Karl-Anton Kreuzer

Karl-Anton Kreuzer

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Karl-Anton Kreuzer

Karl-Anton Kreuzer

Publications by authors named "Karl-Anton Kreuzer"

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Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions.

N Engl J Med 2019 Jun 4;380(23):2225-2236. Epub 2019 Jun 4.

From Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn-Cologne-Duesseldorf, University Hospital Cologne and University of Cologne (K.F., O.A.-S., J.B., A.-M.F., S. Robrecht, B.E., K.-A.K., M.H.), the Oncogeriatric Unit, Department of Geriatric Medicine, St. Marien Hospital (V.G.), CECAD (Center of Excellence on Cellular Stress Responses in Aging-Associated Diseases) (M.H.), Center for Molecular Medicine Cologne (M.H.), Cologne, Department III of Internal Medicine, University Hospital Rostock, Rostock (S.B.), Department III of Internal Medicine, Ulm University, Ulm (E.T., S.S.), the Departments of Hematology, Oncology, Immunology, Palliative Care, Infectious Diseases, and Tropical Medicine, Klinikum Schwabing, Munich (C.-M.W.), Department II of Internal Medicine, Campus Kiel, University of Schleswig-Holstein, Kiel (M.R.), and the Department of Hematology, Oncology, and Rheumatology, Saarland University Medical School, Homburg (S.S.) - all in Germany; Roche Products, Welwyn Garden City, United Kingdom (M.T., M.D., S.W., K.H.); Regional Clinical Hospital N.A. Semashko, Nizhny Novgorod, Russia (O.S.); the Division of Onco-Hematology, Santa Maria Terni Hospital, University of Perugia, Perugia, Italy (A.M.L.); the Department of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL (J.P.-I.); the Haematology Department, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (S.O.); First Internal Department, Multiprofile Hospital for Active Treatment Hristo Botev, Vratsa, Bulgaria (L.S.); the Hematology Department, Clinique Victor Hugo, Le Mans, France (K.L.D.); Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil (L.M.F.); the Department of Hematology, Rigshospitalet, Copenhagen University Hospital, Copenhagen (C.U.N.); Wellington Blood and Cancer Centre, Capital and Coast District Health Board, and Malaghan Institute of Medical Research, Wellington, New Zealand (R.W.); Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada (S. Robinson); Moores Cancer Center, University of California San Diego, San Diego (T.J.K.), and Genentech, South San Francisco (M.M.) - both in California; AbbVie, North Chicago, IL (R.H.); and the Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, the Netherlands (A.W.L.).

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http://www.nejm.org/doi/10.1056/NEJMoa1815281
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http://dx.doi.org/10.1056/NEJMoa1815281DOI Listing
June 2019

CLL2-BIG: sequential treatment with bendamustine, ibrutinib and obinutuzumab (GA101) in chronic lymphocytic leukemia.

Leukemia 2019 05 19;33(5):1161-1172. Epub 2018 Dec 19.

Department I of Internal Medicine and Center of Integrated Oncology Cologne-Bonn, CECAD Cluster of Excellence at the University of Cologne, Clinical Research Unit (KFO) 286, German CLL Study Group, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41375-018-0313-8DOI Listing
May 2019

Effects of all-trans retinoic acid (ATRA) in addition to chemotherapy for adults with acute myeloid leukaemia (AML) (non-acute promyelocytic leukaemia (non-APL)).

Cochrane Database Syst Rev 2018 08 6;8:CD011960. Epub 2018 Aug 6.

Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/14651858.CD011960.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513628PMC
August 2018

CLL2-BXX Phase II trials: sequential, targeted treatment for eradication of minimal residual disease in chronic lymphocytic leukemia.

Future Oncol 2018 Mar 21;14(6):499-513. Epub 2018 Feb 21.

Department I of Internal Medicine & Center of Integrated Oncology Cologne-Bonn, German CLL Study Group, University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.2217/fon-2017-0442DOI Listing
March 2018

Thrombopoietin mimetics for patients with myelodysplastic syndromes.

Cochrane Database Syst Rev 2017 09 30;9:CD009883. Epub 2017 Sep 30.

Department I of Internal Medicine, University Hospital of Cologne, Kerpener Str. 62, Cologne, Germany, 50924.

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http://dx.doi.org/10.1002/14651858.CD009883.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483680PMC
September 2017

In memoriam David Grimwade (1962-2016).

Eur J Haematol 2017 Jan;98(1)

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http://dx.doi.org/10.1111/ejh.12824DOI Listing
January 2017

The CLL12 trial protocol: a placebo-controlled double-blind Phase III study of ibrutinib in the treatment of early-stage chronic lymphocytic leukemia patients with risk of early disease progression.

Future Oncol 2015 ;11(13):1895-903

Department I of Internal Medicine, Center of Integrated Oncology (CIO), & CECAD - Cluster of Excellence 'Cellular Stress Responses in Aging-Associated Diseases,' University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.2217/fon.15.95DOI Listing
April 2016

Angiopoietins Modulate Survival, Migration, and the Components of the Ang-Tie2 Pathway of Chronic Lymphocytic Leukaemia (CLL) Cells In Vitro.

Cancer Microenviron 2016 Apr 5;9(1):13-26. Epub 2016 Feb 5.

Department I of Internal Medicine, University at Cologne, Kerpener Strasse 62, Cologne, Germany.

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http://dx.doi.org/10.1007/s12307-016-0180-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842182PMC
April 2016

Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing.

PLoS One 2015 8;10(6):e0129544. Epub 2015 Jun 8.

Institute of Pathology, University Hospital Cologne, Cologne, Germany; Center for Integrated Oncology (CIO) Cologne-Bonn, University Hospital Cologne, Cologne, Germany; Center of Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0129544PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459702PMC
March 2016

Granulocyte and granulocyte-macrophage colony stimulating factors for newly diagnosed patients with myelodysplastic syndromes.

Cochrane Database Syst Rev 2016 Feb 16;2:CD009310. Epub 2016 Feb 16.

Cochrane Haematological Malignancies Group, Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/14651858.CD009310.pub2DOI Listing
February 2016

Long-term remissions after FCR chemoimmunotherapy in previously untreated patients with CLL: updated results of the CLL8 trial.

Blood 2016 Jan 20;127(2):208-15. Epub 2015 Oct 20.

Department I for Internal Medicine and Center of Integrated Oncology, University of Cologne, Cologne, Germany; Cluster of Excellence Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2015-06-651125DOI Listing
January 2016

Angiogenic factors in chronic lymphocytic leukaemia (CLL): Where do we stand?

Crit Rev Oncol Hematol 2015 Mar 12;93(3):225-36. Epub 2014 Oct 12.

Department I of Internal Medicine, University of Cologne, Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2014.10.007DOI Listing
March 2015

Trichostatin A effectively induces apoptosis in chronic lymphocytic leukemia cells via inhibition of Wnt signaling and histone deacetylation.

J Cancer Res Clin Oncol 2014 Aug 4;140(8):1283-93. Epub 2014 May 4.

Department I of Internal Medicine, University at Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.

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http://dx.doi.org/10.1007/s00432-014-1689-0DOI Listing
August 2014

Rapid remineralization of multiple disseminated bone lesions after high-dose cytarabine in a patient with isolated myeloid sarcoma.

Eur J Haematol 2014 Jun 25;92(6):537-40. Epub 2014 Jan 25.

Department II of Internal Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/ejh.12254DOI Listing
June 2014

Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions.

N Engl J Med 2014 Mar 8;370(12):1101-10. Epub 2014 Jan 8.

From the German CLL Study Group, Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne (V.G., K.F., A.E., B.E., C.M.W., K.-A.K., M.H.), the Department for Geriatric Medicine and Research, St. Marien Hospital and University of Cologne, Cologne (V.G.), Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich (R.B.), Klinikum Schwabing, Munich (C.M.W.), private oncology practice, Dresden (T.I.), Medical Department II, University of Schleswig-Holstein, City Hospital Kiel, Kiel (M.R., M.K.), the Department of Internal Medicine III, Ulm University, Ulm (S.S., H.D.), and Cluster of Excellence "Cellular Stress Responses in Aging-Associated Diseases" (CECAD), University of Cologne, Cologne (M.H.) - all in Germany; Penza Regional Oncology Dispensary, Penza (T.C.), and Regional Clinical Hospital N.A. Semashko, Nizhny Novgorod (O.S.) - both in Russia; Servicio De Hematologia, Hospital Universitario 12 De Octubre, Madrid (J.S.); Hôpital Haut Lévêque, Bordeaux, Pessac, France (M.-S.D.); the Department of Haematology, Monash Medical Centre, Clayton, Australia (S.O.); University of Calgary, Calgary, AB, Canada (C.J.O.); the Department of Immunology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands (A.W.L.); F. Hoffmann-La Roche, Basel, Switzerland (E.A.); F. Hoffmann-La Roche, Welwyn, United Kingdom (K.H.); and Genentech, South San Francisco, CA (M.W.).

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http://dx.doi.org/10.1056/NEJMoa1313984DOI Listing
March 2014

Targeting the vascular endothelial growth factor in hematologic malignancies.

Eur J Haematol 2012 Nov 20;89(5):373-84. Epub 2012 Sep 20.

Department I of Internal Medicine I, University at Cologne, Germany.

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http://dx.doi.org/10.1111/ejh.12009DOI Listing
November 2012

Patient-specific analysis of FLT3 internal tandem duplications for the prognostication and monitoring of acute myeloid leukemia.

Eur J Haematol 2012 Jul 9;89(1):53-62. Epub 2012 May 9.

Department I of Internal Medicine, University at Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/j.1600-0609.2012.01785.xDOI Listing
July 2012

Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL).

Leuk Res 2011 Oct 30;35(10):1360-6. Epub 2011 Apr 30.

Department I of Internal Medicine, Center for Integrated Oncology Köln Bonn, University at Cologne, Kerpener Strasse 62, 50937 Cologne, Germany.

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http://dx.doi.org/10.1016/j.leukres.2011.04.006DOI Listing
October 2011

Flow cytometry and polymerase chain reaction-based analyses of minimal residual disease in chronic lymphocytic leukemia.

Adv Hematol 2010 20;2010. Epub 2010 Sep 20.

Department I of Internal Medicine, University at Cologne, Kerpener Straße 62, 50937 Cologne, Germany.

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http://dx.doi.org/10.1155/2010/272517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945647PMC
July 2011

Physiological inhibitors of Wnt signaling.

Eur J Haematol 2011 Jun;86(6):453-65

Department I of Internal Medicine I, University at Cologne, Germany.

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http://dx.doi.org/10.1111/j.1600-0609.2011.01592.xDOI Listing
June 2011

CD44 in hematological neoplasias.

Ann Hematol 2011 May 22;90(5):493-508. Epub 2011 Jan 22.

Department I of Internal Medicine, University at Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.

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http://link.springer.com/10.1007/s00277-011-1161-z
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http://dx.doi.org/10.1007/s00277-011-1161-zDOI Listing
May 2011

Nitric oxide-donating acetylsalicylic acid induces apoptosis in chronic lymphocytic leukemia cells and shows strong antitumor efficacy in vivo.

Clin Cancer Res 2011 Jan 19;17(2):286-93. Epub 2010 Nov 19.

Department I of Internal Medicine, Center for Integrated Oncology, University at Cologne, Cologne, Germany.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-10-1030DOI Listing
January 2011

Evidence for non-functional Dickkopf-1 (DKK-1) signaling in chronic lymphocytic leukemia (CLL).

Eur J Haematol 2010 Oct 30;85(4):309-13. Epub 2010 Aug 30.

Department I of Internal Medicine I, University at Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/j.1600-0609.2010.01494.xDOI Listing
October 2010

Meta-analysis on hypomethylating agents in myelodysplastic syndromes.

Haematologica 2010 Feb 16;95(2):342-3; author reply 343-4. Epub 2009 Dec 16.

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http://dx.doi.org/10.3324/haematol.2009.019216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817043PMC
February 2010

Targeting the WNT/beta-catenin/TCF/LEF1 axis in solid and haematological cancers: Multiplicity of therapeutic options.

Eur J Cancer 2009 Nov 2;45(16):2759-67. Epub 2009 Sep 2.

Department I of Internal Medicine, University at Cologne, Kerpener Strasse 62, Cologne 50937, Germany.

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http://dx.doi.org/10.1016/j.ejca.2009.08.003DOI Listing
November 2009

High diagnostic value of morphologic examination and molecular analysis of bone marrow biopsies in a case of BCR-ABL+ CML with clusters of blasts.

Int J Hematol 2009 Apr 20;89(3):294-297. Epub 2009 Feb 20.

Institute of Pathology, University Hospital of Cologne, 50924, Cologne, Germany.

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http://dx.doi.org/10.1007/s12185-009-0257-xDOI Listing
April 2009

[Hematology 2008].

Dtsch Med Wochenschr 2008 Jun;133(25-26):1400-4

Klinik I für Innere Medizin, Universitätsklinikum, Joseph-Stelzmann Str. 9, 50924 Köln.

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http://dx.doi.org/10.1055/s-2008-1081088DOI Listing
June 2008

Cytomorphologic signs of severe pernicious anemia obscured in a patient with heterozygous hemoglobin Stanleyville II.

Eur J Haematol 2007 Oct 3;79(4):360-2. Epub 2007 Aug 3.

Department I of Internal Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/j.1600-0609.2007.00918.xDOI Listing
October 2007

Discovery of herpesviruses in multi-infected primates using locked nucleic acids (LNA) and a bigenic PCR approach.

Virol J 2007 Sep 6;4:84. Epub 2007 Sep 6.

P14 Molekulare Genetik und Epidemiologie von Herpesviren, Robert Koch-Institut, Nordufer 20, 13353 Berlin, Germany.

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http://dx.doi.org/10.1186/1743-422X-4-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014757PMC
September 2007

Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor.

Blood Cells Mol Dis 2005 Mar-Apr;34(2):181-5

Medizinische Klinik für Hämatologie und Onkologie, Campus Virchow, Charité, Humboldt Universität, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1016/j.bcmd.2004.11.006DOI Listing
September 2005

Assessment of chemosensitivity by monitoring bcl-2 transcript kinetics in acute myeloid leukemias.

Hematol Oncol 2005 Jun;23(2):68-72

Department of Pathology, Medical College, Jinan University, Guangzhou, Guangdong 510632, China.

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http://dx.doi.org/10.1002/hon.746DOI Listing
June 2005

Quantitative RT-PCR of Wilms tumor gene transcripts (WT1) for the molecular monitoring of patients with accelerated phase bcr/abl + CML.

Leuk Res 2005 Mar;29(3):343-5

Medizinische Klinik m.S. Hämatologie und Onkologie, Campus Virchow-Klinikum, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1016/j.leukres.2004.08.003DOI Listing
March 2005

Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588.

Cancer Chemother Pharmacol 2004 Apr 5;53(4):313-23. Epub 2003 Dec 5.

Medizinische Klinik für Hämatologie und Onkologie, Campus Virchow, Charité, Humboldt Universität Berlin, Germany.

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http://dx.doi.org/10.1007/s00280-003-0741-6DOI Listing
April 2004

Filgrastim-induced stem cell mobilization in chronic myeloid leukaemia patients during imatinib therapy: safety, feasibility and evidence for an efficient in vivo purging.

Br J Haematol 2004 Jan;124(2):195-9

Medizinische Klinik m.S. Hämatologie und Onkologie, Campus Virchow-Klinikum, Universitätsklinikum Charité, Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1046/j.1365-2141.2003.04756.xDOI Listing
January 2004

Quantitation of cytomegalovirus (hCMV) DNA and beta-actin DNA by duplex real-time fluorescence PCR in solid organ (liver) transplant recipients.

Med Microbiol Immunol 2003 Nov 30;192(4):197-204. Epub 2003 Jan 30.

Department of Medicine, Division of Hematology and Oncology, Charité Campus Virchow-Klinikum, Humboldt University Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://link.springer.com/10.1007/s00430-002-0166-6
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http://dx.doi.org/10.1007/s00430-002-0166-6DOI Listing
November 2003

Squamous cutaneous epithelial cell carcinoma in two CML patients with progressive disease under imatinib treatment.

Eur J Haematol 2003 Apr;70(4):231-4

Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Campus Virchow, Charité, Humboldt Universität Berlin, Germany.

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http://dx.doi.org/10.1034/j.1600-0609.2003.00044.xDOI Listing
April 2003

Imatinib-induced acute generalized exanthematous pustulosis (AGEP) in two patients with chronic myeloid leukemia.

Eur J Haematol 2002 Oct;69(4):254-6

Medizinische Klinik m. S. Hämatologie und Onkologie, Universitätsklinikum Charité, Campus Virchow-Klinikum, Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1034/j.1600-0609.2002.02830.xDOI Listing
October 2002

Kinetics of stem cell engraftment and clearance of leukaemia cells after allogeneic stem cell transplantation with reduced intensity conditioning in chronic myeloid leukaemia.

Eur J Haematol 2002 Jul;69(1):7-10

Medizinische Klinik und Poliklinik m. S Hämatologie und Onkologie, Universitätsklinikum Charité, Campus Virchow, Klinikum, Humboldt Universität zu Berlin, Germany.

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http://dx.doi.org/10.1034/j.1600-0609.2002.01761.xDOI Listing
July 2002

Quantitation of the spliced late gene of human cytomegalovirus and its kinetics during experimental infection.

Med Microbiol Immunol 2002 Mar;190(4):161-5

Department of Medicine, Humboldt University Berlin, Germany.

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http://dx.doi.org/10.1007/s004300100094DOI Listing
March 2002