Publications by authors named "Karl Y Hostetler"

65Publications

Octadecyloxyethyl benzyl tenofovir: A novel tenofovir diester provides sustained intracellular levels of tenofovir diphosphate.

Antiviral Res 2019 11 21;171:104614. Epub 2019 Sep 21.

Department of Medicine, Division of Infectious Disease and Global Public Health, University of California San Diego, La Jolla, CA, 92093, USA.

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November 2019

Inhibition of adenovirus serotype 14 infection by octadecyloxyethyl esters of (S)-[(3-hydroxy-2-phosphonomethoxy)propyl]- nucleosides in vitro.

Antiviral Res 2018 10 7;158:122-126. Epub 2018 Aug 7.

Department of Medicine, Division of Infectious Disease, University of California, San Diego, La Jolla, CA, 92093, USA.

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October 2018

Evaluation of ODE-Bn-PMEG, an acyclic nucleoside phosphonate prodrug, as an antiviral against productive HPV infection in 3D organotypic epithelial cultures.

Antiviral Res 2018 02 26;150:164-173. Epub 2017 Dec 26.

Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294-0005, USA.

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February 2018

A novel lipid prodrug strategy for sustained delivery of hexadecyloxypropyl 9-[2-(phosphonomethoxy)ethyl]guanine (HDP-PMEG) on unwanted ocular proliferation.

Drug Deliv 2017 Nov;24(1):1703-1712

a Institute of Ocular Pharmacology , School of Ophthalmology and Optometry, Wenzhou Medical University , Wenzhou , Zhejiang , China.

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November 2017

Micelle formulation of hexadecyloxypropyl-cidofovir (HDP-CDV) as an intravitreal long-lasting delivery system.

Eur J Pharm Biopharm 2015 Jan 13;89:271-9. Epub 2014 Dec 13.

Jacobs Retina Center at Shiley Eye Center, UCSD, La Jolla, CA, USA. Electronic address:

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January 2015

Synthesis and early development of hexadecyloxypropylcidofovir: an oral antipoxvirus nucleoside phosphonate.

Authors:
Karl Y Hostetler

Viruses 2010 Oct 30;2(10):2213-25. Epub 2010 Sep 30.

Department of Medicine, Division of Infectious Disease, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0676, USA; E-Mail: ; Tel.: +1-858-552-8585; Fax +1-858-534-6133.

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October 2010

Inhibition of HIV-1 by octadecyloxyethyl esters of (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] nucleosides and evaluation of their mechanism of action.

Antimicrob Agents Chemother 2011 Nov 6;55(11):5063-72. Epub 2011 Sep 6.

Department of Medical Microbiology and Immunology, Li Ka Shing Institute of Virology, 6020 K, Katz Group Centre, University of Alberta, Edmonton, AB T6G 2E1, Canada.

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November 2011

Application of kinase bypass strategies to nucleoside antivirals.

Antiviral Res 2011 Nov 22;92(2):277-91. Epub 2011 Aug 22.

Gilead Sciences, Inc., Foster City, CA 94404, USA.

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November 2011

Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine.

Bioorg Med Chem 2011 May 23;19(9):2950-8. Epub 2011 Mar 23.

Department of Medicine, Division of Infectious Disease, University of California, San Diego, La Jolla, CA 92093-0676, USA.

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May 2011

Intraocular pharmacokinetics of a crystalline lipid prodrug, octadecyloxyethyl-cyclic-cidofovir, for cytomegalovirus retinitis.

J Ocul Pharmacol Ther 2011 Apr 25;27(2):157-62. Epub 2011 Feb 25.

Department of Ophthalmology, Jacobs Retina Center at Shiley Eye Center, University of California-San Diego, 9415 Campus Point Drive, La Jolla, CA 92093-0946, USA.

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April 2011

Solution structure of a DNA duplex containing the potent anti-poxvirus agent cidofovir.

J Am Chem Soc 2011 Feb 31;133(7):2264-74. Epub 2011 Jan 31.

Department of Biochemistry, University of Alberta, 4-19 Medical Sciences Building, Edmonton, Alberta T6G 2H7, Canada.

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February 2011

Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection.

Antimicrob Agents Chemother 2011 Jan 15;55(1):35-41. Epub 2010 Nov 15.

Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.

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January 2011

Antiproliferative effects of octadecyloxyethyl 9-[2-(phosphonomethoxy)ethyl]guanine against Me-180 human cervical cancer cells in vitro and in vivo.

Chemotherapy 2010 8;56(1):54-9. Epub 2010 Mar 8.

Department of Medicine, University of California, San Diego, La Jolla, Calif., and Veterans Medical Research Foundation, San Diego, CA 92093-0676, USA.

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July 2010