Karen Sachs

Karen Sachs

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Karen Sachs

Karen Sachs

Publications by authors named "Karen Sachs"

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A Bayesian Active Learning Experimental Design for Inferring Signaling Networks.

J Comput Biol 2018 07 21;25(7):709-725. Epub 2018 Jun 21.

4 College of Science, College of Computer and Information Science, Northeastern University , Boston, Massachusetts.

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http://www.liebertpub.com/doi/10.1089/cmb.2017.0247
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http://dx.doi.org/10.1089/cmb.2017.0247DOI Listing
July 2018

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Authors:
Alexandra B Keenan Sherry L Jenkins Kathleen M Jagodnik Simon Koplev Edward He Denis Torre Zichen Wang Anders B Dohlman Moshe C Silverstein Alexander Lachmann Maxim V Kuleshov Avi Ma'ayan Vasileios Stathias Raymond Terryn Daniel Cooper Michele Forlin Amar Koleti Dusica Vidovic Caty Chung Stephan C Schürer Jouzas Vasiliauskas Marcin Pilarczyk Behrouz Shamsaei Mehdi Fazel Yan Ren Wen Niu Nicholas A Clark Shana White Naim Mahi Lixia Zhang Michal Kouril John F Reichard Siva Sivaganesan Mario Medvedovic Jaroslaw Meller Rick J Koch Marc R Birtwistle Ravi Iyengar Eric A Sobie Evren U Azeloglu Julia Kaye Jeannette Osterloh Kelly Haston Jaslin Kalra Steve Finkbiener Jonathan Li Pamela Milani Miriam Adam Renan Escalante-Chong Karen Sachs Alex Lenail Divya Ramamoorthy Ernest Fraenkel Gavin Daigle Uzma Hussain Alyssa Coye Jeffrey Rothstein Dhruv Sareen Loren Ornelas Maria Banuelos Berhan Mandefro Ritchie Ho Clive N Svendsen Ryan G Lim Jennifer Stocksdale Malcolm S Casale Terri G Thompson Jie Wu Leslie M Thompson Victoria Dardov Vidya Venkatraman Andrea Matlock Jennifer E Van Eyk Jacob D Jaffe Malvina Papanastasiou Aravind Subramanian Todd R Golub Sean D Erickson Mohammad Fallahi-Sichani Marc Hafner Nathanael S Gray Jia-Ren Lin Caitlin E Mills Jeremy L Muhlich Mario Niepel Caroline E Shamu Elizabeth H Williams David Wrobel Peter K Sorger Laura M Heiser Joe W Gray James E Korkola Gordon B Mills Mark LaBarge Heidi S Feiler Mark A Dane Elmar Bucher Michel Nederlof Damir Sudar Sean Gross David F Kilburn Rebecca Smith Kaylyn Devlin Ron Margolis Leslie Derr Albert Lee Ajay Pillai

Cell Syst 2018 01 29;6(1):13-24. Epub 2017 Nov 29.

NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cels.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799026PMC
January 2018

From Correlation to Causality: Statistical Approaches to Learning Regulatory Relationships in Large-Scale Biomolecular Investigations.

J Proteome Res 2016 Mar 12;15(3):683-90. Epub 2016 Jan 12.

College of Science, College of Computer and Information Science, Northeastern University , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.jproteome.5b00911DOI Listing
March 2016

NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia.

Blood 2014 Nov 14;124(22):3274-83. Epub 2014 Oct 14.

Department of Genetics, Cell Biology and Development, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN; Center for Genome Engineering and Department of Pediatrics, University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.1182/blood-2013-08-521708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239336PMC
November 2014

Normalization of mass cytometry data with bead standards.

Cytometry A 2013 May 19;83(5):483-94. Epub 2013 Mar 19.

Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1002/cyto.a.22271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688049PMC
May 2013

Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators.

Nat Biotechnol 2012 Sep;30(9):858-67

Baxter Laboratory in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1038/nbt.2317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627543PMC
September 2012

Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.

Blood 2011 Apr 28;117(16):4226-33. Epub 2011 Feb 28.

Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA; Baxter Laboratories for Stem Cell Biology, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1182/blood-2010-07-298232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087474PMC
April 2011

Characterization of patient specific signaling via augmentation of Bayesian networks with disease and patient state nodes.

Conf Proc IEEE Eng Med Biol Soc 2009 ;2009:6624-7

Department of Microbiology and Immunology, Baxter Laboratory in Genetic Pharmacology, Stanford School of Medicine, USA.

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http://dx.doi.org/10.1109/IEMBS.2009.5332563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124088PMC
March 2010

Learning signaling network structures with sparsely distributed data.

J Comput Biol 2009 Feb;16(2):201-12

Department of Microbiology and Immunology, Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, CA, USA.

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http://www.liebertpub.com/doi/10.1089/cmb.2008.07TT
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http://dx.doi.org/10.1089/cmb.2008.07TTDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198894PMC
February 2009

Causal protein-signaling networks derived from multiparameter single-cell data.

Science 2005 Apr;308(5721):523-9

Biological Engineering Division, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1105809DOI Listing
April 2005

Bayesian network approach to cell signaling pathway modeling.

Sci STKE 2002 Sep 3;2002(148):pe38. Epub 2002 Sep 3.

Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/stke.2002.148.pe38DOI Listing
September 2002