Publications by authors named "Karine Castro-Lionard"

6 Publications

  • Page 1 of 1

Severe sensory neuropathy increases risk of heel pressure ulcer in older adults.

J Am Geriatr Soc 2013 Nov;61(11):2050-2

Geriatrics Department, Bretonneau Hospital, Paris, France; Laboratory of Tissue Biology and Therapeutic Engineering, UMR CNRS 5305, University Claude Bernard Lyon 1, Lyon, France.

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November 2013

Use of calcium supplements, vitamin D supplements and specific osteoporosis drugs among French women aged 75-85 years: patterns of use and associated factors.

Drugs Aging 2013 Dec;30(12):1029-38

Département de Gérontologie Clinique, CHU Saint-Etienne, Hôpital Charité, 42055, Saint-Etienne Cedex 2, France,

Background: Despite the availability of effective preventive and curative medications for osteoporosis, and guidelines for its diagnosis and management, few individuals are treated for osteoporosis, even among those who have already had a fracture.

Objectives: Our objective was to describe the patterns of use of medication for osteoporosis, i.e., calcium supplements, vitamin D supplements, and specific anti-osteoporotic drugs, such as bisphosphonates, in a large sample of French older women living at home, and to identify individual factors associated with use of these medications overall and in two specific clinical situations.

Methods: Cross-sectional analysis of data from 4,221 women aged 75-85 years who participated in a balance and mobility examination as part of the screening procedure for the Ossébo study, a randomized controlled trial testing the effectiveness of exercise for the prevention of fall-related injuries. Electoral rolls were used to invite women in 16 towns to participate (participation rate 10.3 %). Information collected through questionnaires included current medication use and, in particular, use of osteoporosis medications (specific osteoporosis drugs, calcium and vitamin D supplementation) in the past 6 months, and history of fracture since the age of 50, including fracture locations. Fractures were categorized in three groups: no fracture, major osteoporotic fracture (hip, humerus, wrist, pelvis, and vertebra), and other fracture.

Results: Nearly 48 % of the participants reported they did not take calcium or vitamin D supplements or any specific osteoporosis drugs. Of the 2,133 women who reported using osteoporosis medication, 85 % used vitamin D supplements (25 % as the sole medication against this disease), 59 % calcium supplements, and 42 % a specific anti-osteoporotic drug (75 % of them combining it with vitamin D supplementation). The use of any osteoporosis medication was significantly associated (p < 0.001) with a history of a major osteoporotic fracture, lower weight, dual-energy X-ray absorptiometry (DXA) bone-density measurement in the past 5 years, a cancer-screening examination in the past 5 years, and a positive attitude toward medication use in general. Living alone was associated with a lower likelihood of using a specific anti-osteoporotic drug, and a higher education level was associated with a higher likelihood of vitamin D supplementation. Of the 1,553 women who had already had a major osteoporotic fracture, one-third (34.8 %) were not taking any osteoporosis medication. In this subgroup, use of this medication was associated with the same factors as in the overall study population. In particular, neither older age nor a history of falls in the previous 12 months was associated with a higher likelihood of using osteoporosis medication. Among the 909 women who reported using a specific osteoporosis drug, vitamin D use was associated with a higher educational level and a more frequent preventive attitude.

Conclusion: In France, as in other western countries, women aged 75 years and over are not managed according to guidelines. Further studies should address the barriers encountered in improving quality of care in osteoporosis management.
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December 2013

[Successful aging: how to improve its occurrence in the elderly?].

Geriatr Psychol Neuropsychiatr Vieil 2012 Jun;10(2):207-14

Département de gérontologie clinique.

Objectives: To assess the seniors' expectations for acceding to successful aging and the impact of preventive actions.

Method: Descriptive study of a representative sample of healthy pensioners using a 20-item questionnaire exploring the difficulties in daily life, the options chosen to achieve successful aging and the impact of preventive actions. Self-rated health feelings and well-being were assessed by visual analogical scales.

Results: The questionnaire was sent to 998 subjects and 651 responses were completed. Mean age of the subjects was 72.9±1.2 years, and 60% were women. Main reported complaints concerned memory loss (20.4%) and mood swings (18.9%). Sleep (82.3%) and physical activity (81.4) were considered as priorities to accede to successful aging. Social activities were significantly more important for subjects with higher educational level than for subjects with lower educational level (p<0.0001). Women and people living alone were more interested in preventive action concerning physical and psychological well-being than men and people living in family (p<0.05).

Conclusion: A better analysis of the complaints and needs of aging subjects should be useful to ensure successful ageing.
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June 2012

Level of physical activity at the age of 65 predicts successful aging seven years later: the PROOF study.

Rejuvenation Res 2011 Apr 31;14(2):215-21. Epub 2011 Mar 31.

Equipe d'Accueil Système Nerveux Autonome, Epidémiologie, Physiologie, Exercice, Santé (SNA-EPIS), PRES Lyon, Université Jean Monnet, Hôpital Universitaire, Saint-Étienne, France.

Background: Physical activity has a pleiotropic effect and is a significant factor in successful aging. This study aims to quantify the relationship between the physical activity of a 65-year-old cohort and the level of life satisfaction and self-rated health 7 years later.

Methods: A total of 988 questionnaires were sent by mail to a representative sample of healthy pensioners. Life satisfaction and health status were estimated on two visual analogical scales in answer to the following questions: (1) How would you estimate your state of health? and (2) Are you generally satisfied with your life? The level of physical activity was estimated using a questionnaire which enabled us to calculate: (1) Daily energy expenditure (DEE), (2) physical activity energy expenditure (PAEE), (3) daily energy expenditure higher than 5 metabolic equivalents (METs) (DEQisa), (4) Activity index (PAEE/DEE), (5) VO(2) peak.

Results: In all, 686 responses were validated. The average age was 72.9 ± 1.2 years old with 59.5% of women (n = 408). Amongst the sample, 98.8% (n = 676) lived in their own homes and 25.2% (n = 172) lived alone. Mean DEE was 10.365 ± 1.964  kJ/24  h, mean PAEE was 4.479 ± 1.170  kJ/24  h, mean activity index was 0.42 ± 0.05, and mean estimated oxygen uptake (VO(2)) peak was 22.5 ± 1.6  mL/min per kg. Activity index and VO(2) peak were the variables most significantly correlated with self-rated health (p = 0.0032 and p = 0.0011, respectively) and life satisfaction (p = 0.0117 and p = 0.0053).

Conclusions: Energy spent in activity and VO(2) peak estimated from DEE, measured at the age of 65, appear to be strong predictors of well-being 7 years later.
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April 2011

Can maintaining cognitive function at 65 years old predict successful ageing 6 years later? The PROOF study.

Age Ageing 2011 Mar 20;40(2):259-65. Epub 2011 Jan 20.

Department of Geriatrics, University Hospital of Saint-Etienne, 42055 Saint Etienne Cedex 2, France.

Background: preservation of cognitive abilities is required to have a good quality of life. The predictive value of cognitive functioning at 65 years old on successful ageing 6 years later is not established.

Methods: nine hundred and seventy-six questionnaires were sent by mail to a sample of healthy and voluntary French pensioners. Successful ageing was defined through health status and well-being. Cognitive abilities had been assessed 6 years earlier according to an objective method (Free and Cued Selective Recall Reminding Test (FCSRT), the Benton visual retention test and the similarities subtest of the Wechsler Adult Intelligence Scale-Revised) and a subjective one (Goldberg's anxiety scale, Mac Nair's scale and a Visual Analogue Scale to evaluate memory abilities change in the last 5 years).

Results: six hundred and eighty-six questionnaires could be analysed. The mean age was 72.9 ± 1.2 years old with 59% of women and 99% lived at home. Well-being was negatively correlated with the FCSRT (r = -0.08, P = 0.0318) but positively related with the Benton (r = 0.09, P = 0.0125) and the similarities tests (r = 0.09, P = 0.0118). There is a negative correlation between anxious and cognitive complaints measured at baseline, and successful ageing indicators 6 years later.

Conclusion: preservation of cognitive abilities at the age of retirement can predict a successful ageing 6 years later. Identifier: NCT00759304.
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March 2011