Karthik B Jeganathan

Karthik B Jeganathan

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Karthik B Jeganathan

Karthik B Jeganathan

Publications by authors named "Karthik B Jeganathan"

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28Publications

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ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage.

Nat Commun 2018 07 16;9(1):2736. Epub 2018 Jul 16.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1038/s41467-018-05161-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048040PMC
July 2018

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer.

Elife 2016 08 16;5. Epub 2016 Aug 16.

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, United States.

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http://dx.doi.org/10.7554/eLife.16620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987139PMC
August 2016

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.

Nat Cell Biol 2016 07 30;18(7):814-21. Epub 2016 May 30.

Departments of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/ncb3369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004208PMC
July 2016

Spartan deficiency causes genomic instability and progeroid phenotypes.

Nat Commun 2014 Dec 11;5:5744. Epub 2014 Dec 11.

1] Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA [2] Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.

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http://www.nature.com/articles/ncomms6744
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http://dx.doi.org/10.1038/ncomms6744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269170PMC
December 2014

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.

EMBO J 2014 Jul 12;33(13):1438-53. Epub 2014 May 12.

Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, MA, USA Department of Pharmacology, School of Medicine The University of New South Wales, Sydney, NSW, Australia

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http://emboj.embopress.org/content/embojnl/33/13/1438.full.p
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http://emboj.embopress.org/cgi/doi/10.15252/embj.201386907
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http://dx.doi.org/10.15252/embj.201386907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194088PMC
July 2014

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation.

PLoS Genet 2012 27;8(12):e1003138. Epub 2012 Dec 27.

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1003138
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http://dx.doi.org/10.1371/journal.pgen.1003138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531486PMC
May 2013

Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.

J Cell Biol 2012 Dec 3;199(6):931-49. Epub 2012 Dec 3.

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1083/jcb.201205115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518220PMC
December 2012

Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

J Cell Biol 2011 Aug;194(4):597-612

Department of Biochemistry and Molecular Biology and 2 Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1083/jcb.201102018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160583PMC
August 2011

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation.

J Cell Biol 2011 Jun 6;193(6):1049-64. Epub 2011 Jun 6.

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1083/jcb.201012035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115799PMC
June 2011

Cdc20 is critical for meiosis I and fertility of female mice.

PLoS Genet 2010 Sep 30;6(9):e1001147. Epub 2010 Sep 30.

Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1001147
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http://dx.doi.org/10.1371/journal.pgen.1001147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947999PMC
September 2010

Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation.

J Cell Biol 2010 Jan;188(1):83-100

Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200906147
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http://dx.doi.org/10.1083/jcb.200906147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812857PMC
January 2010

CAML loss causes anaphase failure and chromosome missegregation.

Cell Cycle 2009 Mar 26;8(6):940-9. Epub 2009 Mar 26.

Department of Immunology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967022PMC
http://dx.doi.org/10.4161/cc.8.6.7948DOI Listing
March 2009

Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition.

Cell Cycle 2006 Feb 15;5(4):366-70. Epub 2006 Feb 15.

Department of Pediatric and Adolescent Medicine, Mayo College of Medicine, Rochester, Minnesota 55905, USA.

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https://www.tandfonline.com/doi/full/10.4161/cc.5.4.2483
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http://dx.doi.org/10.4161/cc.5.4.2483DOI Listing
February 2006

The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.

Nature 2005 Dec;438(7070):1036-9

Department of Pediatric and Adolescent Medicine, Mayo College of Medicine, 200 First Street SW, Rochester, Minnesota 55905, USA.

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http://www.nature.com/articles/nature04221
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http://dx.doi.org/10.1038/nature04221DOI Listing
December 2005

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

Nat Genet 2004 Jul 20;36(7):744-9. Epub 2004 Jun 20.

[1] Departments of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. [2] Departments of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA.

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http://www.nature.com/articles/ng1382
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http://dx.doi.org/10.1038/ng1382DOI Listing
July 2004

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation.

J Cell Biol 2003 Feb 27;160(3):341-53. Epub 2003 Jan 27.

Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1083/jcb.200211048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172680PMC
February 2003