Listing
November 2018

Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.

Mol Pharmacol 2018 07 2;94(1):689-699. Epub 2018 May 2.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California (L.Z., A.S., H.-C.C., S.W.Y., K.M.G.); Pharmacokinetics and Drug Metabolism, Amgen Inc., Cambridge, Massachusetts (A.G.); Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington (B.P., L.W., J.D.U.); and Safety and ADME Translational Sciences, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK (S.H.S., K.S.F.)

View Article

Download full-text PDF

Source
http://molpharm.aspetjournals.org/lookup/doi/10.1124/mol.117
Publisher Site
http://dx.doi.org/10.1124/mol.117.111153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987998PMC
July 2018

Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium.

Clin Pharmacol Ther 2018 11 31;104(5):803-817. Epub 2018 May 31.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cpt.1098
Publisher Site
http://dx.doi.org/10.1002/cpt.1098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348109PMC
November 2018

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.

PLoS Biol 2018 04 16;16(4):e2002907. Epub 2018 Apr 16.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.2002907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919692PMC
April 2018

Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions.

Clin Pharmacol Ther 2018 05 28;103(5):758-760. Epub 2017 Nov 28.

Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cpt.941
Publisher Site
http://dx.doi.org/10.1002/cpt.941DOI Listing
May 2018

Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.

Clin Pharmacol Ther 2018 02 28;103(2):233-242. Epub 2017 Nov 28.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760319PMC
February 2018

PharmGKB summary: very important pharmacogene information for ABCG2.

Pharmacogenet Genomics 2017 11;27(11):420-427

Departments of aGenetics bBioengineering, School of Medicine, Stanford University, Stanford cDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0000000000000305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788016PMC
November 2017

Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer.

Biochemistry 2017 07 29;56(27):3475-3483. Epub 2017 Jun 29.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco , San Francisco, California 94158, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.7b00339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917504PMC
July 2017

Computational Discovery and Experimental Validation of Inhibitors of the Human Intestinal Transporter OATP2B1.

J Chem Inf Model 2017 06 15;57(6):1402-1413. Epub 2017 Jun 15.

Department of Pharmaceutical Chemistry and California Institute of Quantitative Biosciences (QB3), University of California San Francisco , San Francisco, California 94158, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jcim.6b00720DOI Listing
June 2017

Transporters Involved in Metformin Pharmacokinetics and Treatment Response.

J Pharm Sci 2017 09 8;106(9):2245-2250. Epub 2017 May 8.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158; Institute for Human Genetics, University of California, San Francisco, San Francisco, California 94158. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xphs.2017.04.078DOI Listing
September 2017

The Effect of Uremic Solutes on the Organic Cation Transporter 2.

J Pharm Sci 2017 09 5;106(9):2551-2557. Epub 2017 May 5.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xphs.2017.04.076DOI Listing
September 2017

Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1).

J Med Chem 2017 04 15;60(7):2685-2696. Epub 2017 Mar 15.

Department of Bioengineering and Therapeutic Sciences, University of California , San Francisco, California 94143, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.6b01317DOI Listing
April 2017

The use of drug transporters as therapeutic targets.

Clin Adv Hematol Oncol 2016 Nov;14(11):869-871

UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation, UCSF School of Pharmacy, San Francisco, California.

View Article

Download full-text PDF

Source
November 2016

Genomic Characterization of Metformin Hepatic Response.

PLoS Genet 2016 Nov 30;12(11):e1006449. Epub 2016 Nov 30.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1006449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5130177PMC
November 2016

Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine.

Nat Rev Drug Discov 2017 Jan 25;16(1). Epub 2016 Nov 25.

RIKEN Center for Integrative Medical Science, Yokohama 230-0045, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd.2016.234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443656PMC
January 2017

Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3.

Mol Pharm 2016 09 9;13(9):3130-40. Epub 2016 Aug 9.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco , San Francisco, California 94158, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.6b00332DOI Listing
September 2016

Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans.

Front Pharmacol 2016 14;7:135. Epub 2016 Jun 14.

Department of Psychiatry and Behavioral Sciences, Duke UniversityDurham, NC, USA; Duke Institute for Brain Sciences, Duke UniversityDurham, NC, USA.

View Article

Download full-text PDF

Source
http://journal.frontiersin.org/Article/10.3389/fphar.2016.00
Publisher Site
http://dx.doi.org/10.3389/fphar.2016.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906013PMC
July 2016

LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs.

Bioorg Med Chem Lett 2016 06 11;26(11):2616-2621. Epub 2016 Apr 11.

Department of Chemistry, University of Nebraska Kearney, Kearney, NE, 68849.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2016.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875506PMC
June 2016

Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells.

Drug Metab Dispos 2016 Mar 23;44(3):356-64. Epub 2015 Dec 23.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California (H.C.C., A.A.Z., S.W.Y., K.M.G.); Systems Modeling and Simulation (T.S.M.) and Cardiovascular and Metabolic Disease Research Unit (D.O.S.), Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts; RES Group, Inc. (J.T., P.J.) Needham, Massachusetts

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/dmd.115.066647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047207PMC
March 2016

Unmet needs: Research helps regulators do their jobs.

Sci Transl Med 2015 Nov;7(315):315ps22

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, CA 94143-2911, USA. Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aac4369DOI Listing
November 2015

The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin.

Clin Pharmacokinet 2016 06;55(6):711-21

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, 1550 4th St, RH 584, Box 2911, San Francisco, CA, 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40262-015-0346-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876051PMC
June 2016

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).

Mol Pharm 2015 Dec 16;12(12):4301-10. Epub 2015 Nov 16.

Department of Bioengineering and Therapeutic Sciences, University of California , San Francisco, California 94158, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.5b00501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800991PMC
December 2015

Prediction and validation of enzyme and transporter off-targets for metformin.

J Pharmacokinet Pharmacodyn 2015 Oct 3;42(5):463-75. Epub 2015 Sep 3.

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, 94158-2911, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10928-015-9436-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656030PMC
October 2015

SLC transporters as therapeutic targets: emerging opportunities.

Nat Rev Drug Discov 2015 Aug 26;14(8):543-60. Epub 2015 Jun 26.

1] Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, San Francisco, California 94158, USA. [2] Institute for Human Genetics, University of California San Francisco, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrd4626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698371PMC
August 2015

Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin.

Mol Pharmacol 2015 Jul 28;88(1):75-83. Epub 2015 Apr 28.

Department of Bioengineering and Therapeutic Sciences (E.C.C., X.L., S.W.Y., E.G.G, S.L.S., K.M.G.) and Institute for Human Genetics (K.M.G.),University of California, San Francisco, California; and Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, China (L.C.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.114.096776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468641PMC
July 2015

OCT1 in hepatic steatosis and thiamine disposition.

Cell Cycle 2015 ;14(3):283-4

a Department of Pharmacology and Pharmaceutical Sciences, School of Medicine , Tsinghua University ; Beijing , China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15384101.2015.1006532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353231PMC
December 2015

A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome.

Pharmacogenet Genomics 2015 Feb;25(2):82-92

aDepartment of Bioengineering and Therapeutic Sciences bInstitute of Human Genetics, University of California cGenomics Core Facility, Institute for Human Genetics, San Francisco dGilead Sciences Inc., Foster City, California eDivision of Infectious Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/jpharmacogenetics/2015/02000/A_
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/FPC.0000000000000110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331349PMC
February 2015

Genome-wide discovery of drug-dependent human liver regulatory elements.

PLoS Genet 2014 Oct 2;10(10):e1004648. Epub 2014 Oct 2.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, United States of America; Institute for Human Genetics, University of California, San Francisco, San Francisco, California, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183418PMC
October 2014

Metformin pharmacogenomics: current status and future directions.

Diabetes 2014 Aug;63(8):2590-9

Center for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA; and Department of Medicine, Massachusetts General Hospital, Boston, MA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db13-1367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113063PMC
August 2014

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

Proc Natl Acad Sci U S A 2014 Jul 24;111(27):9983-8. Epub 2014 Jun 24.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-2911;Institute for Human Genetics, University of California, San Francisco, CA 94143

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1314939111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103324PMC
July 2014

Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations.

Clin Pharmacokinet 2014 Mar;53(3):283-293

Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40262-013-0117-y
Publisher Site
http://dx.doi.org/10.1007/s40262-013-0117-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927056PMC
March 2014

Molecular modeling and ligand docking for solute carrier (SLC) transporters.

Curr Top Med Chem 2013 ;13(7):843-56

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 1700 4th Street, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056341PMC
http://dx.doi.org/10.2174/1568026611313070007DOI Listing
April 2014

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1.

Proc Natl Acad Sci U S A 2013 Apr 18;110(14):5480-5. Epub 2013 Mar 18.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1218165110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619328PMC
April 2013

Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures.

Mol Pharm 2013 Feb 24;10(2):650-63. Epub 2013 Jan 24.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/mp300429e
Publisher Site
http://dx.doi.org/10.1021/mp300429eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032224PMC
February 2013

Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.

J Med Chem 2013 Feb 22;56(3):781-795. Epub 2013 Jan 22.

University of California, San Francisco, Department of Bioengineering and Therapeutic Sciences RH 581, 1550 4 Street San Francisco, CA 94158, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm301302sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068829PMC
February 2013

Renal transporters in drug development.

Annu Rev Pharmacol Toxicol 2013 8;53:503-29. Epub 2012 Nov 8.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-pharmtox-011112-140317DOI Listing
July 2013

Pharmacogenomics and patient care: one size does not fit all.

Sci Transl Med 2012 Sep;4(153):153ps18

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 94143, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.3003471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963516PMC
September 2012

High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.

J Biol Chem 2012 Nov 29;287(45):37745-56. Epub 2012 Aug 29.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.388157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488050PMC
November 2012

Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong!

Pharm Res 2012 Sep 20;29(9):2345-53. Epub 2012 Jul 20.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 4742C Medical Sciences II, 1150 W. Medical Center Drive, Ann Arbor, Michigan 48109-5633, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-012-0808-3DOI Listing
September 2012

Metformin pathways: pharmacokinetics and pharmacodynamics.

Pharmacogenet Genomics 2012 Nov;22(11):820-7

Department of Genetics, Stanford University Medical Center, Stanford University, Stanford, California 94304, USA.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=01213011-201211000-000
Publisher Site
http://dx.doi.org/10.1097/FPC.0b013e3283559b22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651676PMC
November 2012

Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET.

Proc Natl Acad Sci U S A 2011 Sep 1;108(38):15810-5. Epub 2011 Sep 1.

Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1106030108
Publisher Site
http://dx.doi.org/10.1073/pnas.1106030108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179104PMC
September 2011

Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

J Med Chem 2011 Jul 8;54(13):4548-58. Epub 2011 Jun 8.

Department of Bioengineering and Therapeutic Sciences, University of California-San Francisco, San Francisco, California 94143, United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jm2001629
Publisher Site
http://dx.doi.org/10.1021/jm2001629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257218PMC
July 2011

Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.

Clin Cancer Res 2011 Apr 18;17(8):2339-49. Epub 2011 Mar 18.

Departments of Bioengineering and Therapeutic Sciences, UCSF School of Medicine and UCSF Benioff Children's Hospital, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-10-2949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247296PMC
April 2011

Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins.

Mol Cancer Ther 2011 Mar 20;10(3):531-9. Epub 2011 Jan 20.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-10-0731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063525PMC
March 2011

GABAA receptor open-state conformation determines non-competitive antagonist binding.

Toxicol Appl Pharmacol 2011 Feb 25;250(3):221-8. Epub 2010 Nov 25.

Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2010.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056339PMC
February 2011

Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice.

Pharm Res 2011 Mar 23;28(3):610-25. Epub 2010 Nov 23.

Department of Bioengineering and Therapeutic Sciences, University of California, 1550 4th Street, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11095-010-0312-6
Publisher Site
http://dx.doi.org/10.1007/s11095-010-0312-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040319PMC
March 2011

Consequences of POR mutations and polymorphisms.

Mol Cell Endocrinol 2011 Apr 9;336(1-2):174-9. Epub 2010 Nov 9.

Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143-0978, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2010.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632974PMC
April 2011

Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro.

Pharmacogenet Genomics 2010 Nov;20(11):677-86

Department of Pediatrics, University of California, San Francisco, California 94143-0978, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e32833f4f9bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708132PMC
November 2010

Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.

Pharmacogenet Genomics 2010 Nov;20(11):687-99

Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0b013e32833fe789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976715PMC
November 2010

SLC19A1 pharmacogenomics summary.

Pharmacogenet Genomics 2010 Nov;20(11):708-15

Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=01213011-201011000-000
Publisher Site
http://dx.doi.org/10.1097/FPC.0b013e32833eca92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956130PMC
November 2010

Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase.

Pharmacogenet Genomics 2010 Oct;20(10):611-8

Department of Pediatrics, University of California, San Francisco, California 94143-0978, USA.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=01213011-201010000-000
Publisher Site
http://dx.doi.org/10.1097/FPC.0b013e32833e0cb5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940949PMC
October 2010

Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates.

Am J Physiol Renal Physiol 2010 Oct 28;299(4):F767-75. Epub 2010 Jul 28.

Dept. of Bioengineering and Therapeutics Sciences, University of California, San Francisco, California 94143-2911, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajprenal.00312.2010
Publisher Site
http://dx.doi.org/10.1152/ajprenal.00312.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957254PMC
October 2010

Role of the copper transporter, CTR1, in platinum-induced ototoxicity.

J Neurosci 2010 Jul;30(28):9500-9

Departments of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94143-0449, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.1544-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949060PMC
July 2010

Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.

Mol Cancer Ther 2010 Apr 6;9(4):1058-69. Epub 2010 Apr 6.

Department of Bioengineering and Therapeutic Sciences, University of California, 1550 4th Street, San Francisco, CA 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-09-1084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258025PMC
April 2010

Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine.

Mol Biosyst 2010 Aug 31;6(8):1403-10. Epub 2010 Mar 31.

Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b926588kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257980PMC
August 2010

Pharmacogenomics of membrane transporters: past, present and future.

Pharmacogenomics 2010 Apr;11(4):475-9

School of Pharmacy, University of California San Francisco, CA 94143-2911, USA.

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/pgs.10.22
Publisher Site
http://dx.doi.org/10.2217/pgs.10.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234298PMC
April 2010

Comparison of human solute carriers.

Protein Sci 2010 Mar;19(3):412-28

Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, California.

View Article

Download full-text PDF

Source
http://salilab.org/pdf/Schlessinger_ProteinSci_2010.pdf
Web Search
http://mpec.ucsf.edu/pdfs_new/Pubs_50.pdf
Web Search
http://doi.wiley.com/10.1002/pro.320
Publisher Site
http://dx.doi.org/10.1002/pro.320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866268PMC
March 2010