Kathleen A Stringer

Kathleen A Stringer

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Kathleen A Stringer

Kathleen A Stringer

Publications by authors named "Kathleen A Stringer"

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Disruption of histidine and energy homeostasis in chronic obstructive pulmonary disease.

Int J Chron Obstruct Pulmon Dis 2019 3;14:2015-2025. Epub 2019 Sep 3.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.2147/COPD.S210598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732562PMC
September 2019

Untargeted Metabolomics Differentiates l-Carnitine Treated Septic Shock 1-Year Survivors and Nonsurvivors.

J Proteome Res 2019 May 1;18(5):2004-2011. Epub 2019 Apr 1.

Emergency Medicine , University of Mississippi Medical Center , Jackson , Mississippi 39216 , United States.

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http://dx.doi.org/10.1021/acs.jproteome.8b00774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501183PMC
May 2019

The Physicochemical Basis of Clofazimine-Induced Skin Pigmentation.

J Invest Dermatol 2018 03 16;138(3):697-703. Epub 2017 Oct 16.

Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828885PMC
March 2018

Metabolomics as a Driver in Advancing Precision Medicine in Sepsis.

Pharmacotherapy 2017 Sep 31;37(9):1023-1032. Epub 2017 Jul 31.

Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/phar.1974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600684PMC
September 2017

Macrophage-Mediated Clofazimine Sequestration Is Accompanied by a Shift in Host Energy Metabolism.

J Pharm Sci 2017 04 20;106(4):1162-1174. Epub 2016 Dec 20.

Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109; NMR Metabolomics Laboratory, University of Michigan, Ann Arbor, Michigan 48109; Center for Computational Medicine and Bioinformatics, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2016.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357462PMC
April 2017

Detecting ordered small molecule drug aggregates in live macrophages: a multi-parameter microscope image data acquisition and analysis strategy.

Biomed Opt Express 2017 Feb 13;8(2):860-872. Epub 2017 Jan 13.

Department of Pharmaceutical Sciences, University of Michigan College of Pharmacy, 428 Church Street, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1364/BOE.8.000860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330574PMC
February 2017

1D-¹H-nuclear magnetic resonance metabolomics reveals age-related changes in metabolites associated with experimental venous thrombosis.

J Vasc Surg Venous Lymphat Disord 2016 Apr 24;4(2):221-30. Epub 2015 Nov 24.

Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, Mich; Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Mich. Electronic address:

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http://dx.doi.org/10.1016/j.jvsv.2015.09.010DOI Listing
April 2016

Metabolomics and Its Application to Acute Lung Diseases.

Front Immunol 2016 29;7:44. Epub 2016 Feb 29.

Department of Medicine, University of Alberta , Edmonton, AB , Canada.

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http://dx.doi.org/10.3389/fimmu.2016.00044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770032PMC
March 2016

Whole Blood Reveals More Metabolic Detail of the Human Metabolome than Serum as Measured by 1H-NMR Spectroscopy: Implications for Sepsis Metabolomics.

Shock 2015 Sep;44(3):200-8

*Department of Clinical Pharmacy and the NMR Metabolomics Laboratory, College of Pharmacy, †Center for Computational Medicine and Bioinformatics, and ‡Department of Emergency Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan; §Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi; and ∥Department of Computational Medicine and Bioinformatics, School of Medicine, University of Michigan, Ann Arbor, Michigan.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/SHK.0000000000000406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537695PMC
September 2015

A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages.

Cytometry A 2015 Sep 24;87(9):855-67. Epub 2015 Jun 24.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109.

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http://dx.doi.org/10.1002/cyto.a.22706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553085PMC
September 2015

Immune Abnormalities in Fontan Protein-Losing Enteropathy: A Case-Control Study.

J Pediatr 2015 Aug 23;167(2):331-7. Epub 2015 May 23.

University of Michigan Congenital Heart Center, C.S. Mott Children's Hospital, Ann Arbor, MI.

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http://dx.doi.org/10.1016/j.jpeds.2015.04.061DOI Listing
August 2015

Phagocytosed Clofazimine Biocrystals Can Modulate Innate Immune Signaling by Inhibiting TNFα and Boosting IL-1RA Secretion.

Mol Pharm 2015 Jul 5;12(7):2517-27. Epub 2015 Jun 5.

†Department of Pharmaceutical Sciences and ‡Department of Clinical, Social and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.5b00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576345PMC
July 2015

Pharmacometabolomics of l-carnitine treatment response phenotypes in patients with septic shock.

Ann Am Thorac Soc 2015 Jan;12(1):46-56

1 Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi.

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http://dx.doi.org/10.1513/AnnalsATS.201409-415OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342803PMC
January 2015

Signal intensities derived from different NMR probes and parameters contribute to variations in quantification of metabolites.

PLoS One 2014 21;9(1):e85732. Epub 2014 Jan 21.

Department of Clinical, Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, United States of America ; Department of Computational Medicine and Bioinformatics, School of Medicine, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085732PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897511PMC
October 2014

Untargeted LC-MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health.

J Proteome Res 2014 Feb 9;13(2):640-9. Epub 2013 Dec 9.

Department of Internal Medicine, University of Michigan School of Medicine , Ann Arbor, Michigan, United States.

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http://dx.doi.org/10.1021/pr4007624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068805PMC
February 2014

Pharmacotherapy challenges of Fontan-associated plastic bronchitis: a rare pediatric disease.

Pharmacotherapy 2013 Sep 17;33(9):922-34. Epub 2013 May 17.

Department of Clinical, Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/phar.1290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775973PMC
September 2013

The extracellular microenvironment explains variations in passive drug transport across different airway epithelial cell types.

Pharm Res 2013 Aug 25;30(8):2118-32. Epub 2013 May 25.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1007/s11095-013-1069-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706189PMC
August 2013

Multiscale distribution and bioaccumulation analysis of clofazimine reveals a massive immune system-mediated xenobiotic sequestration response.

Antimicrob Agents Chemother 2013 Mar 21;57(3):1218-30. Epub 2012 Dec 21.

Department of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1128/AAC.01731-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591914PMC
March 2013

Demographic characteristics and estimated prevalence of Fontan-associated plastic bronchitis.

Pediatr Cardiol 2013 Feb 15;34(2):256-61. Epub 2012 Jul 15.

Department of Pharmacy, University of Michigan Hospitals and Health Centers, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1007/s00246-012-0430-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586576PMC
February 2013

Pulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury.

Am J Respir Cell Mol Biol 2012 Sep 3;47(3):280-7. Epub 2012 Feb 3.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University/Atlanta Veterans Affairs Medical Center, 1670 Clairmont Road, Atlanta, GA 30033, USA.

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http://dx.doi.org/10.1165/rcmb.2011-0175OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488693PMC
September 2012

A cell-based computational modeling approach for developing site-directed molecular probes.

PLoS Comput Biol 2012 23;8(2):e1002378. Epub 2012 Feb 23.

Department of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1002378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285574PMC
June 2012

Prospective, longitudinal study of plastic bronchitis cast pathology and responsiveness to tissue plasminogen activator.

Pediatr Cardiol 2011 Dec 24;32(8):1182-9. Epub 2011 Jul 24.

Department of Clinical, Social and Administrative Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1007/s00246-011-0058-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207025PMC
December 2011

The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses.

Am J Respir Crit Care Med 2011 Sep 16;184(6):647-55. Epub 2011 Jun 16.

Department of Anesthesiology, School of Medicine, University of Colorado Denver, Aurora, Colorado, USA.

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http://dx.doi.org/10.1164/rccm.201103-0474CIDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208597PMC
September 2011

Metabolic consequences of sepsis-induced acute lung injury revealed by plasma ¹H-nuclear magnetic resonance quantitative metabolomics and computational analysis.

Am J Physiol Lung Cell Mol Physiol 2011 Jan 1;300(1):L4-L11. Epub 2010 Oct 1.

Dept. of Clinical, Social, and Administrative Sciences, Univ. of Michigan, Ann Arbor, 48109-1065, USA.

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http://dx.doi.org/10.1152/ajplung.00231.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023293PMC
January 2011

Safety of prolonged, repeated administration of a pulmonary formulation of tissue plasminogen activator in mice.

Pulm Pharmacol Ther 2010 Apr 29;23(2):107-14. Epub 2009 Oct 29.

Department of Clinical, Social and Administrative Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA.

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http://dx.doi.org/10.1016/j.pupt.2009.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821999PMC
April 2010

Accelerated dosing frequency of a pulmonary formulation of tissue plasminogen activator is well-tolerated in mice.

Clin Exp Pharmacol Physiol 2008 Dec 29;35(12):1454-60. Epub 2008 Jul 29.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA.

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http://dx.doi.org/10.1111/j.1440-1681.2008.05011.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779770PMC
December 2008

Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury.

Am J Physiol Lung Cell Mol Physiol 2008 Jul 25;295(1):L152-61. Epub 2008 Apr 25.

Department of Anesthesiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA.

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http://dx.doi.org/10.1152/ajplung.00515.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494785PMC
July 2008

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol 2007 Jun 9;292(6):L1572-9. Epub 2007 Mar 9.

Dept. of Clinical Pharmacy, School of Pharmacy, Box C238, Univ. of Colorado Health Sciences Center, 4200 East Ninth Ave., Denver, CO 80262, USA.

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http://dx.doi.org/10.1152/ajplung.00325.2006DOI Listing
June 2007

Emerging role of anticoagulants and fibrinolytics in the treatment of acute respiratory distress syndrome.

Pharmacotherapy 2007 Jun;27(6):860-73

Departments of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80260, USA.

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http://dx.doi.org/10.1592/phco.27.6.860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515375PMC
June 2007

Discrepancies in identification of bleeding events after percutaneous coronary intervention.

Pharmacotherapy 2007 Jan;27(1):36-40

Department of Clinical Pharmacy, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA.

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http://dx.doi.org/10.1592/phco.27.1.36DOI Listing
January 2007

Feasibility of tissue plasminogen activator formulated for pulmonary delivery.

Pharm Res 2005 Oct 22;22(10):1700-7. Epub 2005 Sep 22.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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http://dx.doi.org/10.1007/s11095-005-6335-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040297PMC
October 2005

Inhibition of human neutrophil reactive oxygen species production and p67phox translocation by cigarette smoke extract.

Atherosclerosis 2005 Apr 19;179(2):261-7. Epub 2005 Jan 19.

Department of Clinical Pharmacy, School of Pharmacy, Box C238, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2004.11.011DOI Listing
April 2005

Administration of exogenous tissue plasminogen activator reduces oedema in mice lacking the tissue plasminogen activator gene.

Clin Exp Pharmacol Physiol 2004 May-Jun;31(5-6):327-30

Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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http://dx.doi.org/10.1111/j.1440-1681.2004.03999.xDOI Listing
January 2005

Particulate phase cigarette smoke increases MnSOD, NQO1, and CINC-1 in rat lungs.

Free Radic Biol Med 2004 Nov;37(10):1527-33

Department of Clinical Pharmacy, School of Pharmacy, C238, 4200 East Ninth Avenue, Denver, CO 80262, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089158490400642
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http://dx.doi.org/10.1016/j.freeradbiomed.2004.08.008DOI Listing
November 2004

Impact of a critical pathway on acute myocardial infarction quality indicators.

Pharmacotherapy 2004 Feb;24(2):173-8

University of Colorado Hospital, Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Health Sciences Center, 80262, USA.

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http://dx.doi.org/10.1592/phco.24.2.173.33139DOI Listing
February 2004

Bivalirudin: a direct thrombin inhibitor for percutaneous transluminal coronary angioplasty.

Pharmacotherapy 2002 Aug;22(8):1007-18

Department of Pharmacy, University of Virginia Health System, Charlottesville 22908-0674, USA.

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http://dx.doi.org/10.1592/phco.22.12.1007.33600DOI Listing
August 2002