Publications by authors named "Karolina Hassa"

2 Publications

  • Page 1 of 1

Oxygenation of Phenanthriporphyrin and Copper(III) Phenanthriporphyrin: An Efficient Route to Phenanthribilinones.

Inorg Chem 2019 Sep 27;58(18):12446-12456. Epub 2019 Aug 27.

Department of Chemistry , University of Wrocław , F. Joliot-Curie 14 , 50-383 Wrocław , Poland.

Photooxidation of copper(III) 5,6-dimethoxyphenathriporphyrin and copper(III) 5,6-dioxophenanthriporphyrin, which contain phenanthrene or dioxophenathrene moieties built into the macrocyclic frameworks, resulted in the regioselective cleavage that afforded organometallic copper(III) complexes of open-chain phenanthribilinone-type acyclic ligands terminated by carbonyl groups. The copper(III) coordinates two carbon atoms of phenantherene (dioxophenanthrene) and two nitrogen atoms of pyrrole and pyrrolone units, preserving the donor sets of the paternal complexes. The primary dioxygen attack is located at the carbon atom adjacent to the phenanthrene moiety. Demetalation of copper(III) 21-benzoyl-phenanthribilin-1-one and copper(III) 21-benzoyl-dioxophenanthribilin-1-one yielded mainly two diastereomers [, ] and [, ], which differ in the configurations at two C-C double bonds. The regioselectivity of the cleavage, detected in the course of experimental studies, has been substantiated by DFT investigations. The regioselective cleavage of 5,6-dimethoxyphenanthriporphyrin in reaction with basic iron(III) acetate was detected, providing the synthetically efficient methodology to produce 21-benzoyl-dioxophenanthribilin-1-one.
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http://dx.doi.org/10.1021/acs.inorgchem.9b02183DOI Listing
September 2019

Protective role of zinc in Spodoptera exigua larvae under 135-generational cadmium exposure.

Chemosphere 2019 Nov 28;235:785-793. Epub 2019 Jun 28.

Department of Animal Physiology and Ecotoxicology, University of Silesia in Katowice, Bankowa 9, 40-007, Katowice, Poland. Electronic address:

The aim of this study was to investigate whether zinc supplementation modulates cadmium toxicity in the beet armyworm Spodoptera exigua selected for 135 generations towards cadmium tolerance. To achieve this, larvae originating from three laboratory populations of S. exigua (control strain - C; cadmium-intoxicated for 135 generations strain - Cd, and control strain intoxicated with Cd for 1 generation - CCd) were additionally exposed to zinc in three concentrations (Zn1, 400 μg Zn·g dry mass of food; Zn2; 200 μg Zn·g dry mass of food; Zn3, 100 μg Zn·g dry mass of food). As the markers of toxicity, a life history traits (the duration of L4 and L5 stages), cellular (DNA damage indices) and biochemical parameters (ADP/ATP ratio and ATP and HSP70 concentrations) were chosen. The duration of larval stages of Zn supplemented larvae was prolonged, while cellular and biochemical indicators, in general, appeared to be lower in comparison to the insects from respective reference groups in each laboratory populations. Moreover, the range of the differences depended on zinc concentration in food. We can suspect that zinc supplementation contributed to the protection of S. exigua individuals against negative effects of cadmium intoxication, probably at the cost of growth rate. Significant differences in the response pattern between insects from different laboratory populations indicate that the influence of additional stress factors is dependent on the overall condition of animals and their previous adaptation to other stressors.
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http://dx.doi.org/10.1016/j.chemosphere.2019.06.209DOI Listing
November 2019