Kari Alitalo

Kari Alitalo

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Kari Alitalo

Publications by authors named "Kari Alitalo"

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High baseline Tie1 level predicts poor survival in metastatic breast cancer.

BMC Cancer 2019 Jul 24;19(1):732. Epub 2019 Jul 24.

Department of Oncology, Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, P.O. Box 100, FI-33014, Tampere, Finland.

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http://dx.doi.org/10.1186/s12885-019-5959-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657075PMC
July 2019

Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery.

Methods Mol Biol 2018 ;1846:291-300

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/978-1-4939-8712-2_19DOI Listing
May 2019

Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling.

Circulation 2019 May 29;139(22):2570-2584. Epub 2019 Mar 29.

Wihuri Research Institute, Helsinki, Finland and Translational Cancer Biology Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Finland (R.K., K.A.H., M.R., K.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553980PMC
May 2019

Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury.

Mol Ther 2019 03 24;27(3):600-610. Epub 2019 Jan 24.

Research Unit of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, 90220 Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, 90220 Oulu, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S15250016193001
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http://dx.doi.org/10.1016/j.ymthe.2019.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404100PMC
March 2019

Dural lymphatics regulate clearance of extracellular tau from the CNS.

Mol Neurodegener 2019 02 27;14(1):11. Epub 2019 Feb 27.

Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1186/s13024-019-0312-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391770PMC
February 2019

Cardiac lymphatics in health and disease.

Nat Rev Cardiol 2019 01;16(1):56-68

Wihuri Research Institute and Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland.

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http://www.nature.com/articles/s41569-018-0087-8
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http://dx.doi.org/10.1038/s41569-018-0087-8DOI Listing
January 2019

Genetic Variants of and Are Determinants of Survival in Renal Cell Carcinoma Patients Treated with Sorafenib.

Cancer Res 2019 01 1;79(1):231-241. Epub 2018 Nov 1.

Division of Pharmacotherapy and Experimental Therapeutics, Center for Pharmacogenomics and Individualized Therapy, The University of North Carolina Eshelman School of Pharmacy, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-1089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541205PMC
January 2019

Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells.

Cancer Res 2018 10 28;78(20):5820-5832. Epub 2018 Aug 28.

Translational Cancer Biology Research Program, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0451DOI Listing
October 2018

Consensus guidelines for the use and interpretation of angiogenesis assays.

Angiogenesis 2018 08;21(3):425-532

Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10456-018-9613-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237663PMC
August 2018

Local adventitial anti-angiogenic gene therapy reduces growth of vasa-vasorum and in-stent restenosis in WHHL rabbits.

J Mol Cell Cardiol 2018 08 9;121:145-154. Epub 2018 Jul 9.

A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland; Heart Center, Kuopio University Hospital, Kuopio, Finland; Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222828183040
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http://dx.doi.org/10.1016/j.yjmcc.2018.07.007DOI Listing
August 2018

Vascular endothelial growth factor signaling in development and disease.

Development 2018 07 20;145(14). Epub 2018 Jul 20.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki 00290, Finland

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http://dx.doi.org/10.1242/dev.151019DOI Listing
July 2018

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms.

Nat Commun 2018 04 3;9(1):1296. Epub 2018 Apr 3.

Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjölds väg 20, 751 85, Uppsala, Sweden.

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http://dx.doi.org/10.1038/s41467-018-03692-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882855PMC
April 2018

VEGF-C promotes the development of lymphatics in bone and bone loss.

Elife 2018 04 5;7. Epub 2018 Apr 5.

Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, Dallas, United States.

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http://dx.doi.org/10.7554/eLife.34323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903859PMC
April 2018

Fighting vessel dysmorphia to improve glioma chemotherapy.

EMBO Mol Med 2017 12;9(12):1626-1628

Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.15252/emmm.201708431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709761PMC
December 2017

Development and plasticity of meningeal lymphatic vessels.

J Exp Med 2017 Dec 15;214(12):3645-3667. Epub 2017 Nov 15.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland

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http://dx.doi.org/10.1084/jem.20170391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716035PMC
December 2017

White adipose tissue coloring by intermittent fasting.

Cell Res 2017 11 24;27(11):1300-1301. Epub 2017 Oct 24.

Wihuri Research Institute and Translational Cancer Biology Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/cr.2017.130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674161PMC
November 2017

SnapShot: Angiopoietins and Their Functions.

Cell 2017 Oct;171(3):724-724.e1

University of Helsinki and Wihuri Research Institute, 00290 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.cell.2017.10.009DOI Listing
October 2017

Therapeutic targeting of the angiopoietin-TIE pathway.

Nat Rev Drug Discov 2017 Sep 19;16(9):635-661. Epub 2017 May 19.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1038/nrd.2016.278DOI Listing
September 2017

Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations.

Am J Pathol 2017 Sep 3;187(9):1984-1997. Epub 2017 Jul 3.

Department of Anatomy, Cardiovascular Research Institute, and UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808174PMC
September 2017

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics.

J Clin Invest 2017 Sep 1;127(9):3210-3219. Epub 2017 Sep 1.

Center for Brain Immunology and Glia, Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1172/JCI90603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669566PMC
September 2017

Midkine and Melanoma Metastasis: A Malevolent Mix.

Dev Cell 2017 08;42(3):205-207

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.07.015DOI Listing
August 2017

Lymphangiogenesis guidance by paracrine and pericellular factors.

Genes Dev 2017 08;31(16):1615-1634

Wihuri Research Institute, Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, FI-00014 Helsinki, Finland.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.303776.117
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http://dx.doi.org/10.1101/gad.303776.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647933PMC
August 2017

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1.

Sci Rep 2017 07 7;7(1):4916. Epub 2017 Jul 7.

Translational Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, PO Box 63, Haartmaninkatu 8, Helsinki, 00014, Finland.

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http://dx.doi.org/10.1038/s41598-017-04982-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501841PMC
July 2017

VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling.

Circ Res 2017 Apr 15;120(9):1414-1425. Epub 2017 Mar 15.

From the Wihuri Research Institute and Translational Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Finland (K.H., S.K., G.D'A., T.T., K.A., G.Z.); Biocenter Oulu and Department of Pathology, University of Oulu and Oulu University Hospital, Finland (R.S.); and Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland (L.E.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.310477DOI Listing
April 2017

Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.

Proc Natl Acad Sci U S A 2017 04 10;114(17):4376-4381. Epub 2017 Apr 10.

Wihuri Research Institute, Biomedicum Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland;

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http://dx.doi.org/10.1073/pnas.1616166114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410806PMC
April 2017

ORAI1 Controls the Unique Adjustment of Lymphatics to Fluid Flow.

Circ Res 2017 04;120(9):1373-1375

From the Wihuri Research Institute and Translational Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, Finland.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310917DOI Listing
April 2017

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection.

Proc Natl Acad Sci U S A 2016 11 31;113(46):13144-13149. Epub 2016 Oct 31.

Wihuri Research Institute, Biomedicum Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland;

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http://dx.doi.org/10.1073/pnas.1616168113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135329PMC
November 2016

Simultaneous targeting of VEGF-receptors 2 and 3 with immunoliposomes enhances therapeutic efficacy.

J Drug Target 2016 23;24(1):80-9. Epub 2015 Jul 23.

a Department of Medical Oncology , University Hospital , Basel , Switzerland .

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https://www.tandfonline.com/doi/full/10.3109/1061186X.2015.1
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http://dx.doi.org/10.3109/1061186X.2015.1056189DOI Listing
October 2016

The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation.

Nat Commun 2016 10 12;7:13124. Epub 2016 Oct 12.

Wihuri Research Institute, Biomedicum Helsinki, Haartmaninkatu 8, Helsinki 00290, Finland.

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http://dx.doi.org/10.1038/ncomms13124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064023PMC
October 2016

Critical requirement of VEGF-C in transition to fetal erythropoiesis.

Blood 2016 08 24;128(5):710-20. Epub 2016 Jun 24.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; and.

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http://dx.doi.org/10.1182/blood-2015-12-687970DOI Listing
August 2016

Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice.

Sci Rep 2016 08 11;6:31566. Epub 2016 Aug 11.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, 8093 Zurich, Switzerland.

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http://dx.doi.org/10.1038/srep31566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980670PMC
August 2016

Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis.

Circ Res 2016 07 25;119(2):210-21. Epub 2016 May 25.

From the VA San Diego Healthcare System, Medical and Research Sections, La Jolla, CA (S.C.J., X.Y., R.E., M.M.F.); Division of Pulmonary and Critical Care, Department of Medicine, University of California San Diego, La Jolla (S.C.J., X.Y., R.E., M.M.F.); Marine Drug Research Institute, Huaihai Institute of Technology, Lianyungang, China (X.Y.); Translational Cancer Biology Research Program, Institute of Biomedicine (M.J.) and Helsinki University Central Hospital (K.A.), Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California San Diego, La Jolla (J.R.B., M.S.); Biomatrix Center, New York University (S.A.W.-A.); and Translational Cancer Biology Research Program, Wihuri Research Institute, Helsinki, Finland (K.A.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938725PMC
July 2016

PROX1 and β-catenin are prognostic markers in pancreatic ductal adenocarcinoma.

BMC Cancer 2016 07 13;16:472. Epub 2016 Jul 13.

Department of Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 440, FIN-00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1186/s12885-016-2497-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944261PMC
July 2016

Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.

Neoplasia 2016 07;18(7):436-46

Oulu Center for Cell-Matrix Research, Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, FIN-90014, University of Oulu, Oulu, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954931PMC
July 2016

Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1.

PLoS One 2015 31;10(7):e0134551. Epub 2015 Jul 31.

Research Programs Unit, Molecular Neurology and Biomedicum Stem Cell Centre, University of Helsinki, Helsinki, Finland; Children's Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134551PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521699PMC
May 2016

Lymphatic System in Cardiovascular Medicine.

Circ Res 2016 Feb;118(3):515-30

From the Wihuri Research Institute (A.A., M.R.R., S.K., K.A.) and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (A.A., M.R.R., K.A.); and Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden (T.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.306544DOI Listing
February 2016

VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption.

EMBO Mol Med 2015 Nov;7(11):1418-25

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki University of Helsinki, Helsinki, Finland

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http://dx.doi.org/10.15252/emmm.201505731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644375PMC
November 2015

Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling.

Proc Natl Acad Sci U S A 2015 Oct 1;112(42):13063-8. Epub 2015 Oct 1.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, FI-00290 Helsinki, Finland;

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http://dx.doi.org/10.1073/pnas.1517810112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620883PMC
October 2015

PROX1 is involved in progression of rectal neuroendocrine tumors, NETs.

Virchows Arch 2015 Sep 11;467(3):279-84. Epub 2015 Jun 11.

Department of Pathology, University of Helsinki and Huslab, 00014, Helsinki, Finland,

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http://dx.doi.org/10.1007/s00428-015-1795-7DOI Listing
September 2015

Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis.

J Clin Pathol 2015 Aug 28;68(8):614-21. Epub 2015 May 28.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland Department of Public Health Sciences, Global Health/IHCAR, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1136/jclinpath-2015-202888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518739PMC
August 2015

Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice.

Atherosclerosis 2015 Aug 3;241(2):297-304. Epub 2015 Jun 3.

Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Neulaniementie 2, 70150 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2015.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549395PMC
August 2015

VEGF-C and VEGF-C156S in the pro-lymphangiogenic growth factor therapy of lymphedema: a large animal study.

Angiogenesis 2015 Jul 28;18(3):313-26. Epub 2015 May 28.

Department of Plastic and General Surgery, Turku University Hospital, P.O. Box 52, Kiinamyllynkatu 4-8, 20251, Turku, Finland,

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http://link.springer.com/content/pdf/10.1007/s10456-015-9469
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http://dx.doi.org/10.1007/s10456-015-9469-2DOI Listing
July 2015

Growth factor therapy and lymph node graft for lymphedema.

J Surg Res 2015 Jun 19;196(1):200-7. Epub 2015 Feb 19.

Department of Plastic and General Surgery, Turku University Hospital, Turku, Finland; Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jss.2015.02.031DOI Listing
June 2015

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules.

J Exp Med 2015 Jun 15;212(7):991-9. Epub 2015 Jun 15.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland

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http://dx.doi.org/10.1084/jem.20142290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493418PMC
June 2015

Nonvenous origin of dermal lymphatic vasculature.

Circ Res 2015 May 3;116(10):1649-54. Epub 2015 Mar 3.

From the Department of Immunology, Genetics, and Pathology, Uppsala University, Uppsala, Sweden (I.M.-C., M.H.U., L.S., T.M.); Lymphatic Development Laboratory, Cancer Research UK London Research Institute, London, United Kingdom (I.M.-C., L.S., F.T., T.M.); Howard Hughes Medical Institute, The Jackson Laboratory, Bar Harbor, ME (K.K., S.W.M.J.); Wihuri Research Institute, Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (K.A.); Biotechnology Programme, Spanish National Cancer Research Centre, Madrid, Spain (S.O.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.306170DOI Listing
May 2015

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

Cancer Res 2015 May 25;75(10):2083-94. Epub 2015 Mar 25.

Research Programs Unit, Genome-Scale Biology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Finnish Cancer Institute, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1923DOI Listing
May 2015

Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.

Circ Res 2015 May 26;116(10):1660-9. Epub 2015 Mar 26.

From the Hubrecht Institute, KNAW-UMC Utrecht, Utrecht, The Netherlands (M.G.R., J.P.M., Y.P., F.L.B., S.S.-M., D.S.); Cardiovascular Research Institute, University of California San Francisco (F.L.B.); Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Wihuri Research Institute, Biomedicum Helsinki, Helsinki, Finland (M.J., V.-M. L., K.A.); Institute for Cardiovascular Organogenesis and Regeneration, Faculty of Medicine, WWU, Münster, Germany (Y.P., S.S.M., D.S.); and Cells-in-Motion Cluster of Excellence (EXC 1003-CiM), University of Münster, Münster, Germany (Y.P., S.S.M., D.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.304949DOI Listing
May 2015

cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels.

Cell Rep 2015 Mar 12;10(10):1708-1721. Epub 2015 Mar 12.

The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 752 85 Uppsala, Sweden; Lymphatic Development Laboratory, Cancer Research UK London Research Institute (LRI), 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.026DOI Listing
March 2015

Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humans.

Cell Rep 2015 Feb 19;10(7):1158-72. Epub 2015 Feb 19.

Université Pierre and Marie Curie-Paris 6, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France; INSERM/CNRS U-1127/UMR-7225, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France; APHP, Groupe Hospitalier Pitié-Salpètrière, 75013 Paris, France; Department of Neurology, Yale University School of Medicine, New Haven, CT 06510-3221, USA. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)00074-1.p
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http://genesdev.cshlp.org/content/25/8/831.full.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S221112471500074
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http://dx.doi.org/10.1016/j.celrep.2015.01.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685253PMC
February 2015

VEGFR3 does not sustain retinal angiogenesis without VEGFR2.

Proc Natl Acad Sci U S A 2015 Jan 5;112(3):761-6. Epub 2015 Jan 5.

Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, FIN-00014 Helsinki, Finland;

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http://www.pnas.org/content/112/3/761.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1423278112
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http://dx.doi.org/10.1073/pnas.1423278112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311859PMC
January 2015

Endothelial destabilization by angiopoietin-2 via integrin β1 activation.

Nat Commun 2015 Jan 30;6:5962. Epub 2015 Jan 30.

Wihuri Research Institute and Research Programs Unit, Translational Cancer Biology Program and Department of Virology, University of Helsinki, Biomedicum Helsinki, Haartmaninkatu 8, PO Box 63, Helsinki FI-00014, Finland.

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http://dx.doi.org/10.1038/ncomms6962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316742PMC
January 2015

HIF-1α and HIF-2α induce angiogenesis and improve muscle energy recovery.

Eur J Clin Invest 2014 Oct;44(10):989-99

Department of Biotechnology and Molecular Medicine, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1111/eci.12333DOI Listing
October 2014

Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance.

Cell Rep 2014 Sep 18;8(6):1943-1956. Epub 2014 Sep 18.

Translational Cancer Biology Program, University of Helsinki, Biomedicum Helsinki, 00014 Helsinki, Finland; Wihuri Research Institute, Biomedicum Helsinki, 00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.034DOI Listing
September 2014

Vascular endothelial growth factor-B in physiology and disease.

Physiol Rev 2014 Jul;94(3):779-94

Wihuri Research Institute and Translational Cancer Biology Program, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1152/physrev.00028.2013DOI Listing
July 2014

Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.

Arterioscler Thromb Vasc Biol 2014 Jun 10;34(6):1162-70. Epub 2014 Apr 10.

From the Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland (T.V., J.K., S.E.H., H.S., T.H., S.Y.-H.); Wihuri Research Institute and Translational Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland (H.N., M.R.R., M.Ö., K.A.); Cardiology Division, Department of Medicine, University of Colorado, Aurora (K.M.); and Gene Therapy Unit (S.Y.-H.) and Research Unit (S.Y.-H.), Kuopio University Hospital, Kuopio, Finland.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.302528
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031366PMC
June 2014

CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C activation.

Circulation 2014 May 19;129(19):1962-71. Epub 2014 Feb 19.

Wihuri Research Institute (M.J., A.A., V.-M.L., R.K., K.A.), Translational Cancer Biology Program (M.J., S.K.J., D.T., A.A., T.H., K.A.), and Department of Biomedicine (M.J.), Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; Biotechnology Programme, Spanish National Cancer Research Centre, Madrid, Spain (S.O.); Hubrecht Institute, Utrecht, The Netherlands (T.K.); and Helsinki University Central Hospital, Helsinki, Finland (K.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.002779DOI Listing
May 2014

Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β.

Proc Natl Acad Sci U S A 2014 May 13;111(21):E2229-36. Epub 2014 May 13.

Translational Cancer Biology Program andWihuri Research Institute, Biomedicum Helsinki, University of Helsinki, FI-00014, Helsinki, Finland;

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http://www.pnas.org/cgi/doi/10.1073/pnas.1406444111
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040601PMC
May 2014

Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period.

Circ Res 2014 Feb 15;114(5):806-22. Epub 2014 Jan 15.

From the Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco (L.-C.Y., P.B., D.M.M.); Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden (C.T., L.C.-W.); Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki and University of Helsinki, Helsinki, Finland (D.T., A.A., K.A.); Department of Pathology, Boston Children's Hospital, Harvard University, MA (S.O.V.), and Department of Cell Biology, ImClone Systems, Eli Lilly and Company, New York (B.P.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.303119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969887PMC
February 2014

The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features.

Biochim Biophys Acta 2014 Jan 8;1840(1):454-63. Epub 2013 Oct 8.

Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, FI-70211 Kuopio, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2013.10.005DOI Listing
January 2014

Ex vivo intracoronary gene transfer of adeno-associated virus 2 leads to superior transduction over serotypes 8 and 9 in rat heart transplants.

Transpl Int 2013 Nov 19;26(11):1126-37. Epub 2013 Sep 19.

Transplantation Laboratory, Haartman Institute, University of Helsinki and Department of Cardiac Surgery, Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland.

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http://doi.wiley.com/10.1111/tri.12182
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November 2013

VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy.

EMBO Mol Med 2013 Sep 2;5(9):1415-30. Epub 2013 Aug 2.

Laboratory of Vascular Biology and Stem Cells and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.

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http://dx.doi.org/10.1002/emmm.201302618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799495PMC
September 2013

Receptor tyrosine kinase-mediated angiogenesis.

Cold Spring Harb Perspect Biol 2013 Sep 1;5(9). Epub 2013 Sep 1.

Wihuri Research Institute, Biomedicum Helsinki, University of Helsinki, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1101/cshperspect.a009183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753715PMC
September 2013

Comparison of vascular growth factors in the murine brain reveals placenta growth factor as prime candidate for CNS revascularization.

Blood 2013 Aug 26;122(5):658-65. Epub 2013 Jun 26.

Wihuri Research Institute and Translational Cancer Biology Program, Faculty of Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1182/blood-2012-07-441527DOI Listing
August 2013

Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.

Proc Natl Acad Sci U S A 2013 Aug 22;110(32):12960-5. Epub 2013 Jul 22.

Translational Cancer Biology Program, Institute for Molecular Medicine Finland and Helsinki University Central Hospital, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1073/pnas.1301415110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740881PMC
August 2013

A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.

Cancer Cell 2013 Aug 25;24(2):242-56. Epub 2013 Jul 25.

The Lautenberg Center for Immunology, Institute of Medical Research, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1016/j.ccr.2013.06.005DOI Listing
August 2013

The basis for the distinct biological activities of vascular endothelial growth factor receptor-1 ligands.

Sci Signal 2013 Jul 2;6(282):ra52. Epub 2013 Jul 2.

Translational Cancer Biology Program, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1126/scisignal.2003905DOI Listing
July 2013