Dr. Karina Rodriguez-Capote, MD, PhD - University of British Columbia - Clinical Associate Professor

Dr. Karina Rodriguez-Capote

MD, PhD

University of British Columbia

Clinical Associate Professor

New Westminster, BC | Canada

Main Specialties: Chemical Pathology

Additional Specialties: Biomarkers in neurology, immunology and oncology.

ORCID logohttps://orcid.org/0000-0003-1766-4527


Top Author

Dr. Karina Rodriguez-Capote, MD, PhD - University of British Columbia - Clinical Associate Professor

Dr. Karina Rodriguez-Capote

MD, PhD

Introduction

As a Clinical Biochemist, I am responsible for setting the standards of performance for the Biochemistry Laboratory. As the Scientific Lead for Pre- & Post-Analytical processes at Royal Columbian Hospital, I ensure quality throughout the entire testing process, from patient sample collection to reporting results to physicians. I assist physicians with test selection and interpretation of results. I am a member of the IFCC committee on Evidence-Based Laboratory Medicine and co-chair of the Utilization Management Special Interest Group of the CSCC. Areas of clinical and research interest are: method validation, quality assurance, laboratory test utilization and evidence-based laboratory medicine. I have special interest in the field of biomarkers in neurology, immunology and oncology.

Primary Affiliation: University of British Columbia - New Westminster, BC , Canada

Specialties:

Additional Specialties:

Research Interests:


View Dr. Karina Rodriguez-Capote’s Resume / CV

Education

Jan 2010 - Jun 2010
Canadian Academy of Clinical Biochemistry
Certification in Clinical Biochemistry
Jan 2009
McMaster University
Postdoctoral Fellowship in Clinical Biochemistry
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
Jan 2005 - Jan 2006
University of Western Ontario Schulich School of Medicine and Dentistry
The "Kilee Patchell-Evans" Postdoctoral Fellowship in Neuroscience
Department of Psychology/Neuroscience
May 2005
University of Western Ontario, London, ON, Canada.
PhD Biochemistry
Dr. William Zaharia Award for excellence in the Department of Biochemistry's graduate program, presented to the most outstanding PhD student graduating in the department. University of Western Ontario.
Jan 1998 - Jan 2000
University of Western Ontario Schulich School of Medicine and Dentistry
Postdoctoral Fellowship, Pulmonary Surfactant: Structure, function and development
Department of Biochemistry and Department of Obstetrics and Gynecology
Nov 1997
Higher Institute of Medical Sciences, Havana, Cuba
Specialization in Clinical Biochemistry
Department of Laboratory Medicine and Clinical Biochemistry
Jul 1993
Higher Institute of Medical Sciences, Havana, Cuba
Doctor in Medicine

Experience

Sep 2018
Clinical Associate Professor, UBC
Clinical Associate Professor
Department of Pathology and Laboratory Medicine
Feb 2018
Clinical Biochemist and Medical Lead for Pre-and Post-Analytical, Royal Columbian Hospital
Clinical Biochemist and Medical Lead for Pre-and Post-Analytical, Royal Columbian Hospital
Clinical Biochemist and Medical Lead for Pre-and Post-Analytical, Royal Columbian Hospital
Mar 2016
Clinical Biochemist and Co-Director of Clinical Chemistry, DynaLIFE MEDICAL LABS
Co-Director of Clinical Chemistry
Clinical Biochemistry, DynaLIFE MEDICAL LABS
Jan 2013 - Sep 2013
Clinical Assistant Professor, University of Alberta
Clinical Assistant Professor
Department of Laboratory Medicine and Pathology, University of Alberta
Jan 2012 - Jan 2013
Clinical Lecturer, University of Alberta
Clinical Lecturer
Department of Laboratory Medicine and Pathology
Nov 2011 - Apr 2012
Clinical Research Assistant/Data Extractor, McMaster University
Clinical Research Assistant/Data Extractor
McMaster Evidence-based Practice Center, Department of Clinical Epidemiology and Biostatistics
Sep 2010 - Nov 2011
Research Associate in Clinical Biochemistry, London Health Sciences Centre
Research Associate in Clinical Biochemistry
London Laboratories Service Group
Sep 2006 - Feb 2009
Postdoctoral Fellow in Clinical Biochemistry, McMaster University
Postdoctoral Fellow in Clinical Biochemistry
Department of Pathology and Molecular Medicine
May 2005 - Sep 2006
Postdoctoral Fellowship, The "Kilee Patchell-Evans" Autism Research Group, University of Western Ontario Schulich School of Medicine and Dentistry
Postdoctoral Fellowship, The "Kilee Patchell-Evans" Autism Research Group
Department of Psychology/Neuroscience
Jan 2000 - Jan 2005
Graduate Research Associate, University of Western Ontario Schulich School of Medicine and Dentistry
Graduate Research Associate
Departments of Obstetrics and Gynecology and Biochemistry
Jan 1998 - Jan 2000
Postdoctoral Fellow, University of Western Ontario Schulich School of Medicine and Dentistry
Postdoctoral Fellowship: Pulmonary Surfactant
Department of Biochemistry and Department of Department of Obstetrics
Jan 1997 - Jan 1998
Assistant Professor, Higher Institute of Medical Sciences, Havana, Cuba
Assistant Professor
Department of Laboratory Medicine and Clinical Biochemistry, Higher Institute of Medical Sciences, Havana, Cuba
Jan 1994 - Jan 1997
Lecturer, Higher Institute of Medical Sciences, Havana, Cuba
Instructor (Lecturer)
Department of Laboratory Medicine and Clinical Biochemistry, Higher Institute of Medical Sciences, Havana, Cuba
May 2012
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Publications

31Publications

1121Reads

11Profile Views

155PubMed Central Citations

The practice of evidence based laboratory medicine among worldwide medical laboratory professionals: Competencies and need of training

Clinica Chimica Acta May 2019; 493:S350-S351

Clinica Chimica Acta

Background-aim: This study aimed to gain insights into the opinion of laboratory medicine professionals worldwide regarding their Evidence Based Laboratory Medicine (EBLM) competencies and needs. Methods: A self-completed questionnaire was designed by the EBLM Committee of the Spanish Society of Laboratory Medicine (SEQCML) and adapted to English by the EBLM Committee of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). The questionnaire consisted of six sections (sociodemographic data, EBLM formation, EBLM material access, competences, needs and suggestions) and 36 variables. The variables were scored on a scale of 1 to 10. A pilot study was performed (n =61). The survey was administered via SurveyMonkey® and mailed in April 2017to all Presidents and Representatives of IFCC National Societies. The data analysis was performed using IBM SPSS. The study was performed in accordance with the Ethics Research Committee. Results: 560 professionals responded to the survey. 〈-Cronbach's coefficient=0.860. 71% of respondents were Europeans, 15% Americans, 13% Asians, 1% Africans and 0.5% Australians, and 58% were female. The mean age of respondents was 48 years and mean professional experience was 21 years. 81% reported to have some basic training, 16% advanced training and 3% did not respond. Professionals indicated that they had a low level of satisfaction with their current knowledge of EBLM (average 4.74 points). There is a great interest in learning how to access Evidence Based Clinical Practice Guidelines (average 8.16 points) and in receiving further training on EBLM (average 7.77 points). Factors that showed differences in responses were gender, formal training in EBLM, years of experience and age. Men were more satisfied about their EBLM knowledge than women (5.21 points vs 4.45 points; p =.004) and women were more interested in improving their knowledge (8.26 points vs 7.75 points; p= .034). Conclusions: Laboratory professionals were very interested in EBLM, especially in access to CPGs and other EBLM materials. They also considered EBLM as necessary in their daily practice, even with multiple difficulties implicated while applying it. The findings of this survey will help to plan future training on EBLM for laboratory professionals.

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May 2019
3 Reads

Analytical Concordance of Diverse Point-of-Care and Central Laboratory Troponin I Assays

The Journal of Applied Laboratory Medicine (2019) 3(5) 764-774

The Journal of Applied Laboratory Medicine

Abstract

Background: Cardiac troponin I (cTnI) 99th percentile cutoffs, used in the diagnosis of acute myocardial infarction, are not standardized across cTnI assays. We compared 3 point-of-care (POC) and 1 central laboratory contemporary cTnI assays against the Abbott high-sensitivity (hs) cTnI to evaluate the analytical concordance and the feasibility of using a single cutoff value for all assays.

Methods: Fresh blood samples collected from 102 inpatients in the coronary care unit were measured on central laboratory instruments (Beckman Coulter DxI AccuTnI+3 TnI, Abbott Architect hs-TnI) and cTnI POC analyzers (Alere Triage Troponin I, Radiometer AQT90, Abbott i-STAT). Agreement and correlation between the contemporary cTnI assays and hs-cTnI assay were assessed using regression analysis. Proportional bias was assessed using Bland–Altman plots. Concordance between the contemporary cTnI and hs-cTnI assays was determined by diagnostic contingency tables at specific cutoffs.

Results: Most POC cTnI assays had excellent correlation with the Abbott hs-cTnI method (r2 = 0.955–0.970) except for Alere Triage (r2 = 0.617), while proportional bias is evident between all cTnI assays. Overall concordance between POC contemporary cTnI assays and hs-cTnI assay was 80% to 90% at their respective 99th percentile cutoffs. The concordance increased to 90% to 95% when a fixed cutoff of 0.03 to 0.05 ng/mL was used across the assays.

Conclusions: This study demonstrates poor analytical concordance between cTnI assays at the 99th percentile and supports the notion of a single clinical decision limit for cTnI and consequently standardization of diagnostic protocols despite the analytical differences among these assays.

View Article
February 2019
5 Reads

Point-of-care testing (POCT) and evidence-based laboratory medicine (EBLM) - does it leverage any advantage in clinical decision making?

Crit Rev Clin Lab Sci 2017 Nov - Dec;54(7-8):471-494. Epub 2017 Nov 23.

f University of Stellenbosch and National Health Laboratory Service (NHLS), Tygerberg Hospital , Cape Town , South Africa.

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http://dx.doi.org/10.1080/10408363.2017.1399336DOI Listing
April 2018
179 Reads
3.692 Impact Factor

Analytical sensitivity and diagnostic performance of serum protein electrophoresis on the HYDRAGEL 30 PROTEIN(E) β1-β2 Sebia Hydrasys system.

Clin Biochem 2018 Jan 12;51:80-84. Epub 2017 Sep 12.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada; DynaLIFE(MEDICAL LABS), Edmonton, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2017.09.007DOI Listing
January 2018
172 Reads
2.230 Impact Factor

The use of fructosamine in cystic fibrosis-related diabetes (CFRD) screening.

J Cyst Fibros 2018 01 22;17(1):121-124. Epub 2017 Jun 22.

DynaLIFE Medical Labs, Edmonton T5J 5E2, Canada; Department of Laboratory Medicine and Pathology, University of Alberta, T6G 2R3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcf.2017.05.010DOI Listing
January 2018
62 Reads
3.480 Impact Factor

Does DHEA supplementation in IVF patients result in supraphysiological DHEA-S serum concentrations?

J Assist Reprod Genet 2017 07 17;34(7):957-958. Epub 2017 Apr 17.

Department of Laboratory Medicine and Pathology, University of Alberta, #200, 10150-102 Street, Edmonton, AB, T5J 5E2, Canada.

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http://dx.doi.org/10.1007/s10815-017-0921-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476538PMC
July 2017
14 Reads
1.772 Impact Factor

Stability of specific IgE antibodies to common food and inhalant allergens.

Clin Biochem 2016 Dec 16;49(18):1387-1389. Epub 2016 Mar 16.

DynaLIFE(DX) Diagnostic Laboratory Services, Edmonton, Alberta, Canada; Dept. of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00099120160009
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http://dx.doi.org/10.1016/j.clinbiochem.2016.03.003DOI Listing
December 2016
19 Reads
2 Citations
2.230 Impact Factor

Erroneous HbA1c results in a patient with elevated HbC and HbF.

Clin Chim Acta 2016 Nov 21;462:153-157. Epub 2016 Sep 21.

Department of Laboratory Medicine and Pathology, University of Alberta, Canada; DynaLIFE(Dx), Edmonton, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2016.09.017DOI Listing
November 2016
41 Reads
2.824 Impact Factor

Is the 2-h Sample Really Necessary in the Oral Glucose Tolerance Test in Pregnant Females?

Clin Chem 2016 06 26;62(6):893-4. Epub 2016 Apr 26.

DynaLIFEDx Edmonton, Alberta Canada.

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http://dx.doi.org/10.1373/clinchem.2016.256529DOI Listing
June 2016
2 Reads
7.911 Impact Factor

Hemoglobin Hirose: A rare beta chain variant causing falsely low HbA1c by HPLC.

Clin Biochem 2016 Apr 2;49(6):498-501. Epub 2015 Dec 2.

DynaLIFE(Dx), Edmonton, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2015.11.016DOI Listing
April 2016
54 Reads
2.230 Impact Factor

Identification of Hb Wayne and its effects on HbA1c measurement by 5 methods.

Clin Biochem 2015 Nov 4;48(16-17):1144-50. Epub 2015 Aug 4.

DynaLIFE(DX) Diagnostic Laboratory Services, Edmonton, AB, Canada; Dept Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2015.07.100DOI Listing
November 2015
24 Reads
2.230 Impact Factor

Erroneous diabetes diagnosis: a case of HbA1c interference.

Diabetes Care 2015 Oct 20;38(10):e154-5. Epub 2015 Aug 20.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada Department of Clinical Chemistry, DynaLIFEDx, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.2337/dc15-0733DOI Listing
October 2015
5 Reads
8.420 Impact Factor

A novel double heterozygous Hb Fontainebleau/HbD Punjab hemoglobinopathy.

Clin Biochem 2015 Sep 31;48(13-14):904-7. Epub 2015 May 31.

DynaLIFE(DX) Diagnostic Laboratory Services, Edmonton, Alberta, Canada; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2015.05.020DOI Listing
September 2015
27 Reads
2.230 Impact Factor

Hemoglobin Constant Spring exhibits prolonged ex vivo stability when assessed by HPLC.

Clin Biochem 2015 Jul 9;48(10-11):709-12. Epub 2015 Apr 9.

DynaLIFE(Dx), Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2015.03.021DOI Listing
July 2015
15 Reads
2.230 Impact Factor

Incidence of hemoglobinopathies and thalassemias in Northern Alberta. Establishment of reference intervals for HbF and HbA2.

Clin Biochem 2015 Jul 11;48(10-11):698-702. Epub 2015 Apr 11.

DynaLIFE(DX) Diagnostic Laboratory Services, Edmonton, Alberta, Canada; Dept. Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2015.04.001DOI Listing
July 2015
188 Reads
2.230 Impact Factor

Hemoglobin C in a patient with sickle cell anemia: transfusion-acquired SC disease.

Clin Biochem 2015 Apr 4;48(6):463-4. Epub 2015 Feb 4.

DynaLIFE(Dx)¸ Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2015.01.013DOI Listing
April 2015
8 Reads
2.230 Impact Factor

Analytical evaluation of the Diazyme glycated serum protein assay on the siemens ADVIA 1800: comparison of results against HbA1c for diagnosis and management of diabetes.

J Diabetes Sci Technol 2015 Mar 14;9(2):192-9. Epub 2015 Jan 14.

Dyna LIFE DX Diagnostic Laboratory Services, Edmonton, AB, Canada Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1177/1932296814567894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604597PMC
March 2015
8 Reads
4 Citations

Evaluation of a commercially available carbohydrate deficient transferrin kit to detect beta-2-transferrin in cerebrospinal fluid using capillary electrophoresis.

Clin Biochem 2013 Nov 12;46(16-17):1770-3. Epub 2013 Jul 12.

Department of Pathology and Laboratory Medicine, McMaster University, Ontario, Canada; Hamilton Regional Medicine Program, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2013.07.001DOI Listing
November 2013
7 Reads
1 Citation
2.230 Impact Factor

Assessment of a four hour delay for urine samples stored without preservatives at room temperature for urinalysis.

Clin Biochem 2012 Jul 21;45(10-11):856-8. Epub 2012 Apr 21.

McMaster University, Department of Pathology and Molecular Medicine, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5.

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http://dx.doi.org/10.1016/j.clinbiochem.2012.04.010DOI Listing
July 2012
31 Reads
2 Citations
2.230 Impact Factor

Utility of urine myoglobin for the prediction of acute renal failure in patients with suspected rhabdomyolysis: a systematic review.

Clin Chem 2009 Dec 1;55(12):2190-7. Epub 2009 Oct 1.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1373/clinchem.2009.128546DOI Listing
December 2009
27 Reads
9 Citations
7.911 Impact Factor

Clinical implication of the difference between transcutaneous bilirubinometry and total serum bilirubin for the classification of newborns at risk of hyperbilirubinemia.

Clin Biochem 2009 Feb 2;42(3):176-9. Epub 2008 Oct 2.

Pathology and Laboratory Medicine, McMaster University Medical Centre, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.clinbiochem.2008.09.108DOI Listing
February 2009
4 Reads
4 Citations
2.230 Impact Factor

Modification of tryptophan and methionine residues is implicated in the oxidative inactivation of surfactant protein B.

Biochemistry 2007 May 11;46(18):5604-15. Epub 2007 Apr 11.

Department of Obstetrics and Gynaecology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada N6A 5C1.

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http://dx.doi.org/10.1021/bi062304pDOI Listing
May 2007
3 Reads
13 Citations
3.020 Impact Factor

Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders.

Behav Brain Res 2007 Jan 1;176(1):149-69. Epub 2006 Sep 1.

The Kilee Patchell-Evans Autism Research Group, Department of Psychology, Division of Developmental Disabilities, University of Western Ontario, Social Science Centre, London, Canada.

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http://dx.doi.org/10.1016/j.bbr.2006.07.025DOI Listing
January 2007
48 Reads
74 Citations
3.030 Impact Factor

Reactive oxygen species inactivation of surfactant involves structural and functional alterations to surfactant proteins SP-B and SP-C.

Biophys J 2006 Apr 27;90(8):2808-21. Epub 2006 Jan 27.

Department of Obstetrics/Gynaecology, Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1529/biophysj.105.073106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414557PMC
April 2006
2 Reads
15 Citations
3.972 Impact Factor

Intrinsic structural and functional determinants within the amino acid sequence of mature pulmonary surfactant protein SP-B.

Biochemistry 2005 Jan;44(1):417-30

Departamento de Bioquímica, Facultad de Biología, Universidad Complutense, Madrid, Spain.

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http://dx.doi.org/10.1021/bi048781uDOI Listing
January 2005
6 Reads
4 Citations
3.020 Impact Factor

Disparate effects of two phosphatidylcholine binding proteins, C-reactive protein and surfactant protein A, on pulmonary surfactant structure and function.

Am J Physiol Lung Cell Mol Physiol 2004 Dec 13;287(6):L1145-53. Epub 2004 Aug 13.

Department of Chemistry, Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, University of Western Ontario, London, Ontario, Canada N6A 5A5.

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http://dx.doi.org/10.1152/ajplung.00408.2003DOI Listing
December 2004
62 Reads
3 Citations
4.080 Impact Factor

Physiological and inflammatory response to instillation of an oxidized surfactant in a rat model of surfactant deficiency.

J Appl Physiol (1985) 2004 May 29;96(5):1674-80. Epub 2003 Dec 29.

Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 4V2.

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http://dx.doi.org/10.1152/japplphysiol.01143.2003DOI Listing
May 2004
2 Reads
3 Citations

Effect of acute lung injury on structure and function of pulmonary surfactant films.

Am J Respir Cell Mol Biol 2004 May 20;30(5):641-50. Epub 2003 Nov 20.

Department of Chemistry, Behala College, Kolkata, India.

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http://dx.doi.org/10.1165/rcmb.2003-0279OCDOI Listing
May 2004
28 Reads
10 Citations
3.985 Impact Factor

Pulmonary surfactant protein-A (SP-A) restores the surface properties of surfactant after oxidation by a mechanism that requires the Cys6 interchain disulfide bond and the phospholipid binding domain.

J Biol Chem 2003 Jun 24;278(23):20461-74. Epub 2003 Feb 24.

Departments of Obstetrics/Gynecology and Biochemistry, Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, University of Western Ontario, London N6A 5A5, Canada.

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http://dx.doi.org/10.1074/jbc.M212697200DOI Listing
June 2003
2 Reads
11 Citations
4.573 Impact Factor