Publications by authors named "Karl Rickels"

70Publications

Benzodiazepines, antidepressants and addiction: A plea for conceptual rigor and consistency.

J Psychopharmacol 2019 11 26;33(11):1467-1470. Epub 2019 Sep 26.

Department of Immunology, Tufts University, Boston, MA, USA.

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http://dx.doi.org/10.1177/0269881119878171DOI Listing
November 2019

The Course of Adverse Events in Venlafaxine XR Treatment in Generalized Anxiety Disorder.

J Clin Psychopharmacol 2019 May/Jun;39(3):258-260

Department of General Studies, Harcum College, Media, PA.

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http://dx.doi.org/10.1097/JCP.0000000000001027DOI Listing
August 2019

Benzodiazepines in anxiety disorders: Reassessment of usefulness and safety.

World J Biol Psychiatry 2019 09 25;20(7):514-518. Epub 2018 Sep 25.

Professor of Psychiatry and former Chair, Department of Psychiatry of the Ludwig Maximilian University, Munich, Germany.

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http://dx.doi.org/10.1080/15622975.2018.1500031DOI Listing
September 2019

The Prescription of Benzodiazepines for Panic Disorder: Time for an Evidence-Based Educational Approach.

J Clin Psychopharmacol 2018 Aug;38(4):283-285

Clinical Pharmacology and Toxicology Program, McGill University and Researcher Emeritus, Mental Health Institute of Montreal Fernand Seguin Research Centre, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1097/JCP.0000000000000908DOI Listing
August 2018

Benzodiazepines as a Monotherapy in Depressive Disorders: A Systematic Review.

Psychother Psychosom 2018 21;87(2):65-74. Epub 2018 Feb 21.

Department of Psychology, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1159/000486696DOI Listing
October 2018

The Clinical Inadequacy of the Placebo Model and the Development of an Alternative Conceptual Framework.

Psychother Psychosom 2017 3;86(6):332-340. Epub 2017 Nov 3.

Department of Psychology, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1159/000480038DOI Listing
September 2018

Antidepressant Trials: Are the Diminishing Effect Sizes of Efficacy Trials Avoidable?

J Clin Psychopharmacol 2017 Dec;37(6):648-650

From the *Stuart and Emily Mudd Professor of Human Behavior and Professor of Psychiatry, University of Pennsylvania, Philadelphia, PA; and †Worldwide Drug Development, Shelburne, VT.

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http://dx.doi.org/10.1097/JCP.0000000000000796DOI Listing
December 2017

Genome-wide association study of treatment response to venlafaxine XR in generalized anxiety disorder.

Psychiatry Res 2017 08 14;254:8-11. Epub 2017 Apr 14.

Section on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States; Department of Psychiatry, Mood and Anxiety Disorders Treatment and Research Program, University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.psychres.2017.04.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798606PMC
August 2017

The Items Predicting Non-Remission after 6 Months of Treatment of Patients with Generalized Anxiety Disorder Covered the Eysenck Neuroticism Components of Anxiety, Interpersonal Sensitivity and Depression.

Psychother Psychosom 2016;85(4):229-30. Epub 2016 May 27.

Psychiatric Research Unit, Psychiatric Centre North Zealand, University of Copenhagen, Hillerx00F8;d, Denmark.

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http://dx.doi.org/10.1159/000444454DOI Listing
March 2017

Metabolic Impairments Precede Changes in Hunger and Food Intake Following Short-Term Administration of Second-Generation Antipsychotics.

J Clin Psychopharmacol 2015 Oct;35(5):579-82

From *Monell Chemical Senses Center and †Department of Psychiatry, Mood and Anxiety Disorders Treatment and Research Program and ‡Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1097/JCP.0000000000000393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553098PMC
October 2015

Pharmacological treatment for generalized anxiety disorder in adults: an update.

Expert Opin Pharmacother 2015 ;16(11):1669-81

University of the Sciences in Philadelphia, Department of Pharmacy Practice/Pharmacy Administration , 600 South 43rd Street, Philadelphia, PA 19104-4495 , USA.

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http://dx.doi.org/10.1517/14656566.2015.1059424DOI Listing
November 2015

Need for a realistic appraisal of benzodiazepines.

World Psychiatry 2015 Jun;14(2):243-4

Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/wps.20219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471984PMC
June 2015

Benzodiazepines in Anxiety Disorders.

JAMA Psychiatry 2015 Jul;72(7):733-4

Department of Psychiatry, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamapsychiatry.2015.0182DOI Listing
July 2015

Remission of generalized anxiety disorder after 6 months of open-label treatment with venlafaxine XR.

Psychother Psychosom 2013 20;82(6):363-71. Epub 2013 Sep 20.

Mood and Anxiety Disorders Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pa., USA.

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http://dx.doi.org/10.1159/000351410DOI Listing
April 2014

Should benzodiazepines be replaced by antidepressants in the treatment of anxiety disorders? Fact or fiction?

Authors:
Karl Rickels

Psychother Psychosom 2013 20;82(6):351-2. Epub 2013 Sep 20.

Department of Psychiatry, Mood and Anxiety Disorders Treatment and Research Program, University of Pennsylvania, Philadelphia, Pa., USA.

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http://dx.doi.org/10.1159/000353502DOI Listing
April 2014

Genetic polymorphisms in the PACAP and PAC1 receptor genes and treatment response to venlafaxine XR in generalized anxiety disorder.

Psychiatry Res 2013 Dec 22;210(3):1299-300. Epub 2013 Aug 22.

Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, United States.

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http://dx.doi.org/10.1016/j.psychres.2013.07.038DOI Listing
December 2013

Association analysis between the A118G polymorphism in the OPRM1 gene and treatment response to venlafaxine XR in generalized anxiety disorder.

Hum Psychopharmacol 2013 May 8;28(3):258-62. Epub 2013 May 8.

Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/hup.2317DOI Listing
May 2013

Evidence for the use of vilazodone in the treatment of major depressive disorder.

Expert Opin Pharmacother 2012 Oct 13;13(15):2215-24. Epub 2012 Sep 13.

University of the Sciences, Philadelphia College of Pharmacy, Department of Pharmacy Practice, Administration, PA, USA.

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http://www.tandfonline.com/doi/full/10.1517/14656566.2012.72
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http://dx.doi.org/10.1517/14656566.2012.721776DOI Listing
October 2012

Variation in the catechol-O-methyltransferase (COMT) gene and treatment response to venlafaxine XR in generalized anxiety disorder.

Psychiatry Res 2012 Jun 13;198(1):112-5. Epub 2012 Mar 13.

Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.psychres.2011.12.034DOI Listing
June 2012

Adjunctive therapy with pregabalin in generalized anxiety disorder patients with partial response to SSRI or SNRI treatment.

Int Clin Psychopharmacol 2012 May;27(3):142-50

Department of Psychiatry, Mood and Anxiety Disorders Section, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1097/YIC.0b013e328350b133DOI Listing
May 2012

Short-term dynamic psychotherapy versus pharmacotherapy for major depressive disorder: a randomized, placebo-controlled trial.

J Clin Psychiatry 2012 Jan 29;73(1):66-73. Epub 2011 Nov 29.

Center for Psychotherapy Research, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA.

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http://dx.doi.org/10.4088/JCP.11m06831DOI Listing
January 2012

Clinical subtypes of premenstrual syndrome and responses to sertraline treatment.

Obstet Gynecol 2011 Dec;118(6):1293-300

Department of Obstetrics/Gynecology, the Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1097/AOG.0b013e318236edf2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222869PMC
December 2011

Pharmacological treatment of generalized anxiety disorder.

Expert Opin Pharmacother 2011 Nov 28;12(16):2457-67. Epub 2011 Sep 28.

University of the Sciences, Philadelphia College of Pharmacy, Department of Pharmacy Practice/Pharmacy Administration, PA, USA.

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http://www.tandfonline.com/doi/full/10.1517/14656566.2011.61
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http://dx.doi.org/10.1517/14656566.2011.618496DOI Listing
November 2011

Association analysis between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and treatment response to venlafaxine XR in generalized anxiety disorder.

Neurosci Lett 2011 Oct 26;503(3):200-2. Epub 2011 Aug 26.

Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, United States.

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http://dx.doi.org/10.1016/j.neulet.2011.08.035DOI Listing
October 2011

Combined medication and cognitive therapy for generalized anxiety disorder.

J Anxiety Disord 2011 Dec 27;25(8):1087-94. Epub 2011 Jul 27.

Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, United States.

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http://dx.doi.org/10.1016/j.janxdis.2011.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196054PMC
December 2011

Association analysis between the 5-HTTLPR polymorphism in the SLC6A4 gene and generalized anxiety disorder.

Psychiatr Genet 2011 Oct;21(5):267-8

Departments of Psychiatry, Psychiatric Pharmacogenetics Laboratory, University of Pennsylvania, Philadelphia, USA.

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https://insights.ovid.com/crossref?an=00041444-201110000-000
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http://dx.doi.org/10.1097/YPG.0b013e3283457b51DOI Listing
October 2011

Time to relapse after 6 and 12 months' treatment of generalized anxiety disorder with venlafaxine extended release.

Arch Gen Psychiatry 2010 Dec;67(12):1274-81

Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1001/archgenpsychiatry.2010.170DOI Listing
December 2010

Core symptoms that discriminate premenstrual syndrome.

J Womens Health (Larchmt) 2011 Jan 3;20(1):29-35. Epub 2010 Dec 3.

Department of Obstetrics/Gynecology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1089/jwh.2010.2161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3017419PMC
January 2011

A survey of patient acceptability of repetitive transcranial magnetic stimulation (TMS) during pregnancy.

J Affect Disord 2011 Mar 22;129(1-3):385-90. Epub 2010 Sep 22.

Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States.

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http://dx.doi.org/10.1016/j.jad.2010.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109278PMC
March 2011

Medication guesses in double-blind studies.

Authors:
Karl Rickels

Am J Psychiatry 2010 Sep;167(9):1128-9; author reply 1129

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http://dx.doi.org/10.1176/appi.ajp.2010.10040471DOI Listing
September 2010

Ziprasidone treatment of refractory generalized anxiety disorder: a placebo-controlled, double-blind study.

J Clin Psychopharmacol 2010 Apr;30(2):185-9

Mood and Anxiety Disorders Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1097/JCP.0b013e3181d21951DOI Listing
April 2010

Comparative efficacy of pregabalin and benzodiazepines in treating the psychic and somatic symptoms of generalized anxiety disorder.

Int J Neuropsychopharmacol 2010 Mar 9;13(2):229-41. Epub 2009 Sep 9.

Psychiatry/Mental Health Ralph H. Johnson VA Medical Center, Charleston, SC 29401-5799, USA.

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http://dx.doi.org/10.1017/S1461145709990460DOI Listing
March 2010

Comments on "Clinical trials of antidepressants: time to shift to a new model" by Dr Katz.

J Clin Psychopharmacol 2009 Apr;29(2):197-8; author reply 198-9

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http://dx.doi.org/10.1097/JCP.0b013e318199f275DOI Listing
April 2009

Time to relapse after short- or long-term treatment of severe premenstrual syndrome with sertraline.

Arch Gen Psychiatry 2009 May;66(5):537-44

Department of Obstetrics/Gynecology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104-5509, USA.

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http://dx.doi.org/10.1001/archgenpsychiatry.2008.547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830795PMC
May 2009

Assessment of anxiety and depression in primary care: value of a four-item questionnaire.

J Am Osteopath Assoc 2009 Apr;109(4):216-9

Mood and Anxiety Disorders Section, Department of PsychiatryUniversity of Pennsylvania School of Medicine, 3535 Market St, Philadelphia, PA 19104-3309, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566952PMC
April 2009

Evidence for efficacy and tolerability of vilazodone in the treatment of major depressive disorder: a randomized, double-blind, placebo-controlled trial.

J Clin Psychiatry 2009 Mar 10;70(3):326-33. Epub 2009 Mar 10.

Department of Psychiatry, Mood and Anxiety Disorders Section, University of Pennsylvania, Philadelphia, PA 19104-3309, USA.

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http://dx.doi.org/10.4088/jcp.08m04637DOI Listing
March 2009

A randomized, double-blind, and placebo-controlled trial of quetiapine augmentation of fluoxetine in major depressive disorder.

Int Clin Psychopharmacol 2008 Sep;23(5):269-75

Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10075, USA.

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https://insights.ovid.com/crossref?an=00004850-200809000-000
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http://dx.doi.org/10.1097/YIC.0b013e328301a74cDOI Listing
September 2008

Desvenlafaxine succinate for the treatment of major depressive disorder.

Expert Opin Pharmacother 2008 Aug;9(12):2129-36

University of Pennsylvania School of Medicine Mood and Anxiety Disorders Section, Department of Psychiatry, Center for Neurobiology and Behavior, Translational Research Laboratories, Philadelphia, PA 19104, USA.

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http://www.tandfonline.com/doi/full/10.1517/14656566.9.12.21
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http://dx.doi.org/10.1517/14656566.9.12.2129DOI Listing
August 2008

Physician Withdrawal Checklist (PWC-20).

J Clin Psychopharmacol 2008 Aug;28(4):447-51

Mood and Anxiety Disorders Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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https://insights.ovid.com/crossref?an=00004714-200808000-000
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http://dx.doi.org/10.1097/JCP.0b013e31817efbacDOI Listing
August 2008

Why do clinical trials fail?

J Clin Psychopharmacol 2007 Aug;27(4):420-1; author reply 421

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http://dx.doi.org/10.1097/01.jcp.0000280316.81366.23DOI Listing
August 2007

Selegiline transdermal system for the treatment of major depressive disorder: an 8-week, double-blind, placebo-controlled, flexible-dose titration trial.

J Clin Psychiatry 2006 Sep;67(9):1354-61

Department of Psychiatry, University of Colorado School of Medicine, Denver, CO, USA.

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http://dx.doi.org/10.4088/jcp.v67n0905DOI Listing
September 2006

Sertraline treatment for generalized anxiety disorder: a randomized, double-blind, placebo-controlled study.

J Clin Psychiatry 2006 Jun;67(6):874-81

Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29406, USA.

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http://dx.doi.org/10.4088/jcp.v67n0603DOI Listing
June 2006

Early response and 8-week treatment outcome in GAD.

Depress Anxiety 2006 ;23(8):461-5

Mood and Anxiety Disorders Section, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1002/da.20214DOI Listing
March 2007

Consumer advertising can be misleading.

Authors:
Karl Rickels

PLoS Med 2006 Feb 28;3(2):e119; author reply e116. Epub 2006 Feb 28.

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http://dx.doi.org/10.1371/journal.pmed.0030119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1388068PMC
February 2006

Remission of generalized anxiety disorder: a review of the paroxetine clinical trials database.

J Clin Psychiatry 2006 Jan;67(1):41-7

Mood & Anxiety Disorders Section, Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104-3309, USA.

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http://dx.doi.org/10.4088/jcp.v67n0107DOI Listing
January 2006

The selective GABA reuptake inhibitor tiagabine for the treatment of generalized anxiety disorder: results of a placebo-controlled study.

J Clin Psychiatry 2005 Nov;66(11):1401-8

Anxiety Disorders Program, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Simches Research Building, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.4088/jcp.v66n1109DOI Listing
November 2005

A double-blind, placebo-controlled study of a flexible dose of venlafaxine ER in adult outpatients with generalized social anxiety disorder.

J Clin Psychopharmacol 2004 Oct;24(5):488-96

Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA 19104-3309, USA.

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http://dx.doi.org/10.1097/01.jcp.0000138764.31106.60DOI Listing
October 2004

Paroxetine in the treatment of generalised anxiety disorder.

Expert Opin Pharmacother 2004 Aug;5(8):1799-806

Mood & Anxiety Disorders Section, Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Suite 670, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1517/14656566.5.8.1799DOI Listing
August 2004

Alprazolam extended-release in panic disorder.

Authors:
Karl Rickels

Expert Opin Pharmacother 2004 Jul;5(7):1599-611

University of Pennsylvania, Department of Psychiatry, University of Pennsylvania Medical Center, PA 19104-3309, USA.

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http://dx.doi.org/10.1517/14656566.5.7.1599DOI Listing
July 2004

Continuous or intermittent dosing with sertraline for patients with severe premenstrual syndrome or premenstrual dysphoric disorder.

Am J Psychiatry 2004 Feb;161(2):343-51

Department of Obstetrics/Gynecology, University of Pennsylvania School of Medicine, Philadelphia 19104-5509, USA.

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http://dx.doi.org/10.1176/appi.ajp.161.2.343DOI Listing
February 2004

Imipramine and buspirone in patients with panic disorder who are discontinuing long-term benzodiazepine therapy.

J Clin Psychopharmacol 2003 Oct;23(5):505-8

Mood and Anxiety Disorders Section, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104-3309, USA.

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http://pdfs.journals.lww.com/psychopharmacology/2003/10000/I
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http://dx.doi.org/10.1097/01.jcp.0000088907.24613.3fDOI Listing
October 2003

Paroxetine treatment of generalized anxiety disorder: a double-blind, placebo-controlled study.

Am J Psychiatry 2003 Apr;160(4):749-56

Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia 19104-3309, USA.

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http://dx.doi.org/10.1176/appi.ajp.160.4.749DOI Listing
April 2003

Pharmacotherapy of generalized anxiety disorder.

J Clin Psychiatry 2002 ;63 Suppl 14:9-16

Department of Psychiatry, University of Pennsylvania, Philadelphia, USA.

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February 2003

Allopregnanolone levels and symptom improvement in severe premenstrual syndrome.

J Clin Psychopharmacol 2002 Oct;22(5):516-20

Department of Obstetrics/Gynecology, University of Pennsylvania, Philadelphia 19104, USA.

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http://dx.doi.org/10.1097/00004714-200210000-00013DOI Listing
October 2002