Karl S Lang

Karl S Lang

UNVERIFIED PROFILE

Are you Karl S Lang?   Register this Author

Register author
Karl S Lang

Karl S Lang

Publications by authors named "Karl S Lang"

Are you Karl S Lang?   Register this Author

97Publications

2889Reads

11Profile Views

Map3k14 as a Regulator of Innate and Adaptive Immune Response during Acute Viral Infection.

Pathogens 2020 Feb 4;9(2). Epub 2020 Feb 4.

Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstraße 55, 45147 Essen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pathogens9020096DOI Listing
February 2020

A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.

J Hepatol 2020 Jan 15. Epub 2020 Jan 15.

Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Virology, Technical University of Munich and Helmholtz Zentrum München, Schneckenburgerstrasse 8, 81675 Munich, Germany; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2019.12.019DOI Listing
January 2020

Reply.

Hepatology 2019 Sep;70(3):1074-1075

Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.30600DOI Listing
September 2019

The uric acid crystal receptor Clec12A potentiates type I interferon responses.

Proc Natl Acad Sci U S A 2019 Sep 26;116(37):18544-18549. Epub 2019 Aug 26.

Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1821351116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744871PMC
September 2019

Stand by me(mory): Chronic infection diminishes memory pool via IL-6/STAT1.

J Exp Med 2019 03 19;216(3):474-475. Epub 2019 Feb 19.

Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Essen, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20190066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400542PMC
March 2019

TLR7 Controls VSV Replication in CD169 SCS Macrophages and Associated Viral Neuroinvasion.

Front Immunol 2019 15;10:466. Epub 2019 Mar 15.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture Between the Medical School Hannover and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.00466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428728PMC
March 2019

Interferon in the CNS.

Neurosignals 2019 ;27(S1):44-53

Institute of Immunology, University of Duisburg-Essen, Essen, Germany,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.33594/000000197DOI Listing
January 2019

USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.

J Virol 2018 10 26;92(20). Epub 2018 Sep 26.

Clinic of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00592-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158439PMC
October 2018

Sphingolipids in early viral replication and innate immune activation.

Biol Chem 2018 09;399(10):1115-1123

Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, D-45147 Essen, Germany.

View Article

Download full-text PDF

Source
http://www.degruyter.com/view/j/bchm.2018.399.issue-10/hsz-2
Publisher Site
http://dx.doi.org/10.1515/hsz-2018-0181DOI Listing
September 2018

Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice.

Hepatology 2018 07 14;68(1):200-214. Epub 2018 May 14.

Institute of Experimental Immunology and Hepatology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.29812DOI Listing
July 2018

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.

J Immunol 2017 12 6;199(12):4056-4065. Epub 2017 Nov 6.

The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, Ontario M5G 2M9, Canada;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1600396DOI Listing
December 2017

IRF9 Prevents CD8 T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection.

J Virol 2017 11 27;91(22). Epub 2017 Oct 27.

School of Life and Environmental Sciences, the Marie Bashir Institute for Infectious Diseases and Biosecurity, the Charles Perkins Centre, and the Bosch Institute, The University of Sydney, Sydney, Australia

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01219-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660491PMC
November 2017

Lymphocytes Negatively Regulate NK Cell Activity via Qa-1b following Viral Infection.

Cell Rep 2017 Nov;21(9):2528-2540

Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247173160
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2017.11.001DOI Listing
November 2017

SGLT1 Deficiency Turns Listeria Infection into a Lethal Disease in Mice.

Cell Physiol Biochem 2017 14;42(4):1358-1365. Epub 2017 Jul 14.

Institute of Immunology, University of Duisburg-Essen, Essen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000479197DOI Listing
October 2017

Induction of the type I interferon response in neurological forms of Gaucher disease.

J Neuroinflammation 2016 05 12;13(1):104. Epub 2016 May 12.

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12974-016-0570-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866012PMC
May 2016

Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes.

Cell Physiol Biochem 2016 5;39(3):1209-28. Epub 2016 Sep 5.

Department of Cardiology, Vascular Medicine and Physiology, University of Tuebingen, Tuebigen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000447827DOI Listing
February 2017

Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes.

Cell Physiol Biochem 2016 5;39(3):1209-28. Epub 2016 Sep 5.

Department of Cardiology, Vascular Medicine and Physiology, University of Tuebingen, Tuebigen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000447827DOI Listing
February 2017

Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8 T Cells.

Front Immunol 2017 10;8:113. Epub 2017 Feb 10.

Medical Faculty, Institute of Immunology, University of Duisburg-Essen, Essen, Germany; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2017.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301005PMC
February 2017

Alkaline Cytosolic pH and High Sodium Hydrogen Exchanger 1 (NHE1) Activity in Th9 Cells.

J Biol Chem 2016 Nov 14;291(45):23662-23671. Epub 2016 Sep 14.

From the Departments of Cardiology, Cardiovascular Medicine and Physiology, Eberhard-Karls-Tübingen University, Tübingen, Gmelinstraße5, D-72076 Tübingen, Germany,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.730259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095419PMC
November 2016

Multiple functions of USP18.

Cell Death Dis 2016 11 3;7(11):e2444. Epub 2016 Nov 3.

Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cddis.2016.326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260889PMC
November 2016

Induction of the type I interferon response in neurological forms of Gaucher disease.

J Neuroinflammation 2016 05 12;13(1):104. Epub 2016 May 12.

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, 76100, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12974-016-0570-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866012PMC
May 2016

Two separate mechanisms of enforced viral replication balance innate and adaptive immune activation.

J Autoimmun 2016 Feb 7;67:82-89. Epub 2015 Nov 7.

Institute of Immunology, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany; Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2015.10.004DOI Listing
February 2016

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.

Sci Signal 2015 Nov 3;8(401):ra109. Epub 2015 Nov 3.

Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, University Hospital, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany. Department of Molecular Medicine II, Medical Faculty, Heinrich Heine University Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.aac5356DOI Listing
November 2015

IFN-γ licenses CD11b(+) cells to induce progression of systemic lupus erythematosus.

J Autoimmun 2015 Aug 19;62:11-21. Epub 2015 Jun 19.

Institute of Immunology, Medical Faculty, University Duisburg-Essen, Essen, Germany; Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaut.2015.05.007DOI Listing
August 2015

Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection.

J Virol 2015 May 11;89(9):4748-59. Epub 2015 Feb 11.

Campell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, Ontario, Canada Department of Gastroenterology, Hepatology and Infectious Diseases, University of Düsseldorf, Düsseldorf, Germany Department of Molecular Medicine II, Düsseldorf, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02976-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403498PMC
May 2015

Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR.

J Immunol 2015 May;194(9):4055-7

Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1500222DOI Listing
May 2015

TLR ligand induced IL-6 counter-regulates the anti-viral CD8(+) T cell response during an acute retrovirus infection.

Sci Rep 2015 May 21;5:10501. Epub 2015 May 21.

1] Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany [2] Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep10501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440206PMC
May 2015

T-cell STAT3 is required for the maintenance of humoral immunity to LCMV.

Eur J Immunol 2015 Feb 15;45(2):418-27. Epub 2014 Dec 15.

Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201445060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383653PMC
February 2015

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production.

Nat Commun 2015 Feb 18;6:6217. Epub 2015 Feb 18.

1] Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstrasse 55, Essen 45147, Germany [2] Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Moorenstrasse 5, Düsseldorf 40225, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms7217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346637PMC
February 2015

Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.

Cancer Res 2014 Sep 3;74(17):4772-82. Epub 2014 Jul 3.

Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-0130DOI Listing
September 2014

Activated CD8+ T cells induce expansion of Vβ5+ regulatory T cells via TNFR2 signaling.

J Immunol 2014 Sep 6;193(6):2952-60. Epub 2014 Aug 6.

Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen 45147, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1400649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157120PMC
September 2014

Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.

Immunity 2014 Jun 5;40(6):949-60. Epub 2014 Jun 5.

Department of Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2014.05.004DOI Listing
June 2014

Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells.

Proc Natl Acad Sci U S A 2014 Jan 7;111(3):1060-5. Epub 2014 Jan 7.

The Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1323166111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903229PMC
January 2014

Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes.

PLoS Pathog 2013 Oct 24;9(10):e1003650. Epub 2013 Oct 24.

Institute of Immunology, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany ; Department of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1003650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812017PMC
October 2013

Natural killer cells regulate diverse T cell responses.

Trends Immunol 2013 Jul 17;34(7):342-9. Epub 2013 Apr 17.

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.it.2013.03.002DOI Listing
July 2013

Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection.

PLoS Pathog 2012 9;8(8):e1002868. Epub 2012 Aug 9.

Institute for Virology of the University Hospital in Essen, University of Duisburg-Essen, Essen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1002868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415439PMC
December 2012

The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation.

J Immunol 2012 Sep 18;189(5):2138-50. Epub 2012 Jul 18.

Department of Immunology, University of Toronto, Toronto, Ontario M5S 148, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1103184DOI Listing
September 2012

Tunicamycin inhibits diabetes.

Cell Physiol Biochem 2012 3;29(3-4):595-602. Epub 2012 Apr 3.

Department of Gastroenterology, Hepatology and Infectious diseases, University of Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000338513DOI Listing
August 2012

Genes determining the course of virus persistence in the liver: lessons from murine infection with lymphocytic choriomeningitis virus.

Cell Physiol Biochem 2010 24;26(3):263-72. Epub 2010 Aug 24.

Ontario Cancer Institute, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/320549
Publisher Site
http://dx.doi.org/10.1159/000320549DOI Listing
December 2010

Host mechanisms in viral hepatitis.

Authors:
Karl S Lang

Dig Dis 2010 7;28(1):25-30. Epub 2010 May 7.

Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Düsseldorf, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000282061DOI Listing
September 2010

Oxidized ATP inhibits T-cell-mediated autoimmunity.

Eur J Immunol 2010 Sep;40(9):2401-8

Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, UHN, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200939838DOI Listing
September 2010

Long-lasting immunity by early infection of maternal-antibody-protected infants.

Eur J Immunol 2010 Jan;40(1):113-6

Institute for Experimental Immunology, University Hospital Zürich, Zürich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200939371DOI Listing
January 2010

Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections.

Proc Natl Acad Sci U S A 2009 Apr 7;106(17):7107-12. Epub 2009 Apr 7.

Institute for Experimental Immunology and Department of Pathology, University Hospital Zürich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0901162106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678456PMC
April 2009

TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens.

Eur J Immunol 2009 Jan;39(1):126-35

Medical Research Unit on Immunochemistry, Specialties Hospital of the National Medical Centre Siglo XXI, Mexican Institute for Social Security, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200838185DOI Listing
January 2009

TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens.

Eur J Immunol 2009 Jan;39(1):126-35

Medical Research Unit on Immunochemistry, Specialties Hospital of the National Medical Centre Siglo XXI, Mexican Institute for Social Security, Mexico City, Mexico.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.200838185DOI Listing
January 2009

Erythrocyte ion channels in regulation of apoptosis.

Adv Exp Med Biol 2004 ;559:211-7

Department of Physiology,Eberhard-Karls-University of Tuebingen, Gmelinstrasse 5, D-72076 Tuebingen, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007%2F0-387-23752-6
Web Search
http://dx.doi.org/10.1007/0-387-23752-6_20DOI Listing
September 2008

Antigen kinetics determines immune reactivity.

Proc Natl Acad Sci U S A 2008 Apr 24;105(13):5189-94. Epub 2008 Mar 24.

Unit Experimental Immunotherapy, Department of Dermatology, University Hospital Zurich, Gloriastrasse 31, CH-8091 Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0706296105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278203PMC
April 2008