Karl J Lackner

Karl J Lackner

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Karl J Lackner

Karl J Lackner

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Response to: 'Protective effects of antimalarials in Chinese patients with systemic lupus erythematosus' by Wang .

Ann Rheum Dis 2019 Aug 26;78(8):e81. Epub 2018 Jun 26.

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2018-213853DOI Listing
August 2019

Subtherapeutic Anticoagulation Control under Treatment with Vitamin K-Antagonists-Data from a Specialized Coagulation Service.

Thromb Haemost 2019 Aug 10;119(8):1347-1357. Epub 2019 Jun 10.

Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1055/s-0039-1692175DOI Listing
August 2019

Direct oral anticoagulants and vitamin K antagonists are linked to differential profiles of cardiac function and lipid metabolism.

Clin Res Cardiol 2019 Jul 2;108(7):787-796. Epub 2019 Jan 2.

Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00392-018-1408-yDOI Listing
July 2019

Platelet Activation by Antiphospholipid Antibodies Depends on Epitope Specificity and is Prevented by mTOR Inhibitors.

Thromb Haemost 2019 Jul 24;119(7):1147-1153. Epub 2019 Apr 24.

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1055/s-0039-1685453DOI Listing
July 2019

Cofactor-Independent Antiphospholipid Antibodies: Implications for Pathogenesis, Diagnosis, and Treatment of Antiphospholipid Syndrome.

Hamostaseologie 2019 Jun 12;39(2):188-194. Epub 2018 Nov 12.

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1055/s-0038-1675355DOI Listing
June 2019

Choroidal thickness is associated with cardiovascular risk factors and cardiac health: the Gutenberg Health Study.

Clin Res Cardiol 2019 Jun 5. Epub 2019 Jun 5.

Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center, Johannes Gutenberg-University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1007/s00392-019-01498-8DOI Listing
June 2019

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction.

N Engl J Med 2019 06;380(26):2529-2540

From the University Heart Center Hamburg (J.T.N., R.T., F.O., N.A.S., T.Z., D.W., S.B.), German Center for Cardiovascular Research (DZHK) Partner Site Hamburg-Kiel-Lübeck (J.T.N., N.A.S., T.Z., D.W., S.B.), and the Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf (T.R.), Hamburg, the Department of Cardiology, Heidelberg University Hospital (M.M.-H., H.A.K., E.G.), and DZHK Partner Site Heidelberg-Mannheim (M.M.-H., H.A.K., E.G.), Heidelberg, Cardiology I (T.G., T.M.) and Preventive Cardiology and Preventive Medicine (P.W.), Center for Cardiology, and the Center for Thrombosis and Hemostasis (P.W.), University Medical Center of Johannes Gutenberg University Mainz, and the Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz (K.J.L.), Mainz, DZHK Partner Site Rhine-Main and the Department of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim (C.L., C.H., T.K.), the Department of Cardiology, Justus Liebig University of Giessen and Marburg, Giessen (C.L., C.H.), the Department of Cardiology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin Institute of Health, and DZHK Partner Site Berlin, Berlin (U.L.), and the Institute of Epidemiology, Helmholtz Zentrum, German Research Center for Environmental Health (B.T., A.P.), and DZHK Partner Site Munich Heart Alliance (A.P.), Munich - all in Germany; the Cardiovascular Research Institute Basel and the Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland (R.T., J.B., T.N., P.B., C.M.); the British Heart Foundation Centre for Cardiovascular Science (A.R.C., A.S.V.S., A.A., N.L.M.) and the Usher Institute of Population Health Sciences and Informatics (A.S.V.S., N.L.M.), University of Edinburgh, Edinburgh, the University of Manchester and Manchester University Foundation Trust, Manchester (N.M., R. Body), U.K. Clinical Research Collaboration for Public Health, Queens University of Belfast, Belfast (F.K.), and the Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee (H.T.-P.) - all in the United Kingdom; the Department of Internal and Emergency Medicine, Lund University, Skåne University Hospital, Lund (A.M., U.E.), the Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm (T. Jernberg), the Department of Public Health and Clinical Medicine, and Heart Center, Cardiology, Umeå University, Umeå (S. Söderberg), and the Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala (B.L.) - all in Sweden; the Department of Medicine, University of Otago Christchurch, and Emergency Department, Christchurch Hospital, Christchurch, New Zealand (J.W.P., R.W.T., M.T.); the Departments of Emergency Medicine (J.G., L.A.C.) and Cardiology (W.P.), Royal Brisbane and Women's Hospital, Herston, QLD, and the Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove (J.G., W.P., L.A.C.) - all in Australia; the National Institute for Health and Welfare, Helsinki, Finland (V.S., K.K.); the Department of Epidemiology and Prevention, Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, Pozzilli (L.I.), the Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine, University of Insubria, Varese (L.I., M.M.F., R. Borchini), and the Department of Cardiovascular, Dysmetabolic, and Aging-Associated Diseases, National Institutes of Health, Rome (S.G.) - all in Italy; the Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen (T. Jørgensen), the Research Center for Prevention and Health, Capital Region of Denmark, Glostrup (T. Jørgensen), and the Medical Faculty, Aalborg University, Aalborg (T. Jørgensen) - all in Denmark; the Catalan Department of Health, Barcelona (S. Sans); and the Division of Emergency Medicine (A.W.) and the Department of Pathology and Molecular Medicine (P.A.K.), McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1056/NEJMoa1803377DOI Listing
June 2019

Relative Telomere Length and Cardiovascular Risk Factors.

Biomolecules 2019 May 17;9(5). Epub 2019 May 17.

Clinic of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.3390/biom9050192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572569PMC
May 2019

Cardiovascular risk factors are important determinants of platelet-dependent thrombin generation in adult survivors of childhood cancer.

Clin Res Cardiol 2019 Apr 22;108(4):438-447. Epub 2018 Sep 22.

Clinical Epidemiology, Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00392-018-1374-4DOI Listing
April 2019

Cardiac biomarkers - 2019.

Authors:
Karl J Lackner

Clin Chem Lab Med 2019 Apr;57(5):565-566

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, 55101 Mainz, Germany, Phone: +49 6131 177190, Fax: +49 6131 176627.

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http://dx.doi.org/10.1515/cclm-2019-0205DOI Listing
April 2019

The Prevalence of Visual Impairment in the Adult Population.

Dtsch Arztebl Int 2019 Apr;116(17):289-295

Department of Ophthalmology, Medical Center, University of Mainz; Department of Ophthalmology, University Hospital Hamburg-Eppendorf (UKE); Preventive Cardiology and Medical Prevention, Cardiology I, Medical Center, University of Mainz; Department of Psychosomatic Medicine and Psychotherapy, Medical Center, University of Mainz; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Medical Center, University of Mainz; Institute of Clinical Chemistry and Laboratory Medicine, Medical Center, University of Mainz.

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http://dx.doi.org/10.3238/arztebl.2019.0289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584831PMC
April 2019

Acute deep vein thrombosis suppresses peripheral T cell effector function.

Br J Haematol 2019 Mar 25;184(5):847-850. Epub 2018 Mar 25.

Centre for Thrombosis and Hemostasis (CTH), University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1111/bjh.15192DOI Listing
March 2019

Pathogenesis of antiphospholipid syndrome: recent insights and emerging concepts.

Expert Rev Clin Immunol 2019 Feb 6;15(2):199-209. Epub 2018 Dec 6.

a Institute of Clinical Chemistry and Laboratory Medicine , University Medical Center of the Johannes Gutenberg University , Mainz , Germany.

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http://dx.doi.org/10.1080/1744666X.2019.1546578DOI Listing
February 2019

Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab.

Thromb Haemost 2018 Oct 20;118(10):1743-1751. Epub 2018 Sep 20.

Department of Hematology, Oncology and Pneumology, University Medical Center of the Johannes Gutenberg University, Mainz, Rheinland-Pfalz, Germany.

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http://dx.doi.org/10.1055/s-0038-1668545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202932PMC
October 2018

Prevalence of glaucoma in Germany: results from the Gutenberg Health Study.

Graefes Arch Clin Exp Ophthalmol 2018 Sep 17;256(9):1695-1702. Epub 2018 May 17.

Department of Ophthalmology, University Medical Center Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00417-018-4011-zDOI Listing
September 2018

Diagnosis and Management of the Antiphospholipid Syndrome.

N Engl J Med 2018 09;379(13):1290

University Medical Center Mainz, Mainz, Germany

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http://dx.doi.org/10.1056/NEJMc1808253DOI Listing
September 2018

The Theranos saga and the consequences.

Clin Chem Lab Med 2018 08;56(9):1395-1396

Department of Laboratory Medicine, University-Hospital of Padova, Padova, Italy.

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http://dx.doi.org/10.1515/cclm-2018-0392DOI Listing
August 2018

Mechanisms of Cellular Activation in the Antiphospholipid Syndrome.

Semin Thromb Hemost 2018 Jul 6;44(5):483-492. Epub 2017 Feb 6.

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1055/s-0036-1597290DOI Listing
July 2018

Adverse Outcome Prediction of Iron Deficiency in Patients with Acute Coronary Syndrome.

Biomolecules 2018 07 20;8(3). Epub 2018 Jul 20.

Department of General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany.

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http://dx.doi.org/10.3390/biom8030060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163749PMC
July 2018

Corrigendum to "Prognostic Impact of Interleukin-1 Receptor Antagonist in Patients with documented Coronary Artery Disease" [Int. J. Cardiol. 257 (2018) 24-29].

Int J Cardiol 2018 06 21;261:239. Epub 2018 Mar 21.

Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; German Center of Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.ijcard.2018.03.012DOI Listing
June 2018

Scientific publishing in the "predatory" era.

Clin Chem Lab Med 2018 04;56(5):683-684

CCLM Editor-in-Chief, Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy.

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http://dx.doi.org/10.1515/cclm-2017-1079DOI Listing
April 2018

Prognostic impact of Interleukin-1 receptor antagonist in patients with documented coronary artery disease.

Int J Cardiol 2018 04 1;257:24-29. Epub 2018 Feb 1.

Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; German Center of Cardiovascular Research (DZHK), partner site Hamburg/Lübeck/Kiel, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.ijcard.2018.01.055DOI Listing
April 2018

Associations between degree and sub-dimensions of depression and metabolic syndrome (MetS) in the community: results from the Gutenberg Health Study (GHS).

BMC Psychiatry 2018 04 27;18(1):114. Epub 2018 Apr 27.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1186/s12888-018-1691-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921368PMC
April 2018

Refractive, corneal, and ocular residual astigmatism: distribution in a German population and age dependency-the Gutenberg Health Study.

Graefes Arch Clin Exp Ophthalmol 2018 02 30;256(2):445-446. Epub 2017 Oct 30.

Department of Ophthalmology, University Medical Center Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00417-017-3822-7DOI Listing
February 2018

Refractive, corneal and ocular residual astigmatism: distribution in a German population and age-dependency - the Gutenberg health study.

Graefes Arch Clin Exp Ophthalmol 2017 Dec 19;255(12):2493-2501. Epub 2017 Aug 19.

Department of Ophthalmology, University Medical Center Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00417-017-3775-xDOI Listing
December 2017

The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats.

Redox Biol 2017 10 22;13:370-385. Epub 2017 Jun 22.

Center for Cardiology, Cardiology I - Laboratory of Molecular Cardiology, Medical Center of the Johannes Gutenberg University, Mainz, Germany; Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491464PMC
October 2017

Urinary neutrophil gelatinase-associated lipocalin and cystatin C compared to the estimated glomerular filtration rate to predict risk in patients with suspected acute myocardial infarction.

Int J Cardiol 2017 Oct 25;245:6-12. Epub 2017 Jul 25.

Division of Cardiology, Department of Internal Medicine III, Goethe University Frankfurt, Germany; German Centre for Cardiovascular Research (DZHK), partner site RheinMain, Frankfurt, Germany; Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.07.086DOI Listing
October 2017

Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure.

Hypertension 2017 10 7;70(4):743-750. Epub 2017 Aug 7.

From the General and Interventional Cardiology, University Heart Center Hamburg, Germany (T.Z., C.M., A.J., M.K., J.T.N., R.B.S., F.O., S.B.); DZHK (German Centre for Cardiovascular Research), Germany (T.Z., C.S., C.M., P.S.W., A.T., A.S., A.K., A.J., M.K., J.T.N., T.K., R.B.S., M.D., T.M., K.J.L., S.B.F., U.L., A.Z., U.V., S.B.); Institute of Human Genetics (K.S., T.M., H.P.), Molecular Epidemiology (C.G., S.W.), and Institute of Epidemiology II (C.G., S.W.), Helmholtz Zentrum München, Germany; Institut für Medizinische Biometrie und Statistik, Universitätsklinikum Schleswig-Holstein, Germany (C.M., A.S., A.Z.); Institute for Translational Genomics and Population Sciences, UCLA Medical Center (S.K., J.I.R., X.G.); Preventive Cardiology and Preventive Medicine (P.S.W.), Institute of Clinical Chemistry and Laboratory Medicine (K.J.L.), and Center for Thrombosis and Hemostasis (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, Germany; Institute for Community Medicine (A.T.) and Department of Internal Medicine B (M.D., S.B.F.), University Medicine Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, University Greifswald, Germany (C.S., T.K., U.V., G.H.); Department of Internal Medicine (D.H., J.D.) and Department of Epidemiology and Prevention (Y.L.), Wake Forest School of Medicine, Winston-Salem, NC; Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli IS, Italy (L.I., S.C.); Department of Cardiology and Pneumology, Charite, Universitätsmedizin Berlin, Germany (A.K., U.L.); National Institute for Health and Welfare, Helsinki, Finland (K.K.); Institute for Clinical Diabetology, German Diabetes Center, Duesseldorf, Germany (M.R., M.C.-K., C.H.); Department of Endocrinology and Diabetology, Medical Faculty Düsseldorf, Germany (M.R.); German Center for Diabetes Research (DZD), Munich, Germany (M.R., S.W., M.C.-K., C.H.); Sorbonne Universités, UPMC, INSERM, UMR_S 1166, ICAN Institute for Cardiometabolism and Nutrition, Paris, France (D.-A.T.); Institute of Human Genetics, Technische Universität München, Germany (T.M., P.W., H.P.); ZIK_FunGene, Universität Greifswald, Germany (U.V., G.H.); and Columbia University Medical Center, New York, NY (W.P.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997260PMC
October 2017

High-sensitivity assays for cardiac troponins - continued.

Authors:
Karl J Lackner

Clin Chem Lab Med 2017 10;55(11):1631-1633

.

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http://dx.doi.org/10.1515/cclm-2017-0741DOI Listing
October 2017

Commentary.

Authors:
Karl J Lackner

Clin Chem 2017 10;63(10):1574

Institute of Clinical Chemistry and Laboratory Medicine, and Center for Translational Vascular Biology, University Medical Center Mainz, Germany.

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http://dx.doi.org/10.1373/clinchem.2016.270041DOI Listing
October 2017

Pathophysiological insights into the antiphospholipid syndrome.

Hamostaseologie 2017 Aug 27;37(3):202-207. Epub 2016 Oct 27.

Karl J. Lackner, MD Institute of Clinical Chemistry and Laboratory Medicine University Medical Centre Mainz 55131 Mainz Germany, Tel: +49 6131 177190 Fax: +49 6131 176627 E-Mail:

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http://dx.doi.org/10.5482/HAMO-16-07-0020DOI Listing
August 2017

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study.

PLoS One 2017 20;12(1):e0167742. Epub 2017 Jan 20.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167742PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249120PMC
August 2017

Retinal vessel metrics: normative data and their use in systemic hypertension: results from the Gutenberg Health Study.

J Hypertens 2017 08;35(8):1635-1645

aDepartment of Ophthalmology bDepartment of Preventive Cardiology and Preventive Medicine, Center for Cardiology I cInstitute of Medical Biostatistics, Epidemiology and Informatics, Division of Biostatistics and Bioinformatics dDepartment of Psychosomatic Medicine and Psychotherapy eInstitute of Clinical Chemistry and Laboratory Medicine fCenter for Thrombosis and Hemostasis, University Medical Center gDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Langenbeckstr. 1, Mainz, Germany hDepartment of Ophthalmology, University Hospital Bern, Bern, Switzerland iDardenne Eye Hospital, Bonn-Bad Godesberg, Germany.

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http://dx.doi.org/10.1097/HJH.0000000000001380DOI Listing
August 2017

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.

Authors:
Stephen Zewinger Marcus E Kleber Vinicius Tragante Raymond O McCubrey Amand F Schmidt Kenan Direk Ulrich Laufs Christian Werner Wolfgang Koenig Dietrich Rothenbacher Ute Mons Lutz P Breitling Herrmann Brenner Richard T Jennings Ioannis Petrakis Sarah Triem Mira Klug Alexandra Filips Stefan Blankenberg Christoph Waldeyer Christoph Sinning Renate B Schnabel Karl J Lackner Efthymia Vlachopoulou Ottar Nygård Gard Frodahl Tveitevåg Svingen Eva Ringdal Pedersen Grethe S Tell Juha Sinisalo Markku S Nieminen Reijo Laaksonen Stella Trompet Roelof A J Smit Naveed Sattar J Wouter Jukema Heinrich V Groesdonk Graciela Delgado Tatjana Stojakovic Anna P Pilbrow Vicky A Cameron A Mark Richards Robert N Doughty Yan Gong Rhonda Cooper-DeHoff Julie Johnson Markus Scholz Frank Beutner Joachim Thiery J Gustav Smith Ragnar O Vilmundarson Ruth McPherson Alexandre F R Stewart Sharon Cresci Petra A Lenzini John A Spertus Oliviero Olivieri Domenico Girelli Nicola I Martinelli Andreas Leiherer Christoph H Saely Heinz Drexel Axel Mündlein Peter S Braund Christopher P Nelson Nilesh J Samani Daniel Kofink Imo E Hoefer Gerard Pasterkamp Arshed A Quyyumi Yi-An Ko Jaana A Hartiala Hooman Allayee W H Wilson Tang Stanley L Hazen Niclas Eriksson Claes Held Emil Hagström Lars Wallentin Axel Åkerblom Agneta Siegbahn Igor Karp Christopher Labos Louise Pilote James C Engert James M Brophy George Thanassoulis Peter Bogaty Wojciech Szczeklik Marcin Kaczor Marek Sanak Salim S Virani Christie M Ballantyne Vei-Vei Lee Eric Boerwinkle Michael V Holmes Benjamin D Horne Aroon Hingorani Folkert W Asselbergs Riyaz S Patel Bernhard K Krämer Hubert Scharnagl Danilo Fliser Winfried März Thimoteus Speer

Lancet Diabetes Endocrinol 2017 07 26;5(7):534-543. Epub 2017 May 26.

Department of Internal Medicine IV, Saarland University Hospital, Homburg/Saar, Germany.

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http://dx.doi.org/10.1016/S2213-8587(17)30096-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651679PMC
July 2017

Hydroxychloroquine inhibits proinflammatory signalling pathways by targeting endosomal NADPH oxidase.

Ann Rheum Dis 2017 May 30;76(5):891-897. Epub 2016 Nov 30.

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2016-210012DOI Listing
May 2017

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.

Authors:
Philipp S Wild Janine F Felix Arne Schillert Alexander Teumer Ming-Huei Chen Maarten J G Leening Uwe Völker Vera Großmann Jennifer A Brody Marguerite R Irvin Sanjiv J Shah Setia Pramana Wolfgang Lieb Reinhold Schmidt Alice V Stanton Dörthe Malzahn Albert Vernon Smith Johan Sundström Cosetta Minelli Daniela Ruggiero Leo-Pekka Lyytikäinen Daniel Tiller J Gustav Smith Claire Monnereau Marco R Di Tullio Solomon K Musani Alanna C Morrison Tune H Pers Michael Morley Marcus E Kleber Jayashri Aragam Emelia J Benjamin Joshua C Bis Egbert Bisping Ulrich Broeckel Susan Cheng Jaap W Deckers Fabiola Del Greco M Frank Edelmann Myriam Fornage Lude Franke Nele Friedrich Tamara B Harris Edith Hofer Albert Hofman Jie Huang Alun D Hughes Mika Kähönen Knhi Investigators Jochen Kruppa Karl J Lackner Lars Lannfelt Rafael Laskowski Lenore J Launer Margrét Leosdottir Honghuang Lin Cecilia M Lindgren Christina Loley Calum A MacRae Deborah Mascalzoni Jamil Mayet Daniel Medenwald Andrew P Morris Christian Müller Martina Müller-Nurasyid Stefania Nappo Peter M Nilsson Sebastian Nuding Teresa Nutile Annette Peters Arne Pfeufer Diana Pietzner Peter P Pramstaller Olli T Raitakari Kenneth M Rice Fernando Rivadeneira Jerome I Rotter Saku T Ruohonen Ralph L Sacco Tandaw E Samdarshi Helena Schmidt Andrew S P Sharp Denis C Shields Rossella Sorice Nona Sotoodehnia Bruno H Stricker Praveen Surendran Simon Thom Anna M Töglhofer André G Uitterlinden Rolf Wachter Henry Völzke Andreas Ziegler Thomas Münzel Winfried März Thomas P Cappola Joel N Hirschhorn Gary F Mitchell Nicholas L Smith Ervin R Fox Nicole D Dueker Vincent W V Jaddoe Olle Melander Martin Russ Terho Lehtimäki Marina Ciullo Andrew A Hicks Lars Lind Vilmundur Gudnason Burkert Pieske Anthony J Barron Robert Zweiker Heribert Schunkert Erik Ingelsson Kiang Liu Donna K Arnett Bruce M Psaty Stefan Blankenberg Martin G Larson Stephan B Felix Oscar H Franco Tanja Zeller Ramachandran S Vasan Marcus Dörr

J Clin Invest 2017 May 10;127(5):1798-1812. Epub 2017 Apr 10.

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https://www.jci.org/articles/view/84840
Publisher Site
http://dx.doi.org/10.1172/JCI84840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409098PMC
May 2017

Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study.

Biomarkers 2017 May - Jun;22(3-4):210-218. Epub 2016 Jan 15.

b Department of General and Interventional Cardiology , University Heart Center Hamburg , Hamburg , Germany.

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http://dx.doi.org/10.3109/1354750X.2015.1130745DOI Listing
April 2017

Endosomal Redox Signaling in the Antiphospholipid Syndrome.

Curr Rheumatol Rep 2017 Apr;19(4):20

Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s11926-017-0647-7DOI Listing
April 2017

Loneliness in the general population: prevalence, determinants and relations to mental health.

BMC Psychiatry 2017 03 20;17(1):97. Epub 2017 Mar 20.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Zahlbacher Str. 8, D-55131, Mainz, Germany.

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http://dx.doi.org/10.1186/s12888-017-1262-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359916PMC
March 2017

Biomarkers for characterization of heart failure - Distinction of heart failure with preserved and reduced ejection fraction.

Int J Cardiol 2017 Jan 9;227:272-277. Epub 2016 Nov 9.

University Heart Center Hamburg, Department of General and Interventional Cardiology, Hamburg, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.11.110DOI Listing
January 2017

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics.

Hum Mol Genet 2017 01;26(2):438-453

Statistical Genetics, QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Brisbane, Australia.

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http://dx.doi.org/10.1093/hmg/ddw399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968632PMC
January 2017

Cardiovascular Mortality in Chest Pain Patients: Comparison of Natriuretic Peptides With Novel Biomarkers of Cardiovascular Stress.

Can J Cardiol 2016 12 20;32(12):1470-1477. Epub 2016 May 20.

Department of General and Interventional Cardiology, University Heart Center, Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2016.05.010DOI Listing
December 2016

High-sensitivity troponin and novel biomarkers for the early diagnosis of non-ST-segment elevation myocardial infarction in patients with atrial fibrillation.

Eur Heart J Acute Cardiovasc Care 2016 Oct 12;5(6):419-427. Epub 2015 Oct 12.

Department of General and Interventional Cardiology, University Heart Center, Germany German Center for Cardiovascular research (DZHK), Partner Site Hamburg, Germany

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http://dx.doi.org/10.1177/2048872615611108DOI Listing
October 2016

Myopia and Cognitive Performance: Results From the Gutenberg Health Study.

Invest Ophthalmol Vis Sci 2016 Oct;57(13):5230-5236

Medical Psychology and Medical Sociology, University Medical Center Mainz, Germany 6Medical Psychology and Medical Sociology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1167/iovs.16-19507DOI Listing
October 2016

Prognostic use of soluble fms-like tyrosine kinase-1 and placental growth factor in patients with coronary artery disease.

Biomark Med 2016 7;10(1):95-106. Epub 2015 Dec 7.

Department of General & Interventional Cardiology, University Heart Center Hamburg, Germany.

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http://dx.doi.org/10.2217/bmm.15.111DOI Listing
September 2016

Prevalence of diabetic retinopathy in screening-detected diabetes mellitus: results from the Gutenberg Health Study (GHS).

Diabetologia 2016 09 17;59(9):1913-9. Epub 2016 Jun 17.

Department of Ophthalmology, University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00125-016-4013-5DOI Listing
September 2016

Antiphospholipid antibodies in a large population-based cohort: genome-wide associations and effects on monocyte gene expression.

Thromb Haemost 2016 07 21;116(1):115-23. Epub 2016 Apr 21.

Dr. Karl J. Lackner, Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Langenbeckstrasse 1, D-55131 Mainz, Germany, Tel.: +49 6131 177190, E-mail:

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http://dx.doi.org/10.1160/TH15-12-0947DOI Listing
July 2016

Risk factors for heart failure are associated with alterations of the LV end-diastolic pressure-volume relationship in non-heart failure individuals: data from a large-scale, population-based cohort.

Eur Heart J 2016 06 7;37(23):1807-14. Epub 2016 Apr 7.

Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany DZHK (German Centre for Cardiovascular Research), Partner site Hamburg/Kiel/Lübeck, Hamburg, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehw120DOI Listing
June 2016

Analytical Performance and Validation of a Bioassay for Thyroid-Blocking Antibodies.

Thyroid 2016 05 5;26(5):734-40. Epub 2016 Apr 5.

1 Molecular Thyroid Research Laboratory, Johannes Gutenberg University Medical Center , Mainz, Germany .

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http://dx.doi.org/10.1089/thy.2015.0447DOI Listing
May 2016

Formation of 2-nitrophenol from salicylaldehyde as a suitable test for low peroxynitrite fluxes.

Redox Biol 2016 Apr 27;7:39-47. Epub 2015 Nov 27.

Center of Cardiology, Laboratory of Molecular Cardiology, Medical Center of the Johannes Gutenberg University, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2015.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683390PMC
April 2016

Low Homoarginine Levels in the Prognosis of Patients With Acute Chest Pain.

J Am Heart Assoc 2016 Apr 13;5(4):e002565. Epub 2016 Apr 13.

German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1161/JAHA.115.002565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859271PMC
April 2016

Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study.

Blood 2016 Jan 30;127(2):251-9. Epub 2015 Oct 30.

Center of Thrombosis and Hemostasis, Preventive Cardiology and Medical Prevention, Department of Medicine II, and DZHK, Partner Site Rhein-Main, Mainz, Germany; and.

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http://dx.doi.org/10.1182/blood-2015-07-660308DOI Listing
January 2016

ADMA, subclinical changes and atrial fibrillation in the general population.

Int J Cardiol 2016 Jan 19;203:640-6. Epub 2015 May 19.

Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf, Germany; DZHK (Deutsches Zentrum fuer Herz-Kreislauf-Forschung e.V.), partner site Hamburg/Kiel/Luebeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2015.05.102DOI Listing
January 2016

ADMA and arginine derivatives in relation to non-invasive vascular function in the general population.

Atherosclerosis 2016 Jan 30;244:149-56. Epub 2015 Oct 30.

Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.10.101DOI Listing
January 2016