Publications by authors named "Karl-Peter Hopfner"

100Publications

Structural basis of the (in)activity of the apical DNA damage response kinases ATM, ATR and DNA-PKcs.

Prog Biophys Mol Biol 2020 Nov 7. Epub 2020 Nov 7.

Department of Biochemistry, Ludwig-Maximilians-Universität, Feodor-Lynen-Straße 25, 81377, Munich, Germany; Gene Center, Ludwig-Maximilians-Universität, Feodor-Lynen-Straße 25, 81377, Munich, Germany. Electronic address:

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November 2020

Megadalton chromatin remodelers: common principles for versatile functions.

Curr Opin Struct Biol 2020 Oct 6;64:134-144. Epub 2020 Aug 6.

European Molecular Biology Laboratory (EMBL), Structural and Computational Biology Unit, Heidelberg, Germany. Electronic address:

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October 2020

Molecular mechanisms and cellular functions of cGAS-STING signalling.

Nat Rev Mol Cell Biol 2020 09 18;21(9):501-521. Epub 2020 May 18.

Department of Biochemistry, Ludwig-Maximilians-Universität, Munich, Germany.

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September 2020

Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.

Structure 2020 01 15;28(1):83-95.e5. Epub 2019 Nov 15.

Department of Biochemistry, Ludwig-Maximilians-Universität, Feodor-Lynen-Strasse 25, 81377 Munich, Germany; Gene Center, Ludwig-Maximilians-Universität, Feodor-Lynen-Strasse 25, 81377 Munich, Germany. Electronic address:

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January 2020

Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.

Mol Cell 2019 11 3;76(3):382-394.e6. Epub 2019 Sep 3.

Department of Biochemistry, Ludwig-Maximilians-Universität, 81377 Munich, Germany; Gene Center, Ludwig-Maximilians-Universität, 81377 Munich, Germany; Center for Integrated Protein Science, 81377 Munich, Germany. Electronic address:

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November 2019

A Click-Chemistry Linked 2'3'-cGAMP Analogue.

Chemistry 2019 Feb 17;25(8):2089-2095. Epub 2019 Jan 17.

Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377, Munich, Germany.

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February 2019

Crystal structure of the full Swi2/Snf2 remodeler Mot1 in the resting state.

Elife 2018 10 5;7. Epub 2018 Oct 5.

Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

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October 2018

Molecular architecture and regulation of BCL10-MALT1 filaments.

Nat Commun 2018 10 2;9(1):4041. Epub 2018 Oct 2.

Gene Center, Ludwig-Maximilians University, Feodor-Lynen-Str. 25, 81377, München, Germany.

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October 2018

The bacterial Mre11-Rad50 homolog SbcCD cleaves opposing strands of DNA by two chemically distinct nuclease reactions.

Nucleic Acids Res 2018 11;46(21):11303-11314

Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor Lynen Straße 25, 81377 Munich, Germany.

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November 2018

Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.

Nature 2018 04 11;556(7701):386-390. Epub 2018 Apr 11.

Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

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April 2018

Single-molecule nucleosome remodeling by INO80 and effects of histone tails.

FEBS Lett 2018 02 26;592(3):318-331. Epub 2018 Jan 26.

Faculty of Natural Sciences, Institute of Biophysics, Ulm University, Germany.

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February 2018

Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors.

J Biol Chem 2017 06 14;292(22):9000-9009. Epub 2017 Apr 14.

From the Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität, 81377 Munich and

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June 2017

RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together.

Mol Cell 2016 12 23;64(5):951-966. Epub 2016 Nov 23.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; University of Basel, Faculty of Natural Sciences, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address:

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December 2016

Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth.

ACS Nano 2016 Oct 7;10(10):9156-9164. Epub 2016 Sep 7.

Physik Department and Institute for Advanced Study, Technische Universität München , Am Coulombwall 4a, 85748 Garching near Munich, Germany.

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October 2016

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1.

Sci Rep 2016 06 8;6:27498. Epub 2016 Jun 8.

Ludwig-Maximilians-Universität München, Gene Center and Dept. of Biochemistry, Feodor-Lynen-Str. 25, 81377 Munich, Germany.

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June 2016

RIG-I-Like Receptors: One STrEP Forward.

Trends Microbiol 2016 07 25;24(7):517-519. Epub 2016 May 25.

Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany; Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany; Center for Integrated Protein Science, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:

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July 2016

Invited review: Architectures and mechanisms of ATP binding cassette proteins.

Biopolymers 2016 Aug;105(8):492-504

Department Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377 Munich, Germany.

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August 2016

Editorial overview: Macromolecular machines and assemblies.

Curr Opin Struct Biol 2016 Apr 16;37:vi-viii. Epub 2016 Mar 16.

Department of Biochemistry and Gene Center of the Ludwig-Maximilians-University, Munich, Germany. Electronic address:

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April 2016

Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells.

Oncotarget 2016 Apr;7(16):22579-89

Klinikum der Universität München, Medizinische Klinik und Poliklinik IV, Hematology/Oncology, Munich, Germany.

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April 2016

Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody.

Analyst 2016 Apr;141(7):2284-95

Faculty of Physics and Graduate School of Quantitative Biosciences (QBM), Ludwig-Maximilians-Universität, Munich, Germany.

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April 2016

Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.

EMBO J 2016 Apr 19;35(7):759-72. Epub 2016 Feb 19.

Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, Munich, Germany Center for Integrated Protein Sciences, Munich, Germany

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April 2016

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.

Genes Dev 2016 Feb 21;30(3):337-54. Epub 2016 Jan 21.

Friedrich Miescher Institute for Biomedical Research, CH-4058 Basel, Switzerland; Faculty of Natural Sciences, University of Basel, CH-4056 Basel, Switzerland.

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February 2016

Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1.

Elife 2015 Aug 10;4. Epub 2015 Aug 10.

Gene Center, Department of Biochemistry, Ludwig Maximilian University, Munich, Germany.

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August 2015

Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.

Acta Crystallogr F Struct Biol Commun 2015 Jun 22;71(Pt 6):752-7. Epub 2015 May 22.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.

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June 2015

Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.

Biochem J 2015 Aug 27;469(3):367-74. Epub 2015 May 27.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität, 81377 Munich, Germany

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August 2015

Serendipitous crystallization and structure determination of cyanase (CynS) from Serratia proteamaculans.

Acta Crystallogr F Struct Biol Commun 2015 Apr 21;71(Pt 4):471-6. Epub 2015 Mar 21.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.

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April 2015

Structural basis for dodecameric assembly states and conformational plasticity of the full-length AAA+ ATPases Rvb1 · Rvb2.

Structure 2015 Mar 5;23(3):483-495. Epub 2015 Feb 5.

Department of Biochemistry, Gene Center of the Ludwig-Maximilians University Munich, 81377 Munich, Germany; Center for Integrated Protein Sciences, Ludwig-Maximilians University Munich, Feodor-Lynen-Str. 25, 81377 Munich, Germany. Electronic address:

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March 2015

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas.

Chem Biol 2015 Jan 31;22(1):129-38. Epub 2014 Dec 31.

Research Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany. Electronic address:

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January 2015

Molecular architecture of the HerA-NurA DNA double-strand break resection complex.

FEBS Lett 2014 Dec 11;588(24):4637-44. Epub 2014 Nov 11.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen-Straße 25, D-81377 Munich, Germany; Center for Integrated Protein Sciences, Munich, Germany. Electronic address:

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December 2014

c-di-AMP recognition by Staphylococcus aureus PstA.

FEBS Lett 2015 Jan 28;589(1):45-51. Epub 2014 Nov 28.

Ludwig-Maximilians-Universität München, Gene Center and Dept. of Biochemistry, Feodor-Lynen-Str. 25, 81377 Munich, Germany. Electronic address:

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January 2015

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.

EMBO J 2014 Dec 25;33(24):2937-46. Epub 2014 Nov 25.

Institute of Molecular Medicine, University Hospital University of Bonn, Bonn, Germany

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December 2014

Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.

EMBO J 2014 Dec 27;33(23):2847-59. Epub 2014 Oct 27.

Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, Munich, Germany Center for Integrated Protein Sciences, Munich, Germany

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December 2014

ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.

Bioessays 2014 Dec 11;36(12):1170-8. Epub 2014 Sep 11.

Department of Biochemistry, Gene Center, Ludwig-Maximilians-University, Munich, Germany; Center for Integrated Protein Science Munich, Gene Center, Ludwig-Maximilians-University, Munich, Germany.

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December 2014

RIG-I holds the CARDs in a game of self versus nonself.

Mol Cell 2014 Aug;55(4):505-7

Department Biochemistry, Gene Center, Ludwig-Maximilians University, Feodor-Lynen-Strasse 25, 81377 Munich, Germany; Center for Integrated Protein Sciences, Gene Center, Ludwig-Maximilians University, Feodor-Lynen-Strasse 25, 81377 Munich, Germany; Graduate School for Quantitative Biosciences, Gene Center, Ludwig-Maximilians University, Feodor-Lynen-Strasse 25, 81377 Munich, Germany. Electronic address:

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August 2014

T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell.

Oncotarget 2014 Aug;5(15):6466-83

Klinikum der Universität München, Medizinische Klinik und Poliklinik IV, Haematology/Oncology, Munich, Germany.

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August 2014

Crystal and solution structure of the human RIG-I SF2 domain.

Acta Crystallogr F Struct Biol Commun 2014 Aug 23;70(Pt 8):1027-31. Epub 2014 Jul 23.

Gene Center and Department of Biochemistry, Ludwig-Maximilians University Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.

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August 2014

Structural studies of DNA end detection and resection in homologous recombination.

Cold Spring Harb Perspect Biol 2014 Jul 31;6(10):a017962. Epub 2014 Jul 31.

Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany Center for Integrated Protein Sciences, 81377 Munich, Germany.

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July 2014

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.

Nat Rev Immunol 2014 Aug 18;14(8):521-8. Epub 2014 Jul 18.

Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany.

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August 2014

Crystallization of mouse RIG-I ATPase domain: in situ proteolysis.

Methods Mol Biol 2014 ;1169:27-35

Department of Biochemistry at the Gene Center, Ludwig-Maximilians-University Munich, Feodor-Lynen-Strasse 25, 81377, Munich, Germany.

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February 2015

Single-molecule choreography between telomere proteins and G quadruplexes.

Structure 2014 Jun;22(6):801-2

Department Biochemistry and Gene Center, Ludwig-Maximilians University Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany; Center for Integrated Protein Sciences, Ludwig-Maximilians University Munich, Feodor-Lynen-Strasse 25, 81377 Munich, Germany. Electronic address:

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June 2014

Editorial overview: Theory and simulation: Macromolecular machines.

Curr Opin Struct Biol 2014 Apr 12;25:vi-viii. Epub 2014 May 12.

Danforth Plant Science Center, 975 North Warson Road, Saint Louis, MO 63132, USA. Electronic address:

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April 2014

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production.

Nat Immunol 2014 Jun 28;15(6):538-45. Epub 2014 Apr 28.

Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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June 2014

In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.

PLoS Pathog 2014 Apr 17;10(4):e1004081. Epub 2014 Apr 17.

Gene Center and Department of Biochemistry, Ludwig-Maximilians University Munich, Munich, Germany; Center for Integrated Protein Science Munich, Munich, Germany.

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April 2014

Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.

PLoS One 2014 7;9(3):e89560. Epub 2014 Mar 7.

Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany; Clinical Cooperative Group Leukemia, Helmholtz Center Munich, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

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December 2014

Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.

Cell Host Microbe 2014 Feb;15(2):228-38

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address:

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February 2014

NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2.

J Transl Med 2013 Nov 16;11:289. Epub 2013 Nov 16.

Division of Hematology and Oncology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstrasse 1, D-80336 Munich, Germany.

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November 2013

Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.

Cell 2013 Sep;154(6):1207-19

Department of Biochemistry, Ludwig-Maximilian University, 81377 Munich, Germany; Gene Center, Ludwig-Maximilian University, 81377 Munich, Germany.

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September 2013

Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase.

Angew Chem Int Ed Engl 2013 Sep 14;52(39):10384-7. Epub 2013 Aug 14.

Gene Center, Department of Biochemistry, Ludwig-Maximilians University Munich, Feodor-Lynen-Strasse 25, 80377 Munich (Germany).

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September 2013

Structural mechanism of cytosolic DNA sensing by cGAS.

Nature 2013 Jun 30;498(7454):332-7. Epub 2013 May 30.

Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany.

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June 2013

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

Nature 2013 Jun 30;498(7454):380-4. Epub 2013 May 30.

Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany.

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June 2013

Species-specific detection of the antiviral small-molecule compound CMA by STING.

EMBO J 2013 May 19;32(10):1440-50. Epub 2013 Apr 19.

Unit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Bonn, Germany.

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May 2013

Response to: monoclonal antibodies targeting CD20.

MAbs 2013 May-Jun;5(3):337-8. Epub 2013 Mar 14.

Discovery Oncology; Pharma Research and Early Development (pRED); Roche Diagnostics GmbH; Penzberg, Germany.

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April 2015

Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling.

Science 2013 Feb 17;339(6120):690-3. Epub 2013 Jan 17.

Department of Biochemistry and Gene Center, Ludwig-Maximilians-University, Munich, Germany.

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February 2013

Rustless translation.

Biol Chem 2012 Oct;393(10):1079-88

Department of Biochemistry, Gene Center, Ludwig Maximilians University of Munich, Feodor-Lynen-Str. 25, D-81377 Munich, Germany.

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October 2012

Structure of Actin-related protein 8 and its contribution to nucleosome binding.

Nucleic Acids Res 2012 Nov 12;40(21):11036-46. Epub 2012 Sep 12.

Department of Biochemistry, Gene Center of Ludwig-Maximilians-University Munich, Feodor-Lynen-Str. 25, D-81377 Munich, Germany.

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November 2012

Swi2/Snf2 remodelers: hybrid views on hybrid molecular machines.

Curr Opin Struct Biol 2012 Apr 23;22(2):225-33. Epub 2012 Mar 23.

Department of Biochemistry at the Gene Center, Ludwig-Maximilians-University Munich, Feodor-Lynen-Str. 25, 81377 Munich, Germany.

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April 2012

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea.

Nature 2012 Feb 22;482(7386):501-6. Epub 2012 Feb 22.

Gene Center and Center for integrated Protein Science Munich, Department of Biochemistry, University of Munich, Feodor-Lynen-Straße 25, 81377 Munich, Germany.

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February 2012

Nuclear actin-related proteins take shape.

Bioarchitecture 2011 Jul 1;1(4):192-195. Epub 2011 Jul 1.

Department of Biochemistry; Munich, Germany.

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July 2011

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling.

EMBO Rep 2011 Oct 28;12(11):1127-34. Epub 2011 Oct 28.

Department of Biochemistry at the Gene Center, Ludwig-Maximilians-University Munich, Feodor-Lynen-Strasse 25, Munich 81377, Germany.

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October 2011

Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.

Genes Dev 2011 Oct 22;25(19):2093-105. Epub 2011 Sep 22.

Gene Center, Department of Biochemistry, Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-Universität München, 81377 Munich, Germany.

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October 2011

ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex.

Nucleic Acids Res 2012 Jan 21;40(2):914-27. Epub 2011 Sep 21.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-University Munich, Feodor-Lynen-Strasse 25, 81377, Munich, Germany.

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January 2012

Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin.

EMBO J 2011 Jun 15;30(11):2153-66. Epub 2011 Apr 15.

Department of Biochemistry, Gene Center of the Ludwig-Maximilians-University Munich, Munich, Germany.

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June 2011

Sensing of viral nucleic acids by RIG-I: from translocation to translation.

Eur J Cell Biol 2012 Jan 14;91(1):78-85. Epub 2011 Apr 14.

Division of Clinical Pharmacology, Ludwig-Maximilian University Munich, Munich, Germany.

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January 2012

Processive RNA decay by the exosome: merits of a quantitative Bayesian sampling approach.

RNA Biol 2011 Jan-Feb;8(1):55-60. Epub 2011 Jan 1.

Center for Integrated Protein Sciences, Department of Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany.

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September 2011