Dr. Karl-Heinz Smalla, PhD - Leibniz-Institute for Neurobiology

Dr. Karl-Heinz Smalla

PhD

Leibniz-Institute for Neurobiology

Magdeburg | Germany

Main Specialties: Biology

Additional Specialties: synapse protein biochemistry, proteomics, subcellular fractionations

ORCID logohttps://orcid.org/0000-0002-0269-0311


Top Author

Dr. Karl-Heinz Smalla, PhD - Leibniz-Institute for Neurobiology

Dr. Karl-Heinz Smalla

PhD

Introduction

1. Fernandez-Orth, J., Ehling, P., Ruck, T., Pankratz, S., Hofmann, M. S., Landgraf, P., Dieterich, D. C., Smalla, K. H., Kahne, T., Seebohm, G., Budde, T., Wiendl, H., Bittner, S., and Meuth, S. G. (2017) 14-3-3 Proteins regulate K2P 5.1 surface expression on T lymphocytes. Traffic 18, 29-43
2. Bhattacharya, S., Herrera-Molina, R., Sabanov, V., Ahmed, T., Iscru, E., Stober, F., Richter, K., Fischer, K. D., Angenstein, F., Goldschmidt, J., Beesley, P. W., Balschun, D., Smalla, K. H., Gundelfinger, E. D., and Montag, D. (2017) Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation. Biol Psychiatry 81, 124-135
3. Leutritz, T., Hilfert, L., Busse, U., Smalla, K. H., Speck, O., and Zhong, K. (2016) Contribution of iron and protein contents from rat brain subcellular fractions to MR phase imaging. Magnetic resonance in medicine
4. Kolodziej, A., Smalla, K.H., Richter, S., Engler, A., Pielot, R., Dieterich, D. C., Tischmeyer, W., Naumann, M., and Kahne, T. (2016) High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning. J Vis Exp
5. Kahne, T., Richter, S., Kolodziej, A., Smalla, K. H., Pielot, R., Engler, A., Ohl, F. W., Dieterich, D. C., Seidenbecher, C., Tischmeyer, W., Naumann, M., and Gundelfinger, E. D. (2016) Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain. Journal of neurochemistry 138, 124-138
6. Reichenbach, N., Herrmann, U., Kahne, T., Schicknick, H., Pielot, R., Naumann, M., Dieterich, D. C., Gundelfinger, E. D., Smalla, K. H., and Tischmeyer, W. (2015) Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain. Proteome science 13, 13
7. Seidensticker, M., Ulrich, G., Muehlberg, F. L., Pethe, A., Grosser, O. S., Steffen, I. G., Stiebler, M., Goldschmidt, J., Smalla, K. H., Seidensticker, R., Ricke, J., Amthauer, H., and Mohnike, K. (2014) Tumor cell uptake of 99mTc-labeled 1-thio-beta-D-glucose and 5-thio-D-glucose in comparison with 2-deoxy-2-[18F]fluoro-D-glucose in vitro: kinetics, dependencies, blockage and cell compartment of accumulation. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 16, 189-198
8. Herrera-Molina, R., Sarto-Jackson, I., Montenegro-Venegas, C., Heine, M., Smalla, K. H., Seidenbecher, C. I., Beesley, P. W., Gundelfinger, E. D., and Montag, D. (2014) Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65. The Journal of biological chemistry 289, 8973-8988
9. Beesley, P. W., Herrera-Molina, R., Smalla, K. H., and Seidenbecher, C. (2014) The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function. Journal of neurochemistry 131, 268-283
10. Smalla, K.-H., Klemmer, P., and Wyneken, U. (2013) Isolation of the Postsynaptic Density: A Specialization of the Subsynaptic Cytoskeleton. in The Cytoskeleton, Springer. pp 265-280
11. Sandoval, M., Luarte, A., Herrera-Molina, R., Varas-Godoy, M., Santibanez, M., Rubio, F. J., Smit, A. B., Gundelfinger, E. D., Li, K. W., Smalla, K. H., and Wyneken, U. (2013) The glycolytic enzyme aldolase C is up-regulated in rat forebrain microsomes and in the cerebrospinal fluid after repetitive fluoxetine treatment. Brain research 1520, 1-14
12. Li, L., Sase, A., Patil, S., Sunyer, B., Hoger, H., Smalla, K. H., Stork, O., and Lubec, G. (2013) Distinct set of kinases induced after retrieval of spatial memory discriminate memory modulation processes in the mouse hippocampus. Hippocampus 23, 672-683

13. Leutritz, T., Hilfert, L., Smalla, K. H., Speck, O., and Zhong, K. (2013) Accurate quantification of water-macromolecule exchange induced frequency shift: effects of reference substance. Magnetic resonance in medicine 69, 263-268
14. Schmeisser, M. J., Ey, E., Wegener, S., Bockmann, J., Stempel, A. V., Kuebler, A., Janssen, A. L., Udvardi, P. T., Shiban, E., Spilker, C., Balschun, D., Skryabin, B. V., Dieck, S., Smalla, K. H., Montag, D., Leblond, C. S., Faure, P., Torquet, N., Le Sourd, A. M., Toro, R., Grabrucker, A. M., Shoichet, S. A., Schmitz, D., Kreutz, M. R., Bourgeron, T., Gundelfinger, E. D., and Boeckers, T. M. (2012) Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature 486, 256-260
15. Schicknick, H., Reichenbach, N., Smalla, K. H., Scheich, H., Gundelfinger, E. D., and Tischmeyer, W. (2012) Dopamine modulates memory consolidation of discrimination learning in the auditory cortex. The European journal of neuroscience 35, 763-774
16. Sarto-Jackson, I., Milenkovic, I., Smalla, K. H., Gundelfinger, E. D., Kaehne, T., Herrera-Molina, R., Thomas, S., Kiebler, M. A., and Sieghart, W. (2012) The cell adhesion molecule neuroplastin-65 is a novel interaction partner of gamma-aminobutyric acid type A receptors. The Journal of biological chemistry 287, 14201-14214
17. Pielot, R., Smalla, K. H.*, Muller, A., Landgraf, P., Lehmann, A. C., Eisenschmidt, E., Haus, U. U., Weismantel, R., Gundelfinger, E. D., and Dieterich, D. C. (2012) SynProt: A Database for Proteins of Detergent-Resistant Synaptic Protein Preparations. Frontiers in synaptic neuroscience 4, 1
18. Mlinac, K., Jovanov Milosevic, N., Heffer, M., Smalla, K. H., Schnaar, R. L., and Kalanj Bognar, S. (2012) Neuroplastin expression in the hippocampus of mice lacking complex gangliosides. Journal of molecular neuroscience : MN 48, 161-166
19. Kahne, T., Kolodziej, A., Smalla, K. H.*, Eisenschmidt, E., Haus, U. U., Weismantel, R., Kropf, S., Wetzel, W., Ohl, F. W., Tischmeyer, W., Naumann, M., and Gundelfinger, E. D. (2012) Synaptic proteome changes in mouse brain regions upon auditory discrimination learning. Proteomics 12, 2433-2444
20. Bernstein, H. G., Smalla, K. H., Durrschmidt, D., Keilhoff, G., Dobrowolny, H., Steiner, J., Schmitt, A., Kreutz, M. R., and Bogerts, B. (2012) Increased density of prohibitin-immunoreactive oligodendrocytes in the dorsolateral prefrontal white matter of subjects with schizophrenia suggests extraneuronal roles for the protein in the disease. Neuromolecular medicine 14, 270-280
21. Smalla, K.-H., and Wyneken, U. (2011) Two-Dimensional Gel Electrophoresis-Based Proteomic Analysis of Brain Synapses. in Neuroproteomics, Springer. pp 95-113
22. Sandoval, R., Gonzalez, A., Caviedes, A., Pancetti, F., Smalla, K. H., Kaehne, T., Michea, L., Gundelfinger, E. D., and Wyneken, U. (2011) Homeostatic NMDA receptor down-regulation via brain derived neurotrophic factor and nitric oxide-dependent signalling in cortical but not in hippocampal neurons. Journal of neurochemistry 118, 760-772
23. Goswami, C., Rademacher, N., Smalla, K. H., Kalscheuer, V., Ropers, H. H., Gundelfinger, E. D., and Hucho, T. (2010) TRPV1 acts as a synaptic protein and regulates vesicle recycling. Journal of cell science 123, 2045-2057
24. Smalla, K. H., Sahin, J., Putzke, J., Tischmeyer, W., Gundelfinger, E. D., and Kreutz, M. R. (2009) Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis. Neurochemical research 34, 1405-1409
25. Mikhaylova, M., Reddy, P. P., Munsch, T., Landgraf, P., Suman, S. K., Smalla, K. H., Gundelfinger, E. D., Sharma, Y., and Kreutz, M. R. (2009) Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking. Proceedings of the National Academy of Sciences of the United States of America 106, 9093-9098
26. Juch, M., Smalla, K. H., Kahne, T., Lubec, G., Tischmeyer, W., Gundelfinger, E. D., and Engelmann, M. (2009) Congenital lack of nNOS impairs long-term social recognition memory and alters the olfactory bulb proteome. Neurobiology of learning and memory 92, 469-484
27. Smalla, K. H., Mikhaylova, M., Sahin, J., Bernstein, H. G., Bogerts, B., Schmitt, A., van der Schors, R., Smit, A. B., Li, K. W., Gundelfinger, E. D., and Kreutz, M. R. (2008) A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia. Molecular psychiatry 13, 878-896
28. Schicknick, H., Schott, B. H., Budinger, E., Smalla, K. H., Riedel, A., Seidenbecher, C. I., Scheich, H., Gundelfinger, E. D., and Tischmeyer, W. (2008) Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR. Cerebral cortex 18, 2646-2658
29. Saavedra, M. V., Smalla, K. H., Thomas, U., Sandoval, S., Olavarria, K., Castillo, K., Delgado, M. G., Delgado, R., Gundelfinger, E. D., Bacigalupo, J., and Wyneken, U. (2008) Scaffolding proteins in highly purified rat olfactory cilia membranes. Neuroreport 19, 1123-1126
30. Dieterich, D. C., Karpova, A., Mikhaylova, M., Zdobnova, I., Konig, I., Landwehr, M., Kreutz, M., Smalla, K. H., Richter, K., Landgraf, P., Reissner, C., Boeckers, T. M., Zuschratter, W., Spilker, C., Seidenbecher, C. I., Garner, C. C., Gundelfinger, E. D., and Kreutz, M. R. (2008) Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. PLoS biology 6, e34
31. Sandoval, M., Sandoval, R., Thomas, U., Spilker, C., Smalla, K. H., Falcon, R., Marengo, J. J., Calderon, R., Saavedra, V., Heumann, R., Bronfman, F., Garner, C. C., Gundelfinger, E. D., and Wyneken, U. (2007) Antagonistic effects of TrkB and p75(NTR) on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes. Journal of neurochemistry 101, 1672-1684
32. Putzke, J., Spina, M. G., Buchler, J., Kovar, K. A., Wolf, G., and Smalla, K. H. (2007) The effects of p-chloroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (ecstasy) on the gene expression of cytoskeletal proteins in the rat brain. Addiction biology 12, 69-80
33. Langnaese, K., Richter, K., Smalla, K. H., Krauss, M., Thomas, U., Wolf, G., and Laube, G. (2007) Splice-isoform specific immunolocalization of neuronal nitric oxide synthase in mouse and rat brain reveals that the PDZ-complex-building nNOSalpha beta-finger is largely exposed to antibodies. Developmental neurobiology 67, 422-437
34. Bernstein, H. G., Smalla, K. H., Bogerts, B., Gordon-Weeks, P. R., Beesley, P. W., Gundelfinger, E. D., and Kreutz, M. R. (2007) The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain. Brain research 1134, 107-112
35. Bernstein, H. G., Sahin, J., Smalla, K. H., Gundelfinger, E. D., Bogerts, B., and Kreutz, M. R. (2007) A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia. Schizophrenia research 96, 246-256


36. Wendholt, D., Spilker, C., Schmitt, A., Dolnik, A., Smalla, K. H., Proepper, C., Bockmann, J., Sobue, K., Gundelfinger, E. D., Kreutz, M. R., and Boeckers, T. M. (2006) ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3. The Journal of biological chemistry 281, 13805-13816
37. Mikhaylova, M., Sharma, Y., Reissner, C., Nagel, F., Aravind, P., Rajini, B., Smalla, K. H., Gundelfinger, E. D., and Kreutz, M. R. (2006) Neuronal Ca2+ signaling via caldendrin and calneurons. Biochimica et biophysica acta 1763, 1229-1237
38. John, N., Krugel, H., Frischknecht, R., Smalla, K. H., Schultz, C., Kreutz, M. R., Gundelfinger, E. D., and Seidenbecher, C. I. (2006) Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures. Molecular and cellular neurosciences 31, 774-784
39. Li, K., Hornshaw, M. P., van Minnen, J., Smalla, K. H., Gundelfinger, E. D., and Smit, A. B. (2005) Organelle proteomics of rat synaptic proteins: correlation-profiling by isotope-coded affinity tagging in conjunction with liquid chromatography-tandem mass spectrometry to reveal post-synaptic density specific proteins. Journal of proteome research 4, 725-733
40. Smalla, K.-H., wan Li, K., Smit, A. B., and Gundelfinger, E. D. (2004) Proteomic analysis of synaptic structures.
41. Seidenbecher, C. I., Landwehr, M., Smalla, K. H., Kreutz, M., Dieterich, D. C., Zuschratter, W., Reissner, C., Hammarback, J. A., Bockers, T. M., Gundelfinger, E. D., and Kreutz, M. R. (2004) Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins. Journal of molecular biology 336, 957-970
42. Roumier, A., Bechade, C., Poncer, J. C., Smalla, K. H., Tomasello, E., Vivier, E., Gundelfinger, E. D., Triller, A., and Bessis, A. (2004) Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 11421-11428
43. Li, K. W., Hornshaw, M. P., Van Der Schors, R. C., Watson, R., Tate, S., Casetta, B., Jimenez, C. R., Gouwenberg, Y., Gundelfinger, E. D., Smalla, K. H., and Smit, A. B. (2004) Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology. The Journal of biological chemistry 279, 987-1002
44. Smalla, K. H., Seidenbecher, C. I., Tischmeyer, W., Schicknick, H., Wyneken, U., Bockers, T. M., Gundelfinger, E. D., and Kreutz, M. R. (2003) Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain. Brain research. Molecular brain research 116, 159-162
45. Marzban, H., Khanzada, U., Shabir, S., Hawkes, R., Langnaese, K., Smalla, K. H., Bockers, T. M., Gundelfinger, E. D., Gordon-Weeks, P. R., and Beesley, P. W. (2003) Expression of the immunoglobulin superfamily neuroplastin adhesion molecules in adult and developing mouse cerebellum and their localisation to parasagittal stripes. The Journal of comparative neurology 462, 286-301
46. Dieterich, D. C., Landwehr, M., Reissner, C., Smalla, K. H., Richter, K., Wolf, G., Bockers, T. M., Gundelfinger, E. D., and Kreutz, M. R. (2003) Gliap--a novel untypical L-asparaginase localized to rat brain astrocytes. Journal of neurochemistry 85, 1117-1125

47. Bernstein, H. G., Seidenbecher, C. I., Smalla, K. H., Gundelfinger, E. D., Bogerts, B., and Kreutz, M. R. (2003) Distribution and cellular localization of caldendrin immunoreactivity in adult human forebrain. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 51, 1109-1112
48. Seidenbecher, C. I., Smalla, K. H., Fischer, N., Gundelfinger, E. D., and Kreutz, M. R. (2002) Brevican isoforms associate with neural membranes. Journal of neurochemistry 83, 738-746
49. Laube, G., Seidenbecher, C. I., Richter, K., Dieterich, D. C., Hoffmann, B., Landwehr, M., Smalla, K. H., Winter, C., Bockers, T. M., Wolf, G., Gundelfinger, E. D., and Kreutz, M. R. (2002) The neuron-specific Ca2+-binding protein caldendrin: gene structure, splice isoforms, and expression in the rat central nervous system. Molecular and cellular neurosciences 19, 459-475
50. Chamaon, K., Smalla, K. H.*, Thomas, U., and Gundelfinger, E. D. (2002) Nicotinic acetylcholine receptors of Drosophila: three subunits encoded by genomically linked genes can co-assemble into the same receptor complex. Journal of neurochemistry 80, 149-157
51. Wyneken, U., Smalla, K. H., Marengo, J. J., Soto, D., de la Cerda, A., Tischmeyer, W., Grimm, R., Boeckers, T. M., Wolf, G., Orrego, F., and Gundelfinger, E. D. (2001) Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Neuroscience 102, 65-74
52. Boeckers, T. M., Kreutz, M. R., Winter, C., Zuschratter, W., Smalla, K. H., Sanmarti-Vila, L., Wex, H., Langnaese, K., Bockmann, J., Garner, C. C., and Gundelfinger, E. D. (2001) Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 183, 101
53. Spilker, C., Richter, K., Smalla, K. H., Manahan-Vaughan, D., Gundelfinger, E. D., and Braunewell, K. H. (2000) The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association. Neuroscience 96, 121-129
54. Smalla, K. H.*, Matthies, H., Langnase, K., Shabir, S., Bockers, T. M., Wyneken, U., Staak, S., Krug, M., Beesley, P. W., and Gundelfinger, E. D. (2000) The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses. Proceedings of the National Academy of Sciences of the United States of America 97, 4327-4332
55. Schulz, R., Bertrand, S., Chamaon, K., Smalla, K. H., Gundelfinger, E. D., and Bertrand, D. (2000) Neuronal nicotinic acetylcholine receptors from Drosophila: two different types of alpha subunits coassemble within the same receptor complex. Journal of neurochemistry 74, 2537-2546
56. Matthies, H., Schroeder, H., Smalla, K. H., and Krug, M. (2000) Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus. Learning & memory 7, 227-234
57. Keilhoff, G., Fansa, H., Smalla, K. H., Schneider, W., and Wolf, G. (2000) Neuroma: a donor-age independent source of human Schwann cells for tissue engineered nerve grafts. Neuroreport 11, 3805-3809
58. Chamaon, K., Schulz, R., Smalla, K. H., Seidel, B., and Gundelfinger, E. D. (2000) Neuronal nicotinic acetylcholine receptors of Drosophila melanogaster: the alpha-subunit dalpha3 and the beta-type subunit ARD co-assemble within the same receptor complex. FEBS letters 482, 189-192
59. Matthies, H., Jr., Kretlow, J., Matthies, H., Smalla, K. H., Staak, S., and Krug, M. (1999) Glycosylation of proteins during a critical time window is necessary for the maintenance of long-term potentiation in the hippocampal CA1 region. Neuroscience 91, 175-183
60. Boeckers, T. M., Winter, C., Smalla, K. H., Kreutz, M. R., Bockmann, J., Seidenbecher, C., Garner, C. C., and Gundelfinger, E. D. (1999) Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. Biochemical and biophysical research communications 264, 247-252
61. Boeckers, T. M., Kreutz, M. R., Winter, C., Zuschratter, W., Smalla, K. H., Sanmarti-Vila, L., Wex, H., Langnaese, K., Bockmann, J., Garner, C. C., and Gundelfinger, E. D. (1999) Proline-rich synapse-associated protein-1/cortactin binding protein 1 (ProSAP1/CortBP1) is a PDZ-domain protein highly enriched in the postsynaptic density. The Journal of neuroscience : the official journal of the Society for Neuroscience 19, 6506-6518
62. tom Dieck, S., Sanmarti-Vila, L., Langnaese, K., Richter, K., Kindler, S., Soyke, A., Wex, H., Smalla, K. H., Kampf, U., Franzer, J. T., Stumm, M., Garner, C. C., and Gundelfinger, E. D. (1998) Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals. The Journal of cell biology 142, 499-509
63. Smalla, K. H., Angenstein, F., Richter, K., Gundelfinger, E. D., and Staak, S. (1998) Identification of fucose alpha(1-2) galactose epitope-containing glycoproteins from rat hippocampus. Neuroreport 9, 813-817
64. Seidenbecher, C. I., Langnaese, K., Sanmarti-Vila, L., Boeckers, T. M., Smalla, K. H., Sabel, B. A., Garner, C. C., Gundelfinger, E. D., and Kreutz, M. R. (1998) Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment. The Journal of biological chemistry 273, 21324-21331
65. Matthies Jr, H., Staak, S., Smalla, K., and Krug, M. (1997) Enhancement of Hippocampal Long-Term Potentiation in Vitro by Fucosyl-Carbohydrates. in Neurochemistry, Springer US. pp 905-908
66. Krug, M., Wagner, M., Staak, S., and Smalla, K. H. (1994) Fucose and fucose-containing sugar epitopes enhance hippocampal long-term potentiation in the freely moving rat. Brain research 643, 130-135
67. Zuschratter, W., Seidel, B., Smalla, K. H., Karsten, U., Scheich, H., and Jork, R. (1991) Distribution of (fucogalactosyl-)epitope expressing glycoconjugates in rat brain. Neuroreport 2, 445-448
68. Richter, P., Pohle, W., Grecksch, G., Smalla, K. H., Jork, R., and Matthies, H. (1991) Enhanced development of morphine tolerance in rats treated with 2-deoxy-D-galactose. Psychopharmacology 104, 279-283
69. Jork, R., Smalla, K., Karsten, U., Grecksch, G., Rüthrich, H., and Matthies, H. (1991) Monoclonal antibody specific for histo-blood group antigens H (types 2 and 4) interferes with long-term memory formation in rats. Neuroscience Research Communications 8, 21-27
70. Jork, R., Schnurra, I., Smalla, K., Grecksch, G., Popov, N., and Matthies, H. (1989) Deoxy-galactose mediated amnesia is related to an inhibition of training-induced increase in rat hippocampal glycoprotein fucosylation. Neuroscience Research Communications 5, 3-8

* Shared first authorships

Primary Affiliation: Leibniz-Institute for Neurobiology - Magdeburg , Germany

Specialties:

Additional Specialties:

Research Interests:


View Dr. Karl-Heinz Smalla’s Resume / CV

Metrics

Number of Publications

47

Publications

Number of Profile Views

408

Profile Views

Number of Article Reads

454

Reads

Number of Citations

673

Citations

Education

Dec 1983
Martin-Luther-University Halle-Wittenberg
PhD in Physical Chemistry
Sep 1979 - Aug 1983
Martin-Luther-Universitat Halle-Wittenberg
PhD
Sep 1974 - Aug 1979
Martin-Luther-Universitat Halle-Wittenberg
Diploma
Aug 1979
Martin-Luther-University Halle-Wittenberg
Diploma in Physics

Experience

Mar 1999 - Feb 2001
Otto von Guericke Universität Magdeburg
Researcher
Jan 1998 - Aug 1999
Otto von Guericke Universität Magdeburg
Postdoc
Jan 1992 - Dec 1997
Institute for Neurobiology
Postdoc
Sep 1983 - Dec 1991
Institute for Neurobiology and Brain Research
Staff Scientist
Mar 2001
Leibniz-Institut für Neurobiologie
Researcher/PI

Top co-authors

Eckart D Gundelfinger
Eckart D Gundelfinger

Leibniz Institute for Neurobiology

36
Michael R Kreutz
Michael R Kreutz

Leibniz Institute for Neurobiology

15
Wolfgang Tischmeyer
Wolfgang Tischmeyer

Leibniz Institute for Neurobiology

9
Constanze I Seidenbecher
Constanze I Seidenbecher

Leibniz Institute for Neurobiology

8
Daniela C Dieterich
Daniela C Dieterich

Institute for Pharmacology and Toxicology

8
Dirk Montag
Dirk Montag

Leibniz Institute for Neurobiology

6
Michael Naumann
Michael Naumann

Institute of Experimental Internal Medicine

5
Philip W Beesley
Philip W Beesley

Special Laboratory for Molecular Biology Techniques

5

Publications

47Publications

454Reads

673PubMed Central Citations

Chronic Toxoplasma infection is associated with distinct alterations in the synaptic protein composition.

J Neuroinflammation 2018 Aug 1;15(1):216. Epub 2018 Aug 1.

Institute of Inflammation and Neurodegeneration, Otto von Guericke University Magdeburg, Magdeburg, Germany.

View Article
August 2018
2 Reads
5.410 Impact Factor

A complex of Neuroplastin and Plasma Membrane Ca ATPase controls T cell activation.

Sci Rep 2017 Aug 21;7(1):8358. Epub 2017 Aug 21.

Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, D-39118, Magdeburg, Germany.

View Article
August 2017
24 Reads
2 Citations
5.080 Impact Factor

Contribution of iron and protein contents from rat brain subcellular fractions to MR phase imaging.

Magn Reson Med 2017 05 7;77(5):2028-2039. Epub 2016 Jun 7.

Dept. Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany.

View Article
May 2017
3 Reads
3.570 Impact Factor

14-3-3 Proteins regulate K 5.1 surface expression on T lymphocytes.

Traffic 2017 01 27;18(1):29-43. Epub 2016 Nov 27.

Department of Neurology, Westfälische Wilhelms-Universität, Münster, Germany.

View Article
January 2017
50 Reads
2 Citations
4.350 Impact Factor

Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation.

Biol Psychiatry 2017 01 11;81(2):124-135. Epub 2016 Apr 11.

Neurogenetics Special Laboratory, Leibniz Institute for Neurobiology, Magdeburg, Germany. Electronic address:

View Article
January 2017
13 Reads
5 Citations
10.260 Impact Factor

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning.

J Vis Exp 2016 12 15(118). Epub 2016 Dec 15.

Institute of Experimental Internal Medicine, Medical School, Otto von Guericke University Magdeburg;

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December 2016
9 Reads

Differential effects of dopamine signalling on long-term memory formation and consolidation in rodent brain.

Proteome Sci 2015 18;13:13. Epub 2015 Mar 18.

Special Lab Molecular Biological Techniques, Leibniz Institute for Neurobiology, Magdeburg, 39118 Germany ; Center for Behavioral Brain Sciences, Magdeburg, 39106 Germany.

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April 2015
7 Reads
6 Citations
1.730 Impact Factor

The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function.

J Neurochem 2014 Nov 14;131(3):268-83. Epub 2014 Aug 14.

School of Biological Sciences, Royal Holloway University of London, Egham, UK.

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November 2014
7 Reads
10 Citations
4.280 Impact Factor

Distinct set of kinases induced after retrieval of spatial memory discriminate memory modulation processes in the mouse hippocampus.

Hippocampus 2013 Aug 22;23(8):672-83. Epub 2013 May 22.

Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

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August 2013
5 Reads
1 Citation
4.160 Impact Factor

Accurate quantification of water-macromolecule exchange induced frequency shift: effects of reference substance.

Magn Reson Med 2013 Jan 28;69(1):263-8. Epub 2012 Feb 28.

Department of Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany.

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January 2013
14 Reads
2 Citations
3.570 Impact Factor

SynProt: A Database for Proteins of Detergent-Resistant Synaptic Protein Preparations.

Front Synaptic Neurosci 2012 25;4. Epub 2012 Jun 25.

Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany.

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October 2012
8 Reads
15 Citations

Neuroplastin expression in the hippocampus of mice lacking complex gangliosides.

J Mol Neurosci 2012 Sep 26;48(1):161-6. Epub 2012 May 26.

Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Šalata 12, 10000, Zagreb, Croatia.

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September 2012
8 Reads
2.340 Impact Factor

Synaptic proteome changes in mouse brain regions upon auditory discrimination learning.

Proteomics 2012 Aug;12(15-16):2433-44

Institute of Experimental Internal Medicine, Medical School, Otto von Guericke University, Magdeburg, Germany.

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August 2012
17 Reads
10 Citations
3.810 Impact Factor

The cell adhesion molecule neuroplastin-65 is a novel interaction partner of γ-aminobutyric acid type A receptors.

J Biol Chem 2012 Apr 2;287(17):14201-14. Epub 2012 Mar 2.

Center for Brain Research, Department of Biochemistry and Molecular Biology of the Nervous System, Medical University of Vienna, 1090 Vienna, Austria.

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April 2012
3 Reads
11 Citations
4.570 Impact Factor

Dopamine modulates memory consolidation of discrimination learning in the auditory cortex.

Eur J Neurosci 2012 Mar 17;35(5):763-74. Epub 2012 Feb 17.

Special Lab Molecular Biological Techniques, Leibniz Institute for Neurobiology, Brenneckestrasse 6, D-39118 Magdeburg, Germany.

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March 2012
7 Reads
10 Citations
3.180 Impact Factor

Homeostatic NMDA receptor down-regulation via brain derived neurotrophic factor and nitric oxide-dependent signalling in cortical but not in hippocampal neurons.

J Neurochem 2011 Sep 18;118(5):760-72. Epub 2011 Jul 18.

Laboratorio de Neurotoxicología Ambiental, Facultad de Medicina, Universidad Católica del Norte, Coquimbo, Chile.

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September 2011
5 Reads
4 Citations
4.280 Impact Factor

TRPV1 acts as a synaptic protein and regulates vesicle recycling.

J Cell Sci 2010 Jun 18;123(Pt 12):2045-57. Epub 2010 May 18.

Signal Transduction in Pain and Mental Retardation, Department for Molecular Human Genetics, Max-Planck Institute for Molecular Genetics, Berlin, Germany.

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June 2010
11 Reads
13 Citations
5.430 Impact Factor

Congenital lack of nNOS impairs long-term social recognition memory and alters the olfactory bulb proteome.

Neurobiol Learn Mem 2009 Nov 14;92(4):469-84. Epub 2009 Jun 14.

Otto-von-Guericke-Universität, Institut für Biochemie und Zellbiologie, Leipziger Strasse 44, D-39120, Magdeburg, Germany.

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November 2009
3 Reads
9 Citations
3.650 Impact Factor

Altered postsynaptic-density-levels of caldendrin in the para-chloroamphetamine-induced serotonin syndrome but not in the rat ketamine model of psychosis.

Neurochem Res 2009 Aug 18;34(8):1405-9. Epub 2009 Feb 18.

Special Lab Molecular Biological Techniques, Leibniz-Institute for Neurobiology, Magdeburg, Germany.

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August 2009
4 Reads
2 Citations
2.590 Impact Factor

Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking.

Proc Natl Acad Sci U S A 2009 Jun 19;106(22):9093-8. Epub 2009 May 19.

Project Group Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany.

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June 2009
7 Reads
22 Citations
9.810 Impact Factor

Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR.

Cereb Cortex 2008 Nov 4;18(11):2646-58. Epub 2008 Mar 4.

Leibniz Institute for Neurobiology, D-39118 Magdeburg, Germany.

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November 2008
9 Reads
27 Citations
8.660 Impact Factor

Scaffolding proteins in highly purified rat olfactory cilia membranes.

Neuroreport 2008 Jul;19(11):1123-6

Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile.

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July 2008
4 Reads
2 Citations
1.640 Impact Factor

A reduced number of cortical neurons show increased Caldendrin protein levels in chronic schizophrenia.

Schizophr Res 2007 Nov 23;96(1-3):246-56. Epub 2007 Aug 23.

Department of Psychiatry, Faculty of Medicine, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany.

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November 2007
5 Reads
8 Citations
3.920 Impact Factor

Splice-isoform specific immunolocalization of neuronal nitric oxide synthase in mouse and rat brain reveals that the PDZ-complex-building nNOSalpha beta-finger is largely exposed to antibodies.

Dev Neurobiol 2007 Mar;67(4):422-37

Institut für Medizinische Neurobiologie, Otto-von-Guericke-Universität Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.

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March 2007
12 Reads
1 Citation
3.370 Impact Factor

The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain.

Brain Res 2007 Feb 27;1134(1):107-12. Epub 2006 Dec 27.

Department of Psychiatry, Faculty of Medicine, Otto-von-Guericke University, Magdeburg, Germany.

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February 2007
5 Reads
4 Citations
2.840 Impact Factor

Neuronal Ca2+ signaling via caldendrin and calneurons.

Biochim Biophys Acta 2006 Nov 6;1763(11):1229-37. Epub 2006 Sep 6.

AG Molecular Mechanisms of Plasticity, Department of Neurochemistry/Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany.

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November 2006
5 Reads
22 Citations

Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures.

Mol Cell Neurosci 2006 Apr 28;31(4):774-84. Epub 2006 Feb 28.

Department for Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology Magdeburg, Germany.

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April 2006
6 Reads
26 Citations
3.840 Impact Factor

Organelle proteomics of rat synaptic proteins: correlation-profiling by isotope-coded affinity tagging in conjunction with liquid chromatography-tandem mass spectrometry to reveal post-synaptic density specific proteins.

J Proteome Res 2005 May-Jun;4(3):725-33

Department of Molecular and Cellular Neurobiology, Center of Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.

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October 2005
9 Reads
25 Citations
4.250 Impact Factor

Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse.

J Neurosci 2004 Dec;24(50):11421-8

Laboratoire de Biologie Cellulaire de la Synapse Normale et Pathologique, Institut National de la Santé et de la Recherche Médicale (INSERM) U497, Ecole Normale Supérieure, 75230 Paris Cedex 05, France.

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December 2004
6 Reads
54 Citations
6.340 Impact Factor

Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins.

J Mol Biol 2004 Feb;336(4):957-70

AG Molecular Mechanisms of Plasticity, Department of Neurochemistry/Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestr. 6 39118 Magdeburg, Germany.

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February 2004
5 Reads
20 Citations
4.330 Impact Factor

Proteomics analysis of rat brain postsynaptic density. Implications of the diverse protein functional groups for the integration of synaptic physiology.

J Biol Chem 2004 Jan 7;279(2):987-1002. Epub 2003 Oct 7.

Department of Molecular and Cellular Neurobiology, Research Institute of Neurosciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.

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January 2004
6 Reads
56 Citations
4.570 Impact Factor

Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain.

Brain Res Mol Brain Res 2003 Aug;116(1-2):159-62

AG Molecular Mechanisms of Plasticity, Department of Neurochemistry/Molecular Biology, Leibniz-Institute for Neurobiology, Brenneckestrasse 6, Magdeburg 39118, Germany.

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August 2003
7 Reads
3 Citations

Distribution and cellular localization of caldendrin immunoreactivity in adult human forebrain.

J Histochem Cytochem 2003 Aug;51(8):1109-12

Department of Psychiatry, Otto-von-Guericke-University, Magdeburg, Germany.

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August 2003
3 Reads
4 Citations
1.960 Impact Factor

Expression of the immunoglobulin superfamily neuroplastin adhesion molecules in adult and developing mouse cerebellum and their localisation to parasagittal stripes.

J Comp Neurol 2003 Jun;462(3):286-301

Department of Cell Biology and Anatomy, Genes and Development Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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June 2003
3 Reads
10 Citations
3.230 Impact Factor

Gliap--a novel untypical L-asparaginase localized to rat brain astrocytes.

J Neurochem 2003 Jun;85(5):1117-25

AG Molecular Mechanisms of Plasticity, Department of Neurochemistry and Molecular Biology, Leibniz Institute for Neurobiology, Magdeburg, Germany.

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June 2003
4 Reads
4 Citations
4.280 Impact Factor

Brevican isoforms associate with neural membranes.

J Neurochem 2002 Nov;83(3):738-46

AG Molecular Mechanisms of Plasticity, Department of Neurochemistry/Molecular Biology, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany.

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November 2002
3 Reads
8 Citations
4.280 Impact Factor

Nicotinic acetylcholine receptors of Drosophila: three subunits encoded by genomically linked genes can co-assemble into the same receptor complex.

J Neurochem 2002 Jan;80(1):149-57

Leibniz Institute for Neurobiology, Department of Neurochemistry and Molecular Biology, Magdeburg, Germany.

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January 2002
5 Reads
11 Citations
4.280 Impact Factor

Top co-authors

Eckart D Gundelfinger
Eckart D Gundelfinger

Leibniz Institute for Neurobiology

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Michael R Kreutz
Michael R Kreutz

Leibniz Institute for Neurobiology

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Wolfgang Tischmeyer
Wolfgang Tischmeyer

Leibniz Institute for Neurobiology

9
Constanze I Seidenbecher
Constanze I Seidenbecher

Leibniz Institute for Neurobiology

8
Daniela C Dieterich
Daniela C Dieterich

Institute for Pharmacology and Toxicology

8
Dirk Montag
Dirk Montag

Leibniz Institute for Neurobiology

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Michael Naumann
Michael Naumann

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Philip W Beesley
Philip W Beesley

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