Katharine R Trenholme

Katharine R Trenholme

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Katharine R Trenholme

Katharine R Trenholme

Publications by authors named "Katharine R Trenholme"

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Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay.

SLAS Discov 2019 01 24;24(1):38-46. Epub 2018 Aug 24.

2 School of Medicine, University of Queensland, Herston, Queensland, Australia.

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http://dx.doi.org/10.1177/2472555218796410DOI Listing
January 2019

The development of sexual stage malaria gametocytes in a Wave Bioreactor.

Parasit Vectors 2017 May 2;10(1):216. Epub 2017 May 2.

Institute of Parasitology, McGill University, 21111 Lakeshore Road, Sainte-Anne-de-Bellevue, Québec, H9X 3 V9, Canada.

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http://dx.doi.org/10.1186/s13071-017-2155-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414375PMC
May 2017

A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability.

Exp Parasitol 2016 Oct 30;169:13-21. Epub 2016 Jun 30.

School of Natural Sciences, Griffith University, Brisbane, Queensland 4111, Australia; Eskitis Institute for Drug Discovery, Griffith University, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2016.06.013DOI Listing
October 2016

Plasmodium falciparum gametocytes: playing hide and seek.

Ann Transl Med 2015 Mar;3(4):45

1 School of Medicine, University of Queensland, Herston, Brisbane 4006, Australia ; 2 Australian Institute of Tropical Health & Medicine, James Cook University, Smithfield, QLD 4878, Australia ; 3 Department of Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.

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http://dx.doi.org/10.3978/j.issn.2305-5839.2015.01.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381475PMC
March 2015

Plasmodium falciparum gametocytes: with a view to a kill.

Parasitology 2013 Dec 19;140(14):1718-34. Epub 2013 Aug 19.

Queensland Institute of Medical Research, Brisbane, Australia.

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http://dx.doi.org/10.1017/S0031182013001236DOI Listing
December 2013

Plasmodium gametocyte inhibition identified from a natural-product-based fragment library.

ACS Chem Biol 2013 Dec 3;8(12):2654-9. Epub 2013 Oct 3.

Eskitis Institute for Drug Discovery, Griffith University , Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1021/cb400582bDOI Listing
December 2013

Enhanced gametocyte formation in erythrocyte progenitor cells: a site-specific adaptation by Plasmodium falciparum.

J Infect Dis 2013 Oct 11;208(7):1170-4. Epub 2013 Jul 11.

Malaria Biology Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia.

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http://dx.doi.org/10.1093/infdis/jit309DOI Listing
October 2013

Temporal evaluation of commitment to sexual development in Plasmodium falciparum.

Malar J 2013 Apr 22;12:134. Epub 2013 Apr 22.

Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, QLD 4006, Australia.

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http://dx.doi.org/10.1186/1475-2875-12-134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659030PMC
April 2013

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP.

J Mol Biol 2012 Sep 16;422(4):495-507. Epub 2012 Jun 16.

Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne, VIC 3800, Australia.

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http://dx.doi.org/10.1016/j.jmb.2012.06.006DOI Listing
September 2012

Anti-malarial drugs: how effective are they against Plasmodium falciparum gametocytes?

Malar J 2012 Feb 6;11:34. Epub 2012 Feb 6.

Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston 4006, Queensland, Australia.

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http://dx.doi.org/10.1186/1475-2875-11-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293736PMC
February 2012

A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes.

Mol Biochem Parasitol 2011 Dec 16;180(2):127-31. Epub 2011 Sep 16.

Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd., Herston, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.molbiopara.2011.09.002DOI Listing
December 2011

Genetic ablation of a Maurer's cleft protein prevents assembly of the Plasmodium falciparum virulence complex.

Mol Microbiol 2011 Aug 7;81(4):982-93. Epub 2011 Jul 7.

La Trobe Institute for Molecular Science, Department of Biochemistry and Centre of Excellence for Coherent X-ray Science, La Trobe University, Vic. 3086, Australia.

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http://dx.doi.org/10.1111/j.1365-2958.2011.07740.xDOI Listing
August 2011

An improved method for undertaking limiting dilution assays for in vitro cloning of Plasmodium falciparum parasites.

Malar J 2011 Apr 18;10:95. Epub 2011 Apr 18.

Clinical Tropical Medicine Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, 4006, Australia.

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http://dx.doi.org/10.1186/1475-2875-10-95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089786PMC
April 2011

Dual stage synthesis and crucial role of cytoadherence-linked asexual gene 9 in the surface expression of malaria parasite var proteins.

Proc Natl Acad Sci U S A 2010 Sep 7;107(38):16643-8. Epub 2010 Sep 7.

Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1073/pnas.1002568107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944715PMC
September 2010

Aminopeptidases of malaria parasites: new targets for chemotherapy.

Infect Disord Drug Targets 2010 Jun;10(3):217-25

Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, QLD, 4006, Australia.

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http://dx.doi.org/10.2174/187152610791163363DOI Listing
June 2010

Antimalarial asexual stage-specific and gametocytocidal activities of HIV protease inhibitors.

Antimicrob Agents Chemother 2010 Mar 22;54(3):1334-7. Epub 2009 Dec 22.

Queensland Institute of Medical Research, 300 Herston Rd., Herston, Queensland, Australia.

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http://dx.doi.org/10.1128/AAC.01512-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825985PMC
March 2010

Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials.

Trends Biochem Sci 2010 Jan 30;35(1):53-61. Epub 2009 Sep 30.

Malaria Biology Laboratory, Queensland Institute of Medical Research, Herston, QLD 4006, Australia.

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http://dx.doi.org/10.1016/j.tibs.2009.08.004DOI Listing
January 2010

Effect of antimalarial drugs on Plasmodium falciparum gametocytes.

J Infect Dis 2009 Nov;200(10):1518-21

Malaria Biology Laboratory, Queensland Institute of Medical Research, Herston, 4006 Victoria, Australia.

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http://dx.doi.org/10.1086/644645DOI Listing
November 2009

Plasmodium falciparum: new molecular targets with potential for antimalarial drug development.

Expert Rev Anti Infect Ther 2009 Nov;7(9):1087-98

Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, QLD 4006, Australia.

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http://dx.doi.org/10.1586/eri.09.93DOI Listing
November 2009

The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors.

Biochemistry 2009 Jun;48(23):5435-9

Institute for the Biotechnology of Infectious Diseases (IBID), University of Technology Sydney (UTS), Level 6, Building 4, Corner of Thomas and Harris Street, Ultimo, Sydney, NSW 2007, Australia.

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http://dx.doi.org/10.1021/bi9003638DOI Listing
June 2009

REX1 and Pf62: are they one and the same?

Parasitol Res 2009 Apr;104(5):967-8

Malaria Biology Laboratory, Queensland Institute of Medical Research, Herston, Brisbane, Australia.

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http://link.springer.com/10.1007/s00436-009-1382-4
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http://dx.doi.org/10.1007/s00436-009-1382-4DOI Listing
April 2009

A green fluorescent protein-based assay for determining gametocyte production in Plasmodium falciparum.

Mol Biochem Parasitol 2009 Feb 5;163(2):123-6. Epub 2008 Nov 5.

Malaria Biology Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia.

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http://dx.doi.org/10.1016/j.molbiopara.2008.10.004DOI Listing
February 2009

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase.

Proc Natl Acad Sci U S A 2009 Feb 5;106(8):2537-42. Epub 2009 Feb 5.

Department of Biochemistry and Molecular Biology and Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria, 3800, Australia.

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http://dx.doi.org/10.1073/pnas.0807398106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636733PMC
February 2009

Targeting of the ring exported protein 1 to the Maurer's clefts is mediated by a two-phase process.

Traffic 2008 Aug 19;9(8):1316-26. Epub 2008 May 19.

Malaria Biology Laboratory, Queensland Institute of Medical Research, Herston, QLD, Australia.

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http://dx.doi.org/10.1111/j.1600-0854.2008.00768.xDOI Listing
August 2008

Targeted mutagenesis of the ring-exported protein-1 of Plasmodium falciparum disrupts the architecture of Maurer's cleft organelles.

Mol Microbiol 2008 Aug 28;69(4):938-53. Epub 2008 Jun 28.

Department of Biochemistry and Centre of Excellence for Coherent X-ray Science, La Trobe University, VIC 3086, Australia.

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http://dx.doi.org/10.1111/j.1365-2958.2008.06329.xDOI Listing
August 2008

Sex in Plasmodium: a sign of commitment.

Trends Parasitol 2008 Apr 14;24(4):168-75. Epub 2008 Mar 14.

Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4006, Australia.

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http://dx.doi.org/10.1016/j.pt.2008.01.004DOI Listing
April 2008

Invasion of Rh Null Cells by Plasmodium falciparum identifies a new invasion pathway.

Parasitol Res 2008 Jan 4;102(2):259-63. Epub 2007 Oct 4.

Division of Infectious Diseases and Immunology, The Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, Herston Brisbane, 4006, Australia.

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http://dx.doi.org/10.1007/s00436-007-0756-8DOI Listing
January 2008

Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.

J Med Chem 2007 Nov 26;50(24):6024-31. Epub 2007 Oct 26.

Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Herston, Queensland 4029, Australia.

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http://dx.doi.org/10.1021/jm070733vDOI Listing
November 2007

The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.

J Biol Chem 2007 Oct 20;282(42):30817-26. Epub 2007 Aug 20.

Malaria Biology Laboratory, The Queensland Institute of Medical Research, 300 Herston Rd, Herston, Brisbane, Queensland 4006, Australia.

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http://dx.doi.org/10.1074/jbc.M704938200DOI Listing
October 2007

The CLAG/RhopH1 locus on chromosome 3 of Plasmodium falciparum: two genes or two alleles of the same gene?

Mol Biochem Parasitol 2007 Feb 1;151(2):229-32. Epub 2006 Dec 1.

Malaria and Scabies Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.

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http://dx.doi.org/10.1016/j.molbiopara.2006.11.004DOI Listing
February 2007

Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase. A protease involved in amino acid regulation with potential for antimalarial drug development.

J Biol Chem 2007 Jan 15;282(3):2069-80. Epub 2006 Nov 15.

Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Level 6, Building 4, Corner of Thomas and Harris Street, Ultimo, Sydney, New South Wales 2007, Australia.

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http://dx.doi.org/10.1074/jbc.M609251200DOI Listing
January 2007

Reliable transfection of Plasmodium falciparum using non-commercial plasmid mini preparations.

Int J Parasitol 2006 Oct 28;36(12):1245-8. Epub 2006 Jul 28.

Infectious Diseases and Immunology Division, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Qld 4029, Australia.

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http://dx.doi.org/10.1016/j.ijpara.2006.06.017DOI Listing
October 2006

Organization of ETRAMPs and EXP-1 at the parasite-host cell interface of malaria parasites.

Mol Microbiol 2006 Feb;59(3):779-94

Infectious Diseases and Immunology Division, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, QLD 4029, Australia.

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http://dx.doi.org/10.1111/j.1365-2958.2005.04983.xDOI Listing
February 2006

Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin.

J Biol Chem 2006 Jan 14;281(3):1741-5. Epub 2005 Nov 14.

Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, 300 Herston Road, Herston, Brisbane QLD 4029, Australia.

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http://dx.doi.org/10.1074/jbc.M508955200DOI Listing
January 2006

Enhanced invasion of blood group A1 erythrocytes by Plasmodium falciparum.

Mol Biochem Parasitol 2005 Nov;144(1):128-30

Malaria and Scabies Laboratory, Division of Infectious Diseases and Immunology, The Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Qld 4006, Australia.

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http://dx.doi.org/10.1016/j.molbiopara.2005.08.004DOI Listing
November 2005

Antibody reactivity to linear epitopes of Plasmodium falciparum cytoadherence-linked asexual gene 9 in asymptomatic children and adults from papua new Guinea.

Am J Trop Med Hyg 2005 Jun;72(6):708-13

Division of Infectious Diseases and Immunology, The Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, Brisbane, Queensland, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532502PMC
June 2005

Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis.

Mol Biochem Parasitol 2005 Apr 19;140(2):153-60. Epub 2005 Jan 19.

Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, 300 Herston Road, Herston, Qld 4006, Australia.

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http://dx.doi.org/10.1016/j.molbiopara.2004.12.010DOI Listing
April 2005

CLAG 9 is located in the rhoptries of Plasmodium falciparum.

Parasitol Res 2004 May 21;93(1):64-7. Epub 2004 Apr 21.

Malaria Biology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research, 300 Herston Road, 4006 Herston, Queensland, Australia.

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http://dx.doi.org/10.1007/s00436-004-1098-4DOI Listing
May 2004

Malaria transfection and transfection vectors.

Trends Parasitol 2003 Sep;19(9):381-3

Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, a joint program of the Queensland Institute of Medical Research and the School of Population Health, University of Queensland, Herston.

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http://dx.doi.org/10.1016/s1471-4922(03)00187-9DOI Listing
September 2003

Comparison of Plasmodium falciparum transfection methods.

Malar J 2003 Jun 27;2:19. Epub 2003 Jun 27.

Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, University of Queensland, Australia.

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http://dx.doi.org/10.1186/1475-2875-2-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166142PMC
June 2003