Karl Zech

Karl Zech

UNVERIFIED PROFILE

Are you Karl Zech?   Register this Author

Register author
Karl Zech

Karl Zech

Publications by authors named "Karl Zech"

Are you Karl Zech?   Register this Author

24Publications

393Reads

12Profile Views

Sensitive quantification of roflumilast and roflumilast N-oxide in human plasma by LC-MS/MS employing parallel chromatography and electrospray ionisation.

J Chromatogr B Analyt Technol Biomed Life Sci 2012 Apr 3;893-894:82-91. Epub 2012 Mar 3.

Department of Bioanalytics, Nycomed GmbH, Byk-Gulden Strasse 2, 78467 Konstanz, Germany.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S157002321200128
Publisher Site
http://dx.doi.org/10.1016/j.jchromb.2012.02.038DOI Listing
April 2012

A novel screening strategy to identify ABCB1 substrates and inhibitors.

Naunyn Schmiedebergs Arch Pharmacol 2009 Jan 29;379(1):11-26. Epub 2008 Aug 29.

Division of Drug Metabolism and Pharmacokinetics, Altana Pharma AG, Konstanz, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s00210-008-0345
Web Search
http://link.springer.com/10.1007/s00210-008-0345-0
Publisher Site
http://dx.doi.org/10.1007/s00210-008-0345-0DOI Listing
January 2009

Effect of single and repeated doses of ketoconazole on the pharmacokinetics of roflumilast and roflumilast N-oxide.

J Clin Pharmacol 2008 Nov 29;48(11):1339-49. Epub 2008 Aug 29.

Nycomed GmbH, Department of Pharmacometrics and Pharmacokinetics, Byk-Gulden-Str. 2, 78467 Konstanz, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1177/0091270008321941
Publisher Site
http://dx.doi.org/10.1177/0091270008321941DOI Listing
November 2008

Single-dose pharmacokinetics of roflumilast in children and adolescents.

J Clin Pharmacol 2008 Aug 28;48(8):978-85. Epub 2008 May 28.

Department of Pediatrics, University of Missouri-Kansas City and the Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64079, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1177/0091270008319466
Publisher Site
http://dx.doi.org/10.1177/0091270008319466DOI Listing
August 2008

Sensitive simultaneous determination of ciclesonide, ciclesonide-M1-metabolite and fluticasone propionate in human serum by HPLC-MS/MS with APPI.

J Chromatogr B Analyt Technol Biomed Life Sci 2008 Jun 16;869(1-2):84-92. Epub 2008 May 16.

Pharm-analyt Laboratory GmbH, Analytical department, Ferdinand-Pichler-Gasse 2, Baden, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2008.05.015DOI Listing
June 2008

Effect of fluvoxamine on the pharmacokinetics of roflumilast and roflumilast N-oxide.

Clin Pharmacokinet 2007 ;46(7):613-22

Exploratory Medicine, ALTANA Pharma AG, Konstanz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2165/00003088-200746070-00006DOI Listing
September 2007

The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue.

Biochem Pharmacol 2007 May 28;73(10):1657-64. Epub 2007 Jan 28.

Toxicology Unit, Clinical and Laboratory Sciences, The University of Newcastle, Newcastle upon Tyne, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2007.01.031DOI Listing
May 2007

Magnesium hydroxide/aluminium hydroxide-containing antacid does not affect the pharmacokinetics of the targeted phosphodiesterase 4 inhibitor roflumilast.

J Clin Pharmacol 2007 May 20;47(5):660-6. Epub 2007 Mar 20.

Department of Exploratory Medicine, ALTANA Pharma AG, Byk-Gulden-Str. 2, 78467 Konstanz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0091270006297920DOI Listing
May 2007

Investigation of a potential food effect on the pharmacokinetics of roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, in healthy subjects.

J Clin Pharmacol 2006 Oct;46(10):1146-53

Department of Clinical Pharmacology, ALTANA Pharma AG, Byk-Gulden-Str. 2, D-78467 Konstanz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0091270006291621DOI Listing
October 2006

In Vitro metabolism of ciclesonide in human lung and liver precision-cut tissue slices.

Biopharm Drug Dispos 2006 May;27(4):197-207

ALTANA Pharma AG, Konstanz, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/bdd.500
Publisher Site
http://dx.doi.org/10.1002/bdd.500DOI Listing
May 2006

Identification and characterization of CYP3A4*20, a novel rare CYP3A4 allele without functional activity.

Clin Pharmacol Ther 2006 Apr 28;79(4):339-49. Epub 2006 Feb 28.

Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1016/j.clpt.2005.11.015
Publisher Site
http://dx.doi.org/10.1016/j.clpt.2005.11.015DOI Listing
April 2006

Lower oropharyngeal deposition of inhaled ciclesonide via hydrofluoroalkane metered-dose inhaler compared with budesonide via chlorofluorocarbon metered-dose inhaler in healthy subjects.

Eur J Clin Pharmacol 2005 May 12;61(3):203-8. Epub 2005 Apr 12.

ALTANA Pharma AG, Byk-Gulden-Str. 2, 78467, Konstanz, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00228-005-0910-0DOI Listing
May 2005

Risk-benefit value of inhaled corticosteroids: a pharmacokinetic/pharmacodynamic perspective.

Chest 2003 Mar;123(3 Suppl):430S-1S

Aventis Pharmaceuticals, Bridgewater, NJ 08807-0800, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1378/chest.123.3_suppl.430s-aDOI Listing
March 2003