Katherine Siminovitch

Katherine Siminovitch

UNVERIFIED PROFILE

Are you Katherine Siminovitch?   Register this Author

Register author
Katherine Siminovitch

Katherine Siminovitch

Publications by authors named "Katherine Siminovitch"

Are you Katherine Siminovitch?   Register this Author

100Publications

3162Reads

12Profile Views

Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.

Oncotarget 2019 Mar 5;10(19):1760-1774. Epub 2019 Mar 5.

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.26678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442994PMC
March 2019

New perspectives on the complexity of genetic predisposition to autoimmune liver disease in indigenous Canadians.

Liver Int 2018 05;38(5):789-791

Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/liv.13722
Publisher Site
http://dx.doi.org/10.1111/liv.13722DOI Listing
May 2018

Corrigendum to "Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome" [Clin. Immunol. 168 (2016) 25-29].

Clin Immunol 2018 02 7;187:137-138. Epub 2017 Dec 7.

Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2017.11.012DOI Listing
February 2018

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Authors:
Philip C Haycock Stephen Burgess Aayah Nounu Jie Zheng George N Okoli Jack Bowden Kaitlin Hazel Wade Nicholas J Timpson David M Evans Peter Willeit Abraham Aviv Tom R Gaunt Gibran Hemani Massimo Mangino Hayley Patricia Ellis Kathreena M Kurian Karen A Pooley Rosalind A Eeles Jeffrey E Lee Shenying Fang Wei V Chen Matthew H Law Lisa M Bowdler Mark M Iles Qiong Yang Bradford B Worrall Hugh Stephen Markus Rayjean J Hung Chris I Amos Amanda B Spurdle Deborah J Thompson Tracy A O'Mara Brian Wolpin Laufey Amundadottir Rachael Stolzenberg-Solomon Antonia Trichopoulou N Charlotte Onland-Moret Eiliv Lund Eric J Duell Federico Canzian Gianluca Severi Kim Overvad Marc J Gunter Rosario Tumino Ulrika Svenson Andre van Rij Annette F Baas Matthew J Bown Nilesh J Samani Femke N G van t'Hof Gerard Tromp Gregory T Jones Helena Kuivaniemi James R Elmore Mattias Johansson James Mckay Ghislaine Scelo Robert Carreras-Torres Valerie Gaborieau Paul Brennan Paige M Bracci Rachel E Neale Sara H Olson Steven Gallinger Donghui Li Gloria M Petersen Harvey A Risch Alison P Klein Jiali Han Christian C Abnet Neal D Freedman Philip R Taylor John M Maris Katja K Aben Lambertus A Kiemeney Sita H Vermeulen John K Wiencke Kyle M Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew-Kee Low Krina T Zondervan Grant W Montgomery Dale R Nyholt David A van Heel Karen Hunt Dan E Arking Foram N Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand Mary E Comeau W Mark Brown Edwin K Silverman John E Hokanson Michael H Cho Jennie Hui Manuel A Ferreira Philip J Thompson Alanna C Morrison Janine F Felix Nicholas L Smith Angela M Christiano Lynn Petukhova Regina C Betz Xing Fan Xuejun Zhang Caihong Zhu Carl D Langefeld Susan D Thompson Feijie Wang Xu Lin David A Schwartz Tasha Fingerlin Jerome I Rotter Mary Frances Cotch Richard A Jensen Matthias Munz Henrik Dommisch Arne S Schaefer Fang Han Hanna M Ollila Ryan P Hillary Omar Albagha Stuart H Ralston Chenjie Zeng Wei Zheng Xiao-Ou Shu Andre Reis Steffen Uebe Ulrike Hüffmeier Yoshiya Kawamura Takeshi Otowa Tsukasa Sasaki Martin Lloyd Hibberd Sonia Davila Gang Xie Katherine Siminovitch Jin-Xin Bei Yi-Xin Zeng Asta Försti Bowang Chen Stefano Landi Andre Franke Annegret Fischer David Ellinghaus Carlos Flores Imre Noth Shwu-Fan Ma Jia Nee Foo Jianjun Liu Jong-Won Kim David G Cox Olivier Delattre Olivier Mirabeau Christine F Skibola Clara S Tang Merce Garcia-Barcelo Kai-Ping Chang Wen-Hui Su Yu-Sun Chang Nicholas G Martin Scott Gordon Tracey D Wade Chaeyoung Lee Michiaki Kubo Pei-Chieng Cha Yusuke Nakamura Daniel Levy Masayuki Kimura Shih-Jen Hwang Steven Hunt Tim Spector Nicole Soranzo Ani W Manichaikul R Graham Barr Bratati Kahali Elizabeth Speliotes Laura M Yerges-Armstrong Ching-Yu Cheng Jost B Jonas Tien Yin Wong Isabella Fogh Kuang Lin John F Powell Kenneth Rice Caroline L Relton Richard M Martin George Davey Smith

JAMA Oncol 2017 May;3(5):636-651

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoncol.2016.5945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638008PMC
May 2017

Prevalence and Clinical Implication of Double Mutations in Hypertrophic Cardiomyopathy: Revisiting the Gene-Dose Effect.

Circ Cardiovasc Genet 2017 Apr;10(2)

From the Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, Toronto, Ontario, Canada (D.F., A.W.-S., W.H., R.H.C., M.H.G., H.R., A.A.); Fred A. Litwin & Family Center in Genetic Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada (M.C., K.A.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.116.001685DOI Listing
April 2017

Monoclonal Antibodies for the Treatment of Hypercholesterolemia: Targeting PCSK9.

Can J Cardiol 2016 12 3;32(12):1552-1560. Epub 2016 May 3.

Cardiovascular Research Laboratories, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0828282X163005
Publisher Site
http://dx.doi.org/10.1016/j.cjca.2016.04.013DOI Listing
December 2016

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.

Clin Immunol 2016 07 22;168:25-29. Epub 2016 Apr 22.

Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Medical Service, Department of Veterans Affairs Medical Center, Oklahoma City, OK, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2016.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940221PMC
July 2016

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome.

Arthritis Rheumatol 2016 05;68(5):1290-1300

College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.39560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019501PMC
May 2016

Efficient production of sTNFRII-gAD fusion protein in large quantity by use of the modified CHO-S cell expression system.

PLoS One 2014 23;9(10):e111229. Epub 2014 Oct 23.

Zhejiang Provincial Key Laboratory for Technology & Application of Model Organisms, School of Laboratory Medicine & Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111229PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207793PMC
January 2016

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.

Authors:
S Hong Lee Enda M Byrne Christina M Hultman Anna Kähler Anna A E Vinkhuyzen Stephan Ripke Ole A Andreassen Thomas Frisell Alexander Gusev Xinli Hu Robert Karlsson Vasilis X Mantzioris John J McGrath Divya Mehta Eli A Stahl Qiongyi Zhao Kenneth S Kendler Patrick F Sullivan Alkes L Price Michael O'Donovan Yukinori Okada Bryan J Mowry Soumya Raychaudhuri Naomi R Wray William Byerley Wiepke Cahn Rita M Cantor Sven Cichon Paul Cormican David Curtis Srdjan Djurovic Valentina Escott-Price Pablo V Gejman Lyudmila Georgieva Ina Giegling Thomas F Hansen Andrés Ingason Yunjung Kim Bettina Konte Phil H Lee Andrew McIntosh Andrew McQuillin Derek W Morris Markus M Nöthen Colm O'Dushlaine Ann Olincy Line Olsen Carlos N Pato Michele T Pato Benjamin S Pickard Danielle Posthuma Henrik B Rasmussen Marcella Rietschel Dan Rujescu Thomas G Schulze Jeremy M Silverman Srinivasa Thirumalai Thomas Werge Ingrid Agartz Farooq Amin Maria H Azevedo Nicholas Bass Donald W Black Douglas H R Blackwood Richard Bruggeman Nancy G Buccola Khalid Choudhury Robert C Cloninger Aiden Corvin Nicholas Craddock Mark J Daly Susmita Datta Gary J Donohoe Jubao Duan Frank Dudbridge Ayman Fanous Robert Freedman Nelson B Freimer Marion Friedl Michael Gill Hugh Gurling Lieuwe De Haan Marian L Hamshere Annette M Hartmann Peter A Holmans René S Kahn Matthew C Keller Elaine Kenny George K Kirov Lydia Krabbendam Robert Krasucki Jacob Lawrence Todd Lencz Douglas F Levinson Jeffrey A Lieberman Dan-Yu Lin Don H Linszen Patrik K E Magnusson Wolfgang Maier Anil K Malhotra Manuel Mattheisen Morten Mattingsdal Steven A McCarroll Helena Medeiros Ingrid Melle Vihra Milanova Inez Myin-Germeys Benjamin M Neale Roel A Ophoff Michael J Owen Jonathan Pimm Shaun M Purcell Vinay Puri Digby J Quested Lizzy Rossin Douglas Ruderfer Alan R Sanders Jianxin Shi Pamela Sklar David St Clair T Scott Stroup Jim Van Os Peter M Visscher Durk Wiersma Stanley Zammit S Louis Bridges Hyon K Choi Marieke J H Coenen Niek de Vries Philippe Dieud Jeffrey D Greenberg Tom W J Huizinga Leonid Padyukov Katherine A Siminovitch Paul P Tak Jane Worthington Philip L De Jager Joshua C Denny Peter K Gregersen Lars Klareskog Xavier Mariette Robert M Plenge Mart van Laar Piet van Riel

Int J Epidemiol 2015 Oct;44(5):1706-21

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ije/dyv136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881824PMC
October 2015

14-3-3η Autoantibodies: Diagnostic Use in Early Rheumatoid Arthritis.

J Rheumatol 2015 Sep 15;42(9):1587-94. Epub 2015 Jul 15.

From the Department of Medicine, University of Alberta, Edmonton, Alberta; Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Quebec; Mount Sinai Hospital, University of Toronto, Toronto; Augurex Life Sciences Corp., North Vancouver, British Columbia, Canada; Jan van Breemen Research Institute/Reade; VU University Medical Center; Academic Medical Center, Amsterdam; Division of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands; Hospital for Special Surgery, New York, New York, USA; University of Cambridge, Cambridge; GlaxoSmithKline Inc., Brentford, UK.W.P. Maksymowych, MD, Professor of Medicine, Department of Medicine, University of Alberta; G. Boire, MD, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke; D. van Schaardenburg, MD, Jan van Breemen Research Institute/Reade; S. Wichuk, MD, Department of Medicine, University of Alberta; S. Turk, MD, Jan van Breemen Research Institute/Reade; M. Boers, MD, Professor of Clinical Epidemiology, VU University Medical Center; K.A. Siminovitch, MD, Professor of Medicine, Mount Sinai Hospital, University of Toronto; V. Bykerk, MD, Hospital for Special Surgery; E. Keystone, MD, Professor of Medicine, Mount Sinai Hospital, University of Toronto; P.P. Tak, MD, Academic Medical Center, and University of Cambridge, and GlaxoSmithKline Inc.; A.W. van Kuijk, MD; Robert Landewé, MD, Academic Medical Center; D. van der Heijde, MD, Division of Rheumatology, Leiden University Medical Center; M. Murphy, PhD; A. Marotta, PhD, Augurex Life Sciences Corp.

View Article

Download full-text PDF

Source
http://www.jrheum.org/content/42/9/1587.full.pdf
Web Search
http://www.jrheum.org/cgi/doi/10.3899/jrheum.141385
Publisher Site
http://dx.doi.org/10.3899/jrheum.141385DOI Listing
September 2015

Genetics in PBC: what do the "risk genes" teach us?

Clin Rev Allergy Immunol 2015 Jun;48(2-3):176-81

Centre for Liver Research, NIHR Biomedical Research Unit, University of Birmingham, B15 2TT, Birmingham, UK,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12016-014-8419-xDOI Listing
June 2015

Pharmacogenetics of the G protein-coupled receptors.

Methods Mol Biol 2014 ;1175:189-242

Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-0956-8_9DOI Listing
May 2015

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.

Hum Mol Genet 2015 Jan 8;24(2):582-96. Epub 2014 Sep 8.

Division of Rheumatology, Center for Autoimmune Genomics and Etiology and US Department of Veterans Affairs Medical Center, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddu455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275071PMC
January 2015

The Arabidopsis SWI2/SNF2 chromatin Remodeler BRAHMA regulates polycomb function during vegetative development and directly activates the flowering repressor gene SVP.

PLoS Genet 2015 Jan 23;11(1):e1004944. Epub 2015 Jan 23.

Agriculture and Agri-Food Canada, Southern Crop Protection and Food Research Centre, London, Ontario, Canada; Department of Biology, Western University, London, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304717PMC
January 2015

Serum 14-3-3η is a novel marker that complements current serological measurements to enhance detection of patients with rheumatoid arthritis.

J Rheumatol 2014 Nov 15;41(11):2104-13. Epub 2014 Aug 15.

From the University of Alberta, Edmonton, Alberta; Augurex Life Sciences Corp., North Vancouver, British Columbia; Mount Sinai Hospital, Toronto, Ontario, Canada; Quest Diagnostics Nichols Institute, San Juan Capistrano; Stanford University Medical Center, Palo Alto, California; Hospital for Special Surgery, New York, New York; Brigham and Women's Hospital, Boston, Massachusetts, USA; Vrije Universiteit University Medical Center; Academic Medical Center/University of Amsterdam; Jan van Breemen Research Institute, Reade organization, Amsterdam; the Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands; University of Cambridge, Cambridge; GlaxoSmithKline, Stevenage, UK.W.P. Maksymowych, MD, Professor of Medicine, University of Alberta; S.J. Naides, MD, Quest Diagnostics Nichols Institute; V. Bykerk, MD, Hospital for Special Surgery; K.A. Siminovitch, MD, Mount Sinai Hospital; D. van Schaardenburg, MD, Jan van Breemen Research Institute; M. Boers, MD, Vrije Universiteit University Medical Center; R. Landewé, MD, Academic Medical Center/University of Amsterdam; D. van der Heijde, MD, Department of Rheumatology, Leiden University Medical Center; P-P. Tak, MD, Academic Medical Center/University of Amsterdam, University of Cambridge, GlaxoSmithKline; M.C. Genovese, MD, Stanford University Medical Center; M.E. Weinblatt, MD, Brigham and Women's Hospital; E.C. Keystone, MD, Mount Sinai Hospital; O.S. Zhukov, MS; R.W. Abolhosn, BS; J.M. Popov, MD, PhD, Quest Diagnostics Nichols Institute; K. Britsemmer, MD, Jan van Breemen Research Institute; A.W. van Kuijk, MD, Academic Medical Center/University of Amsterdam; A. Marotta, PhD, Augurex Life Sciences Corp.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.131446DOI Listing
November 2014

A role for noncoding variation in schizophrenia.

Cell Rep 2014 Nov 6;9(4):1417-29. Epub 2014 Nov 6.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

View Article

Download full-text PDF

Source
http://www.cell.com/cell-reports/pdf/S2211-1247(14)00869-9.p
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S221112471400869
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2014.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255904PMC
November 2014

Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene.

PLoS One 2014 10;9(2):e87645. Epub 2014 Feb 10.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087645PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919745PMC
October 2014

Mammalian diaphanous-related formin 1 regulates GSK3β-dependent microtubule dynamics required for T cell migratory polarization.

PLoS One 2013 18;8(11):e80500. Epub 2013 Nov 18.

Departments of Immunology and Molecular Genetics, University of Toronto, Mount Sinai Hospital, Samuel Lunenfeld Research Institute and Toronto General Research Institutes, Toronto, Ontario, Canada ; Department of Hematology, Xijing Hospital, Xian, Shaanxi, China.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080500PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832380PMC
August 2014

Genotype-positive status in patients with hypertrophic cardiomyopathy is associated with higher rates of heart failure events.

Circ Cardiovasc Genet 2014 Aug 8;7(4):416-22. Epub 2014 Jun 8.

From the Division of Cardiology, Peter Munk Cardiac Center, Toronto General Hospital, Toronto, Ontario, Canada (Q.L., L.W., A.W., H.R.); Division of Cardiology, University Hospital of Zurich, Zurich, Switzerland (C.G.); Department of Medicine (Cardiovascular Division) and Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (R.H.C.); Fred A. Litwin and Family Center in Genetic Medicine, Mount Sinai Hospital, University Health Network, Toronto, Ontario, Canada (M.C., K.S.); and Department of Medicine, University of Toronto and Samuel Lunenfeld and Toronto General Research Institutes, Toronto, Ontario, Canada (K.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.113.000331DOI Listing
August 2014

Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ.

Hepatology 2014 May 1;59(5):1803-15. Epub 2014 Apr 1.

Department of Medicine, Cardiology Axis of the Institut Universitaire de Cardiologie et de Pneumologie de Québec (Hôpital Laval), Ste-Foy, Québec, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.26957DOI Listing
May 2014

Reply: To PMID 23740775.

Arthritis Rheumatol 2014 May;66(5):1401

Boston University School of Medicine, Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.38366DOI Listing
May 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Nature 2014 Feb 25;506(7488):376-81. Epub 2013 Dec 25.

1] Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098PMC
February 2014

Deep basal inferoseptal crypts occur more commonly in patients with hypertrophic cardiomyopathy due to disease-causing myofilament mutations.

Radiology 2013 Oct 14;269(1):68-76. Epub 2013 Jun 14.

Department of Medical Imaging and Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University of Toronto, 585 University Ave, 1c-544 NCSB, Toronto, ON, Canada M5G 2N2.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1148/radiol.13122344DOI Listing
October 2013

Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis.

Ann Rheum Dis 2013 Jul 6;72(7):1249-54. Epub 2012 Dec 6.

Mount Sinai Hospital Samuel Lunenfeld Research Institute and Toronto General Research Institute, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2012-202076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686260PMC
July 2013

Toronto hypertrophic cardiomyopathy genotype score for prediction of a positive genotype in hypertrophic cardiomyopathy.

Circ Cardiovasc Genet 2013 Feb 13;6(1):19-26. Epub 2012 Dec 13.

Division of Cardiology, Toronto General Hospital, Peter Munk Cardiac Center, 4N-504, 200 Elizabeth St, Toronto, ON M5G 2C4, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.112.963363DOI Listing
February 2013

Genetic testing in combination with preventive donepezil treatment for patients with amnestic mild cognitive impairment: an exploratory economic evaluation of personalized medicine.

Mol Diagn Ther 2012 Dec;16(6):389-99

Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40291-012-0010-7DOI Listing
December 2012

Vitamin D receptor polymorphism rs2228570 (Fok1) is associated with rheumatoid arthritis in North American natives.

J Rheumatol 2012 Sep 1;39(9):1792-7. Epub 2012 Aug 1.

Department of Internal Medicine, University of Manitoba, RR149, 800 Sherbrook St., Winnipeg, Manitoba R3A 1M4, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.120387DOI Listing
September 2012

Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance.

Diabetes 2012 Aug 14;61(8):1949-58. Epub 2012 Jun 14.

Department of Medicine, Faculty of Medicine, Cardiology Axis of the Institut Universitaire de Cardiologie et de Pneumologie de Québec (Hôpital Laval), Québec, Québec, Canada.

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db11-15
Publisher Site
http://dx.doi.org/10.2337/db11-1502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402325PMC
August 2012

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.

Authors:
John C Chambers Weihua Zhang Joban Sehmi Xinzhong Li Mark N Wass Pim Van der Harst Hilma Holm Serena Sanna Maryam Kavousi Sebastian E Baumeister Lachlan J Coin Guohong Deng Christian Gieger Nancy L Heard-Costa Jouke-Jan Hottenga Brigitte Kühnel Vinod Kumar Vasiliki Lagou Liming Liang Jian'an Luan Pedro Marques Vidal Irene Mateo Leach Paul F O'Reilly John F Peden Nilufer Rahmioglu Pasi Soininen Elizabeth K Speliotes Xin Yuan Gudmar Thorleifsson Behrooz Z Alizadeh Larry D Atwood Ingrid B Borecki Morris J Brown Pimphen Charoen Francesco Cucca Debashish Das Eco J C de Geus Anna L Dixon Angela Döring Georg Ehret Gudmundur I Eyjolfsson Martin Farrall Nita G Forouhi Nele Friedrich Wolfram Goessling Daniel F Gudbjartsson Tamara B Harris Anna-Liisa Hartikainen Simon Heath Gideon M Hirschfield Albert Hofman Georg Homuth Elina Hyppönen Harry L A Janssen Toby Johnson Antti J Kangas Ido P Kema Jens P Kühn Sandra Lai Mark Lathrop Markus M Lerch Yun Li T Jake Liang Jing-Ping Lin Ruth J F Loos Nicholas G Martin Miriam F Moffatt Grant W Montgomery Patricia B Munroe Kiran Musunuru Yusuke Nakamura Christopher J O'Donnell Isleifur Olafsson Brenda W Penninx Anneli Pouta Bram P Prins Inga Prokopenko Ralf Puls Aimo Ruokonen Markku J Savolainen David Schlessinger Jeoffrey N L Schouten Udo Seedorf Srijita Sen-Chowdhry Katherine A Siminovitch Johannes H Smit Timothy D Spector Wenting Tan Tanya M Teslovich Taru Tukiainen Andre G Uitterlinden Melanie M Van der Klauw Ramachandran S Vasan Chris Wallace Henri Wallaschofski H-Erich Wichmann Gonneke Willemsen Peter Würtz Chun Xu Laura M Yerges-Armstrong Goncalo R Abecasis Kourosh R Ahmadi Dorret I Boomsma Mark Caulfield William O Cookson Cornelia M van Duijn Philippe Froguel Koichi Matsuda Mark I McCarthy Christa Meisinger Vincent Mooser Kirsi H Pietiläinen Gunter Schumann Harold Snieder Michael J E Sternberg Ronald P Stolk Howard C Thomas Unnur Thorsteinsdottir Manuela Uda Gérard Waeber Nicholas J Wareham Dawn M Waterworth Hugh Watkins John B Whitfield Jacqueline C M Witteman Bruce H R Wolffenbuttel Caroline S Fox Mika Ala-Korpela Kari Stefansson Peter Vollenweider Henry Völzke Eric E Schadt James Scott Marjo-Riitta Järvelin Paul Elliott Jaspal S Kooner

Nat Genet 2011 Oct 16;43(11):1131-8. Epub 2011 Oct 16.

Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK.

View Article

Download full-text PDF

Source
http://hmg.oxfordjournals.org/content/early/2012/09/04/hmg.d
Web Search
http://www.nature.com/doifinder/10.1038/ng.970
Publisher Site
http://dx.doi.org/10.1038/ng.970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482372PMC
October 2011

Sarcomere protein gene mutations in patients with apical hypertrophic cardiomyopathy.

Circ Cardiovasc Genet 2011 Jun 21;4(3):288-95. Epub 2011 Apr 21.

Division of Cardiology, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.110.958
Publisher Site
http://dx.doi.org/10.1161/CIRCGENETICS.110.958835DOI Listing
June 2011

A review of economic evaluations of genetic testing services and interventions (2004-2009).

Genet Med 2011 Feb;13(2):89-94

Centre for Research on Inner City Health, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://www.nature.com/doifinder/10.1097/GIM.0b013e3182003294
Publisher Site
http://dx.doi.org/10.1097/GIM.0b013e3182003294DOI Listing
February 2011

Locus category based analysis of a large genome-wide association study of rheumatoid arthritis.

Hum Mol Genet 2010 Oct 16;19(19):3863-72. Epub 2010 Jul 16.

Robert S. Boas Center for Human Genetics and Genomics, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddq304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935861PMC
October 2010

Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation.

J Immunol 2010 Sep 28;185(5):2819-27. Epub 2010 Jul 28.

National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0902182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422635PMC
September 2010

Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells.

Blood 2010 Aug 14;116(8):1272-9. Epub 2010 May 14.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-12-26
Publisher Site
http://dx.doi.org/10.1182/blood-2009-12-261487DOI Listing
August 2010

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Nat Genet 2010 Jun 9;42(6):508-14. Epub 2010 May 9.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243840PMC
June 2010

Fibrocyte activation in rheumatoid arthritis.

Rheumatology (Oxford) 2010 Apr 25;49(4):640-51. Epub 2009 Oct 25.

Toronto General Research Institute, University Health Network, 67 College Street, 4-424, Toronto, Ontario M5G 2M1, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kep265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909797PMC
April 2010

Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ Treg.

Eur J Immunol 2010 Apr;40(4):1022-35

Physiology and Experimental Medicine Research Program, Hospital for Sick Children, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200939782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603937PMC
April 2010

Navigating the road to personalized medicine: can we believe?

CMAJ 2010 Apr 6;182(7):651-2. Epub 2010 Apr 6.

Liver Centre, Toronto Western Hospital, Toronto, Ont.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1503/cmaj.100300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855909PMC
April 2010

Apoptotic dendritic cells induce tolerance in mice through suppression of dendritic cell maturation and induction of antigen-specific regulatory T cells.

J Immunol 2009 Dec 16;183(11):7104-18. Epub 2009 Nov 16.

Physiology and Experimental Medicine Research Program, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.

View Article

Download full-text PDF

Source
http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0900824
Publisher Site
http://dx.doi.org/10.4049/jimmunol.0900824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603940PMC
December 2009

Contributions of Wiskott-Aldrich syndrome family cytoskeletal regulatory adapters to immune regulation.

Immunol Rev 2009 Nov;232(1):175-94

Department of Medicine, University of Toronto, Mount Sinai Hospital Samuel Lunenfeld Research Institute, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1600-065X.2009.00846.x
Publisher Site
http://dx.doi.org/10.1111/j.1600-065X.2009.00846.xDOI Listing
November 2009

Genetic variants in IL-23R and ATG16L1 independently predispose to increased susceptibility to Crohn's disease in a Canadian population.

J Clin Gastroenterol 2009 May-Jun;43(5):444-7

Academic Department of Medical Genetics, University of Manchester, Manchester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCG.0b013e318168bdf0DOI Listing
September 2009

Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling.

J Biol Chem 2009 Jul 3;284(31):20763-72. Epub 2009 Jun 3.

Canadian Institutes of Health Research Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5S 3E2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M808828200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742840PMC
July 2009

Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia.

Clin Cancer Res 2009 Jul 7;15(14):4750-8. Epub 2009 Jul 7.

Chronic Myelogenous Leukemia Group, Department of Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-09-0145DOI Listing
July 2009

Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia.

Blood 2009 Mar 13;113(11):2517-25. Epub 2009 Jan 13.

Chronic Myelogenous Leukemia Group, Department of Hematology/Medical Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-07-16
Publisher Site
http://dx.doi.org/10.1182/blood-2008-07-169110DOI Listing
March 2009

Utility of incorporating genetic variants for the early detection of prostate cancer.

Clin Cancer Res 2009 Mar 17;15(5):1787-93. Epub 2009 Feb 17.

Division of Urology, Sunnybrook Research Institute, Department of Radiation Oncology, Sunnybrook Health Sciences, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-08-1593DOI Listing
March 2009

The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis.

J Immunol 2009 Mar;182(6):3837-45

Department of Medicine, Samuel Lunenfeld and Toronto Hospital Research Institutes, University of Toronto, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0803838DOI Listing
March 2009

Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils.

Biochem Cell Biol 2009 Feb;87(1):207-16

Department of Medicine, Immunology, and Molecular and Medical Genetics, University of Toronto, Toronto, ONM5G1X5, Canada.

View Article

Download full-text PDF

Source
http://www.nrcresearchpress.com/doi/10.1139/O08-130
Publisher Site
http://dx.doi.org/10.1139/O08-130DOI Listing
February 2009

Geroderma osteodysplastica maps to a 4 Mb locus on chromosome 1q24.

Am J Med Genet A 2008 Dec;146A(23):3034-7

Academic Department of Medical Genetics, University of Manchester, and Regional Genetics Service, St Mary's Hospital, Manchester, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.32564DOI Listing
December 2008

G protein-coupled receptor pharmacogenetics.

Methods Mol Biol 2008 ;448:139-85

Department of Laboratory Medicine and Pathobiology, Banting Institute, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-205-2_8DOI Listing
May 2008

Primer: genomic and proteomic tools for the molecular dissection of disease.

Nat Clin Pract Rheumatol 2007 Oct;3(10):580-9

Mount Sinai Hospital, Toronto, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncprheum0595DOI Listing
October 2007

T cell responses in mammalian diaphanous-related formin mDia1 knock-out mice.

J Biol Chem 2007 Aug 26;282(34):25152-8. Epub 2007 Jun 26.

Laboratory of Cell Structure and Signal Integration, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M703243200DOI Listing
August 2007

Nonreceptor protein-tyrosine phosphatases in immune cell signaling.

Annu Rev Immunol 2007 ;25:473-523

Cancer Biology Program, Division of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev.immunol.23.021704.115647DOI Listing
June 2007

Genetic variation at the calcium-sensing receptor (CASR) locus: implications for clinical molecular diagnostics.

Clin Biochem 2007 May 18;40(8):551-61. Epub 2007 Jan 18.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinbiochem.2006.12.011DOI Listing
May 2007

WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).

Proc Natl Acad Sci U S A 2007 Jan 9;104(3):926-31. Epub 2007 Jan 9.

Division of Immunology, Children's Hospital Boston, One Blackfan Circle, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0610275104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783416PMC
January 2007

Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signaling.

J Biol Chem 2006 Oct 11;281(41):31093-105. Epub 2006 Aug 11.

Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M606392200DOI Listing
October 2006