Karolina Edlund

Gene expression-based prediction of neoadjuvant chemotherapy response in early breast cancer: results of the prospective multicenter EXPRESSION trial.

Clin Cancer Res 2021 Feb 4. Epub 2021 Feb 4.

Dept. Systems Toxicology, IfADo - Leibniz Research Centre for Working Environment and Human Factors

February 2021

Prognostic Significance of Interferon-γ and Its Signaling Pathway in Early Breast Cancer Depends on the Molecular Subtypes.

Authors:

Anne-Sophie Heimes Franziska Härtner Katrin Almstedt Slavomir Krajnak Antje Lebrecht Marco J Battista Karolina Edlund Walburgis Brenner Annette Hasenburg Ugur Sahin Mathias Gehrmann Jan G Hengstler Marcus Schmidt

Int J Mol Sci 2020 Sep 29;21(19). Epub 2020 Sep 29.

Department of Obstetrics and Gynecology, University Medical Center Mainz, 55131 Mainz, Germany.

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September 2020

Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses.

Arch Toxicol 2020 05 8;94(5):1375-1415. Epub 2020 May 8.

Department of Toxicology, Leibniz Research Centre for Working Environment and Human Factors (IfADo), Dortmund, Germany.

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May 2020

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease.

Arch Toxicol 2020 01 9;94(1):205-217. Epub 2020 Jan 9.

IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.

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January 2020

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.

Arch Toxicol 2019 06 27;93(6):1609-1637. Epub 2019 Jun 27.

Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.

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June 2019

Road Map for Development of Stem Cell-Based Alternative Test Methods.

Authors:

Agapios Sachinidis Wiebke Albrecht Patrick Nell Anna Cherianidou Nicola J Hewitt Karolina Edlund Jan G Hengstler

Trends Mol Med 2019 06 23;25(6):470-481. Epub 2019 May 23.

Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund (IfADo), 44139 Dortmund, Germany. Electronic address:

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June 2019

HR-MAS NMR Based Quantitative Metabolomics in Breast Cancer.

Authors:

Mikheil Gogiashvili Jessica Nowacki Roland Hergenröder Jan G Hengstler Jörg Lambert Karolina Edlund

Metabolites 2019 Jan 22;9(2). Epub 2019 Jan 22.

Leibniz Research Centre for Working Environment and Human Factors (IfADo), 44139 Dortmund, Germany.

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January 2019

LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.

Int J Cancer 2019 08 7;145(4):901-915. Epub 2019 Feb 7.

Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), Dortmund, Germany.

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August 2019

Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC.

Authors:

Karolina Edlund Katrin Madjar Johanna S M Mattsson Dijana Djureinovic Cecilia Lindskog Hans Brunnström Hirsh Koyi Eva Brandén Karin Jirström Fredrik Pontén Jörg Rahnenführer Patrick Micke Jan G Hengstler

J Thorac Oncol 2019 04 9;14(4):628-640. Epub 2019 Jan 9.

Leibniz Research Centre for Working Environment and Human Factors (IfADo) at TU Dortmund University, Dortmund, Germany.

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April 2019

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes.

Arch Toxicol 2018 12 3;92(12):3517-3533. Epub 2018 Dec 3.

Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.

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December 2018

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.

Authors:

Xiaolong Gu Wiebke Albrecht Karolina Edlund Franziska Kappenberg Jörg Rahnenführer Marcel Leist Wolfgang Moritz Patricio Godoy Cristina Cadenas Rosemarie Marchan Tim Brecklinghaus Laia Tolosa Pardo José V Castell Iain Gardner Bo Han Jan G Hengstler Regina Stoeber

Arch Toxicol 2018 12 13;92(12):3505-3515. Epub 2018 Oct 13.

Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.

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December 2018

Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high-resolution magic angle spinning H NMR spectroscopy.

Authors:

Mikheil Gogiashvili Salome Horsch Rosemarie Marchan Kathrin Gianmoena Cristina Cadenas Berno Tanner Sabrina Naumann Diana Ersova Frank Lippek Jörg Rahnenführer Jan T Andersson Roland Hergenröder Jörg Lambert Jan G Hengstler Karolina Edlund

NMR Biomed 2018 02 5;31(2). Epub 2017 Dec 5.

Leibniz Research Center for Working Environment and Human Factors (IfADo), Dortmund, Germany.

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February 2018

RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.

Genes Dev 2017 10 8;31(20):2099-2112. Epub 2017 Nov 8.

Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna 1030, Austria.

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October 2017

Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer.

Authors:

Verena Jabs Karolina Edlund Helena König Marianna Grinberg Katrin Madjar Jörg Rahnenführer Simon Ekman Michael Bergkvist Lars Holmberg Katja Ickstadt Johan Botling Jan G Hengstler Patrick Micke

PLoS One 2017 7;12(11):e0187246. Epub 2017 Nov 7.

Dept. of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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November 2017

Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma.

Cancer Res 2017 09 26;77(17):4589-4601. Epub 2017 Jun 26.

Department of Toxicology, Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund (IfADo), Dortmund, Germany.

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September 2017

Reaching the limits of prognostication in non-small cell lung cancer: an optimized biomarker panel fails to outperform clinical parameters.

Authors:

Marianna Grinberg Dijana Djureinovic Hans Rr Brunnström Johanna Sm Mattsson Karolina Edlund Jan G Hengstler Linnea La Fleur Simon Ekman Hirsh Koyi Eva Branden Elisabeth Ståhle Karin Jirström Derek K Tracy Fredrik Pontén Johan Botling Jörg Rahnenführer Patrick Micke

Mod Pathol 2017 07 10;30(7):964-977. Epub 2017 Mar 10.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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July 2017

Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy.

Authors:

Birte Hellwig Katrin Madjar Karolina Edlund Rosemarie Marchan Cristina Cadenas Anne-Sophie Heimes Katrin Almstedt Antje Lebrecht Isabel Sicking Marco J Battista Patrick Micke Marcus Schmidt Jan G Hengstler Jörg Rahnenführer

PLoS One 2016 7;11(12):e0167585. Epub 2016 Dec 7.

Department of Statistics, TU Dortmund University, Dortmund, Germany.

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July 2017

Metabolic profiling of ob/ob mouse fatty liver using HR-MAS H-NMR combined with gene expression analysis reveals alterations in betaine metabolism and the transsulfuration pathway.

Authors:

Mikheil Gogiashvili Karolina Edlund Kathrin Gianmoena Rosemarie Marchan Alexander Brik Jan T Andersson Jörg Lambert Katrin Madjar Birte Hellwig Jörg Rahnenführer Jan G Hengstler Roland Hergenröder Cristina Cadenas

Anal Bioanal Chem 2017 Feb 28;409(6):1591-1606. Epub 2016 Nov 28.

Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.

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February 2017

Profiling cancer testis antigens in non-small-cell lung cancer.

JCI Insight 2016 07 7;1(10):e86837. Epub 2016 Jul 7.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

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July 2016

Inconsistent results in the analysis of ALK rearrangements in non-small cell lung cancer.

Authors:

Johanna S M Mattsson Hans Brunnström Verena Jabs Karolina Edlund Karin Jirström Stephanie Mindus Linnéa la Fleur Fredrik Pontén Mats G Karlsson Christina Karlsson Hirsh Koyi Eva Brandén Johan Botling Gisela Helenius Patrick Micke Maria A Svensson

BMC Cancer 2016 08 5;16:603. Epub 2016 Aug 5.

Clinical Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

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August 2016

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.

Arch Toxicol 2016 Oct 23;90(10):2513-29. Epub 2016 Jun 23.

IfADo-Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund, Ardeystrasse 67, 44139, Dortmund, Germany.

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October 2016

Corrigendum to "Gene networks and transcription factor motifs defining the differentiation of human stem cells into hepatocyte-like cells" [J Hepatol 2015;63:934-942].

J Hepatol 2016 02 2;64(2):525-526. Epub 2015 Dec 2.

IfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany. Electronic address:

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February 2016

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.

Authors:

Erna Raja Kalliopi Tzavlaki Robin Vuilleumier Karolina Edlund Kaoru Kahata Agata Zieba Anita Morén Yukihide Watanabe Iryna Voytyuk Johan Botling Ola Söderberg Patrick Micke George Pyrowolakis Carl-Henrik Heldin Aristidis Moustakas

Oncotarget 2016 Jan;7(2):1120-43

Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

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January 2016

Identification of sample annotation errors in gene expression datasets.

Authors:

Miriam Lohr Birte Hellwig Karolina Edlund Johanna S M Mattsson Johan Botling Marcus Schmidt Jan G Hengstler Patrick Micke Jörg Rahnenführer

Arch Toxicol 2015 Dec 25;89(12):2265-72. Epub 2015 Nov 25.

Department of Statistics, TU Dortmund University, Vogelpothsweg 87, 44227, Dortmund, Germany.

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December 2015

The Human Endometrium-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling.

Authors:

Agata Zieba Evelina Sjöstedt Matts Olovsson Linn Fagerberg Björn M Hallström Linda Oskarsson Karolina Edlund Anna Tolf Mathias Uhlen Fredrik Ponten

OMICS 2015 Nov 21;19(11):659-68. Epub 2015 Oct 21.

1 Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University , Uppsala, Sweden .

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November 2015

Gelsolin Is Associated with Longer Metastasis-free Survival and Reduced Cell Migration in Estrogen Receptor-positive Breast Cancer.

Authors:

Anna-Maria Stock Franziska Klee Karolina Edlund Marianna Grinberg Seddik Hammad Rosemarie Marchan Cristina Cadenas Bernd Niggemann Kurt S Zänker Jörg Rahnenführer Marcus Schmidt Jan G Hengstler Frank Entschladen

Anticancer Res 2015 Oct;35(10):5277-85

Institute of Immunology and Experimental Oncology, Center for Biomedical Education and Research, Faculty of Health, School of Medicine, Witten/Herdecke University, Witten, Germany.

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October 2015