Karim Mekhail

Karim Mekhail

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Karim Mekhail

Karim Mekhail

Publications by authors named "Karim Mekhail"

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DNA repair by Rad52 liquid droplets.

Nat Commun 2020 Feb 4;11(1):695. Epub 2020 Feb 4.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, MaRS Centre, 661 University Ave., Toronto, ON, M5G 1M1, Canada.

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http://dx.doi.org/10.1038/s41467-020-14546-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000754PMC
February 2020

Mobility and Repair of Damaged DNA: Random or Directed?

Trends Cell Biol 2019 Dec 10. Epub 2019 Dec 10.

Center for Advanced Imaging, Harvard University, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2019.11.003DOI Listing
December 2019

Roles for Non-coding RNAs in Spatial Genome Organization.

Front Cell Dev Biol 2019 19;7:336. Epub 2019 Dec 19.

Department of Laboratory Medicine and Pathobiology, MaRS Centre, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fcell.2019.00336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930868PMC
December 2019

Phase Separation as a Melting Pot for DNA Repeats.

Trends Genet 2019 Aug 31;35(8):589-600. Epub 2019 May 31.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 661 University Avenue, Toronto, ONT, M5G 1M1, Canada; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ONT, M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2019.05.001DOI Listing
August 2019

Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair.

Nat Commun 2018 07 2;9(1):2567. Epub 2018 Jul 2.

Department of Laboratory Medicine and Pathobiology, MaRS Centre, University of Toronto, West Tower, 661 University Avenue, Toronto, ON, M5G 1M1, Canada.

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http://dx.doi.org/10.1038/s41467-018-05009-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028458PMC
July 2018

Assays to Study Repair of Inducible DNA Double-Strand Breaks at Telomeres.

Methods Mol Biol 2018 ;1672:375-385

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 661 University Ave., Toronto, ON, M5G 1M1, Canada.

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http://dx.doi.org/10.1007/978-1-4939-7306-4_26DOI Listing
June 2018

Catch the live show: Visualizing damaged DNA in vivo.

Methods 2018 06 6;142:24-29. Epub 2018 Mar 6.

Department of Laboratory Medicine and Pathobiology, University of Toronto, MaRS Centre, West Tower, 661 University Avenue, Toronto, Ontario M5G 1M1, Canada; Canada Research Chairs Program, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2018.02.023DOI Listing
June 2018

Corrigendum: Defining the Damaged DNA Mobility Paradox as Revealed by the Study of Telomeres, DSBs, Microtubules and Motors.

Authors:
Karim Mekhail

Front Genet 2018 30;9:157. Epub 2018 Apr 30.

Department of Laboratory Medicine and Pathobiology, University of Toronto, MaRS Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fgene.2018.00157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936969PMC
April 2018

Defining the Damaged DNA Mobility Paradox as Revealed by the Study of Telomeres, DSBs, Microtubules and Motors.

Authors:
Karim Mekhail

Front Genet 2018 20;9:95. Epub 2018 Mar 20.

Department of Laboratory Medicine and Pathobiology, University of Toronto, MaRS Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fgene.2018.00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869915PMC
March 2018

Non-Coding RNA Molecules Connect Calorie Restriction and Lifespan.

J Mol Biol 2017 10 22;429(21):3196-3214. Epub 2016 Aug 22.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.08.020DOI Listing
October 2017

Ataxin-2: From RNA Control to Human Health and Disease.

Genes (Basel) 2017 Jun 5;8(6). Epub 2017 Jun 5.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1M1, Canada.

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http://dx.doi.org/10.3390/genes8060157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485521PMC
June 2017

Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes.

Nucleus 2017 Mar;8(2):162-181

a Department of Laboratory Medicine and Pathobiology , Faculty of Medicine, University of Toronto , Toronto, Ontario , Canada.

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http://dx.doi.org/10.1080/19491034.2017.1292193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403138PMC
March 2017

Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids.

Nucleic Acids Res 2016 Oct 29;44(18):8870-8884. Epub 2016 Aug 29.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada Canada Research Chairs Program, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada

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http://dx.doi.org/10.1093/nar/gkw752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063000PMC
October 2016

Editorial: Non-coding RNA Regulation: Lessons from Model Organisms and Impact on Human Health.

Authors:
Karim Mekhail

Front Genet 2016 31;7:49. Epub 2016 Mar 31.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fgene.2016.00049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814549PMC
April 2016

R-loops highlight the nucleus in ALS.

Nucleus 2015 ;6(1):23-9

a Department of Laboratory Medicine and Pathobiology; Faculty of Medicine ; University of Toronto ; Toronto , ON Canada.

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http://www.tandfonline.com/doi/full/10.1080/19491034.2015.10
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http://dx.doi.org/10.1080/19491034.2015.1004952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615755PMC
November 2015

Repair by a molecular DNA ambulance.

Oncotarget 2015 Aug;6(23):19358-9

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637287PMC
http://dx.doi.org/10.18632/oncotarget.5140DOI Listing
August 2015

Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process.

Nat Commun 2015 Jul 24;6:7742. Epub 2015 Jul 24.

1] Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8 [2] Canada Research Chairs Program, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.

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http://dx.doi.org/10.1038/ncomms8742DOI Listing
July 2015

Non-coding RNA in neural function, disease, and aging.

Front Genet 2015 9;6:87. Epub 2015 Mar 9.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto Toronto, ON, Canada ; Canada Research Chairs Program, Faculty of Medicine, University of Toronto Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fgene.2015.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353379PMC
March 2015

The fine line between lifespan extension and shortening in response to caloric restriction.

Nucleus 2014 Jan-Feb;5(1):56-65. Epub 2014 Jan 27.

Department of Laboratory Medicine and Pathobiology; Faculty of Medicine, University of Toronto; Toronto, ON Canada; Canada Research Chairs Program; Faculty of Medicine, University of Toronto; Toronto, ON Canada.

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http://dx.doi.org/10.4161/nucl.27929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028356PMC
January 2015

Roles for Pbp1 and caloric restriction in genome and lifespan maintenance via suppression of RNA-DNA hybrids.

Dev Cell 2014 Jul;30(2):177-91

Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Canada Research Chairs Program, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.05.013DOI Listing
July 2014

Enforcement of a lifespan-sustaining distribution of Sir2 between telomeres, mating-type loci, and rDNA repeats by Rif1.

Aging Cell 2013 Feb 23;12(1):67-75. Epub 2012 Nov 23.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, M5S 1A8.

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http://dx.doi.org/10.1111/acel.12020DOI Listing
February 2013

Effects of Perinuclear Chromosome Tethers in the Telomeric URA3/5FOA System Reflect Changes to Gene Silencing and not Nucleotide Metabolism.

Front Genet 2012 2;3:144. Epub 2012 Aug 2.

Faculty of Medicine, Department of Laboratory Medicine and Pathobiology, University of Toronto Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fgene.2012.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410493PMC
October 2012

Cohesin and related coiled-coil domain-containing complexes physically and functionally connect the dots across the genome.

Cell Cycle 2011 Aug 15;10(16):2669-82. Epub 2011 Aug 15.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219537PMC
http://dx.doi.org/10.4161/cc.10.16.17113DOI Listing
August 2011

The nuclear envelope in genome organization, expression and stability.

Nat Rev Mol Cell Biol 2010 May;11(5):317-28

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 Kings College Circle, Toronto, Ontario, Canada.

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http://www.nature.com/articles/nrm2894
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http://dx.doi.org/10.1038/nrm2894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246372PMC
May 2010

Regulation of Spo12 phosphorylation and its essential role in the FEAR network.

Curr Biol 2009 Mar 5;19(6):449-60. Epub 2009 Mar 5.

David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, 40 Ames Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.cub.2009.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692463PMC
March 2009

eEF1A is a novel component of the mammalian nuclear protein export machinery.

Mol Biol Cell 2008 Dec 17;19(12):5296-308. Epub 2008 Sep 17.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.

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http://dx.doi.org/10.1091/mbc.e08-06-0562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592675PMC
December 2008

Role for perinuclear chromosome tethering in maintenance of genome stability.

Nature 2008 Dec 9;456(7222):667-70. Epub 2008 Nov 9.

Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nature07460
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http://dx.doi.org/10.1038/nature07460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596277PMC
December 2008

Cancer-causing mutations in a novel transcription-dependent nuclear export motif of VHL abrogate oxygen-dependent degradation of hypoxia-inducible factor.

Mol Cell Biol 2008 Jan 29;28(1):302-14. Epub 2007 Oct 29.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01044-07
Publisher Site
http://dx.doi.org/10.1128/MCB.01044-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223288PMC
January 2008

Identification of a common subnuclear localization signal.

Mol Biol Cell 2007 Oct 25;18(10):3966-77. Epub 2007 Jul 25.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ONT, Canada, K1H 8M5.

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http://dx.doi.org/10.1091/mbc.e07-03-0295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995723PMC
October 2007

Restriction of rRNA synthesis by VHL maintains energy equilibrium under hypoxia.

Cell Cycle 2006 Oct 16;5(20):2401-13. Epub 2006 Oct 16.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.4161/cc.5.20.3387DOI Listing
October 2006

Regulation of ubiquitin ligase dynamics by the nucleolus.

J Cell Biol 2005 Aug;170(5):733-44

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

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http://dx.doi.org/10.1083/jcb.200506030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171338PMC
August 2005

Oxygen sensing by H+: implications for HIF and hypoxic cell memory.

Cell Cycle 2004 Aug 7;3(8):1027-9. Epub 2004 Aug 7.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

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August 2004

HIF activation by pH-dependent nucleolar sequestration of VHL.

Nat Cell Biol 2004 Jul 6;6(7):642-7. Epub 2004 Jun 6.

Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.

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http://dx.doi.org/10.1038/ncb1144DOI Listing
July 2004

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells.

J Biol Chem 2003 Nov 27;278(45):44966-74. Epub 2003 Aug 27.

Department of Cellular and Molecular Medicine and Kidney Research Center, Faculty of Medicine, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1074/jbc.M305502200DOI Listing
November 2003