Karim C El Kasmi

Karim C El Kasmi

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Karim C El Kasmi

Karim C El Kasmi

Publications by authors named "Karim C El Kasmi"

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Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming.

Antioxid Redox Signal 2018 Jan 14;28(3):230-250. Epub 2017 Aug 14.

2 Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratories, University of Colorado - Denver , Colorado.

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http://dx.doi.org/10.1089/ars.2017.7217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737722PMC
January 2018

Cancer-promoting mechanisms of tumor-associated neutrophils.

Am J Surg 2017 Nov 10;214(5):938-944. Epub 2017 Aug 10.

University of Colorado, School of Medicine, Department of Surgery, Denver, CO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.amjsurg.2017.08.003DOI Listing
November 2017

A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension.

J Immunol 2017 06 12;198(12):4802-4812. Epub 2017 May 12.

Cardiovascular Pulmonary Research Laboratories, Departments of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;

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http://dx.doi.org/10.4049/jimmunol.1601692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501258PMC
June 2017

Developmental origins of NAFLD: a womb with a clue.

Nat Rev Gastroenterol Hepatol 2017 02 26;14(2):81-96. Epub 2016 Oct 26.

Department of Pediatrics, Section of Neonatology, University of Colorado, Anschutz Medical Campus, 12801 East 17th Avenue, MS 8106, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1038/nrgastro.2016.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725959PMC
February 2017

Metabolic Reprogramming Regulates the Proliferative and Inflammatory Phenotype of Adventitial Fibroblasts in Pulmonary Hypertension Through the Transcriptional Corepressor C-Terminal Binding Protein-1.

Circulation 2016 Oct 25;134(15):1105-1121. Epub 2016 Aug 25.

From Cardiovascular Pulmonary Research Laboratories, Department of Pediatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO (M.L., S.R., H.Z., A.F., B.A.M., M.F., S.K., M.A.F., K.R.S.); Department of Biochemistry and Molecular Genetics and Biological Mass Spectrometry Shared Resource (A.D., K.C.H.), Department of Anesthesiology (N.J.S.), Advanced Light Microscopy Core Facility (R.M.), Department of Dermatology (H.L., H.L., Q.Z.), and Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition (K.C.E.K.), University of Colorado, Denver; Department of Mitochondrial Physiology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic (L.P.-H., P.J.); Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany (D.I., S.P.); Center for Genetic Improvement of Livestock, Department of Animal Bioscience, University of Guelph, Guelph, ON, Canada (A.C.); Department of Animal Science, University of California-Davis, Davis (J.F.M.); and Department of Animal Science, Colorado State University, Fort Collins (M.G.T.).

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http://circ.ahajournals.org/content/134/15/1105.full.pdf?dow
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069179PMC
http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023171DOI Listing
October 2016

Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension.

Am J Respir Cell Mol Biol 2016 07;55(1):47-57

2 Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratory, University of Colorado, Denver, Colorado.

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http://dx.doi.org/10.1165/rcmb.2015-0142OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942204PMC
July 2016

Endotoxemia Induces IκBβ/NF-κB-Dependent Endothelin-1 Expression in Hepatic Macrophages.

J Immunol 2015 Oct 4;195(8):3866-79. Epub 2015 Sep 4.

Section of Neonatology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO 80045;

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http://dx.doi.org/10.4049/jimmunol.1501017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730915PMC
October 2015

Contribution of metabolic reprogramming to macrophage plasticity and function.

Semin Immunol 2015 Aug 9;27(4):267-75. Epub 2015 Oct 9.

University of Colorado Denver, School of Medicine, Section of Pediatric Critical Care and Cardiovascular Pulmonary Research, Department of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1016/j.smim.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677817PMC
August 2015

Specific microbiome changes in a mouse model of parenteral nutrition associated liver injury and intestinal inflammation.

PLoS One 2014 20;9(10):e110396. Epub 2014 Oct 20.

Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110396PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203793PMC
July 2015

The role of inflammation in hypoxic pulmonary hypertension: from cellular mechanisms to clinical phenotypes.

Am J Physiol Lung Cell Mol Physiol 2015 Feb 21;308(3):L229-52. Epub 2014 Nov 21.

Developmental Lung Biology, Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Departments of Medicine and Pediatrics, University of Colorado, Anschutz Medical Campus, Aurora, Colorado;

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http://www.physiology.org/doi/10.1152/ajplung.00238.2014
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http://dx.doi.org/10.1152/ajplung.00238.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338929PMC
February 2015

Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.

J Immunol 2014 Jul 13;193(2):597-609. Epub 2014 Jun 13.

Division of Critical Care Medicine/Cardiovascular Pulmonary Research Laboratories, Department of Pediatrics and Medicine, School of Medicine, University of Colorado Denver, Aurora, CO 80045;

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http://dx.doi.org/10.4049/jimmunol.1303048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100597PMC
July 2014

Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.

PLoS One 2013 24;8(4):e61961. Epub 2013 Apr 24.

Program in Barrier Immunity and Repair, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061961PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634833PMC
December 2013

Phytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease.

Sci Transl Med 2013 Oct;5(206):206ra137

Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1126/scitranslmed.3006898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070735PMC
October 2013

The adventitia: essential regulator of vascular wall structure and function.

Annu Rev Physiol 2013 3;75:23-47. Epub 2012 Dec 3.

Division of Pediatric Critical Care, University of Colorado Denver, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1146/annurev-physiol-030212-183802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762248PMC
August 2013

Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change.

Pulm Circ 2012 Jan-Mar;2(1):3-14

Department of Pediatric Gastroenterology, Pediatric Critical Care-Developmental Lung Biology Laboratory, University of Colorado, Aurora, Colorado, USA.

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http://dx.doi.org/10.4103/2045-8932.94817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342746PMC
August 2012

Toll-like receptor 4-dependent Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition and intestinal injury.

Hepatology 2012 May 18;55(5):1518-28. Epub 2012 Mar 18.

Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado School of Medicine, Aurora, CO, USA.

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http://doi.wiley.com/10.1002/hep.25500
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http://dx.doi.org/10.1002/hep.25500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986925PMC
May 2012

Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis.

PLoS Pathog 2009 Apr 10;5(4):e1000371. Epub 2009 Apr 10.

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1371/journal.ppat.1000371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660425PMC
April 2009

LAG-3 regulates plasmacytoid dendritic cell homeostasis.

J Immunol 2009 Feb;182(4):1885-91

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.4049/jimmunol.0800185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675170PMC
February 2009

Modulation of adaptive immunity by different adjuvant-antigen combinations in mice lacking Nod2.

Vaccine 2008 Oct 27;26(46):5808-13. Epub 2008 Sep 27.

Department of Infectious Diseases, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.vaccine.2008.08.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586078PMC
October 2008

ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia.

PLoS One 2008 Jul 30;3(7):e2801. Epub 2008 Jul 30.

Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Tübingen, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002801PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474679PMC
July 2008

The HIF2A gene in familial erythrocytosis.

N Engl J Med 2008 05;358(18):1965-6; author reply 1966-7

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http://www.nejm.org/doi/abs/10.1056/NEJMc080274
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http://dx.doi.org/10.1056/NEJMc080274DOI Listing
May 2008

STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils.

Blood 2006 Dec 3;108(12):3682-90. Epub 2006 Aug 3.

Department of Immunology, The University of Texas M. D. Anderson Cancer Center, PO Box 301402, Unit 902, Houston, TX 77030-1903, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2006-02-00
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http://dx.doi.org/10.1182/blood-2006-02-003012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895456PMC
December 2006

Cell wall-mediated neuronal damage in early sepsis.

Infect Immun 2006 Jul;74(7):3783-9

Infectious Diseases, St. Jude Children's Research Hospital, Mailstop 320 IRC 8057, 332 N. Lauderdale Rd., Memphis, TN 38105, USA.

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http://dx.doi.org/10.1128/IAI.00022-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489725PMC
July 2006