Publications by authors named "Katalin Susztak"

100Publications

Podocytopathies.

Nat Rev Dis Primers 2020 Aug 13;6(1):68. Epub 2020 Aug 13.

Department of Clinical and Experimental Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.

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http://dx.doi.org/10.1038/s41572-020-0196-7DOI Listing
August 2020

Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses.

J Immunol 2020 Jul 10;205(2):377-386. Epub 2020 Jun 10.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.4049/jimmunol.1901463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368461PMC
July 2020

The interdependence of renal epithelial and endothelial metabolism and cell state.

Sci Signal 2020 Jun 9;13(635). Epub 2020 Jun 9.

Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scisignal.abb8834DOI Listing
June 2020

Unravelling the complex genetics of common kidney diseases: from variants to mechanisms.

Nat Rev Nephrol 2020 Jun 8. Epub 2020 Jun 8.

Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41581-020-0298-1DOI Listing
June 2020

Complexities of Understanding Function from CKD-Associated DNA Variants.

Clin J Am Soc Nephrol 2020 Jul 8;15(7):1028-1040. Epub 2020 Jun 8.

Renal, Electrolyte, and Hypertension Division, Department of Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania

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http://dx.doi.org/10.2215/CJN.15771219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341770PMC
July 2020

Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis.

Nat Commun 2020 05 11;11(1):2338. Epub 2020 May 11.

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1038/s41467-020-15851-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214470PMC
May 2020

ASEP: Gene-based detection of allele-specific expression across individuals in a population by RNA sequencing.

PLoS Genet 2020 05 11;16(5):e1008786. Epub 2020 May 11.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241832PMC
May 2020

It Takes Two to Tango: The Role of Dysregulated Metabolism and Inflammation in Kidney Disease Development.

Semin Nephrol 2020 03;40(2):199-205

Renal, Electrolyte, and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

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http://dx.doi.org/10.1016/j.semnephrol.2020.01.010DOI Listing
March 2020

Phenome-wide association analysis suggests the APOL1 linked disease spectrum primarily drives kidney-specific pathways.

Kidney Int 2020 05 17;97(5):1032-1041. Epub 2020 Feb 17.

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2020.01.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265573PMC
May 2020

and -Decommissioned Fetal Enhancers are Linked to Kidney Disease.

J Am Soc Nephrol 2020 Apr 3;31(4):765-782. Epub 2020 Mar 3.

Department of Medicine, Renal Electrolyte and Hypertension Division, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

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http://dx.doi.org/10.1681/ASN.2019080797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191927PMC
April 2020

Rationale and design of the Transformative Research in Diabetic Nephropathy (TRIDENT) Study.

Kidney Int 2020 01;97(1):10-13

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.kint.2019.09.020DOI Listing
January 2020

Loss of ELK1 has differential effects on age-dependent organ fibrosis.

Int J Biochem Cell Biol 2020 03 23;120:105668. Epub 2019 Dec 23.

Nottingham NIHR Biomedical Research Centre, Division of Respiratory Medicine, University of Nottingham, Nottingham University Hospitals, City Campus, Nottingham, NG5 1PB, UK. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2019.105668DOI Listing
March 2020

Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies.

Sci Rep 2019 11 26;9(1):17610. Epub 2019 Nov 26.

Laboratory of Disease Modeling and Therapeutics, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.

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http://dx.doi.org/10.1038/s41598-019-53855-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879515PMC
November 2019

Author Correction: FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy.

Sci Rep 2019 Oct 24;9(1):15552. Epub 2019 Oct 24.

Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1038/s41598-019-51739-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811579PMC
October 2019

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.

Authors:
Adrienne Tin Jonathan Marten Victoria L Halperin Kuhns Yong Li Matthias Wuttke Holger Kirsten Karsten B Sieber Chengxiang Qiu Mathias Gorski Zhi Yu Ayush Giri Gardar Sveinbjornsson Man Li Audrey Y Chu Anselm Hoppmann Luke J O'Connor Bram Prins Teresa Nutile Damia Noce Masato Akiyama Massimiliano Cocca Sahar Ghasemi Peter J van der Most Katrin Horn Yizhe Xu Christian Fuchsberger Sanaz Sedaghat Saima Afaq Najaf Amin Johan Ärnlöv Stephan J L Bakker Nisha Bansal Daniela Baptista Sven Bergmann Mary L Biggs Ginevra Biino Eric Boerwinkle Erwin P Bottinger Thibaud S Boutin Marco Brumat Ralph Burkhardt Eric Campana Archie Campbell Harry Campbell Robert J Carroll Eulalia Catamo John C Chambers Marina Ciullo Maria Pina Concas Josef Coresh Tanguy Corre Daniele Cusi Sala Cinzia Felicita Martin H de Borst Alessandro De Grandi Renée de Mutsert Aiko P J de Vries Graciela Delgado Ayşe Demirkan Olivier Devuyst Katalin Dittrich Kai-Uwe Eckardt Georg Ehret Karlhans Endlich Michele K Evans Ron T Gansevoort Paolo Gasparini Vilmantas Giedraitis Christian Gieger Giorgia Girotto Martin Gögele Scott D Gordon Daniel F Gudbjartsson Vilmundur Gudnason Toomas Haller Pavel Hamet Tamara B Harris Caroline Hayward Andrew A Hicks Edith Hofer Hilma Holm Wei Huang Nina Hutri-Kähönen Shih-Jen Hwang M Arfan Ikram Raychel M Lewis Erik Ingelsson Johanna Jakobsdottir Ingileif Jonsdottir Helgi Jonsson Peter K Joshi Navya Shilpa Josyula Bettina Jung Mika Kähönen Yoichiro Kamatani Masahiro Kanai Shona M Kerr Wieland Kiess Marcus E Kleber Wolfgang Koenig Jaspal S Kooner Antje Körner Peter Kovacs Bernhard K Krämer Florian Kronenberg Michiaki Kubo Brigitte Kühnel Martina La Bianca Leslie A Lange Benjamin Lehne Terho Lehtimäki Jun Liu Markus Loeffler Ruth J F Loos Leo-Pekka Lyytikäinen Reedik Magi Anubha Mahajan Nicholas G Martin Winfried März Deborah Mascalzoni Koichi Matsuda Christa Meisinger Thomas Meitinger Andres Metspalu Yuri Milaneschi Christopher J O'Donnell Otis D Wilson J Michael Gaziano Pashupati P Mishra Karen L Mohlke Nina Mononen Grant W Montgomery Dennis O Mook-Kanamori Martina Müller-Nurasyid Girish N Nadkarni Mike A Nalls Matthias Nauck Kjell Nikus Boting Ning Ilja M Nolte Raymond Noordam Jeffrey R O'Connell Isleifur Olafsson Sandosh Padmanabhan Brenda W J H Penninx Thomas Perls Annette Peters Mario Pirastu Nicola Pirastu Giorgio Pistis Ozren Polasek Belen Ponte David J Porteous Tanja Poulain Michael H Preuss Ton J Rabelink Laura M Raffield Olli T Raitakari Rainer Rettig Myriam Rheinberger Kenneth M Rice Federica Rizzi Antonietta Robino Igor Rudan Alena Krajcoviechova Renata Cifkova Rico Rueedi Daniela Ruggiero Kathleen A Ryan Yasaman Saba Erika Salvi Helena Schmidt Reinhold Schmidt Christian M Shaffer Albert V Smith Blair H Smith Cassandra N Spracklen Konstantin Strauch Michael Stumvoll Patrick Sulem Salman M Tajuddin Andrej Teren Joachim Thiery Chris H L Thio Unnur Thorsteinsdottir Daniela Toniolo Anke Tönjes Johanne Tremblay André G Uitterlinden Simona Vaccargiu Pim van der Harst Cornelia M van Duijn Niek Verweij Uwe Völker Peter Vollenweider Gerard Waeber Melanie Waldenberger John B Whitfield Sarah H Wild James F Wilson Qiong Yang Weihua Zhang Alan B Zonderman Murielle Bochud James G Wilson Sarah A Pendergrass Kevin Ho Afshin Parsa Peter P Pramstaller Bruce M Psaty Carsten A Böger Harold Snieder Adam S Butterworth Yukinori Okada Todd L Edwards Kari Stefansson Katalin Susztak Markus Scholz Iris M Heid Adriana M Hung Alexander Teumer Cristian Pattaro Owen M Woodward Veronique Vitart Anna Köttgen

Nat Genet 2019 10 2;51(10):1459-1474. Epub 2019 Oct 2.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41588-019-0504-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858555PMC
October 2019

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.

J Am Soc Nephrol 2019 10 19;30(10):2000-2016. Epub 2019 Sep 19.

Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts;

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http://dx.doi.org/10.1681/ASN.2019030218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779358PMC
October 2019

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Authors:
Alexander Teumer Yong Li Sahar Ghasemi Bram P Prins Matthias Wuttke Tobias Hermle Ayush Giri Karsten B Sieber Chengxiang Qiu Holger Kirsten Adrienne Tin Audrey Y Chu Nisha Bansal Mary F Feitosa Lihua Wang Jin-Fang Chai Massimiliano Cocca Christian Fuchsberger Mathias Gorski Anselm Hoppmann Katrin Horn Man Li Jonathan Marten Damia Noce Teresa Nutile Sanaz Sedaghat Gardar Sveinbjornsson Bamidele O Tayo Peter J van der Most Yizhe Xu Zhi Yu Lea Gerstner Johan Ärnlöv Stephan J L Bakker Daniela Baptista Mary L Biggs Eric Boerwinkle Hermann Brenner Ralph Burkhardt Robert J Carroll Miao-Li Chee Miao-Ling Chee Mengmeng Chen Ching-Yu Cheng James P Cook Josef Coresh Tanguy Corre John Danesh Martin H de Borst Alessandro De Grandi Renée de Mutsert Aiko P J de Vries Frauke Degenhardt Katalin Dittrich Jasmin Divers Kai-Uwe Eckardt Georg Ehret Karlhans Endlich Janine F Felix Oscar H Franco Andre Franke Barry I Freedman Sandra Freitag-Wolf Ron T Gansevoort Vilmantas Giedraitis Martin Gögele Franziska Grundner-Culemann Daniel F Gudbjartsson Vilmundur Gudnason Pavel Hamet Tamara B Harris Andrew A Hicks Hilma Holm Valencia Hui Xian Foo Shih-Jen Hwang M Arfan Ikram Erik Ingelsson Vincent W V Jaddoe Johanna Jakobsdottir Navya Shilpa Josyula Bettina Jung Mika Kähönen Chiea-Chuen Khor Wieland Kiess Wolfgang Koenig Antje Körner Peter Kovacs Holly Kramer Bernhard K Krämer Florian Kronenberg Leslie A Lange Carl D Langefeld Jeannette Jen-Mai Lee Terho Lehtimäki Wolfgang Lieb Su-Chi Lim Lars Lind Cecilia M Lindgren Jianjun Liu Markus Loeffler Leo-Pekka Lyytikäinen Anubha Mahajan Joseph C Maranville Deborah Mascalzoni Barbara McMullen Christa Meisinger Thomas Meitinger Kozeta Miliku Dennis O Mook-Kanamori Martina Müller-Nurasyid Josyf C Mychaleckyj Matthias Nauck Kjell Nikus Boting Ning Raymond Noordam Jeffrey O' Connell Isleifur Olafsson Nicholette D Palmer Annette Peters Anna I Podgornaia Belen Ponte Tanja Poulain Peter P Pramstaller Ton J Rabelink Laura M Raffield Dermot F Reilly Rainer Rettig Myriam Rheinberger Kenneth M Rice Fernando Rivadeneira Heiko Runz Kathleen A Ryan Charumathi Sabanayagam Kai-Uwe Saum Ben Schöttker Christian M Shaffer Yuan Shi Albert V Smith Konstantin Strauch Michael Stumvoll Benjamin B Sun Silke Szymczak E-Shyong Tai Nicholas Y Q Tan Kent D Taylor Andrej Teren Yih-Chung Tham Joachim Thiery Chris H L Thio Hauke Thomsen Unnur Thorsteinsdottir Anke Tönjes Johanne Tremblay André G Uitterlinden Pim van der Harst Niek Verweij Suzanne Vogelezang Uwe Völker Melanie Waldenberger Chaolong Wang Otis D Wilson Charlene Wong Tien-Yin Wong Qiong Yang Masayuki Yasuda Shreeram Akilesh Murielle Bochud Carsten A Böger Olivier Devuyst Todd L Edwards Kevin Ho Andrew P Morris Afshin Parsa Sarah A Pendergrass Bruce M Psaty Jerome I Rotter Kari Stefansson James G Wilson Katalin Susztak Harold Snieder Iris M Heid Markus Scholz Adam S Butterworth Adriana M Hung Cristian Pattaro Anna Köttgen

Nat Commun 2019 09 11;10(1):4130. Epub 2019 Sep 11.

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41467-019-11576-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739370PMC
September 2019

Understanding the kidney one cell at a time.

Kidney Int 2019 10 26;96(4):862-870. Epub 2019 Jul 26.

Renal, Electrolyte, and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.03.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777841PMC
October 2019

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis.

Cell Metab 2019 10 29;30(4):784-799.e5. Epub 2019 Aug 29.

Renal, Electrolyte, and Hypertension Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131193043
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http://dx.doi.org/10.1016/j.cmet.2019.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054893PMC
October 2019

Cytosine Methylation Studies in Patients with Diabetic Kidney Disease.

Curr Diab Rep 2019 08 30;19(10):91. Epub 2019 Aug 30.

Renal Electrolyte and Hypertension Division, Department of Medicine and Genetics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, 12-123 Smilow Translational Research Building, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s11892-019-1214-6DOI Listing
August 2019

Functional methylome analysis of human diabetic kidney disease.

JCI Insight 2019 06 6;4(11). Epub 2019 Jun 6.

Department of Medicine, Renal Electrolyte and Hypertension Division, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/jci.insight.128886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629092PMC
June 2019

Genomic Mismatch at Locus and Kidney Allograft Rejection.

N Engl J Med 2019 05;380(20):1918-1928

From the Department of Medicine, Division of Nephrology (N.J.S., Y.L., J.A.D., C.F., L.L., K.X., Y.-J.N., Y.D.N., J.Y.Z., R.S., O.B., D.B., N.O., F.O., S.G., K.M., J.W., S.M., J.R., D.J.C., J.B., A.G.G., K.K.), the Department of Surgery (L.E.R.), and the Department of Pathology and Cell Biology (E.-R.M.V., G.V., V.D.), Vagelos College of Physicians and Surgeons, and the Departments of Epidemiology (S.M.) and Biostatistics (I.I.-L.), Mailman School of Public Health, Columbia University, New York; Immunogenetics and Biology of Transplantation, Città della Salute e della Scienza, University Hospital of Turin, and Medical Genetics, Department of Medical Sciences, University of Turin, Turin (Z.D., S.D., A.A.), and the Division of Nephrology, Azienda Ospedaliera Spedali Civili of Brescia, Montichiari Hospital, University of Brescia, Brescia (F.S.) - all in Italy; the Department of Pathology, M.D. Anderson Cancer Center, Houston (F.Z.J.); the Division of Genetics and Genomics, Boston Children's Hospital, and the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston (M.R.); the Department of Pediatrics, Division of Pediatric Nephrology, University of Michigan School of Medicine, Ann Arbor (C.E.G., M.G.S.); the Department of Medicine, Renal, Electrolyte, and Hypertension Division, University of Pennsylvania, Philadelphia (Y.-A.K., K.S.); the Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey (Y.C.); the Nephrology Research Group, Queen's University of Belfast, Belfast, United Kingdom (A.E.C., A.P.M., A.J.M.); and the Department of Internal Medicine, Division of Nephrology (S.J.L.B., M.H.B.), and the Department of Epidemiology, Unit of Genetic Epidemiology and Bioinformatics (H.S.), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1056/NEJMoa1803731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589355PMC
May 2019

FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy.

Sci Rep 2019 04 30;9(1):6693. Epub 2019 Apr 30.

Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1038/s41598-019-42328-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491468PMC
April 2019

DNMT1 in Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development.

J Am Soc Nephrol 2019 04 8;30(4):594-609. Epub 2019 Mar 8.

Renal-Electrolyte and Hypertension Division, Department of Medicine,

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http://dx.doi.org/10.1681/ASN.2018070687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442333PMC
April 2019

Long-Range Chromatin Interactions in the Kidney.

J Am Soc Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Renal-Electrolyte and Hypertension Division, Department of Medicine and

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http://dx.doi.org/10.1681/ASN.2019010044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405157PMC
February 2019

Bulk tissue cell type deconvolution with multi-subject single-cell expression reference.

Nat Commun 2019 01 22;10(1):380. Epub 2019 Jan 22.

Department of Biostatistics, Epidemiology & Informatics, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://www.nature.com/articles/s41467-018-08023-x
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http://dx.doi.org/10.1038/s41467-018-08023-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342984PMC
January 2019

Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting.

PLoS Genet 2019 01 9;15(1):e1007874. Epub 2019 Jan 9.

Department of Bioengineering, University of Pennsylvania, Skirkanich Hall, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342324PMC
January 2019

Associations of Fenofibrate Therapy With Incidence and Progression of CKD in Patients With Type 2 Diabetes.

Kidney Int Rep 2019 Jan 18;4(1):94-102. Epub 2018 Sep 18.

Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S24680249183020
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http://dx.doi.org/10.1016/j.ekir.2018.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308372PMC
January 2019

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

Authors:
Ayush Giri Jacklyn N Hellwege Jacob M Keaton Jihwan Park Chengxiang Qiu Helen R Warren Eric S Torstenson Csaba P Kovesdy Yan V Sun Otis D Wilson Cassianne Robinson-Cohen Christianne L Roumie Cecilia P Chung Kelly A Birdwell Scott M Damrauer Scott L DuVall Derek Klarin Kelly Cho Yu Wang Evangelos Evangelou Claudia P Cabrera Louise V Wain Rojesh Shrestha Brian S Mautz Elvis A Akwo Muralidharan Sargurupremraj Stéphanie Debette Michael Boehnke Laura J Scott Jian'an Luan Jing-Hua Zhao Sara M Willems Sébastien Thériault Nabi Shah Christopher Oldmeadow Peter Almgren Ruifang Li-Gao Niek Verweij Thibaud S Boutin Massimo Mangino Ioanna Ntalla Elena Feofanova Praveen Surendran James P Cook Savita Karthikeyan Najim Lahrouchi Chunyu Liu Nuno Sepúlveda Tom G Richardson Aldi Kraja Philippe Amouyel Martin Farrall Neil R Poulter Markku Laakso Eleftheria Zeggini Peter Sever Robert A Scott Claudia Langenberg Nicholas J Wareham David Conen Colin Neil Alexander Palmer John Attia Daniel I Chasman Paul M Ridker Olle Melander Dennis Owen Mook-Kanamori Pim van der Harst Francesco Cucca David Schlessinger Caroline Hayward Tim D Spector Marjo-Riitta Jarvelin Branwen J Hennig Nicholas J Timpson Wei-Qi Wei Joshua C Smith Yaomin Xu Michael E Matheny Edward E Siew Cecilia Lindgren Karl-Heinz Herzig George Dedoussis Joshua C Denny Bruce M Psaty Joanna M M Howson Patricia B Munroe Christopher Newton-Cheh Mark J Caulfield Paul Elliott J Michael Gaziano John Concato Peter W F Wilson Philip S Tsao Digna R Velez Edwards Katalin Susztak Christopher J O'Donnell Adriana M Hung Todd L Edwards

Nat Genet 2019 01 21;51(1):51-62. Epub 2018 Dec 21.

Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.

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http://www.nature.com/articles/s41588-018-0303-9
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http://dx.doi.org/10.1038/s41588-018-0303-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365102PMC
January 2019

Epigenetics and Epigenomics: Implications for Diabetes and Obesity.

Diabetes 2018 10;67(10):1923-1931

Department of Genetics and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

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http://dx.doi.org/10.2337/db18-0537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463748PMC
October 2018

Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming.

PLoS Biol 2018 09 18;16(9):e2005233. Epub 2018 Sep 18.

Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.plos.org/10.1371/journal.pbio.2005233
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http://dx.doi.org/10.1371/journal.pbio.2005233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161902PMC
September 2018

APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease.

Trends Mol Med 2018 08 7;24(8):682-695. Epub 2018 Jun 7.

Renal-Electrolyte and Hypertension Division of Department of Medicine, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101980PMC
August 2018

Cytosine methylation predicts renal function decline in American Indians.

Kidney Int 2018 06 27;93(6):1417-1431. Epub 2018 Apr 27.

Renal, Electrolyte, and Hypertension Division, Department of Medicine, Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.kint.2018.01.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973533PMC
June 2018

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease.

Science 2018 05 5;360(6390):758-763. Epub 2018 Apr 5.

Renal Electrolyte and Hypertension Division, Department of Medicine and Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.aar2131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188645PMC
May 2018

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease.

Semin Nephrol 2018 03;38(2):121-126

Renal-Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.semnephrol.2018.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958619PMC
March 2018

Screening Drugs for Kidney Disease: Targeting the Podocyte.

Cell Chem Biol 2018 02;25(2):126-127

Renal-Electrolyte and Hypertension Division of Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.01.018DOI Listing
February 2018

Human Kidney Tubule-Specific Gene Expression Based Dissection of Chronic Kidney Disease Traits.

EBioMedicine 2017 Oct 18;24:267-276. Epub 2017 Sep 18.

Department Genetics and Medicine, Renal-Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652292PMC
October 2017

and Cardiovascular Disease: A Story in Evolution.

Arterioscler Thromb Vasc Biol 2017 09;37(9):1587-1589

From the Division of General Internal Medicine, Department of Medicine (A.B.), Renal Electrolyte and Hypertension Division, Department of Medicine (K.S.), Department of Genetics (K.S.), Division of Vascular Surgery, Department of Surgery (S.M.D.), University of Pennsylvania, Philadelphia; and Department of Surgery, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA (S.M.D.)

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http://dx.doi.org/10.1161/ATVBAHA.117.309756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657568PMC
September 2017

PGC-1 Protects from Notch-Induced Kidney Fibrosis Development.

J Am Soc Nephrol 2017 Nov 27;28(11):3312-3322. Epub 2017 Jul 27.

Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1681/ASN.2017020130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661291PMC
November 2017

A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice.

Kidney Blood Press Res 2017 27;42(3):468-482. Epub 2017 Jul 27.

Departments of Biochemistry, Bronx, New York, USA.

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http://dx.doi.org/10.1159/000479383DOI Listing
June 2018

Increasing the level of peroxisome proliferator-activated receptor γ coactivator-1α in podocytes results in collapsing glomerulopathy.

JCI Insight 2017 Jul 20;2(14). Epub 2017 Jul 20.

Renal-Electrolyte and Hypertension Division of Department of Medicine, and Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1172/jci.insight.92930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518556PMC
July 2017

Genetic-Variation-Driven Gene-Expression Changes Highlight Genes with Important Functions for Kidney Disease.

Am J Hum Genet 2017 Jun;100(6):940-953

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473735PMC
June 2017

Therapeutics for APOL1 nephropathies: putting out the fire in the podocyte.

Nephrol Dial Transplant 2017 01;32(suppl_1):i65-i70

Kidney Disease Section, NIDDK, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1093/ndt/gfw402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837624PMC
January 2017

Precision Medicine Approaches to Diabetic Kidney Disease: Tissue as an Issue.

Curr Diab Rep 2017 05;17(5):30

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 415 Curie Blvd, 415 Clinical Research Building, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1007/s11892-017-0854-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772762PMC
May 2017

Developing Treatments for Chronic Kidney Disease in the 21st Century.

Semin Nephrol 2016 11;36(6):436-447

Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1016/j.semnephrol.2016.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423404PMC
November 2016

The next generation of therapeutics for chronic kidney disease.

Nat Rev Drug Discov 2016 08 27;15(8):568-88. Epub 2016 May 27.

Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nrd.2016.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511522PMC
August 2016

Partitioning-Defective 1a/b Depletion Impairs Glomerular and Proximal Tubule Development.

J Am Soc Nephrol 2016 Dec 16;27(12):3725-3737. Epub 2016 May 16.

Division of Pediatric Nephrology, Children's Hospital at Montefiore, Bronx, New York;

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http://dx.doi.org/10.1681/ASN.2014111124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118470PMC
December 2016

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog.

Nat Rev Nephrol 2016 07 3;12(7):426-39. Epub 2016 May 3.

Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 415 Curie Boulevard, 415 Clinical Research Building, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nrneph.2016.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529143PMC
July 2016

Fat Burning Problem in Cystic Kidneys: an Emerging Common Mechanism of Chronic Kidney Disease.

EBioMedicine 2016 Mar 23;5:22-3. Epub 2016 Feb 23.

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ebiom.2016.02.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816831PMC
March 2016

Podocytes: the Weakest Link in Diabetic Kidney Disease?

Curr Diab Rep 2016 May;16(5):45

Renal-Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064850PMC
http://dx.doi.org/10.1007/s11892-016-0735-5DOI Listing
May 2016

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Authors:
Cristian Pattaro Alexander Teumer Mathias Gorski Audrey Y Chu Man Li Vladan Mijatovic Maija Garnaas Adrienne Tin Rossella Sorice Yong Li Daniel Taliun Matthias Olden Meredith Foster Qiong Yang Ming-Huei Chen Tune H Pers Andrew D Johnson Yi-An Ko Christian Fuchsberger Bamidele Tayo Michael Nalls Mary F Feitosa Aaron Isaacs Abbas Dehghan Pio d'Adamo Adebowale Adeyemo Aida Karina Dieffenbach Alan B Zonderman Ilja M Nolte Peter J van der Most Alan F Wright Alan R Shuldiner Alanna C Morrison Albert Hofman Albert V Smith Albert W Dreisbach Andre Franke Andre G Uitterlinden Andres Metspalu Anke Tonjes Antonio Lupo Antonietta Robino Åsa Johansson Ayse Demirkan Barbara Kollerits Barry I Freedman Belen Ponte Ben A Oostra Bernhard Paulweber Bernhard K Krämer Braxton D Mitchell Brendan M Buckley Carmen A Peralta Caroline Hayward Catherine Helmer Charles N Rotimi Christian M Shaffer Christian Müller Cinzia Sala Cornelia M van Duijn Aude Saint-Pierre Daniel Ackermann Daniel Shriner Daniela Ruggiero Daniela Toniolo Yingchang Lu Daniele Cusi Darina Czamara David Ellinghaus David S Siscovick Douglas Ruderfer Christian Gieger Harald Grallert Elena Rochtchina Elizabeth J Atkinson Elizabeth G Holliday Eric Boerwinkle Erika Salvi Erwin P Bottinger Federico Murgia Fernando Rivadeneira Florian Ernst Florian Kronenberg Frank B Hu Gerjan J Navis Gary C Curhan George B Ehret Georg Homuth Stefan Coassin Gian-Andri Thun Giorgio Pistis Giovanni Gambaro Giovanni Malerba Grant W Montgomery Gudny Eiriksdottir Gunnar Jacobs Guo Li H-Erich Wichmann Harry Campbell Helena Schmidt Henri Wallaschofski Henry Völzke Hermann Brenner Heyo K Kroemer Holly Kramer Honghuang Lin I Mateo Leach Ian Ford Idris Guessous Igor Rudan Inga Prokopenko Ingrid Borecki Iris M Heid Ivana Kolcic Ivana Persico J Wouter Jukema James F Wilson Janine F Felix Jasmin Divers Jean-Charles Lambert Jeanette M Stafford Jean-Michel Gaspoz Jennifer A Smith Jessica D Faul Jie Jin Wang Jingzhong Ding Joel N Hirschhorn John Attia John B Whitfield John Chalmers Jorma Viikari Josef Coresh Joshua C Denny Juha Karjalainen Jyotika K Fernandes Karlhans Endlich Katja Butterbach Keith L Keene Kurt Lohman Laura Portas Lenore J Launer Leo-Pekka Lyytikäinen Loic Yengo Lude Franke Luigi Ferrucci Lynda M Rose Lyudmyla Kedenko Madhumathi Rao Maksim Struchalin Marcus E Kleber Margherita Cavalieri Margot Haun Marilyn C Cornelis Marina Ciullo Mario Pirastu Mariza de Andrade Mark A McEvoy Mark Woodward Martin Adam Massimiliano Cocca Matthias Nauck Medea Imboden Melanie Waldenberger Menno Pruijm Marie Metzger Michael Stumvoll Michele K Evans Michele M Sale Mika Kähönen Mladen Boban Murielle Bochud Myriam Rheinberger Niek Verweij Nabila Bouatia-Naji Nicholas G Martin Nick Hastie Nicole Probst-Hensch Nicole Soranzo Olivier Devuyst Olli Raitakari Omri Gottesman Oscar H Franco Ozren Polasek Paolo Gasparini Patricia B Munroe Paul M Ridker Paul Mitchell Paul Muntner Christa Meisinger Johannes H Smit Peter Kovacs Philipp S Wild Philippe Froguel Rainer Rettig Reedik Mägi Reiner Biffar Reinhold Schmidt Rita P S Middelberg Robert J Carroll Brenda W Penninx Rodney J Scott Ronit Katz Sanaz Sedaghat Sarah H Wild Sharon L R Kardia Sheila Ulivi Shih-Jen Hwang Stefan Enroth Stefan Kloiber Stella Trompet Benedicte Stengel Stephen J Hancock Stephen T Turner Sylvia E Rosas Sylvia Stracke Tamara B Harris Tanja Zeller Tatijana Zemunik Terho Lehtimäki Thomas Illig Thor Aspelund Tiit Nikopensius Tonu Esko Toshiko Tanaka Ulf Gyllensten Uwe Völker Valur Emilsson Veronique Vitart Ville Aalto Vilmundur Gudnason Vincent Chouraki Wei-Min Chen Wilmar Igl Winfried März Wolfgang Koenig Wolfgang Lieb Ruth J F Loos Yongmei Liu Harold Snieder Peter P Pramstaller Afshin Parsa Jeffrey R O'Connell Katalin Susztak Pavel Hamet Johanne Tremblay Ian H de Boer Carsten A Böger Wolfram Goessling Daniel I Chasman Anna Köttgen W H Linda Kao Caroline S Fox

Nat Commun 2016 Jan 21;7:10023. Epub 2016 Jan 21.

NHLBI's Framingham Heart Study and the Center for Population Studies, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.

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http://dx.doi.org/10.1038/ncomms10023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735748PMC
January 2016

APOL1 Variants: From Parasites to Kidney Function to Cardiovascular Disease.

Arterioscler Thromb Vasc Biol 2016 Feb;36(2):219-20

From the Fred Hutchinson Cancer Research Center, WHI Clinical Coordinating Center/Public Health Sciences (A.P.R.), and Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (K.S.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732577PMC
February 2016

Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice.

Cell Rep 2016 Feb 14;14(4):861-871. Epub 2016 Jan 14.

Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247150152
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http://dx.doi.org/10.1016/j.celrep.2015.12.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854207PMC
February 2016

Epithelial Plasticity versus EMT in Kidney Fibrosis.

Trends Mol Med 2016 Jan 11;22(1):4-6. Epub 2015 Dec 11.

Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://www.cell.com/trends/molecular-medicine/pdf/S1471-4914
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http://linkinghub.elsevier.com/retrieve/pii/S147149141500227
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http://dx.doi.org/10.1016/j.molmed.2015.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854190PMC
January 2016

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

Authors:
Alexander Teumer Adrienne Tin Rossella Sorice Mathias Gorski Nan Cher Yeo Audrey Y Chu Man Li Yong Li Vladan Mijatovic Yi-An Ko Daniel Taliun Alessandro Luciani Ming-Huei Chen Qiong Yang Meredith C Foster Matthias Olden Linda T Hiraki Bamidele O Tayo Christian Fuchsberger Aida Karina Dieffenbach Alan R Shuldiner Albert V Smith Allison M Zappa Antonio Lupo Barbara Kollerits Belen Ponte Bénédicte Stengel Bernhard K Krämer Bernhard Paulweber Braxton D Mitchell Caroline Hayward Catherine Helmer Christa Meisinger Christian Gieger Christian M Shaffer Christian Müller Claudia Langenberg Daniel Ackermann David Siscovick Eric Boerwinkle Florian Kronenberg Georg B Ehret Georg Homuth Gerard Waeber Gerjan Navis Giovanni Gambaro Giovanni Malerba Gudny Eiriksdottir Guo Li H Erich Wichmann Harald Grallert Henri Wallaschofski Henry Völzke Herrmann Brenner Holly Kramer I Mateo Leach Igor Rudan Hans L Hillege Jacques S Beckmann Jean Charles Lambert Jian'an Luan Jing Hua Zhao John Chalmers Josef Coresh Joshua C Denny Katja Butterbach Lenore J Launer Luigi Ferrucci Lyudmyla Kedenko Margot Haun Marie Metzger Mark Woodward Matthew J Hoffman Matthias Nauck Melanie Waldenberger Menno Pruijm Murielle Bochud Myriam Rheinberger Niek Verweij Nicholas J Wareham Nicole Endlich Nicole Soranzo Ozren Polasek Pim van der Harst Peter Paul Pramstaller Peter Vollenweider Philipp S Wild Ron T Gansevoort Rainer Rettig Reiner Biffar Robert J Carroll Ronit Katz Ruth J F Loos Shih-Jen Hwang Stefan Coassin Sven Bergmann Sylvia E Rosas Sylvia Stracke Tamara B Harris Tanguy Corre Tanja Zeller Thomas Illig Thor Aspelund Toshiko Tanaka Uwe Lendeckel Uwe Völker Vilmundur Gudnason Vincent Chouraki Wolfgang Koenig Zoltan Kutalik Jeffrey R O'Connell Afshin Parsa Iris M Heid Andrew D Paterson Ian H de Boer Olivier Devuyst Jozef Lazar Karlhans Endlich Katalin Susztak Johanne Tremblay Pavel Hamet Howard J Jacob Carsten A Böger Caroline S Fox Cristian Pattaro Anna Köttgen

Diabetes 2016 Mar 2;65(3):803-17. Epub 2015 Dec 2.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD Renal Division, Medical Center, University of Freiburg, Freiburg, Germany

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http://diabetes.diabetesjournals.org/content/early/2015/11/2
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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db15
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http://dx.doi.org/10.2337/db15-1313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764151PMC
March 2016

The long noncoding RNA landscape in hypoxic and inflammatory renal epithelial injury.

Am J Physiol Renal Physiol 2015 Dec 23;309(11):F901-13. Epub 2015 Sep 23.

Cardiovascular Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1152/ajprenal.00290.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669357PMC
December 2015

Kick it up a notch: Notch signaling and kidney fibrosis.

Kidney Int Suppl (2011) 2014 Nov;4(1):91-96

Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/kisup.2014.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536967PMC
November 2014

Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development.

Diabetes 2015 Dec 20;64(12):4099-111. Epub 2015 Aug 20.

Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

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http://dx.doi.org/10.2337/db15-0260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657584PMC
December 2015

Role of DNA methylation in renal cell carcinoma.

J Hematol Oncol 2015 Jul 22;8:88. Epub 2015 Jul 22.

Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10467, USA.

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http://dx.doi.org/10.1186/s13045-015-0180-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511443PMC
July 2015

Diet-Induced Podocyte Dysfunction in Drosophila and Mammals.

Cell Rep 2015 Jul 16;12(4):636-47. Epub 2015 Jul 16.

Department of Developmental and Regenerative Biology and School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029-1020, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.06.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532696PMC
July 2015

Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism.

J Am Soc Nephrol 2016 Feb 8;27(2):439-53. Epub 2015 Jun 8.

Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;

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http://dx.doi.org/10.1681/ASN.2014121181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731117PMC
February 2016

The evolving understanding of the contribution of lipid metabolism to diabetic kidney disease.

Curr Diab Rep 2015 Jul;15(7):40

Oxidative Stress and Disease Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.

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http://dx.doi.org/10.1007/s11892-015-0611-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548922PMC
July 2015

Diabetic kidney disease.

Nat Rev Dis Primers 2015 07 30;1:15018. Epub 2015 Jul 30.

Baker IDI Heart &Diabetes Institute, 75 Commercial Road, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1038/nrdp.2015.18DOI Listing
July 2015

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development.

Nat Med 2015 Jan 1;21(1):37-46. Epub 2014 Dec 1.

Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nm.3762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444078PMC
January 2015

Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD.

J Am Soc Nephrol 2015 Mar 17;26(3):692-714. Epub 2014 Sep 17.

Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

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http://dx.doi.org/10.1681/ASN.2014010028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341476PMC
March 2015

Sweet debate: fructose versus glucose in diabetic kidney disease.

J Am Soc Nephrol 2014 Nov 29;25(11):2386-8. Epub 2014 May 29.

Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

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http://dx.doi.org/10.1681/ASN.2014050433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214542PMC
November 2014

Epigenetics: a new way to look at kidney diseases.

Nephrol Dial Transplant 2014 Oct 27;29(10):1821-7. Epub 2014 Mar 27.

Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1093/ndt/gfu026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173816PMC
October 2014

Notch ties a knot on fistula maturation.

J Am Soc Nephrol 2014 Apr 30;25(4):648-50. Epub 2014 Jan 30.

Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1681/ASN.2014010005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968513PMC
April 2014

The hyperglycemic and hyperinsulinemic combo gives you diabetic kidney disease immediately. Focus on "Combined acute hyperglycemic and hyperinsulinemic clamp induced profibrotic and proinflammatory responses in the kidney".

Am J Physiol Cell Physiol 2014 Feb 11;306(3):C198-9. Epub 2013 Dec 11.

Renal Electrolyte and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and.

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http://www.physiology.org/doi/10.1152/ajpcell.00371.2013
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http://dx.doi.org/10.1152/ajpcell.00371.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919999PMC
February 2014

A multicolor podocyte reporter highlights heterogeneous podocyte changes in focal segmental glomerulosclerosis.

Kidney Int 2014 Apr 27;85(4):972-80. Epub 2013 Nov 27.

Renal Electrolyte and Hypertension Division, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ki.2013.463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987991PMC
April 2014