Publications by authors named "Karin Hek"

28Publications

Guideline Adherence in Antibiotic Prescribing to Patients with Respiratory Diseases in Primary Care: Prevalence and Practice Variation.

Antibiotics (Basel) 2020 Sep 3;9(9). Epub 2020 Sep 3.

Nivel, Netherlands Institute for Health Services Research, 3500 BN Utrecht, The Netherlands.

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http://dx.doi.org/10.3390/antibiotics9090571DOI Listing
September 2020

Socioeconomic inequalities in out-of-hours primary care use: an electronic health records linkage study.

Eur J Public Health 2020 Aug 18. Epub 2020 Aug 18.

Department of Integrated Primary Care, Netherlands Institute for Health Services Research (Nivel), Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/eurpub/ckaa116DOI Listing
August 2020

Use of Opioids Increases With Age in Older Adults: An Observational Study (2005-2017).

Front Pharmacol 2020 14;11:648. Epub 2020 May 14.

Pharmaceutical Care, Netherlands Institute for Health Services Research (Nivel), Utrecht, Netherlands.

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http://dx.doi.org/10.3389/fphar.2020.00648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241279PMC
May 2020

Laxative co-medication and changes in defecation patterns during opioid use.

J Oncol Pharm Pract 2019 Oct 27;25(7):1613-1621. Epub 2018 Sep 27.

3 Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

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http://journals.sagepub.com/doi/10.1177/1078155218801066
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http://dx.doi.org/10.1177/1078155218801066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716205PMC
October 2019

Non-adherence to cardiovascular drugs in older patients with depression: A population-based cohort study.

Int J Cardiol 2019 Jan 1;274:366-371. Epub 2018 Sep 1.

University of Groningen, University Medical Center Groningen, Department of General Practice, Groningen, the Netherlands; NIVEL, Netherlands Institute for Health Services Research, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.ijcard.2018.08.100DOI Listing
January 2019

Does shared decision-making reduce antibiotic prescribing in primary care?

J Antimicrob Chemother 2018 11;73(11):3199-3205

Nivel, the Netherlands Institute for Health Services Research, BN Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/jac/dky321DOI Listing
November 2018

Partner notification and partner treatment for chlamydia: attitude and practice of general practitioners in the Netherlands; a landscape analysis.

BMC Fam Pract 2017 Dec 20;18(1):103. Epub 2017 Dec 20.

Epidemiology and Surveillance Unit, Centre for Infectious Diseases Control, RIVM, Bilthoven, The Netherlands.

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http://dx.doi.org/10.1186/s12875-017-0676-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738758PMC
December 2017

Adverse events recording in electronic health record systems in primary care.

BMC Med Inform Decis Mak 2017 Dec 6;17(1):163. Epub 2017 Dec 6.

NIVEL, Netherlands Institute for Health Services Research, P.O. Box 1568, 3500 BN, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s12911-017-0565-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719640PMC
December 2017

An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype.

Authors:
Nese Direk Stephanie Williams Jennifer A Smith Stephan Ripke Tracy Air Azmeraw T Amare Najaf Amin Bernhard T Baune David A Bennett Douglas H R Blackwood Dorret Boomsma Gerome Breen Henriette N Buttenschøn Enda M Byrne Anders D Børglum Enrique Castelao Sven Cichon Toni-Kim Clarke Marilyn C Cornelis Udo Dannlowski Philip L De Jager Ayse Demirkan Enrico Domenici Cornelia M van Duijn Erin C Dunn Johan G Eriksson Tonu Esko Jessica D Faul Luigi Ferrucci Myriam Fornage Eco de Geus Michael Gill Scott D Gordon Hans Jörgen Grabe Gerard van Grootheest Steven P Hamilton Catharina A Hartman Andrew C Heath Karin Hek Albert Hofman Georg Homuth Carsten Horn Jouke Jan Hottenga Sharon L R Kardia Stefan Kloiber Karestan Koenen Zoltán Kutalik Karl-Heinz Ladwig Jari Lahti Douglas F Levinson Cathryn M Lewis Glyn Lewis Qingqin S Li David J Llewellyn Susanne Lucae Kathryn L Lunetta Donald J MacIntyre Pamela Madden Nicholas G Martin Andrew M McIntosh Andres Metspalu Yuri Milaneschi Grant W Montgomery Ole Mors Thomas H Mosley Joanne M Murabito Bertram Müller-Myhsok Markus M Nöthen Dale R Nyholt Michael C O'Donovan Brenda W Penninx Michele L Pergadia Roy Perlis James B Potash Martin Preisig Shaun M Purcell Jorge A Quiroz Katri Räikkönen John P Rice Marcella Rietschel Margarita Rivera Thomas G Schulze Jianxin Shi Stanley Shyn Grant C Sinnamon Johannes H Smit Jordan W Smoller Harold Snieder Toshiko Tanaka Katherine E Tansey Alexander Teumer Rudolf Uher Daniel Umbricht Sandra Van der Auwera Erin B Ware David R Weir Myrna M Weissman Gonneke Willemsen Jingyun Yang Wei Zhao Henning Tiemeier Patrick F Sullivan

Biol Psychiatry 2017 09 8;82(5):322-329. Epub 2016 Dec 8.

Department of Psychiatry, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Center for Psychiatric Genomics, Genomic Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden.

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http://dx.doi.org/10.1016/j.biopsych.2016.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462867PMC
September 2017

Genetic variants in RBFOX3 are associated with sleep latency.

Eur J Hum Genet 2016 10 4;24(10):1488-95. Epub 2016 May 4.

Unit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ejhg.2016.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027680PMC
October 2016

Inter-practice variation in polypharmacy prevalence amongst older patients in primary care.

Pharmacoepidemiol Drug Saf 2016 09 2;25(9):1033-41. Epub 2016 May 2.

NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/pds.4016DOI Listing
September 2016

Antibiotic prescribing for children in primary care and adherence to treatment guidelines.

J Antimicrob Chemother 2016 06 5;71(6):1707-14. Epub 2016 Mar 5.

NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands.

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http://dx.doi.org/10.1093/jac/dkw030DOI Listing
June 2016

Factors associated with variation in urgency of primary out-of-hours contacts in the Netherlands: a cross-sectional study.

BMJ Open 2015 Oct 15;5(10):e008421. Epub 2015 Oct 15.

NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/bmjopen-2015-008421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611245PMC
October 2015

To what extent does sociodemographic composition of the neighbourhood explain regional differences in demand of primary out-of-hours care: a multilevel study.

BMC Fam Pract 2015 May 6;16:54. Epub 2015 May 6.

NIVEL, Netherlands Institute for Health Services Research, P.O. Box 1568, 3500 BN, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s12875-015-0275-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424822PMC
May 2015

A genome-wide association study of depressive symptoms.

Biol Psychiatry 2013 Apr 3;73(7):667-78. Epub 2013 Jan 3.

Research Centre O3 (KH, CLM, HT), Department of Psychiatry, and Department of Epidemiology (KH, AH, MK, AGU, HT), Erasmus MC, Rotterdam, The Netherlands; Institute of Behavioural Sciences (JL, KRa), University of Helsinki, Helsinki, Finland; Clinical Research Branch (TT), National Institute on Aging, Baltimore, Maryland; Interfaculty Institute for Genetics and Functional Genomics (ATeu), University Medicine Greifswald, Greifswald, Germany; Department of Nutrition (MCC, FBH, EBR, MKJ), Harvard School of Public Health, Boston, Massachusetts; Department of Epidemiology (EB, AVD-R, SK), University of Michigan School of Public Health, Ann Arbor, Michigan; Institute of Epidemiology II (JB, RE, K-HL), Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Department of Internal Medicine (JD), Division of Geriatrics, and Department of Epidemiology and Prevention (YL), Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina; Department of Medicine (KM), Cardiovascular Health Research Unit, University of Washington, Seattle, Washington; National Institute on Aging (ATer, OM, ARS), National Institutes of Health, Department of Health and Human Services, Baltimore; and Laboratory of Neurogenetics (MAN, ABS), Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland; Department of Epidemiology (YVS), Emory University, Atlanta, Georgia; EMGO Institute for Health and Care Research (NV, BPe), and Department of Psychiatry (NV, BPe), VU University Medical Center, Amsterdam, The Netherlands; Rush Alzheimer's Disease Center (LY, DAB), and Department of Neurological Sciences (LY, DAB), Rush University Medical Center, Chicago, Illinois; Geriatric Unit Azienda Sanitaria di Firenze (SB), Firenze, Italy; National Heart, Lung, and Blood Institute's Framingham Heart Study (EJB, MK-H, JMM, KLL, JM), Framingham; and Department of Medicine (EJB), Section of Cardiology and Preventive Medicine, Boston University School of Medicine and Public Health, Boston, Massachusetts; Department of Biological Psychology (DB, EdG), VU University, Amsterdam, The Netherlands; Istituto di Ricerca Genetica e Biomedica (AC, AMul, FC), Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy; Division of Public Health Sciences (LHC), Wake Forest School of Medicine, Winston-Salem, North Carolina; Department of Neurology (PLDJ), Program in Translational NeuroPsychiatric Genomics, Brigham and Women's Hospital, Harvard Medical School, Boston; Department of Psychiatry (SP), Massachusetts General Hospital and Harvard Medical School, Boston, and the Broad Institute, Cambridge; and Department of Epidemiology (FBH, EBR), Harvard School of Public Health, Boston, Massachusetts; Department of Biostatistics (KRi), University of Washington, Seattle, Washington; Center of Biostatistics and Department of Medicine (ADP), University of Mississippi Medical Center, Jackson, Mississippi; Medical Genetics Institute (JIR), Cedars Sinai Medical Center, Los Angeles, California; Division of Cardiology (NS), and Cardiovascular Health Research Unit (NS), Department of Medicine, University of Washington, Seattle, Washington; National Institute for Health and Welfare (JGE); Department of General Practice and Primary Health Care (JGE), University of Helsinki; Unit of General Practice (JGE), Helsinki University Central Hospital; and Folkhalsan Research Centre (JGE), Helsinki; and Vasa Central Hospital (JGE), Vasa, Finland; Department of Internal Medicine (DAE), Rush Institute for Health Aging, Rush University Medical Center, Chicago, Illinois; Longitudinal Studies Section (LF), Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland; Brown Foundation Institute of Molecular Medicine (MF), University of Texas Health Science Center at Houston, Houston, Texas; Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging (AH, AGU, CMvD, HT), Leiden, The Netherlands; Research Unit of Molecular Epidemiology (TI), Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Department of Neurology (MK-H), Boston University School of Medicine, Boston, Massachusetts; Department of Epidemiology (KK), Mailman School of Public Health, Columbia University, New York, New York; Department of Biostatistics (JMM), Boston University School of Public Health, Boston, Massachusetts; Epidemiology and Public Health (DM, LCP, DJL), Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom; Center for Medical Systems Biology (CMvD), Leiden, The Netherlands; Institute of Biomedical and Clinical Sciences (AMur), Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, United Kingdom; Mental Health Center BavoEuropoort (CLM), and Department of Clinical Genetics (BAO), Erasmus MC, Rotterdam, The Netherlands; Wellcome Trust Sanger Institute (APa), Wellcome Trust Genome Campus, Cambridge, United Kingdom; Institute for Molecular Medicine Finland (APa, EW), University of Helsinki, and Department of Medical Genetics (APa), University of Helsinki and University Central Hospital, Helsinki, Finland; Program in Medical and Population Genetics and Genetics Analysis Platform (APa), The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts; Department of Psychiatry (BPe), Leiden University Medical Centre, Leiden, and Department of Psychiatry (BPe), University Medical Centre Groningen, Groningen, The Netherlands; Institute of Clinical Chemistry and Laboratory Medicine (APe), University Medicine Greifswald, Greifswald, Germany; Cardiovascular Health Research Unit (BPs), Departments of Medicine, Epidemiology, and Health Services, University of Washington, and Group Health Research Institute (BPs), Group Health Cooperative, Seattle, Washington; Institute of Genetic Epidemiology (RR), Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Neurogenomics Division (EMR), Translational Genomics Research Institute, and Banner Alzheimer's Institute (EMR), Phoenix, Arizona; Department of Psychiatry and Psychotherapy (AS, HJG), University Medicine Greifswald, Helios-Hospital, Stralsund, Germany; Laboratory of Behavioral Neuroscience (ABZ), National Institute on Aging, Baltimore, Maryland; Department of Internal Medicine (AGU), Erasmus MC, Rotterdam, The Netherlands; Institute for Community Medicine (HV), University Medicine Greifswald, Germany; Department of Psychiatry (KY), University of California San Francisco, San Francisco, California; Icelandic Heart Association (VG, AVS), Kopavogur, Iceland; Departments of Neurology (KY) and Epidemiology and Biostatistics (KY), University of California San Francisco, San Francisco, California; Laboratory of Epidemiology, Demography and Biometry (TH, LJL), National Institute on Aging, Bethesda, Maryland; Department of Biostatistics (KLL), Boston University School of Public Health, Boston, Massachusetts; Department of Medicine (THM), University of Mississippi Medical Center, Jackson, Mississippi; Department of Medicine (JM), Section of General Internal Medicine, Boston University School of Medicine; Program in Molecular and Genetic Epidemiology (DJH, PK), Harvard School of Public Health; and Brigham and Women's Hospital (GC), Harvard Medical School, Boston, Massachusetts; Department of Epidemiology (ABN), Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Medicine (VG, AVS), University of Iceland, Reykjavik, Iceland; Hannover Unified Biobank (TI), Hannover Medical School, Hannover, Germany; College of Medicine (ATer, ARS), Florida State University, Tallahassee, Florida; Genetic Epidemiology Unit (AD, NA, BAO, CMvD), Departments of Epidemiology and Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands; and Departments of Neurology and Molecular Human Genetics (JMS), Baylor College of Medicine, Houston, Texas.

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http://dx.doi.org/10.1016/j.biopsych.2012.09.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845085PMC
April 2013

Anxiety disorders and salivary cortisol levels in older adults: a population-based study.

Psychoneuroendocrinology 2013 Feb 7;38(2):300-5. Epub 2012 Jul 7.

Research Center O3, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.psyneuen.2012.06.006DOI Listing
February 2013

Anxiety disorders and comorbid depression in community dwelling older adults.

Int J Methods Psychiatr Res 2011 Sep;20(3):157-68

O3 Research Centre, Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/mpr.344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878519PMC
September 2011

The prevalence and characteristics of complicated grief in older adults.

J Affect Disord 2011 Jul 12;132(1-2):231-8. Epub 2011 Mar 12.

Department of Epidemiology, Erasmus University Medical Centre, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S01650327110007
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http://dx.doi.org/10.1016/j.jad.2011.02.021DOI Listing
July 2011

Atherosclerosis and incident depression in late life.

Arch Gen Psychiatry 2010 Nov;67(11):1144-51

Department of Epidemiology, Erasmus University Medical Centre, the Netherlands.

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http://archpsyc.jamanetwork.com/article.aspx?doi=10.1001/arc
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http://dx.doi.org/10.1001/archgenpsychiatry.2010.142DOI Listing
November 2010

The PCLO gene and depressive disorders: replication in a population-based study.

Hum Mol Genet 2010 Feb 26;19(4):731-4. Epub 2009 Nov 26.

O3 Research Center, Department of Psychiatry, Erasmus University Medical Center, PO Box 2040, Rotterdam 3000 CA, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddp529DOI Listing
February 2010