Publications by authors named "Karuna Ganesh"

23Publications

Targeting metastatic cancer.

Authors:
Karuna Ganesh Joan Massagué

Nat Med 2021 01 13;27(1):34-44. Epub 2021 Jan 13.

Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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January 2021

Characterization and Clinical Outcomes of DNA Mismatch Repair Deficient (MMR-D) Small Bowel Adenocarcinoma.

Authors:
Alicia Latham Jinru Shia Zalak Patel Diane L Reidy-Lagunes Neil H Segal Rona Yaeger Karuna Ganesh Louise Connell Nancy E Kemeny David P Kelsen Jaclyn F Hechtman Garrett M Nash Philip B Paty Ahmet Zehir Kaitlyn Tkachuk Rania Sheikh Arnold J Markowitz Diana Mandelker Kenneth Offit Michael F Berger Andrea Cercek Julio Garcia-Aguilar Leonard B Saltz Martin R Weiser Zsofia K Stadler

Clin Cancer Res 2020 Nov 16. Epub 2020 Nov 16.

Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College

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November 2020

L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer.

Authors:
Karuna Ganesh Harihar Basnet Yasemin Kaygusuz Ashley M Laughney Lan He Roshan Sharma Kevin P O'Rourke Vincent P Reuter Yun-Han Huang Mesruh Turkekul Ekrem Emrah Ignas Masilionis Katia Manova-Todorova Martin R Weiser Leonard B Saltz Julio Garcia-Aguilar Richard Koche Scott W Lowe Dana Pe'er Jinru Shia Joan Massagué

Nat Cancer 2020 Jan 13;1(1):28-45. Epub 2020 Jan 13.

Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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January 2020

Lineage Reversion Drives WNT Independence in Intestinal Cancer.

Authors:
Teng Han Sukanya Goswami Yang Hu Fanying Tang Maria Paz Zafra Charles Murphy Zhen Cao John T Poirier Ekta Khurana Olivier Elemento Jaclyn F Hechtman Karuna Ganesh Rona Yaeger Lukas E Dow

Cancer Discov 2020 Oct 16;10(10):1590-1609. Epub 2020 Jun 16.

Sandra and Edward Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, New York.

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October 2020

Plasticity in Motion: Shape-Shifting Lgr5Cells Initiate Colorectal Cancer Metastasis.

Authors:
Karuna Ganesh

Cell Stem Cell 2020 04;26(4):469-471

Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

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April 2020

Mismatch Repair-Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy.

Authors:
Andrea Cercek Gustavo Dos Santos Fernandes Campbell S Roxburgh Karuna Ganesh Shu Ng Francisco Sanchez-Vega Rona Yaeger Neil H Segal Diane L Reidy-Lagunes Anna M Varghese Arnold Markowitz Chao Wu Bryan Szeglin Charles-Etienne Gabriel Sauvé Erin Salo-Mullen Christina Tran Zalak Patel Asha Krishnan Kaitlyn Tkachuk Garrett M Nash Jose Guillem Philip B Paty Jinru Shia Nikolaus Schultz Julio Garcia-Aguilar Luis A Diaz Karyn Goodman Leonard B Saltz Martin R Weiser J Joshua Smith Zsofia K Stadler

Clin Cancer Res 2020 07 6;26(13):3271-3279. Epub 2020 Mar 6.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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July 2020

Coaltered and Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer.

Authors:
Jashodeep Datta J Joshua Smith Walid K Chatila John C McAuliffe Cyriac Kandoth Efsevia Vakiani Timothy L Frankel Karuna Ganesh Isaac Wasserman Marla Lipsyc-Sharf Jose Guillem Garrett M Nash Philip B Paty Martin R Weiser Leonard B Saltz Michael F Berger William R Jarnagin Vinod Balachandran T Peter Kingham Nancy E Kemeny Andrea Cercek Julio Garcia-Aguilar Barry S Taylor Agnes Viale Rona Yaeger David B Solit Nikolaus Schultz Michael I D'Angelica

Clin Cancer Res 2020 03 12;26(5):1077-1085. Epub 2019 Nov 12.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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March 2020

A rectal cancer organoid platform to study individual responses to chemoradiation.

Authors:
Karuna Ganesh Chao Wu Kevin P O'Rourke Bryan C Szeglin Youyun Zheng Charles-Etienne Gabriel Sauvé Mohammad Adileh Isaac Wasserman Michael R Marco Amanda S Kim Maha Shady Francisco Sanchez-Vega Wouter R Karthaus Helen H Won Seo-Hyun Choi Raphael Pelossof Afsar Barlas Peter Ntiamoah Emmanouil Pappou Arthur Elghouayel James S Strong Chin-Tung Chen Jennifer W Harris Martin R Weiser Garrett M Nash Jose G Guillem Iris H Wei Richard N Kolesnick Harini Veeraraghavan Eduardo J Ortiz Iva Petkovska Andrea Cercek Katia O Manova-Todorova Leonard B Saltz Jessica A Lavery Ronald P DeMatteo Joan Massagué Philip B Paty Rona Yaeger Xi Chen Sujata Patil Hans Clevers Michael F Berger Scott W Lowe Jinru Shia Paul B Romesser Lukas E Dow Julio Garcia-Aguilar Charles L Sawyers J Joshua Smith

Nat Med 2019 10 7;25(10):1607-1614. Epub 2019 Oct 7.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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October 2019

Colorectal carcinoma with double somatic mismatch repair gene inactivation: clinical and pathological characteristics and response to immune checkpoint blockade.

Authors:
Tao Wang Lik Hang Lee Monika Vyas Liying Zhang Karuna Ganesh Canan Firat Neil H Segal Avni Desai Jaclyn F Hechtman Peter Ntiamoah Martin R Weiser Arnold J Markowitz Efsevia Vakiani David S Klimstra Zsofia K Stadler Jinru Shia

Mod Pathol 2019 10 7;32(10):1551-1562. Epub 2019 Jun 7.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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October 2019

Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization.

Authors:
Harihar Basnet Lin Tian Karuna Ganesh Yun-Han Huang Danilo G Macalinao Edi Brogi Lydia Ws Finley Joan Massagué

Elife 2019 03 26;8. Epub 2019 Mar 26.

Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States.

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March 2019

Immunotherapy in colorectal cancer: rationale, challenges and potential.

Authors:
Karuna Ganesh Zsofia K Stadler Andrea Cercek Robin B Mendelsohn Jinru Shia Neil H Segal Luis A Diaz

Nat Rev Gastroenterol Hepatol 2019 06;16(6):361-375

Department of Medicine, Memorial Sloan Kettering Cancer Center, York Avenue, New York, NY, USA.

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June 2019

Assessment of a Watch-and-Wait Strategy for Rectal Cancer in Patients With a Complete Response After Neoadjuvant Therapy.

Authors:
J Joshua Smith Paul Strombom Oliver S Chow Campbell S Roxburgh Patricio Lynn Anne Eaton Maria Widmar Karuna Ganesh Rona Yaeger Andrea Cercek Martin R Weiser Garrett M Nash Jose G Guillem Larissa K F Temple Sree B Chalasani James L Fuqua Iva Petkovska Abraham J Wu Marsha Reyngold Efsevia Vakiani Jinru Shia Neil H Segal James D Smith Christopher Crane Marc J Gollub Mithat Gonen Leonard B Saltz Julio Garcia-Aguilar Philip B Paty

JAMA Oncol 2019 Apr 11;5(4):e185896. Epub 2019 Apr 11.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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April 2019

SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance.

Authors:
Isaac Wasserman Lik Hang Lee Shuji Ogino Michael R Marco Chao Wu Xi Chen Jashodeep Datta Eran Sadot Bryan Szeglin Jose G Guillem Philip B Paty Martin R Weiser Garrett M Nash Leonard Saltz Afsar Barlas Katia Manova-Todorova Srijaya Prakash Babu Uppada Arthur E Elghouayel Peter Ntiamoah Jonathan N Glickman Tsuyoshi Hamada Keisuke Kosumi Kentaro Inamura Andrew T Chan Reiko Nishihara Andrea Cercek Karuna Ganesh Nancy E Kemeny Punita Dhawan Rona Yaeger Charles L Sawyers Julio Garcia-Aguilar Marios Giannakis Jinru Shia J Joshua Smith

Clin Cancer Res 2019 03 26;25(6):1948-1956. Epub 2018 Dec 26.

Colorectal Service, Memorial Sloan Kettering Cancer Center, New York, New York.

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March 2019

Author Correction: Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.

Authors:
Ekrem Emrah Er Manuel Valiente Karuna Ganesh Yilong Zou Saloni Agrawal Jing Hu Bailey Griscom Marc Rosenblum Adrienne Boire Edi Brogi Filippo G Giancotti Melitta Schachner Srinivas Malladi Joan Massagué

Nat Cell Biol 2019 Mar;21(3):408

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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March 2019

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.

Authors:
Ekrem Emrah Er Manuel Valiente Karuna Ganesh Yilong Zou Saloni Agrawal Jing Hu Bailey Griscom Marc Rosenblum Adrienne Boire Edi Brogi Filippo G Giancotti Melitta Schachner Srinivas Malladi Joan Massagué

Nat Cell Biol 2018 08 23;20(8):966-978. Epub 2018 Jul 23.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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August 2018

TGF-β Inhibition and Immunotherapy: Checkmate.

Authors:
Karuna Ganesh Joan Massagué

Immunity 2018 04;48(4):626-628

Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

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April 2018

Clinical and genetic determinants of ovarian metastases from colorectal cancer.

Authors:
Karuna Ganesh Ronak H Shah Efsevia Vakiani Garrett M Nash Hugh P Skottowe Rona Yaeger Andrea Cercek Anne Lincoln Christina Tran Neil H Segal Diane L Reidy Anna Varghese Andrew S Epstein Yukio Sonoda Dennis Chi Jose Guillem Larissa Temple Philip Paty Jaclyn Hechtman Jinru Shia Martin Weiser Julio Garcia Aguilar Nancy Kemeny Michael F Berger Leonard Saltz Zsofia K Stadler

Cancer 2017 04 22;123(7):1134-1143. Epub 2016 Nov 22.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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April 2017

Acute myeloid leukemia masquerading as hepatocellular carcinoma.

Authors:
Ghaith F Abu-Zeinah Paul Weisman Karuna Ganesh Seth S Katz Ahmet Dogan Ghassan K Abou-Alfa Eytan M Stein William Jarnagin Michael J Mauro James J Harding

J Gastrointest Oncol 2016 Jun;7(3):E31-5

1 Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 2 Department of Medicine, Weill Cornell Medical College, New York, NY, USA ; 3 Departments of Pathology and Laboratory Medicine, 4 Department of Radiology, 5 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA ; 6 Department of Surgery, Weill Cornell Medical College, New York, NY, USA.

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June 2016

CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.

Authors:
Febe van Maldegem Sarah Maslen Christopher M Johnson Anita Chandra Karuna Ganesh Mark Skehel Cristina Rada

Nucleic Acids Res 2015 Aug 29;43(14):7058-69. Epub 2015 Jun 29.

MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK

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August 2015

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α.

Authors:
Karuna Ganesh Febe van Maldegem Stephanie B Telerman Paul Simpson Christopher M Johnson Roger L Williams Michael S Neuberger Cristina Rada

FEBS Lett 2014 Jan 20;588(1):21-7. Epub 2013 Nov 20.

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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January 2014

The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification.

Authors:
Karuna Ganesh Michael S Neuberger

FASEB J 2011 Apr;25(4):1123-32

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

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April 2011

CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.

Authors:
Karuna Ganesh Salome Adam Benjamin Taylor Paul Simpson Cristina Rada Michael Neuberger

J Biol Chem 2011 May 8;286(19):17091-102. Epub 2011 Mar 8.

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, United Kingdom.

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May 2011

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1.

Authors:
Silvestro G Conticello Karuna Ganesh Kanmin Xue Mason Lu Cristina Rada Michael S Neuberger

Mol Cell 2008 Aug;31(4):474-84

Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB20QH, UK.

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August 2008