Karl Welte

Karl Welte

UNVERIFIED PROFILE

Are you Karl Welte?   Register this Author

Register author
Karl Welte

Karl Welte

Publications by authors named "Karl Welte"

Are you Karl Welte?   Register this Author

100Publications

2031Reads

6Profile Views

Ultra-Sensitive Deep Sequencing in Patients With Severe Congenital Neutropenia.

Front Immunol 2019 28;10:116. Epub 2019 Feb 28.

Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, University Hospital Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.00116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413711PMC
February 2019

Severe congenital neutropenias.

Nat Rev Dis Primers 2017 Jun 8;3:17032. Epub 2017 Jun 8.

University Children's Hospital, Department of General Pediatrics and Pediatric Hematology and Oncology, Hoppe-Seyler-Str. 1, Tübingen 72076, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrdp.2017.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821468PMC
June 2017

GM-CSF treatment is not effective in congenital neutropenia patients due to its inability to activate NAMPT signaling.

Ann Hematol 2017 Mar 14;96(3):345-353. Epub 2016 Dec 14.

Department of Hematology, Oncology and Bone Marrow Transplantation, Children's Hospital, University Hospital Tübingen, Hoppe-Seyler-Str. 1, 72076, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-016-2894-5DOI Listing
March 2017

Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1α-dependent activation of a BMP4 autoregulatory loop.

Ann N Y Acad Sci 2016 07;1375(1):38-51

Departments of Hematology, Oncology, Immunology, Rheumatology, and Pulmonology, University Hospital Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.13138DOI Listing
July 2016

Two cases of cyclic neutropenia with acquired CSF3R mutations, with 1 developing AML.

Blood 2016 05 30;127(21):2638-41. Epub 2016 Mar 30.

Department of Molecular Hematopoiesis and Severe Chronic Neutropenia International Registry, and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-12-685784DOI Listing
May 2016

Leukemogenic potency of the novel FLT3-N676K mutant.

Ann Hematol 2016 Apr 19;95(5):783-91. Epub 2016 Feb 19.

Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-016-2616-zDOI Listing
April 2016

Role of CSF3R mutations in the pathomechanism of congenital neutropenia and secondary acute myeloid leukemia.

Ann N Y Acad Sci 2016 04;1370(1):119-25

Department of Hematology, Oncology, Immunology, Rheumatology and Pulmonology, University Hospital Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.13097DOI Listing
April 2016

ELANE mutant-specific activation of different UPR pathways in congenital neutropenia.

Br J Haematol 2016 Jan 16;172(2):219-27. Epub 2015 Nov 16.

Department of Haematology, Oncology, Immunology, Rheumatology and Pulmonology, University Hospital Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.13823DOI Listing
January 2016

The diversity of mutations and clinical outcomes for ELANE-associated neutropenia.

Curr Opin Hematol 2015 Jan;22(1):3-11

aDepartment of Medicine, University of Washington, Seattle, USA bDepartment of Molecular Hematopoiesis, Kinderklinik, MedizinischeHochschule, Hannover cInternal Medicine II, University Hospital, Tübingen, Tübingen, Germany dDepartment of Medicine, University of Washington, Severe Chronic Neutropenia International Registry, Seattle ePediatric Hematology Oncology, University of Michigan, Ann Arbor fPediatric Hematology Oncology, Saint Joseph's Children's Hospital, Paterson gDepartments of Pediatrics and Cancer Biology, University of Massachusetts Medical School, Worcester hPediatric Hematology/Oncology, Fred Hutchinson Cancer Research Center, Seattle iBiostatistics Branch, National Cancer Institute at the National Institutes of Health, Division of Cancer Epidemiology & Genetics, Bethesda jDivision of Oncology, Washington University, St Louis, USA *Vahagn Makaryan and Cornelia Zeidler contributed equally to the writing of this article.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOH.0000000000000105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380169PMC
January 2015

G-CSF: filgrastim, lenograstim and biosimilars.

Authors:
Karl Welte

Expert Opin Biol Ther 2014 Jul 7;14(7):983-93. Epub 2014 Apr 7.

Medical School, Department of Molecular Hematopoiesis , Kinderklinik, Carl-Neuberg-Str. 1, Hannover 30625 , Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/14712598.2014.905537DOI Listing
July 2014

High-content cytometry and transcriptomic biomarker profiling of human B-cell activation.

J Allergy Clin Immunol 2014 Jan 5;133(1):172-80.e1-10. Epub 2013 Sep 5.

Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2013.06.047DOI Listing
January 2014

Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells.

Int J Cancer 2013 Feb 12;132(4):766-74. Epub 2012 Aug 12.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str-1, 30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.27726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562481PMC
February 2013

Defective G-CSFR signaling pathways in congenital neutropenia.

Hematol Oncol Clin North Am 2013 Feb 27;27(1):75-88, viii. Epub 2012 Nov 27.

Department of Molecular Hematopoiesis, Children's Hospital, Hannover Medical School, Carl-Neuberg Strasse 1, Hannover 30625, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hoc.2012.11.001DOI Listing
February 2013

Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells.

Biochem Biophys Res Commun 2012 Aug 21;424(3):371-7. Epub 2012 Jun 21.

Department of Pediatrics, Hematology and Oncology, Hannover Medical School, Carl Neuberg Str-1, 30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2012.06.075DOI Listing
August 2012

Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway.

Biochem Biophys Res Commun 2012 Jul 23;424(2):245-50. Epub 2012 Jun 23.

Department of Pediatrics Hematology and Oncology, Hannover Medical School, Carl Neuberg Str-1, 30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2012.06.084DOI Listing
July 2012

NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression.

Biochem Biophys Res Commun 2012 Apr 10;420(4):714-20. Epub 2012 Mar 10.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl Neuberg Str-1, 30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2012.03.017DOI Listing
April 2012

Oxaliplatin, irinotecan, and gemcitabine: a novel combination in the therapy of progressed, relapsed, or refractory tumors in children.

J Pediatr Hematol Oncol 2011 Jul;33(5):344-9

Department of Pediatrics and Adolescent Medicine, Pediatric Hematology and Oncology, Hannover Medical School Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MPH.0b013e31820994ecDOI Listing
July 2011

Cyclic and chronic neutropenia.

Cancer Treat Res 2011 ;157:97-108

Department of Medicine, University of Washington, Seattle, WA 98195, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4419-7073-2_6DOI Listing
February 2011

Digenic mutations in severe congenital neutropenia.

Haematologica 2010 Jul 10;95(7):1207-10. Epub 2010 Mar 10.

Department of Pediatric Hematology and Oncology/Molecular Hematopoiesis, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2009.017665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895047PMC
July 2010

Genetic insights into congenital neutropenia.

Clin Rev Allergy Immunol 2010 Feb;38(1):68-74

Department of Pediatric Hematology/Oncology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12016-009-8130-5DOI Listing
February 2010

Gene therapy of MPL deficiency: challenging balance between leukemia and pancytopenia.

Mol Ther 2010 Feb 20;18(2):343-52. Epub 2009 Oct 20.

Department of Experimental Hematology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2009.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839299PMC
February 2010

Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1.

Blood 2009 Oct 20;114(14):3044-51. Epub 2009 Jul 20.

Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2008-11-188755DOI Listing
October 2009

Dysregulation of myeloid-specific transcription factors in congenital neutropenia.

Ann N Y Acad Sci 2009 Sep;1176:94-100

Department of Molecular Hematopoiesis, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2009.04963.xDOI Listing
September 2009

Kinetics of the in vivo expression of glucocorticoid receptor splice variants during prednisone treatment in childhood acute lymphoblastic leukaemia.

Pediatr Blood Cancer 2009 Apr;52(4):459-63

Department of Paediatrics and Adolescent Medicine, Division of Paediatric Haematology and Oncology, University of Freiburg, Mathildenstrasse, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.21867DOI Listing
April 2009

Severe congenital neutropenia.

Hematol Oncol Clin North Am 2009 Apr;23(2):307-20

Department of Molecular Hematopoiesis, Kinderklinik, Medizinische Hochschule Hannover, Carl-Neuberg-Str.1, D-30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hoc.2009.01.013DOI Listing
April 2009

Clinical implications of ELA2-, HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia.

Br J Haematol 2009 Feb 10;144(4):459-67. Epub 2008 Dec 10.

Department of Paediatric Haematology/Oncology, Medical University Hannover, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2141.2008.07425.xDOI Listing
February 2009

NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway.

Nat Med 2009 Feb 1;15(2):151-8. Epub 2009 Feb 1.

Department of Molecular Hematopoiesis, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm.1913DOI Listing
February 2009

In vivo expansion of cells expressing acquired CSF3R mutations in patients with severe congenital neutropenia.

Blood 2009 Jan 19;113(3):668-70. Epub 2008 Nov 19.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2008-09-178087DOI Listing
January 2009

Lethal graft-versus-host disease in congenital neutropenia caused by p14 deficiency after allogeneic bone marrow transplantation from an HLA-identical sibling.

Pediatr Blood Cancer 2008 Sep;51(3):436-8

Department of Pediatric Hematology and Oncology, Hannover Medical School, OE 6780, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.21643DOI Listing
September 2008

G-CSF receptor mutations in patients with congenital neutropenia.

Curr Opin Hematol 2008 Jul;15(4):332-7

Department of Pediatric Hematology/Oncology, Medical University Hannover, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOH.0b013e328303b9f6DOI Listing
July 2008

Cytotoxic T cells reactive to an immunodominant leukemia-associated antigen can be specifically primed and expanded by combining a specific priming step with nonspecific large-scale expansion.

J Immunother 2008 Feb-Mar;31(2):121-31

Transplantationsforschungszentrum, Department of Pediatric Hematology/Oncology Medizinische Hochschule Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CJI.0b013e31815aaf24DOI Listing
June 2008

Congenital neutropenia syndromes.

Immunol Allergy Clin North Am 2008 May;28(2):259-75, vii-viii

Department of Pediatric Hematology/Oncology, Medical School Hannover, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.iac.2008.01.007DOI Listing
May 2008

Severe congenital neutropenia: new genes explain an old disease.

Curr Opin Rheumatol 2007 Nov;19(6):644-50

Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BOR.0b013e3282f05cc2DOI Listing
November 2007

DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells.

Int J Cancer 2007 Aug;121(4):706-13

Department of Medicine, Hematology and Oncology, University of Münster, Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.22634DOI Listing
August 2007

Hematopoietic growth factors for the treatment of inherited cytopenias.

Semin Hematol 2007 Jul;44(3):133-7

Department of Pediatric Hematology/Oncology, Medical School Hannover, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.seminhematol.2007.04.003DOI Listing
July 2007

LEF-1 is a decisive transcription factor in neutrophil granulopoiesis.

Ann N Y Acad Sci 2007 Jun 14;1106:143-51. Epub 2007 Mar 14.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1392.012DOI Listing
June 2007

Incidence of CSF3R mutations in severe congenital neutropenia and relevance for leukemogenesis: Results of a long-term survey.

Blood 2007 Jan 19;109(1):93-9. Epub 2006 Sep 19.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2006-02-004275DOI Listing
January 2007

Severe congenital neutropenia: inheritance and pathophysiology.

Curr Opin Hematol 2007 Jan;14(1):22-8

Department of Pediatric Hematology/Oncology, Medical University Hannover, Hannover, Germany.

View Article

Download full-text PDF

Source
January 2007

G-CSF mobilised granulocyte transfusions in 32 paediatric patients with neutropenic sepsis.

Support Care Cancer 2006 Sep 19;14(9):910-6. Epub 2006 Apr 19.

Department of Paediatric Haematology and Oncology, OE 6780 Medizinische Hochschule Hannover, Hannover, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00520-006-0041-x
Publisher Site
http://dx.doi.org/10.1007/s00520-006-0041-xDOI Listing
September 2006

Secondary prophylaxis of invasive fungal infections with combination antifungal therapy and G-CSF-mobilized granulocyte transfusions in three children with hematological malignancies.

Support Care Cancer 2006 Jul 16;14(7):783-6. Epub 2006 Feb 16.

Department of Paediatric Haematology and Oncology, Medizinische Hochschule Hannover, OE 6780, Carl-Neuberg Str. 1, D-30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00520-005-0910-8DOI Listing
July 2006

Mutations in neutrophil elastase causing congenital neutropenia lead to cytoplasmic protein accumulation and induction of the unfolded protein response.

Blood 2006 Jul 21;108(2):493-500. Epub 2006 Mar 21.

Institute of Cell and Molecular Pathology, the Institute of Virology, the Department of Pediatric Hematology and Oncology, Hannover Medical School, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2005-11-4689DOI Listing
July 2006

Severe congenital neutropenia.

Semin Hematol 2006 Jul;43(3):189-95

Department of Pediatric Hematology/Oncology, Medical School Hannover, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.seminhematol.2006.04.004DOI Listing
July 2006

MTHFR 677 (C-->T) polymorphism is not relevant for prognosis or therapy-associated toxicity in pediatric NHL: results from 484 patients of multicenter trial NHL-BFM 95.

Ann Hematol 2006 May 7;85(5):291-300. Epub 2006 Feb 7.

Department of Pediatric Hematology and Oncology, Hannover Medical School, Carl-Neuberg-Str 1, D-30625, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-005-0072-2DOI Listing
May 2006

MPL mutations in 23 patients suffering from congenital amegakaryocytic thrombocytopenia: the type of mutation predicts the course of the disease.

Hum Mutat 2006 Mar;27(3):296

Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.9415DOI Listing
March 2006

Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.

Blood 2006 Feb 29;107(3):1133-40. Epub 2005 Sep 29.

Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule Hannover (MHH), Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2005-05-1771DOI Listing
February 2006

Congenital amegakaryocytic thrombocytopenia: a retrospective clinical analysis of 20 patients.

Br J Haematol 2005 Dec;131(5):636-44

Department of Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2141.2005.05819.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2141.2005.05819.xDOI Listing
December 2005

Multiple spleen and liver abscesses due to Yersinia enterocolitica septicemia in a child with congenital sideroblastic anemia.

J Pediatr Hematol Oncol 2005 Nov;27(11):624-6

Medizinische Hochschule Hannover, Department of Paediatric Haematology and Oncology, Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.mph.0000188630.03392.12DOI Listing
November 2005

Thrombopoietin regulates differentiation of rhesus monkey embryonic stem cells to hematopoietic cells.

Ann N Y Acad Sci 2005 Jun;1044:29-40

Hannover Medical School, Department of Pediatric Hematology and Oncology, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1349.005DOI Listing
June 2005

The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function.

Immunity 2005 Jun;22(6):717-28

Department of Pediatric Hematology/Oncology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2005.04.007DOI Listing
June 2005

Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells.

Oncogene 2005 Apr;24(16):2739-44

Department of Medicine, Hematology/Oncology, University of Münster, Domagkstr. 3, 48149 Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1208356DOI Listing
April 2005

GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia.

Int J Hematol 2005 Jan;81(1):39-44

Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

Source
January 2005