Publications by authors named "Katherine Lansu"

11Publications

VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.

Cell 2019 07 4;178(3):748-761.e17. Epub 2019 Jul 4.

Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27514, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.05.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660416PMC
July 2019

Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling.

Anesthesiology 2019 07;131(1):132-147

From the Laboratory of Anesthesiology Research, Department of Anesthesiology (T.L.Y., K.A.E., S.K., R.R., Y.Z., Y.H., F.W., D.Q., S.A.M., J.J.S.) Department of Dermatology (Z.W., A.D.) Division of Trauma, Department of Surgery (B.P.E.), University of California, San Diego, California the Department of Pharmacology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina (K.L., W.K.K) Montreal Clinical Research Institute and the Department of Pharmacology and Physiology, University of Montreal, Quebec, Canada (P.W.S.) Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nurnberg, Erlangen, Germany (P.G.) Implantables Research and Technology, Medtronic, Inc., Restorative Therapies Group, Minneapolis, Minnesota (L.M.P., K.R.H.).

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http://dx.doi.org/10.1097/ALN.0000000000002730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590697PMC
July 2019

Structural determinants of 5-HT receptor activation and biased agonism.

Nat Struct Mol Biol 2018 09 20;25(9):787-796. Epub 2018 Aug 20.

National Institute of Mental Health Psychoactive Drug Screening Program, Department of Pharmacology and Division of Chemical Biology and Medicinal Chemistry, University of North Carolina Chapel Hill Medical School, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/s41594-018-0116-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237183PMC
September 2018

5-HT Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

Cell 2018 02 1;172(4):719-730.e14. Epub 2018 Feb 1.

iHuman Institute, ShanghaiTech University, Shanghai 201210, China; Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming 650500, China; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309861PMC
February 2018

In silico design of novel probes for the atypical opioid receptor MRGPRX2.

Nat Chem Biol 2017 05 13;13(5):529-536. Epub 2017 Mar 13.

Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nchembio.2334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391270PMC
May 2017

Crystal Structure of an LSD-Bound Human Serotonin Receptor.

Cell 2017 01;168(3):377-389.e12

Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA; National Institute of Mental Health Psychoactive Drug Screening Program (NIMH PDSP), School of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599-7365, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.12.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289311PMC
January 2017

Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma.

Oncotarget 2016 Apr;7(16):21991-2004

Department of Molecular Pharmacology & Therapeutics, Loyola University, Chicago, IL-60153, USA.

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http://dx.doi.org/10.18632/oncotarget.7831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008339PMC
April 2016

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

Nat Struct Mol Biol 2015 May 20;22(5):362-9. Epub 2015 Apr 20.

1] Department of Pharmacology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA. [2] National Institute of Mental Health Psychoactive Drug Screening Program, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA. [3] Program in Neuroscience, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA. [4] Division of Chemical Biology and Medicinal Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/nsmb.3014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424118PMC
May 2015

Long QT2 mutation on the Kv11.1 ion channel inhibits current activity by ablating a protein kinase Cα consensus site.

Mol Pharmacol 2012 Sep 31;82(3):428-37. Epub 2012 May 31.

Departments of Molecular Pharmacology and Therapeutics, Loyola University, Chicago, Illinois, USA.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.112.07
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http://dx.doi.org/10.1124/mol.112.077966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673708PMC
September 2012