Publications by authors named "Karl Kunzelmann"

100Publications

Assessment of Distinct Electrophysiological Parameters in Rectal Biopsies for the Choice of the Best Diagnosis/Prognosis Biomarkers for Cystic Fibrosis.

Front Physiol 2020 23;11:604580. Epub 2020 Dec 23.

BioISI - Biosystems and Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, Lisbon, Portugal.

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December 2020

Ca Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl Channels.

Front Cell Dev Biol 2020 1;8:596879. Epub 2020 Dec 1.

Physiological Institute, University of Regensburg, Regensburg, Germany.

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December 2020

Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo.

Nat Commun 2020 08 28;11(1):4320. Epub 2020 Aug 28.

Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

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August 2020

GABA, but Not Bestrophin-1, Is Localized in Astroglial Processes in the Mouse Hippocampus and the Cerebellum.

Front Mol Neurosci 2020 28;13:135. Epub 2020 Jul 28.

Section of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

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July 2020

Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A>G.

Biochim Biophys Acta Mol Basis Dis 2020 11 28;1866(11):165905. Epub 2020 Jul 28.

University of Lisboa, Faculty of Sciences, BioISI - Biosystems & Integrative Sciences Institute, Campo Grande, C8 bdg, 1749-016 Lisboa, Portugal. Electronic address:

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November 2020

Transport properties in CFTR-/- knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na absorption.

Pflugers Arch 2020 10 25;472(10):1507-1519. Epub 2020 Jul 25.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.

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October 2020

Impaired Renal HCO Excretion in Cystic Fibrosis.

J Am Soc Nephrol 2020 Aug 23;31(8):1711-1727. Epub 2020 Jul 23.

Department of Biomedicine, Physiology and Biophysics, Aarhus University, Aarhus, Denmark

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August 2020

KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway.

Cells 2020 07 2;9(7). Epub 2020 Jul 2.

BioISI-Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, 1749-016 Lisbon, Portugal.

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July 2020

Targeting of Intracellular TMEM16 Proteins to the Plasma Membrane and Activation by Purinergic Signaling.

Int J Mol Sci 2020 Jun 5;21(11). Epub 2020 Jun 5.

Institut für Physiologie, Universität Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany.

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June 2020

Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation.

Cells 2020 05 5;9(5). Epub 2020 May 5.

Physiological Institute, University of Regensburg, University Street 31, D-93053 Regensburg, Germany.

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May 2020

TMEM16A drives renal cyst growth by augmenting Ca signaling in M1 cells.

J Mol Med (Berl) 2020 05 18;98(5):659-671. Epub 2020 Mar 18.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

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May 2020

TMEM16F/Anoctamin 6 in Ferroptotic Cell Death.

Cancers (Basel) 2019 May 5;11(5). Epub 2019 May 5.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.

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May 2019

Plasma membrane-localized TMEM16 proteins are indispensable for expression of CFTR.

J Mol Med (Berl) 2019 05 26;97(5):711-722. Epub 2019 Mar 26.

Physiological Institute, University of Regensburg, University Street 31, D-93053, Regensburg, Germany.

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May 2019

Contribution of Anoctamins to Cell Survival and Cell Death.

Cancers (Basel) 2019 Mar 19;11(3). Epub 2019 Mar 19.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.

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March 2019

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

Front Pharmacol 2019 29;10. Epub 2019 Jan 29.

Institut für Physiologie, Universität Regensburg, Regensburg, Germany.

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January 2019

Lipid Peroxidation Drives Renal Cyst Growth through Activation of TMEM16A.

J Am Soc Nephrol 2019 02 3;30(2):228-242. Epub 2019 Jan 3.

Department of Physiology, University of Regensburg, Regensburg, Germany; and

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February 2019

TMEM16A is indispensable for basal mucus secretion in airways and intestine.

FASEB J 2019 03 26;33(3):4502-4512. Epub 2018 Dec 26.

Institut für Physiologie, Universität Regensburg, Regensburg, Germany.

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March 2019

Anoctamin-6 regulates ADAM sheddase function.

Biochim Biophys Acta Mol Cell Res 2018 11 23;1865(11 Pt A):1598-1610. Epub 2018 Aug 23.

Dept. of Dermatology, University of Kiel, 24105 Kiel, Germany. Electronic address:

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November 2018

HIF-1α promotes cyst progression in a mouse model of autosomal dominant polycystic kidney disease.

Kidney Int 2018 11 30;94(5):887-899. Epub 2018 Aug 30.

Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany. Electronic address:

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November 2018

Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria.

Am J Physiol Renal Physiol 2018 12 29;315(6):F1777-F1786. Epub 2018 Aug 29.

Internal Medicine D University Hospital of Muenster , Muenster Germany.

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December 2018

Regulation and Function of TMEM16F in Renal Podocytes.

Int J Mol Sci 2018 Jun 18;19(6). Epub 2018 Jun 18.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.

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June 2018

Contribution of TMEM16F to pyroptotic cell death.

Cell Death Dis 2018 02 20;9(3):300. Epub 2018 Feb 20.

Physiological institute, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.

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February 2018

Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1.

Cell Signal 2018 04 10;44:10-19. Epub 2018 Jan 10.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany. Electronic address:

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April 2018

A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic.

Biochim Biophys Acta Mol Cell Res 2018 Feb 15;1865(2):421-431. Epub 2017 Nov 15.

University of Lisboa, Faculty of Sciences, BioISI - Biosystems & Integrative Sciences Institute, Campo Grande, C8, 1749-016 Lisboa, Portugal; Cell Biology and Biophysics Unit and Advanced Light Microscopy Facility, European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, 69117 Heidelberg, Germany. Electronic address:

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February 2018

Regulation of TMEM16A/ANO1 and TMEM16F/ANO6 ion currents and phospholipid scrambling by Ca and plasma membrane lipid.

J Physiol 2018 01 18;596(2):217-229. Epub 2017 Dec 18.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.

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January 2018

Epithelial Chloride Transport by CFTR Requires TMEM16A.

Sci Rep 2017 09 29;7(1):12397. Epub 2017 Sep 29.

Physiological institute, University of Regensburg, University street 31, D-93053, Regensburg, Germany.

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September 2017

CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6).

Pflugers Arch 2018 02 5;470(2):305-314. Epub 2017 Sep 5.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

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February 2018

Bicarbonate in cystic fibrosis.

J Cyst Fibros 2017 Nov 18;16(6):653-662. Epub 2017 Jul 18.

Professor Emeritus, Department of Pediatrics, Dr. V. Hauner Childrens Hospital, Ludwig-Maximilian-University, Munich, Germany.

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November 2017

Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling.

Cell Signal 2017 01 10;30:41-49. Epub 2016 Nov 10.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany. Electronic address:

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January 2017

Expression of anoctamins in retinal pigment epithelium (RPE).

Pflugers Arch 2016 11 7;468(11-12):1921-1929. Epub 2016 Nov 7.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

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November 2016

TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report.

Arterioscler Thromb Vasc Biol 2016 11 15;36(11):2152-2157. Epub 2016 Sep 15.

From the Rudolf Virchow Center for Experimental Biomedicine (A.A.B., E.J.H., D.S., B.N.), Institute of Experimental Biomedicine (A.A.B., E.J.H., S.B., D.S., A.B., B.N.), and Department of Neurology (E.G., M.K.S., C.K.), University Hospital of Würzburg and University of Würzburg, Germany; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands (F.S., J.W.M.H.); Department of Physiology, University of Regensburg, Germany (P.W., K.K.); and Clinic for Neurology, University of Duisburg-Essen Medical Facility, Essen, Germany (C.K.).

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November 2016

P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells.

Purinergic Signal 2016 12 26;12(4):687-695. Epub 2016 Aug 26.

Department of Nephrology and Hypertension, Friedrich-Alexander University of Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Germany.

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December 2016

Ca signals, cell membrane disintegration, and activation of TMEM16F during necroptosis.

Cell Mol Life Sci 2017 01 17;74(1):173-181. Epub 2016 Aug 17.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

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January 2017

Relationship between TMEM16A/anoctamin 1 and LRRC8A.

Pflugers Arch 2016 10 12;468(10):1751-63. Epub 2016 Aug 12.

Physiological Institute, University of Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany.

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October 2016

Cl channels in apoptosis.

Eur Biophys J 2016 Oct 7;45(7):599-610. Epub 2016 Jun 7.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

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October 2016

Ion channels in regulated cell death.

Authors:
Karl Kunzelmann

Cell Mol Life Sci 2016 06 18;73(11-12):2387-403. Epub 2016 Apr 18.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

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June 2016

Non-essential contribution of LRRC8A to volume regulation.

Pflugers Arch 2016 05 13;468(5):805-16. Epub 2016 Feb 13.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

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May 2016

Modulating Ca²⁺ signals: a common theme for TMEM16, Ist2, and TMC.

Pflugers Arch 2016 Mar 23;468(3):475-90. Epub 2015 Dec 23.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

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March 2016

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage.

FASEB J 2016 Feb 19;30(2):727-37. Epub 2015 Oct 19.

*Department of Cell Biochemistry of Thrombosis and Haemostasis Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, Maastricht, The Netherlands; Department of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, University of Würzburg, Würzburg, Germany; Walter Brendel Centre of Experimental Medicine and German Centre of Cardiovascular Research, Munich Heart Alliance, Ludwig-Maximilians-Universität München, München, Germany; Department of Developmental Biology, Centre for Medical Biotechnology, University of Duisburg-Essen, Duisburg-Essen, Germany; Aragon Institute of Health Sciences I+CS/IIS and ARAID, Zaragoza, Spain; School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom; Institute of Physiology, University of Regensburg, Regensburg, Germany; **Arthur Bloom Haemophilia Centre, School of Medicine, Cardiff University, Cardiff, United Kingdom

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February 2016

Cellular volume regulation by anoctamin 6: Ca²⁺, phospholipase A2 and osmosensing.

Pflugers Arch 2016 Feb 6;468(2):335-49. Epub 2015 Oct 6.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

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February 2016

Glucose promotes secretion-dependent renal cyst growth.

J Mol Med (Berl) 2016 Jan 3;94(1):107-17. Epub 2015 Sep 3.

Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Germany.

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January 2016

TMEM16, LRRC8A, bestrophin: chloride channels controlled by Ca(2+) and cell volume.

Authors:
Karl Kunzelmann

Trends Biochem Sci 2015 Sep 4;40(9):535-43. Epub 2015 Aug 4.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany. Electronic address:

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September 2015

Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery.

Sci Rep 2015 Mar 12;5:9038. Epub 2015 Mar 12.

University of Lisboa, Faculty of Sciences, BioISI - Biosystems &Integrative Sciences Institute, Campo Grande, C8, 1749-016 Lisboa, Portugal.

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March 2015

Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages.

Nat Commun 2015 Feb 5;6:6245. Epub 2015 Feb 5.

Physiological Institute, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.

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February 2015

Anoctamin-6 controls bone mineralization by activating the calcium transporter NCX1.

J Biol Chem 2015 Mar 14;290(10):6270-80. Epub 2015 Jan 14.

From the Institut für Physiologie, Universität Regensburg, D-93053 Regensburg and

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March 2015

Chloride secretion, anoctamin 1 and Ca(2+) signaling.

Channels (Austin) 2014 ;8(5):387-8

a Institut für Physiologie ; Universität Regensburg ; Regensburg , Germany.

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September 2015

TMC8 (EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation of Cl- currents.

Cell Signal 2014 Dec 15;26(12):2826-33. Epub 2014 Sep 15.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany. Electronic address:

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December 2014

Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine.

Pflugers Arch 2015 Jun 1;467(6):1203-13. Epub 2014 Jul 1.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

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June 2015

Role of anoctamins in cancer and apoptosis.

Philos Trans R Soc Lond B Biol Sci 2014 Mar 3;369(1638):20130096. Epub 2014 Feb 3.

Institut für Physiologie, Universität Regensburg, , Universitätsstraße 31, Regensburg 93053, Germany.

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March 2014

CFTR: a hub for kinases and crosstalk of cAMP and Ca2+.

FEBS J 2013 Sep 27;280(18):4417-29. Epub 2013 Aug 27.

Institut für Physiologie, Universität Regensburg, Germany.

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September 2013

Expression and functional significance of the Ca(2+)-activated Cl(-) channel ANO6 in dendritic cells.

Cell Physiol Biochem 2012 22;30(5):1319-32. Epub 2012 Oct 22.

Department of Physiology, University of Tübingen, Tübingen, Germany.

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September 2014

CFTR mutations altering CFTR fragmentation.

Biochem J 2013 Jan;449(1):295-305

Division of Medical Sciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, U.K.

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January 2013

Anoctamins are a family of Ca2+-activated Cl- channels.

J Cell Sci 2012 Nov 3;125(Pt 21):4991-8. Epub 2012 Sep 3.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany.

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November 2012

Role of KCNMA1 in breast cancer.

PLoS One 2012 10;7(8):e41664. Epub 2012 Aug 10.

Institute of Pathology, University of Basel, Basel, Switzerland.

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March 2013

Airway epithelial cells--functional links between CFTR and anoctamin dependent Cl- secretion.

Int J Biochem Cell Biol 2012 Nov 16;44(11):1897-900. Epub 2012 Jun 16.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.

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November 2012

TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression.

Cancer Res 2012 Jul 7;72(13):3270-81. Epub 2012 May 7.

Department of Otolaryngology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine and Magee-Women's Research Institute, Pittsburgh, Pennsylvania 15213, USA.

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July 2012

Airway epithelial cells--hyperabsorption in CF?

Int J Biochem Cell Biol 2012 Aug 21;44(8):1232-5. Epub 2012 Apr 21.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.

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August 2012

CFTR and TMEM16A are separate but functionally related Cl- channels.

Cell Physiol Biochem 2011 14;28(4):715-24. Epub 2011 Dec 14.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, Regensburg, Germany.

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April 2012

The competition between enamel and dentin adhesion within a cavity: an in vitro evaluation of class V restorations.

Clin Oral Investig 2012 Aug 21;16(4):1125-35. Epub 2011 Oct 21.

Division of Cariology and Endodontics, School of Dentistry, University of Geneva, Rue Barthelemy Menn, 19, CH-1205 Geneva, Switzerland.

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August 2012

Anoctamin 6 is an essential component of the outwardly rectifying chloride channel.

Proc Natl Acad Sci U S A 2011 Nov 17;108(44):18168-72. Epub 2011 Oct 17.

Institut für Physiologie, Universität Regensburg, D-93053 Regensburg, Germany.

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November 2011

Expression and function of epithelial anoctamins.

Exp Physiol 2012 Feb 9;97(2):184-92. Epub 2011 Sep 9.

Universität Regensburg, Institut für Physiologie, Universitätsstraße 31, Regensburg, Germany.

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February 2012

Differential contribution of SLC26A9 to Cl(-) conductance in polarized and non-polarized epithelial cells.

J Cell Physiol 2012 Jun;227(6):2323-9

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, Regensburg, Germany.

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June 2012

CFTR induces extracellular acid sensing in Xenopus oocytes which activates endogenous Ca²⁺-activated Cl⁻ conductance.

Pflugers Arch 2011 Sep 7;462(3):479-87. Epub 2011 Jun 7.

Department of Physiology, University of Regensburg, Regensburg, Germany.

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September 2011

Anoctamins.

Pflugers Arch 2011 Aug 21;462(2):195-208. Epub 2011 May 21.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, Regensburg, Germany.

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August 2011

Introduction to section V: assessment of CFTR function.

Authors:
Karl Kunzelmann

Methods Mol Biol 2011 ;741:407-18

Department of Physiology, University of Regensburg, 93053, Regensburg, Germany.

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September 2011

Functional genomics assays to study CFTR traffic and ENaC function.

Methods Mol Biol 2011 ;742:249-64

Faculty of Sciences, BioFiG-Centre for Biodiversity and Functional and Integrative Genomics, University of Lisboa, Lisboa, Portugal.

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September 2011

Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption.

Pflugers Arch 2011 May 12;461(5):579-89. Epub 2011 Mar 12.

Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.

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May 2011