Karsten Peppel

Karsten Peppel

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Karsten Peppel

Karsten Peppel

Publications by authors named "Karsten Peppel"

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S100A6 Regulates Endothelial Cell Cycle Progression by Attenuating Antiproliferative Signal Transducers and Activators of Transcription 1 Signaling.

Arterioscler Thromb Vasc Biol 2016 09 7;36(9):1854-67. Epub 2016 Jul 7.

From the Cardiovascular Research Center, Massachusetts General Hospital (C.L., F.D., A.R.), Cardiovascular Institute, Beth Israel Deaconess Medical Center (F.D.), and Boston Children's Hospital (V.J.B.), Harvard Medical School, Boston, MA; Molecular and Translational Cardiology (MTC), Department of Internal Medicine III, University Hospital Heidelberg, Germany (C.L., J.H., I.K., M. Busch, P.M.); Department of Pathology and Immunology, University of Geneva, Switzerland (M.-L.B.-P.); DZHK (German Center for Cardiovascular Research), Partner site Heidelberg/Mannheim, University of Heidelberg, Germany (K.H., M. Busch, H.A.K., P.M.); Center for Translational Medicine, Jefferson Medical College, Philadelphia, PA (K.P., P.M.); Systems Biology of the Cellular Microenvironment Group, Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University, Freiburg, Germany (H.B., M. Boerries); German Cancer Consortium (DKTK), Freiburg, Germany (H.B., M. Boerries); and German Cancer Research Center (DKFZ), Heidelberg, Germany (H.B., M. Boerries).

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http://dx.doi.org/10.1161/ATVBAHA.115.306415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001879PMC
September 2016

S100A1 DNA-based Inotropic Therapy Protects Against Proarrhythmogenic Ryanodine Receptor 2 Dysfunction.

Mol Ther 2015 Aug 25;23(8):1320-1330. Epub 2015 May 25.

Molecular and Translational Cardiology, Department of Internal Medicine III, Heidelberg University Hospital, Heidelberg, Germany; Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg, Germany; uniQure GmbH Germany, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1038/mt.2015.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817858PMC
August 2015

Cardiomyocytes, endothelial cells and cardiac fibroblasts: S100A1's triple action in cardiovascular pathophysiology.

Future Cardiol 2015 May;11(3):309-21

2German Centre for Cardiovascular Research (DZHK), partner site Heidelberg/Mannheim, Heidelberg University Hospital, Heidelberg University, INF 410, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.2217/fca.15.18DOI Listing
May 2015

MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1.

PLoS One 2013 11;8(11):e78684. Epub 2013 Nov 11.

Center for Translational Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078684PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823839PMC
July 2014

S100A1 is released from ischemic cardiomyocytes and signals myocardial damage via Toll-like receptor 4.

EMBO Mol Med 2014 Jun 6;6(6):778-94. Epub 2014 Apr 6.

Section of Molecular and Translational Cardiology, Department of Internal Medicine III, Heidelberg University Hospital Heidelberg University, Heidelberg, Germany Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim Heidelberg University Hospital Heidelberg University, Heidelberg, Germany

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http://embomolmed.embopress.org/cgi/doi/10.15252/emmm.201303
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http://dx.doi.org/10.15252/emmm.201303498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203355PMC
June 2014

Induction of microRNA-138 by pro-inflammatory cytokines causes endothelial cell dysfunction.

FEBS Lett 2014 Mar 31;588(6):906-14. Epub 2014 Jan 31.

Center for Translational Medicine, Jefferson Medical College, Philadelphia, PA, USA. Electronic address:

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http://doi.wiley.com/10.1016/j.febslet.2014.01.033
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http://dx.doi.org/10.1016/j.febslet.2014.01.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975049PMC
March 2014

Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density.

Am J Physiol Heart Circ Physiol 2011 Nov 2;301(5):H1932-40. Epub 2011 Sep 2.

Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1152/ajpheart.00755.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213957PMC
November 2011

The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition.

Circ Res 2011 Jan 24;108(1):27-39. Epub 2010 Nov 24.

Center for Molecular and Translational Cardiology (M.V, C.W., N.H., K.S., P.M.), Department of Internal Medicine III (O.J.M, S.S., H.J.H., H.A.K.), Division of Cardiology, INF 350, University of Heidelberg, 69120 Heidelberg, Germany; Institute of Physiology and Pathophysiology (F.W., O.F.) Medical Biophysics, INF 326, University of Heidelberg, 69120 Heidelberg, Germany; George Zallie & Family Laboratory for Cardiovascular Gene Therapy (J.E.R., H.B., W.J.K.), Eugene Feiner Laboratory for Vascular Biology and Thrombosis (A.D.E.), Laboratory for Cardiac Stem Cell and Gene Therapy (G.Q., K.P., P.M.), Center for Translational Medicine, Thomas Jefferson University, 19107 Philadelphia, PA, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.225201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013502PMC
January 2011

Tumor necrosis factor receptor-2 signaling attenuates vein graft neointima formation by promoting endothelial recovery.

Arterioscler Thromb Vasc Biol 2008 Feb 15;28(2):284-9. Epub 2007 Nov 15.

Department of Medicine (Cardiology), Duke University Medical Center, Durham, NC, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.107.151613
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http://dx.doi.org/10.1161/ATVBAHA.107.151613DOI Listing
February 2008

Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis.

Arterioscler Thromb Vasc Biol 2007 May;27(5):1087-94

Departments of Medicine (Cardiology), Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1161/ATVBAHA.0000261548.49790.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2522308PMC
May 2007

Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.

J Biol Chem 2006 Dec 3;281(49):37758-72. Epub 2006 Oct 3.

Department of Medicine (Cardiology), Duke University, Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M605756200DOI Listing
December 2006

The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism for feedback inhibition.

J Biol Chem 2005 Sep 1;280(35):31027-35. Epub 2005 Jul 1.

Department of Medicine (Cardiology), Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M501473200DOI Listing
September 2005

Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms.

Cardiovasc Res 2005 Feb;65(3):674-82

Department of Medicine (Cardiology), Duke University Medical Center, Box 3187, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.cardiores.2004.10.031DOI Listing
February 2005

Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells.

Arterioscler Thromb Vasc Biol 2004 Dec 14;24(12):2277-83. Epub 2004 Oct 14.

Duke University Department of Medicine (Cardiology), Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1161/01.ATV.0000147766.68987.0dDOI Listing
December 2004

Phosphorylation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-2 reduces receptor signaling and interaction with the Na(+)/H(+) exchanger regulatory factor.

J Biol Chem 2004 Oct 22;279(40):41775-82. Epub 2004 Jul 22.

Department of Medicine (Cardiology), Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M403274200DOI Listing
October 2004

Graft-extrinsic cells predominate in vein graft arterialization.

Arterioscler Thromb Vasc Biol 2004 Mar 15;24(3):470-6. Epub 2004 Jan 15.

Duke University Department of Medicine (Cardiology), Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1161/01.ATV.0000116865.98067.31DOI Listing
March 2004

The adaptor protein beta-arrestin2 enhances endocytosis of the low density lipoprotein receptor.

J Biol Chem 2003 Nov 27;278(45):44238-45. Epub 2003 Aug 27.

Department of Medicine (Cardiology), Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M309450200DOI Listing
November 2003

Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth.

J Biol Chem 2003 Sep 17;278(39):37569-73. Epub 2003 Jul 17.

Department of Surgery, Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M306276200DOI Listing
September 2003

Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes.

FASEB J 2003 Mar 21;17(3):523-5. Epub 2003 Jan 21.

Institute of Pharmacology and Toxicology, Friedrich Alexander University Erlangen, Germany.

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http://dx.doi.org/10.1096/fj.02-0660fjeDOI Listing
March 2003

Phosphorylation of the platelet-derived growth factor receptor-beta and epidermal growth factor receptor by G protein-coupled receptor kinase-2. Mechanisms for selectivity of desensitization.

J Biol Chem 2002 Dec 14;277(50):48261-9. Epub 2002 Oct 14.

Department of Medicine (Cardiology), Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1074/jbc.M204431200DOI Listing
December 2002

Neointimal hyperplasia rapidly reaches steady state in a novel murine vein graft model.

J Vasc Surg 2002 Oct;36(4):824-32

Department of Medicine (Cardiology), Duke University Medical Center, Durham, NC 27710, USA.

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October 2002

Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia.

J Mol Cell Cardiol 2002 Oct;34(10):1399-1409

Duke University Department of Medicine (Cardiology), Duke University Medical Center, Durham, NC 27710, USA.

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October 2002