Dr. Karoly Szuhai, MD, PhD - Leiden University Medical Center - Associate Professor

Dr. Karoly Szuhai

MD, PhD

Leiden University Medical Center

Associate Professor

Leiden | Netherlands

Main Specialties: Biology

Additional Specialties: molecular pathology

Dr. Karoly Szuhai, MD, PhD - Leiden University Medical Center - Associate Professor

Dr. Karoly Szuhai

MD, PhD

Introduction

Primary Affiliation: Leiden University Medical Center - Leiden , Netherlands

Specialties:

Additional Specialties:

Research Interests:

Publications

139Publications

3720Reads

-Profile Views

1860PubMed Central Citations

More Cases of Benign Testicular Teratomas are Detected in Adults than in Children. A Clinicopathological Study of 543 Testicular Germ Cell Tumor Cases.

Pathol Oncol Res 2017 Jul 28;23(3):513-517. Epub 2016 Oct 28.

Faculty of Medicine, Department of Pathology 2nd Diagnostic Laboratory, Rákóczi u 2, PÉCS, H-7624, Hungary.

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http://link.springer.com/10.1007/s12253-016-0120-3
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http://dx.doi.org/10.1007/s12253-016-0120-3DOI Listing
July 2017
35 Reads
1.810 Impact Factor

p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.

Nat Commun 2016 12 22;7:13874. Epub 2016 Dec 22.

Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/ncomms13874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192218PMC
December 2016
100 Reads
4 Citations
10.742 Impact Factor

Expression of CCL21 in Ewing sarcoma shows an inverse correlation with metastases and is a candidate target for immunotherapy.

Cancer Immunol Immunother 2016 08 1;65(8):995-1002. Epub 2016 Jul 1.

Department of Pathology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00262-016-1862-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956712PMC
August 2016
92 Reads
3.941 Impact Factor

Activation of the vitamin D receptor selectively interferes with calcineurin-mediated inflammation: a clinical evaluation in the abdominal aortic aneurysm.

Lab Invest 2016 07 30;96(7):784-90. Epub 2016 May 30.

Department of Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/labinvest.2016.55DOI Listing
July 2016
39 Reads
2 Citations
3.680 Impact Factor

DOG1 expression in giant-cell-containing bone tumours.

Histopathology 2016 May 21;68(6):942-5. Epub 2015 Dec 21.

Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/his.12873DOI Listing
May 2016
23 Reads
1 Citation
3.453 Impact Factor

BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells.

Stem Cell Reports 2016 Jan 17;6(1):85-94. Epub 2015 Dec 17.

Department Anatomy and Embryology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands; Department Reproductive Medicine, Ghent University Hospital, Ghent 9000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720007PMC
January 2016
91 Reads
5 Citations

Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma.

Am J Surg Pathol 2015 Nov;39(11):1576-83

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://pdfs.journals.lww.com/ajsp/2015/11000/Mutation_Analys
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAS.0000000000000512DOI Listing
November 2015
72 Reads
10 Citations
5.145 Impact Factor

A translocation t(6;14) in two cases of leiomyosarcoma: Molecular cytogenetic and array-based comparative genomic hybridization characterization.

Cancer Genet 2015 Nov 31;208(11):537-44. Epub 2015 Jul 31.

Department of Molecular Cell Biology, LUMC, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2015.07.005DOI Listing
November 2015
30 Reads
2.420 Impact Factor

Microarray Techniques to Analyze Copy-Number Alterations in Genomic DNA: Array Comparative Genomic Hybridization and Single-Nucleotide Polymorphism Array.

J Invest Dermatol 2015 Oct;135(10):e37

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/jid.2015.308DOI Listing
October 2015
6 Reads
7.220 Impact Factor

Fusion events lead to truncation of FOS in epithelioid hemangioma of bone.

Genes Chromosomes Cancer 2015 Sep 14;54(9):565-74. Epub 2015 Jul 14.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/gcc.22269DOI Listing
September 2015
42 Reads
4 Citations
4.041 Impact Factor

Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes.

Int J Mol Sci 2015 Jul 16;16(7):16176-215. Epub 2015 Jul 16.

Department of Pathology, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands.

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http://dx.doi.org/10.3390/ijms160716176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519945PMC
July 2015
19 Reads
7 Citations
2.862 Impact Factor

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer.

Proc Natl Acad Sci U S A 2015 Jul 22;112(27):8409-14. Epub 2015 Jun 22.

Division of Molecular Pathology and Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1500223112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500240PMC
July 2015
40 Reads
15 Citations
9.810 Impact Factor

Expression of the immune regulation antigen CD70 in osteosarcoma.

Cancer Cell Int 2015 18;15:31. Epub 2015 Mar 18.

Department of Pediatrics, Leiden University Medical Center, 2333ZA Leiden, The Netherlands.

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http://www.cancerci.com/content/15/1/31
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http://dx.doi.org/10.1186/s12935-015-0181-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365554PMC
March 2015
39 Reads
1 Citation
1.990 Impact Factor

Array CGH analysis identifies two distinct subgroups of primary angiosarcoma of bone.

Genes Chromosomes Cancer 2015 Feb 18;54(2):72-81. Epub 2014 Sep 18.

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/gcc.22219DOI Listing
February 2015
42 Reads
5 Citations
4.041 Impact Factor

Sequential and hierarchical chromosomal changes and chromosome instability are distinct features of high hyperdiploid pediatric acute lymphoblastic leukemia.

Pediatr Blood Cancer 2014 Dec 30;61(12):2208-14. Epub 2014 Aug 30.

Department of Pathology, University of Pécs Medical Center, Pécs, Hungary.

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http://dx.doi.org/10.1002/pbc.25217DOI Listing
December 2014
12 Reads
2.562 Impact Factor

Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53.

J Pathol 2014 Aug 27;233(4):415-24. Epub 2014 Jun 27.

Institute of Biology, Leiden University, The Netherlands; Department of Pathology, Leiden University Medical Center, The Netherlands.

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http://doi.wiley.com/10.1002/path.4378
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http://dx.doi.org/10.1002/path.4378DOI Listing
August 2014
24 Reads
9 Citations
7.430 Impact Factor

Recurrent chromosome 22 deletions in osteoblastoma affect inhibitors of the Wnt/beta-catenin signaling pathway.

PLoS One 2013 13;8(11):e80725. Epub 2013 Nov 13.

Department of Clinical Genetics, University and Regional Laboratories, Skåne University Hospital, Lund University, Lund, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080725PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827481PMC
July 2014
27 Reads
8 Citations
3.234 Impact Factor

GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma.

Nat Genet 2014 May 23;46(5):474-7. Epub 2014 Mar 23.

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/ng.2927DOI Listing
May 2014
6 Reads
13 Citations
29.352 Impact Factor

Generation of induced pluripotent stem cells from human foetal fibroblasts using the Sleeping Beauty transposon gene delivery system.

Differentiation 2013 Jul-Sep;86(1-2):30-7. Epub 2013 Aug 7.

Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands; Netherlands Proteomics Institute, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2013.06.002DOI Listing
April 2014
41 Reads
6 Citations
3.440 Impact Factor

Further evidence of the existence of benign teratomas of the postpubertal testis.

Am J Surg Pathol 2014 Apr;38(4):580-1

*Department of Pathology, University of Pecs, Pecs, Hungary †Leiden University Medical Center Leiden, The Netherlands.

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http://dx.doi.org/10.1097/PAS.0000000000000186DOI Listing
April 2014
4 Reads
5.145 Impact Factor

Transactivating mutation of the MYOD1 gene is a frequent event in adult spindle cell rhabdomyosarcoma.

J Pathol 2014 Feb;232(3):300-7

Department of Molecular Cell Biology, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1002/path.4307DOI Listing
February 2014
9 Reads
17 Citations
7.430 Impact Factor

Multiplex ligation-dependent probe amplification and fluorescence in situ hybridization are complementary techniques to detect cytogenetic abnormalities in multiple myeloma.

Genes Chromosomes Cancer 2013 Sep 30;52(9):785-93. Epub 2013 May 30.

Department of Pathology, Medical School, University of Pecs, Pecs, Hungary.

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http://dx.doi.org/10.1002/gcc.22074DOI Listing
September 2013
28 Reads
6 Citations
4.041 Impact Factor

Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity.

Hum Pathol 2013 Aug 19;44(8):1597-604. Epub 2013 Mar 19.

Department of Pathology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.humpath.2013.01.006DOI Listing
August 2013
3 Reads
12 Citations
2.770 Impact Factor

Intronic deletion and duplication proximal of the EXT1 gene: a novel causative mechanism for multiple osteochondromas.

Genes Chromosomes Cancer 2013 Apr 23;52(4):431-6. Epub 2013 Jan 23.

Department of Pathology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.

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http://dx.doi.org/10.1002/gcc.22041DOI Listing
April 2013
9 Reads
4 Citations
4.041 Impact Factor

'The chicken or the egg?' dilemma strikes back for the controlling mechanism in chordoma(#).

J Pathol 2012 Nov;228(3):261-5

Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2330 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/path.4102DOI Listing
November 2012
3 Reads
4 Citations
7.430 Impact Factor

Characterization of a new human cell line (CH-3573) derived from a grade II chondrosarcoma with matrix production.

Pathol Oncol Res 2012 Oct 15;18(4):793-802. Epub 2012 Feb 15.

Department of Pathology, University of Valencia, Avda. Blasco Ibañez, 17, 46010, Valencia, Spain.

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http://dx.doi.org/10.1007/s12253-012-9505-0DOI Listing
October 2012
14 Reads
5 Citations
1.810 Impact Factor

Genetic characterization of mesenchymal, clear cell, and dedifferentiated chondrosarcoma.

Genes Chromosomes Cancer 2012 Oct 4;51(10):899-909. Epub 2012 Jun 4.

Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/gcc.21974DOI Listing
October 2012
34 Reads
10 Citations
4.041 Impact Factor

Molecular pathology and its diagnostic use in bone tumors.

Cancer Genet 2012 May;205(5):193-204

Department of Molecular Cell Biology, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1016/j.cancergen.2012.04.001DOI Listing
May 2012
18 Reads
14 Citations
2.420 Impact Factor

Angiomatoid fibrous histiocytoma: pleomorphic variant associated with multiplication of EWSR1-CREB1 fusion gene.

Pathol Oncol Res 2012 Apr 26;18(2):545-8. Epub 2011 Oct 26.

Department of Pathology, II. Diagnostic Laboratory, Faculty of Medicine, Clinical Center, Pécs University, Rákóczi út 2., 7623, Pécs, Hungary.

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http://dx.doi.org/10.1007/s12253-011-9468-6DOI Listing
April 2012
2 Citations
1.810 Impact Factor

Establishment and detailed functional and molecular genetic characterisation of a novel sacral chordoma cell line, MUG-Chor1.

Int J Oncol 2012 Feb 14;40(2):443-51. Epub 2011 Oct 14.

Center for Medical Research, Medical University of Graz, Austria.

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http://dx.doi.org/10.3892/ijo.2011.1235DOI Listing
February 2012
8 Reads
14 Citations
3.025 Impact Factor

Analysis of stromal cells in osteofibrous dysplasia and adamantinoma of long bones.

Mod Pathol 2012 Jan 7;25(1):56-64. Epub 2011 Oct 7.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford, UK.

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http://dx.doi.org/10.1038/modpathol.2011.141DOI Listing
January 2012
33 Reads
3 Citations
6.190 Impact Factor

Anti-EGFR antibody cetuximab enhances the cytolytic activity of natural killer cells toward osteosarcoma.

Clin Cancer Res 2012 Jan 16;18(2):432-41. Epub 2011 Nov 16.

Department of Pediatrics, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2277DOI Listing
January 2012
34 Reads
24 Citations
8.722 Impact Factor

Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts.

Mol Cancer 2011 Sep 12;10:111. Epub 2011 Sep 12.

Department of Molecular Cell Biology, Leiden University Medical Center, P,O, Box 9600, 2300 RC Leiden, The Netherlands.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1476-4598-10-111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179748PMC
September 2011
34 Reads
6 Citations
4.260 Impact Factor

Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations.

Science 2011 Sep;333(6051):1895-8

Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, Netherlands.

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http://dx.doi.org/10.1126/science.1210214DOI Listing
September 2011
5 Reads
177 Citations
31.480 Impact Factor

Maffucci syndrome: a genome-wide analysis using high resolution single nucleotide polymorphism and expression arrays on four cases.

Genes Chromosomes Cancer 2011 Sep 16;50(9):673-9. Epub 2011 May 16.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/gcc.20889
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http://dx.doi.org/10.1002/gcc.20889DOI Listing
September 2011
27 Reads
1 Citation
4.041 Impact Factor

Breakpoint characterization of large deletions in EXT1 or EXT2 in 10 multiple osteochondromas families.

BMC Med Genet 2011 Jun 26;12:85. Epub 2011 Jun 26.

Department of Medical Genetics, University and University Hospital of Antwerp, 2650 Edegem, Belgium.

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http://dx.doi.org/10.1186/1471-2350-12-85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152881PMC
June 2011
9 Reads
6 Citations
2.083 Impact Factor

A short-term in vivo model for giant cell tumor of bone.

BMC Cancer 2011 Jun 13;11:241. Epub 2011 Jun 13.

Department of Trauma and Orthopedic Surgery, University of Witten-Herdecke, Cologne-Merheim Medical Center, Ostmerheimer Str, Cologne, Germany.

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http://dx.doi.org/10.1186/1471-2407-11-241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125284PMC
June 2011
5 Reads
17 Citations
3.362 Impact Factor

Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression.

J Pathol 2011 May 14;224(1):10-21. Epub 2011 Mar 14.

Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/path.2861DOI Listing
May 2011
25 Reads
14 Citations
7.430 Impact Factor

Tiling resolution array-CGH shows that somatic mosaic deletion of the EXT gene is causative in EXT gene mutation negative multiple osteochondromas patients.

Hum Mutat 2011 Feb 7;32(2):E2036-49. Epub 2010 Dec 7.

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/humu.21423DOI Listing
February 2011
10 Reads
9 Citations
5.144 Impact Factor

Genome-wide analysis of Ollier disease: Is it all in the genes?

Orphanet J Rare Dis 2011 Jan 14;6. Epub 2011 Jan 14.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1750-1172-6-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027091PMC
January 2011
30 Reads
8 Citations
3.360 Impact Factor

Opening the archives for state of the art tumour genetic research: sample processing for array-CGH using decalcified, formalin-fixed, paraffin-embedded tissue-derived DNA samples.

BMC Res Notes 2011 Jan 4;4. Epub 2011 Jan 4.

Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2333ZC Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1756-0500-4-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024235PMC
January 2011
30 Reads
4 Citations

Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma.

Genes Chromosomes Cancer 2010 Dec;49(12):1095-103

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/gcc.20817DOI Listing
December 2010
31 Reads
14 Citations
4.041 Impact Factor

Two distinct regions in 2q24.2-q24.3 associated with idiopathic epilepsy.

Epilepsia 2010 Dec 30;51(12):2457-60. Epub 2010 Sep 30.

Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1111/j.1528-1167.2010.02742.xDOI Listing
December 2010
90 Reads
18 Citations
4.571 Impact Factor

Centriole movements in mammalian epithelial cells during cytokinesis.

BMC Cell Biol 2010 May 21;11:34. Epub 2010 May 21.

Cancer Research Laboratory, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1186/1471-2121-11-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893098PMC
May 2010
12 Reads
4 Citations
2.341 Impact Factor

Cutaneous anaplastic large cell lymphoma and peripheral T-cell lymphoma NOS show distinct chromosomal alterations and differential expression of chemokine receptors and apoptosis regulators.

J Invest Dermatol 2010 Feb 27;130(2):563-75. Epub 2009 Aug 27.

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/jid.2009.270DOI Listing
February 2010
35 Reads
4 Citations
7.220 Impact Factor

Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2.

J Pathol 2009 Nov;219(3):294-305

Department of Pathology, Leiden University Medical Centre, The Netherlands.

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http://dx.doi.org/10.1002/path.2603DOI Listing
November 2009
60 Reads
77 Citations
7.430 Impact Factor

LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization.

Genes Chromosomes Cancer 2009 Aug;48(8):679-93

Department of Tumor Biology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway.

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http://doi.wiley.com/10.1002/gcc.20675
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http://dx.doi.org/10.1002/gcc.20675DOI Listing
August 2009
7 Reads
27 Citations
4.041 Impact Factor

BRCA2 heterozygosity delays cytokinesis in primary human fibroblasts.

Cell Oncol 2009 ;31(3):191-201

Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.3233/CLO-2009-0465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618909PMC
July 2009
23 Reads
8 Citations

Genomic instability in giant cell tumor of bone. A study of 52 cases using DNA ploidy, relocalization FISH, and array-CGH analysis.

Genes Chromosomes Cancer 2009 Jun;48(6):468-79

1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Ulloi út 26, Budapest 1085, Hungary.

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http://dx.doi.org/10.1002/gcc.20656DOI Listing
June 2009
17 Reads
4 Citations
4.041 Impact Factor

The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology.

Clin Cancer Res 2009 Apr 24;15(7):2259-68. Epub 2009 Mar 24.

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2184DOI Listing
April 2009
57 Reads
32 Citations
8.722 Impact Factor

No genomic aberrations in Langerhans cell histiocytosis as assessed by diverse molecular technologies.

Genes Chromosomes Cancer 2009 Mar;48(3):239-49

Department of Pediatrics, Immunology Laboratory, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/gcc.20634DOI Listing
March 2009
41 Reads
15 Citations
4.041 Impact Factor

Long-term culture of primary human lymphoblastic leukemia cells in the absence of serum or hematopoietic growth factors.

Exp Hematol 2009 Mar 9;37(3):376-85. Epub 2009 Jan 9.

Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.exphem.2008.11.002DOI Listing
March 2009
45 Reads
18 Citations
2.480 Impact Factor

Aberrant heparan sulfate proteoglycan localization, despite normal exostosin, in central chondrosarcoma.

Am J Pathol 2009 Mar 29;174(3):979-88. Epub 2009 Jan 29.

Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.2353/ajpath.2009.080623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665757PMC
March 2009
1 Read
14 Citations
4.591 Impact Factor

Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome.

Blood 2009 Jan 1;113(1):127-36. Epub 2008 Oct 1.

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.bloodjournal.org/content/113/1/127.full.pdf
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-04-15
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http://dx.doi.org/10.1182/blood-2008-04-153031DOI Listing
January 2009
39 Reads
33 Citations
10.452 Impact Factor

EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma.

Clin Cancer Res 2007 Dec;13(24):7322-8

Department of Pathology, Regional Hospital, Treviso, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1744DOI Listing
December 2007
38 Reads
20 Citations
8.722 Impact Factor

Chromosome abnormalities in two patients with features of autosomal dominant Robinow syndrome.

Am J Med Genet A 2007 Aug;143A(15):1790-5

Centro de Estudos do Genoma Humano, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1002/ajmg.a.31661DOI Listing
August 2007
15 Reads
4 Citations
2.160 Impact Factor

Optimized amplification and fluorescent labeling of small cell samples for genomic array-CGH.

Cytometry A 2007 Aug;71(8):585-91

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/cyto.a.20412DOI Listing
August 2007
10 Reads
6 Citations
2.930 Impact Factor

Physical status of multiple human papillomavirus genotypes in flow-sorted cervical cancer cells.

Cancer Genet Cytogenet 2007 Jun;175(2):132-7

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.cancergencyto.2007.02.009DOI Listing
June 2007
5 Reads
6 Citations

COBRA: combined binary ratio labeling of nucleic-acid probes for multi-color fluorescence in situ hybridization karyotyping.

Nat Protoc 2006 ;1(1):264-75

Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600 (zone S1-P), 2300 RC Leiden, The Netherlands.

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http://www.nature.com/doifinder/10.1038/nprot.2006.41
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http://dx.doi.org/10.1038/nprot.2006.41DOI Listing
June 2007
9 Reads
19 Citations

Ring chromosome formation as a novel escape mechanism in patients with inverted duplication and terminal deletion.

Eur J Hum Genet 2007 May 7;15(5):548-55. Epub 2007 Mar 7.

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/sj.ejhg.5201807DOI Listing
May 2007
9 Reads
17 Citations
4.350 Impact Factor

The role of EXT1 in nonhereditary osteochondroma: identification of homozygous deletions.

J Natl Cancer Inst 2007 Mar;99(5):396-406

Department of Pathology, Leiden University Medical Center, PO Box 9600 L1-Q, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1093/jnci/djk067DOI Listing
March 2007
29 Reads
20 Citations
12.583 Impact Factor

High-resolution copy number analysis of paraffin-embedded archival tissue using SNP BeadArrays.

Genome Res 2007 Mar 31;17(3):368-76. Epub 2007 Jan 31.

Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1101/gr.5686107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800928PMC
March 2007
35 Reads
22 Citations
14.630 Impact Factor

Diagnosis of genetic abnormalities in developmentally delayed patients: a new strategy combining MLPA and array-CGH.

Am J Med Genet A 2007 Mar;143A(6):610-4

Center for Human and Clinical Genetics, Leiden University Medical Center, RC Leiden, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.a.31593DOI Listing
March 2007
19 Reads
9 Citations
2.160 Impact Factor

Sarcoma derived from cultured mesenchymal stem cells.

Stem Cells 2007 Feb 12;25(2):371-9. Epub 2006 Oct 12.

Department of Pediatrics, Division of Hematology-Oncology, Blood and Marrow Transplant and Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1634/stemcells.2005-0620DOI Listing
February 2007
106 Reads
173 Citations

Gene-expression profiling and array-based CGH classify CD4+CD56+ hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities.

Blood 2007 Feb 26;109(4):1720-7. Epub 2006 Oct 26.

Department of Dermatology, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1182/blood-2006-04-018143DOI Listing
February 2007
12 Reads
14 Citations

Detection and molecular cytogenetic characterization of a novel ring chromosome in a histological variant of Ewing sarcoma.

Cancer Genet Cytogenet 2007 Jan;172(1):12-22

Department of Molecular Cell Biology, Leiden University Medical Center, Post Zone S-01-P, PO Box 9600, 2300RC Leiden, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S016546080600469
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http://dx.doi.org/10.1016/j.cancergencyto.2006.07.007DOI Listing
January 2007
9 Reads
5 Citations

Peters Plus syndrome is caused by mutations in B3GALTL, a putative glycosyltransferase.

Am J Hum Genet 2006 Sep 19;79(3):562-6. Epub 2006 Jul 19.

Center for Human and Clinical Genetics, Department of Clinical Genetics, K5-R, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S000292970762756
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http://dx.doi.org/10.1086/507567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559553PMC
September 2006
39 Reads
40 Citations

A complex rearrangement on chromosome 22 affecting both homologues; haplo-insufficiency of the Cat eye syndrome region may have no clinical relevance.

Hum Genet 2006 Aug 18;120(1):77-84. Epub 2006 May 18.

Center for Human and Clinical Genetics, Leiden University Medical Center, Einthovenweg, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00439-006-0185-2DOI Listing
August 2006
12 Reads
3 Citations

Genomic analysis of early adenocarcinoma of the esophagus or gastroesophageal junction: tumor progression is associated with alteration of 1q and 8p sequences.

Genes Chromosomes Cancer 2006 May;45(5):516-25

Department of Pathology, Erasmus MC University Medical Center, Josephine Nefkens Institute, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/gcc.20315DOI Listing
May 2006
7 Reads
2 Citations

Genomic array and expression analysis of frequent high-level amplifications in adenocarcinomas of the gastro-esophageal junction.

Cancer Genet Cytogenet 2006 Apr;166(2):157-62

Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.cancergencyto.2005.11.002DOI Listing
April 2006
6 Reads
9 Citations

Molecular cytogenetic characterization of four previously established and two newly established Ewing sarcoma cell lines.

Cancer Genet Cytogenet 2006 Apr;166(2):173-9

Department of Molecular Cell Biology, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.cancergencyto.2005.11.006DOI Listing
April 2006
17 Reads
7 Citations

Hypoparathyroidism-retardation-dysmorphism syndrome in a girl: A new variant not caused by a TBCE mutation--clinical report and review.

Am J Med Genet A 2006 Mar;140(6):611-7

Department of Medical Genetics, University Hospital Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1002/ajmg.a.31122DOI Listing
March 2006
32 Reads
1 Citation

Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model.

Mod Pathol 2006 Mar;19(3):407-16

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/modpathol.3800550DOI Listing
March 2006
6 Reads
12 Citations

Expression analysis of candidate breast tumour suppressor genes on chromosome 16q.

Breast Cancer Res 2005 18;7(6):R998-1004. Epub 2005 Oct 18.

Department of Pathology, Leiden University Medical Center, Albiniusdreef 2, 2333ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1186/bcr1337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1410740PMC
February 2006
4 Reads
11 Citations

Distinct nuclear gene expression profiles in cells with mtDNA depletion and homoplasmic A3243G mutation.

Mutat Res 2005 Oct;578(1-2):43-52

Department of Molecular Cell Biology, Leiden University Medical Center, P.O. Box 9503, 2300 RA Leiden, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S002751070500081
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http://dx.doi.org/10.1016/j.mrfmmm.2005.02.002DOI Listing
October 2005
33 Reads
14 Citations

Rapid detection of genomic imbalances using micro-arrays consisting of pooled BACs covering all human chromosome arms.

Nucleic Acids Res 2005 Oct 12;33(18):e159. Epub 2005 Oct 12.

Department of Molecular Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://dx.doi.org/10.1093/nar/gni161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253841PMC
October 2005
25 Reads
5 Citations

Array CGH detection of a cryptic deletion in a complex chromosome rearrangement.

Hum Genet 2005 Apr 22;116(5):390-4. Epub 2005 Feb 22.

Laboratory of Cytochemistry and Cytometry, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00439-004-1248-xDOI Listing
April 2005
8 Reads
5 Citations

Insights from genomic microarrays into structural chromosome rearrangements.

Am J Med Genet A 2005 Jan;132A(1):36-40

Laboratory for Cytochemistry and Cytometry, Department of Molecular Cell Biology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.a.30378DOI Listing
January 2005
8 Reads
11 Citations

Primary synovial sarcoma of the heart: a cytogenetic and molecular genetic analysis combining RT-PCR and COBRA-FISH of a case with a complex karyotype.

Mod Pathol 2004 Nov;17(11):1434-9

Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://www.nature.com/doifinder/10.1038/modpathol.3800200
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http://dx.doi.org/10.1038/modpathol.3800200DOI Listing
November 2004
13 Reads
5 Citations

Multicolor fluorescence in situ hybridization analysis of a synovial sarcoma of the larynx with a t(X;18)(p11.2;q11.2) and trisomies 2 and 8.

Cancer Genet Cytogenet 2004 Aug;153(1):48-52

Department of Molecular Cell Biology, Leiden University Medical Center, Albinusdreef2, 2333ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.cancergencyto.2003.12.012DOI Listing
August 2004
27 Reads
1 Citation

Disruption of Drosophila Rad50 causes pupal lethality, the accumulation of DNA double-strand breaks and the induction of apoptosis in third instar larvae.

DNA Repair (Amst) 2004 Jun;3(6):603-15

Department of Toxicogenetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.dnarep.2004.02.001DOI Listing
June 2004
43 Reads
12 Citations

A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene.

Cancer Genet Cytogenet 2004 Feb;149(1):72-6

Laboratory of Cytochemistry and Cytometry, Department of Molecular Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://dx.doi.org/10.1016/s0165-4608(03)00302-9DOI Listing
February 2004
56 Reads
10 Citations

Real-time monitoring of rolling-circle amplification using a modified molecular beacon design.

Nucleic Acids Res 2002 Jul;30(14):e66

Department of Molecular Cell Biology, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135767PMC
http://dx.doi.org/10.1093/nar/gnf065DOI Listing
July 2002
4 Reads
20 Citations
9.110 Impact Factor

Connexin 26 mutations in cases of sensorineural deafness in eastern Austria.

Eur J Hum Genet 2002 Jul;10(7):427-32

Department of Otorhinolaryngology, AKH-8J, Währinger Gürtel 18-20, Vienna, Austria, A-1090.

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http://dx.doi.org/10.1038/sj.ejhg.5200826DOI Listing
July 2002
14 Reads
5 Citations
4.350 Impact Factor

Simultaneous mapping of human papillomavirus integration sites and molecular karyotyping in short-term cultures of cervical carcinomas by using 49-color combined binary ratio labeling fluorescence in situ hybridization.

Cancer Genet Cytogenet 2002 Apr;134(2):145-50

Laboratory for Cytochemistry and Cytometry, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/s0165-4608(01)00620-3DOI Listing
April 2002
14 Reads
2 Citations

A novel strategy for human papillomavirus detection and genotyping with SybrGreen and molecular beacon polymerase chain reaction.

Am J Pathol 2001 Nov;159(5):1651-60

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867051PMC
http://dx.doi.org/10.1016/S0002-9440(10)63012-XDOI Listing
November 2001
5 Reads
5 Citations
4.590 Impact Factor

A Rett syndrome patient with a ring X chromosome: further evidence for skewing of X inactivation and heterogeneity in the aetiology of the disease.

Eur J Hum Genet 2001 Mar;9(3):171-7

Laboratory of Cytochemistry and Cytometry, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/sj.ejhg.5200604DOI Listing
March 2001
4 Reads
4.350 Impact Factor

[Incidence and distribution of t(12;21) in prognostic groups of pediatric acute lymphoblastic leukemia].

Orv Hetil 2000 Jul;141(27):1495-500

Pécsi Tudományegyetem, Altalános Orvostudományi Kar.

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July 2000
3 Reads

Simultaneous molecular karyotyping and mapping of viral DNA integration sites by 25-color COBRA-FISH.

Genes Chromosomes Cancer 2000 May;28(1):92-7

Laboratory for Cytochemistry, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/(sici)1098-2264(200005)28:1<92::aid-gcc11>3.0.co;2-2DOI Listing
May 2000
2 Reads
7 Citations
4.040 Impact Factor

Silent Philadelphia chromosome: a distinct developmental stage in a philadelphia chromosome-positive chronic myeloproliferation?

Cancer Genet Cytogenet 2000 Apr;118(1):14-9

Department of Pathology, University Medical School of Pécs, Pécs, Hungary.

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http://dx.doi.org/10.1016/s0165-4608(99)00168-5DOI Listing
April 2000
7 Reads

Recurrent integration of human papillomaviruses 16, 45, and 67 near translocation breakpoints in new cervical cancer cell lines.

Cancer Res 1999 Nov;59(21):5615-24

Department of Pathology, Leiden University Medical Center, The Netherlands.

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November 1999
4 Reads
18 Citations
9.330 Impact Factor

Combined metaphase, interphase cytogenetic, and flow cytometric analysis of DNA content of pediatric acute lymphoblastic leukemia.

Cytometry 1998 Apr;34(2):87-94

Department of Pathology, University Medical School of Pécs, Hungary.

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April 1998
3 Reads
1 Citation

[Application of interphase cytogenetics for the determination of changes in the DNA content in acute childhood lymphoid leukemia].

Orv Hetil 1997 Dec;138(49):3111-9

Pécsi Orvostudományi Egyetem, Pathologiai Intézet.

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December 1997
1 Read

Multiple tumor case: report and analysis of an autopsy case.

Tumori 1997 May-Jun;83(3):715-7

Department of Pathology, University Medical School of Pécs, Hungary.

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September 1997
6 Reads
1.090 Impact Factor

Top co-authors

Jeroen Knijnenburg
Jeroen Knijnenburg

Leiden University Medical Center

13
Anne-Marie Cleton-Jansen
Anne-Marie Cleton-Jansen

Leiden University Medical Center

13
Hans J Tanke
Hans J Tanke

Leiden University Medical Center

12
Raf Sciot
Raf Sciot

KU Leuven and University Hospitals Leuven

8
Carla Rosenberg
Carla Rosenberg

Institute of Biosciences

6