Kathleen Freson

Kathleen Freson

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Kathleen Freson

Kathleen Freson

Publications by authors named "Kathleen Freson"

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Blood platelet research in autism spectrum disorders: In search of biomarkers.

Res Pract Thromb Haemost 2019 Oct 16;3(4):566-577. Epub 2019 Jul 16.

Department of Cardiovascular Sciences Center for Molecular and Vascular Biology KU Leuven Leuven Belgium.

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http://dx.doi.org/10.1002/rth2.12239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781926PMC
October 2019

Curated disease-causing genes for bleeding, thrombotic, and platelet disorders: Communication from the SSC of the ISTH.

J Thromb Haemost 2019 Aug 9;17(8):1253-1260. Epub 2019 Jun 9.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/jth.14479DOI Listing
August 2019

Hyperactive GPIb-von Willebrand factor interaction as cause of thrombocytopenia: altered platelet formation clearance.

Authors:
Kathleen Freson

Haematologica 2019 Jul;104(7):1298-1299

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.3324/haematol.2019.219832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601106PMC
July 2019

De novo variant in tyrosine kinase SRC causes thrombocytopenia: case report of a second family.

Platelets 2019 17;30(7):931-934. Epub 2019 Jun 17.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1080/09537104.2019.1628197DOI Listing
June 2019

The Influence of the Duration of Breastfeeding on the Infant's Metabolic Epigenome.

Nutrients 2019 Jun 22;11(6). Epub 2019 Jun 22.

Department of Public Health and Primary Care, Environment and Health, KU Leuven-University of Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.3390/nu11061408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628078PMC
June 2019

Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for .

Clin Epigenetics 2017 3;9:107. Epub 2017 Oct 3.

Department of Neurosciences, Genetic Research About Stress and Psychiatry (GRASP), KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/s13148-017-0408-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627482PMC
May 2018

Cell-Specific PEAR1 Methylation Studies Reveal a Locus that Coordinates Expression of Multiple Genes.

Int J Mol Sci 2018 Apr 3;19(4). Epub 2018 Apr 3.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.3390/ijms19041069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979289PMC
April 2018

Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients.

J Psychosom Res 2018 01 20;104:55-60. Epub 2017 Nov 20.

Genetic Research About Stress and Psychiatry (GRASP), Department of Neurosciences, KU Leuven, Leuven, Belgium; University Psychiatric Center, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jpsychores.2017.11.011DOI Listing
January 2018

GATA1 gene variants associated with thrombocytopenia and anemia.

Platelets 2017 11 12;28(7):731-734. Epub 2017 Sep 12.

a Department of Cardiovascular Sciences , Center for Molecular and Vascular Biology , KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1080/09537104.2017.1361525DOI Listing
November 2017

Pituitary adenylate cyclase-activating polypeptide (PACAP) in zebrafish models of nephrotic syndrome.

PLoS One 2017 31;12(7):e0182100. Epub 2017 Jul 31.

Department of Pediatric Nephrology & Growth and Regeneration, University Hospitals Leuven, KU Leuven - University of Leuven, Leuven, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182100PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536324PMC
September 2017

Maternal intake of methyl-group donors affects DNA methylation of metabolic genes in infants.

Clin Epigenetics 2017 7;9:16. Epub 2017 Feb 7.

Department of Public Health and Primary Care, Environment and Health, KU Leuven - University of Leuven, Kapucijnenvoer 35 blok D box 7001, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1186/s13148-017-0321-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297118PMC
July 2017

PIGO deficiency: palmoplantar keratoderma and novel mutations.

Orphanet J Rare Dis 2017 05 25;12(1):101. Epub 2017 May 25.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/s13023-017-0654-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445308PMC
May 2017

Methylome analysis for spina bifida shows hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development.

Clin Epigenetics 2016 13;8:108. Epub 2016 Oct 13.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, O&N1, Herestraat 49, Box 911, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1186/s13148-016-0272-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064967PMC
April 2017

The transcription factor GATA1 regulates NBEAL2 expression through a long-distance enhancer.

Haematologica 2017 04 12;102(4):695-706. Epub 2017 Jan 12.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, KULeuven, Belgium

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http://dx.doi.org/10.3324/haematol.2016.152777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395110PMC
April 2017

Distribution and Function of PACAP and Its Receptors in the Healthy and Nephrotic Kidney.

Nephron 2016 7;132(4):301-11. Epub 2016 Apr 7.

Pediatric Nephrology, Department of Development and Regeneration, University Hospitals of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1159/000445035DOI Listing
February 2017

Dietary and supplemental maternal methyl-group donor intake and cord blood DNA methylation.

Epigenetics 2017 01 10;12(1):1-10. Epub 2016 Nov 10.

a KU Leuven - University of Leuven , Department of Public Health and Primary Care , Environment and Health , Leuven , Belgium.

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http://dx.doi.org/10.1080/15592294.2016.1257450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270634PMC
January 2017

From pseudohypoparathyroidism to inactivating PTH/PTHrP signalling disorder (iPPSD), a novel classification proposed by the EuroPHP network.

Eur J Endocrinol 2016 Dec 11;175(6):P1-P17. Epub 2016 Jul 11.

APHPReference Center for rare disorders of the Calcium and Phosphate Metabolism, filière OSCAR and Plateforme d'Expertise Maladies Rares Paris-Sud, Hôpital Bicêtre Paris Sud, Le Kremlin Bicêtre, France

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http://dx.doi.org/10.1530/EJE-16-0107DOI Listing
December 2016

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

Cell 2016 11;167(5):1415-1429.e19

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; Department of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge CB1 8RN, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300907PMC
November 2016

Platelet abnormalities in nephrotic syndrome.

Pediatr Nephrol 2016 08 13;31(8):1267-79. Epub 2015 Aug 13.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00467-015-3173-8DOI Listing
August 2016

Allele-specific DNA methylation reinforces PEAR1 enhancer activity.

Blood 2016 08 16;128(7):1003-12. Epub 2016 Jun 16.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology.

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http://dx.doi.org/10.1182/blood-2015-11-682153DOI Listing
August 2016

Maternal Methyl-Group Donor Intake and Global DNA (Hydroxy)Methylation before and during Pregnancy.

Nutrients 2016 Aug 6;8(8). Epub 2016 Aug 6.

KU Leuven, Department of Public Health and Primary Care, Environment and Health, Kapucijnenvoer 35 blok D box 7001, 3000 Leuven, Belgium.

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http://dx.doi.org/10.3390/nu8080474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997387PMC
August 2016

Nutri-epigenomic Studies Related to Neural Tube Defects: Does Folate Affect Neural Tube Closure Via Changes in DNA Methylation?

Mini Rev Med Chem 2015 ;15(13):1095-102

Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, O&N1, Herestraat 49, Box 911, 3000 Leuven, Belgium.

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http://dx.doi.org/10.2174/1389557515666150909144828DOI Listing
June 2016

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Blood 2016 06 15;127(23):2791-803. Epub 2016 Apr 15.

Department of Haematology, University of Cambridge, National Institute for Health Research BioResource-Rare Diseases, Cambridge University Hospitals, and National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Cambridge, United Kingdom;

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http://dx.doi.org/10.1182/blood-2015-12-688267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016734PMC
June 2016

Inherited platelet disorders: toward DNA-based diagnosis.

Blood 2016 06 19;127(23):2814-23. Epub 2016 Apr 19.

Department of Haematology, University of Cambridge, Cambridge, United Kingdom; National Health Service Blood and Transplant, Cambridge, United Kingdom; National Institute for Health Research BioResource-Rare Diseases, Cambridge University Hospitals, Cambridge, United Kingdom; and Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1182/blood-2016-03-378588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972611PMC
June 2016

Genome-wide DNA methylation analysis of pseudohypoparathyroidism patients with GNAS imprinting defects.

Clin Epigenetics 2016 26;8:10. Epub 2016 Jan 26.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, O&N1, Herestraat 49, Box 911, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1186/s13148-016-0175-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728790PMC
April 2016

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.

Sci Transl Med 2016 Mar 2;8(328):328ra30. Epub 2016 Mar 2.

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. National Institute for Health Research (NIHR) BioResource-Rare Diseases, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK. Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1126/scitranslmed.aad7666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903547PMC
March 2016

Chronic Fatigue Syndrome and DNA Hypomethylation of the Glucocorticoid Receptor Gene Promoter 1F Region: Associations With HPA Axis Hypofunction and Childhood Trauma.

Psychosom Med 2015 Oct;77(8):853-62

From the Genetic Research About Stress and Psychiatry (GRASP) (Vangeel, Hompes, Claes), University Psychiatric Center (Hompes, Claes), Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology (Izzi, Freson), and Laboratory of Translational Genetics, Department of Oncology (Lambrechts), University of Leuven, Leuven, Belgium; University Department of Psychiatry (Van Den Eede), Campus Antwerp University Hospital, Antwerp, Edegem, Belgium; Collaborative Antwerp Psychiatric Research Institute (CAPRI) (Van Den Eede) and Department of Molecular Genetics VIB8 (Del Favero), Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium; Department of Internal Medicine (Moorkens), Antwerp University Hospital, Antwerp, Edegem, Belgium; and Vesalius Research Center (VRC) (Lambrechts), VIB, Leuven, Belgium.

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http://dx.doi.org/10.1097/PSY.0000000000000224DOI Listing
October 2015

Platelet studies in autism spectrum disorder patients and first-degree relatives.

Mol Autism 2015 23;6:57. Epub 2015 Oct 23.

Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Gasthuisberg Campus, O & N I, Herestraat 49-b911, 3000 Leuven, Belgium ; The LAuRes Consortium, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/s13229-015-0051-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619313PMC
October 2015

Novel GATA1 mutation in residue D218 leads to macrothrombocytopenia and clinical bleeding problems.

Platelets 2014 23;25(4):305-7. Epub 2013 Aug 23.

Department of Haematology, Haemostasis and Thrombosis Unit, Cliniques Universitaires Saint-Luc , Brussels , Belgium .

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http://www.tandfonline.com/doi/full/10.3109/09537104.2013.81
Publisher Site
http://dx.doi.org/10.3109/09537104.2013.815339DOI Listing
January 2015

The contribution of platelet studies to the understanding of disease mechanisms in complex and monogenetic neurological disorders.

Dev Med Child Neurol 2014 Aug 3;56(8):724-31. Epub 2014 Mar 3.

Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium; Department of Child Neurology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/dmcn.12421DOI Listing
August 2014

The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data.

Nucleic Acids Res 2014 Jan 11;42(Database issue):D966-74. Epub 2013 Nov 11.

Institute for Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany, Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany, Lawrence Berkeley National Laboratory, Mail Stop 84R0171, Berkeley, CA 94720, USA, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK, Department of Medical Genetics, Cambridge University Addenbrooke's Hospital, Cambridge CB2 2QQ, UK, Université Paul Sabatier, Faculté de Chirurgie Dentaire, CHU Toulouse, France, Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre (MAHSC), Manchester, UK, Centre for Genomic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, MAHSC, Manchester M13 9WL, UK, Institute of Genetic Medicine. Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK, Department of Computer Science, University of Toronto, Ontario, Canada, Centre for Computational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Clinical Genetics, Leeds Teaching Hospitals NHS Trust, Leeds LS2 9NS, UK, MRC Human Genetics Unit, MRC Institute of Genetic and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK, The Jackson Laboratory, Bar Harbor, ME 04609, USA, Center for Molecular and Vascular Biology, University of Leuven, Belgium, Department of Neuropediatrics, University Medical Center Schleswig-Holstein, Kiel Campus, 24105 Kiel, Germany, NE Thames Genetics Service, Great Ormond Street Hospital, London WC1N 3JH, UK, Drexel University College of Medicine, Philadelphia, PA 19102, USA, Department of Haematology, University of Cambridge and NHS Blood and Transplant Cambridge, CB2 0PT Cambridge, UK, Autism and Developmental Medicine Institute, Geisinger Health System

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http://dx.doi.org/10.1093/nar/gkt1026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965098PMC
January 2014

Platelet defects in congenital variant of Rett syndrome patients with FOXG1 mutations or reduced expression due to a position effect at 14q12.

Eur J Hum Genet 2013 Dec 1;21(12):1349-55. Epub 2013 May 1.

1] Department of cardiovascular sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium [2] Department of Pediatrics, UZ Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/ejhg.2013.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831085PMC
December 2013

PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.

Blood 2013 Jun 10;121(26):5208-17. Epub 2013 May 10.

Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1182/blood-2012-10-462887DOI Listing
June 2013

Regulated granule trafficking in platelets and neurons: a common molecular machinery.

Eur J Paediatr Neurol 2013 Mar 28;17(2):117-25. Epub 2012 Aug 28.

Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ejpn.2012.08.005DOI Listing
March 2013

Homozygosity for aquaporin 7 G264V in three unrelated children with hyperglyceroluria and a mild platelet secretion defect.

Genet Med 2013 Jan 16;15(1):55-63. Epub 2012 Aug 16.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/gim.2012.90DOI Listing
January 2013

Novel targets for platelet inhibition.

Handb Exp Pharmacol 2012 (210):369-94

Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, 3000, Leuven, Belgium.

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http://link.springer.com/10.1007/978-3-642-29423-5_15
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http://dx.doi.org/10.1007/978-3-642-29423-5_15DOI Listing
January 2013

Recent advances in platelet proteomics.

Expert Rev Proteomics 2012 Aug;9(4):451-66

Center for Molecular and Vascular Biology, UZ-Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1586/epr.12.31DOI Listing
August 2012

Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system.

FASEB J 2012 May 3;26(5):2125-36. Epub 2012 Feb 3.

Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O&N1, Herestraat 49, Box 911, 3000 Leuven, Belgium.

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http://www.fasebj.org/doi/10.1096/fj.11-198739
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http://dx.doi.org/10.1096/fj.11-198739DOI Listing
May 2012

A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1.

Blood 2012 Apr 27;119(17):4056-65. Epub 2012 Feb 27.

Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, Leuven, Belgium.

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http://www.bloodjournal.org/content/119/17/4056.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-11-39
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http://dx.doi.org/10.1182/blood-2011-11-392787DOI Listing
April 2012

From genetics to epigenetics in platelet research.

Thromb Res 2012 Mar 20;129(3):325-9. Epub 2011 Dec 20.

Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.thromres.2011.11.050DOI Listing
March 2012

Effect of VPAC1 Blockade on Adipose Tissue Formation and Composition in Mouse Models of Nutritionally Induced Obesity.

J Obes 2010 30;2010. Epub 2010 Jun 30.

Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O & N 1, Herestraat 49, P.O. Box 911, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1155/2010/359527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915750PMC
July 2011

A new approach to imprinting mutation detection in GNAS by Sequenom EpiTYPER system.

Clin Chim Acta 2010 Dec 31;411(23-24):2033-9. Epub 2010 Aug 31.

Center for Molecular and Vascular Biology, University of Leuven, Leuven, 3000, Belgium.

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http://dx.doi.org/10.1016/j.cca.2010.08.034DOI Listing
December 2010

Thrombopoietic effect of VPAC1 inhibition during megakaryopoiesis.

Br J Haematol 2010 Oct 5;151(1):54-61. Epub 2010 Aug 5.

Centre for Molecular and Vascular Biology ThromboGenics Department of Paediatrics, University of Leuven, Herestraat 49, Leuven, Belgium.

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http://dx.doi.org/10.1111/j.1365-2141.2010.08327.xDOI Listing
October 2010

Compound heterozygous mutations in the GNAS gene of a boy with morbid obesity, thyroid-stimulating hormone resistance, pseudohypoparathyroidism, and a prothrombotic state.

J Clin Endocrinol Metab 2008 Dec 16;93(12):4844-9. Epub 2008 Sep 16.

Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1210/jc.2008-0233DOI Listing
December 2008

GNAS defects identified by stimulatory G protein alpha-subunit signalling studies in platelets.

J Clin Endocrinol Metab 2008 Dec 23;93(12):4851-9. Epub 2008 Sep 23.

Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1210/jc.2008-0883DOI Listing
December 2008

Emerging treatments for thrombocytopenia: increasing platelet production.

Drug Discov Today 2008 Sep 17;13(17-18):798-806. Epub 2008 Jul 17.

Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, Leuven, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S135964460800219
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http://dx.doi.org/10.1016/j.drudis.2008.06.002DOI Listing
September 2008

Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disorders.

Eur J Pediatr 2008 Jul 8;167(7):723-9. Epub 2008 May 8.

Department of Pediatrics, University Hospital, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1007/s00431-008-0740-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2413085PMC
July 2008

PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications.

Blood 2008 Feb 13;111(4):1885-93. Epub 2007 Nov 13.

Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1182/blood-2007-06-098558DOI Listing
February 2008

What's new in using platelet research? To unravel thrombopathies and other human disorders.

Eur J Pediatr 2007 Dec 10;166(12):1203-10. Epub 2007 Jul 10.

Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1007/s00431-007-0543-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2042511PMC
December 2007

Mechanisms of action and targets for actual and future antiplatelet drugs.

Mini Rev Med Chem 2006 Jun;6(6):719-26

Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.2174/138955706777435661DOI Listing
June 2006

The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure.

Blood 2005 Oct 14;106(7):2356-62. Epub 2005 Jun 14.

Center for Molecular and Vascular Biology, Department of Pathology, Cardiovascular Rehabilitation Unit, University of Leuven, Belgium.

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http://dx.doi.org/10.1182/blood-2005-02-0723DOI Listing
October 2005

G protein diseases: newly recognized causes of metabolic encephalopathy.

Eur J Paediatr Neurol 2003 ;7(5):211-5

Center for Metabolic Disease, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/s1090-3798(03)00102-8DOI Listing
December 2003

Functional polymorphisms in the paternally expressed XLalphas and its cofactor ALEX decrease their mutual interaction and enhance receptor-mediated cAMP formation.

Hum Mol Genet 2003 May;12(10):1121-30

Center of Molecular and Vascular Biology and Department of Pediatrics, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1093/hmg/ddg130DOI Listing
May 2003

Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.

Hum Genet 2003 Jan 16;112(1):42-9. Epub 2002 Oct 16.

Center for Molecular and Vascular Biology, University of Leuven, UZ-Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1007/s00439-002-0832-1DOI Listing
January 2003