Karen-Lise Garm Spindler

Leeds Institute of Medical Research at St James's, University of Leeds and Leeds Cancer Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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March 2020

Correlation between early dynamics in circulating tumour DNA and outcome from FOLFIRI treatment in metastatic colorectal cancer.

Authors:

Iben Lyskjær Camilla Skovhus Kronborg Mads Heilskov Rasmussen Boe Sandahl Sørensen Christina Demuth Mona Rosenkilde Amanda Frydendahl Boll Johansen Michael Knudsen Søren Vang Søren Rasmus Palmelund Krag Karen-Lise Garm Spindler Claus Lindbjerg Andersen

Sci Rep 2019 08 8;9(1):11542. Epub 2019 Aug 8.

Department of Molecular Medicine, Aarhus University Hospital, DK-8200, Aarhus, Denmark.

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August 2019

Cell-free DNA and preoperative chemoradiotherapy for rectal cancer: a systematic review.

Authors:

Anders Kindberg Boysen Jakob Vasehus Schou Karen-Lise Garm Spindler

Clin Transl Oncol 2019 Jul 1;21(7):874-880. Epub 2018 Dec 1.

Department of Experimental Clinical Oncology, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus, Denmark.

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July 2019

Total cell-free DNA, carcinoembryonic antigen, and C-reactive protein for assessment of prognosis in patients with metastatic colorectal cancer.

Authors:

Karen-Lise Garm Spindler Christina Demuth Boe Sandahl Sorensen Julia S Johansen Dorte Nielsen Niels Pallisgaard Estrid Hoegdall Per Pfeiffer Benny Vittrup Jensen

Tumour Biol 2018 Nov;40(11):1010428318811207

4 Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Hellerup, Denmark.

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November 2018

KRAS mutation status, comorbidity, and mortality in patients with metastatic colorectal cancer in Denmark.

Authors:

Anne Gulbech Ording Buket Öztürk Karen-Lise Garm Spindler Henrik Toft Sørensen Margaret McCusker Vera Ehrenstein

Acta Oncol 2018 12 28;57(12):1727-1729. Epub 2018 Sep 28.

a Department of Clinical Epidemiology , Aarhus University Hospital , Aarhus , Denmark.

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December 2018

Measuring KRAS Mutations in Circulating Tumor DNA by Droplet Digital PCR and Next-Generation Sequencing.

Authors:

Christina Demuth Karen-Lise Garm Spindler Julia S Johansen Niels Pallisgaard Dorte Nielsen Estrid Hogdall Benny Vittrup Boe Sandahl Sorensen

Transl Oncol 2018 Oct 4;11(5):1220-1224. Epub 2018 Aug 4.

Department of Clinical Biochemistry, Aarhus University Hospital, Denmark. Electronic address:

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October 2018

Can we ave the rectum by watchful waiting or ransnal microsurgery following (chemo) adiotherapy versus otal mesorectal excision for early ctal ancer (STAR-TREC study)?: protocol for a multicentre, randomised feasibility study.

BMJ Open 2017 12 28;7(12):e019474. Epub 2017 Dec 28.

Department of Surgery, Radboud University Medical Centre, Nijmegen, The Netherlands.

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December 2017

Cell-free DNA levels and correlation to stage and outcome following treatment of locally advanced rectal cancer.

Authors:

Anders Kindberg Boysen Yvonne Wettergren Boe Sandahl Sorensen Helena Taflin Bengt Gustavson Karen-Lise Garm Spindler

Tumour Biol 2017 Nov;39(11):1010428317730976

1 Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.

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November 2017

Systematic review: brain metastases from colorectal cancer--Incidence and patient characteristics.

Authors:

Troels Dreier Christensen Karen-Lise Garm Spindler Jesper Andreas Palshof Dorte Lisbet Nielsen

BMC Cancer 2016 Apr 1;16:260. Epub 2016 Apr 1.

Department of Oncology, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730, Herlev, Denmark.

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April 2016

Colorectal cancer, comorbidity, and risk of venous thromboembolism: assessment of biological interactions in a Danish nationwide cohort.

Authors:

Thomas P Ahern Erzsébet Horváth-Puhó Karen-Lise Garm Spindler Henrik Toft Sørensen Anne G Ording Rune Erichsen

Br J Cancer 2016 Jan 1;114(1):96-102. Epub 2015 Dec 1.

Department of Clinical Epidemiology, Aarhus University Hospital, Olof Palmes Allé 43-45, DK-8200 Aarhus N, Denmark.

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January 2016

Clinical utility of KRAS status in circulating plasma DNA compared to archival tumour tissue from patients with metastatic colorectal cancer treated with anti-epidermal growth factor receptor therapy.

Authors:

Karen-Lise Garm Spindler Niels Pallisgaard Ane Lindegaard Appelt Rikke Fredslund Andersen Jakob V Schou Dorte Nielsen Per Pfeiffer Mette Yilmaz Julia S Johansen Estrid V Hoegdall Anders Jakobsen Benny V Jensen

Eur J Cancer 2015 Nov 24;51(17):2678-85. Epub 2015 Oct 24.

Department of Oncology, Copenhagen University Hospital at Herlev, Herlev, Denmark.

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November 2015

Controls to validate plasma samples for cell free DNA quantification.

Authors:

Niels Pallisgaard Karen-Lise Garm Spindler Rikke Fredslund Andersen Ivan Brandslund Anders Jakobsen

Clin Chim Acta 2015 Jun 18;446:141-6. Epub 2015 Apr 18.

Department of Oncology, Vejle Hospital, Kabbeltoft 25, DK-7100 Vejle, Denmark. Electronic address:

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June 2015

Circulating free DNA as biomarker and source for mutation detection in metastatic colorectal cancer.

Authors:

Karen Lise Garm Spindler Niels Pallisgaard Rikke Fredslund Andersen Ivan Brandslund Anders Jakobsen

PLoS One 2015 13;10(4):e0108247. Epub 2015 Apr 13.

Department of Oncology, Vejle Hospital, Vejle, Denmark.

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April 2016

Reirradiation of locally recurrent rectal cancer: a systematic review.

Authors:

Marianne Grønlie Guren Christine Undseth Bernt Louni Rekstad Morten Brændengen Svein Dueland Karen-Lise Garm Spindler Rob Glynne-Jones Kjell Magne Tveit

Radiother Oncol 2014 Nov 26;113(2):151-7. Epub 2014 Nov 26.

Department of Oncology, Oslo University Hospital, Norway; K.G.Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, Norway; University of Oslo, Norway.

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November 2014

TIMP-1 and CEA as biomarkers in third-line treatment with irinotecan and cetuximab for metastatic colorectal cancer.

Authors:

Karen-Lise Garm Spindler Ib Jarle Christensen Hans Jørgen Nielsen Anders Jakobsen Nils Brünner

Tumour Biol 2015 Jun 23;36(6):4301-8. Epub 2015 Jan 23.

Department of Oncology, Vejle Hospital, Kabbeltoft 25, 7100, Vejle, Denmark,

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June 2015

Improved sensitivity of circulating tumor DNA measurement using short PCR amplicons.

Authors:

Rikke Fredslund Andersen Karen-Lise Garm Spindler Ivan Brandslund Anders Jakobsen Niels Pallisgaard

Clin Chim Acta 2015 Jan 20;439:97-101. Epub 2014 Oct 20.

Dept. of Clinical Immunology and Biochemistry, Vejle Hospital, Kabbeltoft 25, 7100 Vejle, Denmark.

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January 2015

FCGR polymorphisms and cetuximab efficacy in chemorefractory metastatic colorectal cancer: an international consortium study.

Gut 2015 Jun 10;64(6):921-8. Epub 2014 Jul 10.

Laboratory of Molecular Digestive Oncology, University Hospital Gasthuisberg, Leuven, Belgium.

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June 2015

Cell-free DNA in healthy individuals, noncancerous disease and strong prognostic value in colorectal cancer.

Authors:

Karen-Lise Garm Spindler Ane L Appelt Niels Pallisgaard Rikke F Andersen Ivan Brandslund Anders Jakobsen

Int J Cancer 2014 Dec 17;135(12):2984-91. Epub 2014 Jun 17.

Department of Oncology, Vejle Hospital, Vejle, Denmark; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.

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December 2014

Changes in mutational status during third-line treatment for metastatic colorectal cancer--results of consecutive measurement of cell free DNA, KRAS and BRAF in the plasma.

Authors:

Karen-Lise Garm Spindler Niels Pallisgaard Rikke Fredslund Andersen Anders Jakobsen

Int J Cancer 2014 Nov 17;135(9):2215-22. Epub 2014 Apr 17.

Department of Oncology, Vejle Hospital, Vejle, Denmark; Department of Oncology, Aarhus University Hospital, Denmark.

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November 2014

Levels of cell-free DNA and plasma KRAS during treatment of advanced NSCLC.

Authors:

Anneli Dowler Nygaard Karen-Lise Garm Spindler Niels Pallisgaard Rikke Fredslund Andersen Anders Jakobsen

Oncol Rep 2014 Feb 6;31(2):969-74. Epub 2013 Dec 6.

Department of Oncology, Vejle Hospital, DK-7100 Vejle, Denmark.

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February 2014

Assessment of the topoisomerase I gene copy number as a predictive biomarker of objective response to irinotecan in metastatic colorectal cancer.

Authors:

Sune Boris Nygård Ib Jarle Christensen Signe Lykke Nielsen Hans Jørgen Nielsen Nils Brünner Karen-Lise Garm Spindler

Scand J Gastroenterol 2014 Jan 21;49(1):84-91. Epub 2013 Nov 21.

Section for Molecular Disease Biology, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen , 49 Strandboulevarden, DK-2100 Copenhagen Ø , Denmark.

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January 2014

The prognostic value of KRAS mutated plasma DNA in advanced non-small cell lung cancer.

Authors:

Anneli Dowler Nygaard Karen-Lise Garm Spindler Niels Pallisgaard Rikke Fredslund Andersen Anders Jakobsen

Lung Cancer 2013 Mar 11;79(3):312-7. Epub 2012 Dec 11.

Department of Oncology, Vejle Hospital, Kabbeltoft 25, Vejle, Denmark.

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March 2013

Single nucleotide polymorphisms in the HIF-1α gene and chemoradiotherapy of locally advanced rectal cancer.

Authors:

Birgitte Mayland Havelund Karen-Lise Garm Spindler John Ploen Rikke Fredslund Andersen Anders Jakobsen

Oncol Lett 2012 Nov 31;4(5):1056-1060. Epub 2012 Jul 31.

Department of Oncology, Vejle Hospital, Vejle 7100; ; Faculty of Health Sciences, Institute of Regional Health Services Research, University of Southern Denmark , Odense 5000;

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November 2012