Karen S Anderson

Karen S Anderson

UNVERIFIED PROFILE

Are you Karen S Anderson?   Register this Author

Register author
Karen S Anderson

Karen S Anderson

Publications by authors named "Karen S Anderson"

Are you Karen S Anderson?   Register this Author

100Publications

2096Reads

37Profile Views

Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase.

FEBS Lett 2019 Aug 18;593(15):2069-2078. Epub 2019 Jun 18.

Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/1873-3468.13474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690774PMC
August 2019

Molecular and cellular studies evaluating a potent 2-cyanoindolizine catechol diether NNRTI targeting wildtype and Y181C mutant HIV-1 reverse transcriptase.

Bioorg Med Chem Lett 2019 Aug 26;29(16):2182-2188. Epub 2019 Jun 26.

Department of Pharmacology, Yale University, 333 Cedar Street, New Haven, CT 06520, United States; Department of Molecular Biophysics and Biochemistry, Yale University, 333 Cedar Street, New Haven, CT 06520, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2019.06.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690785PMC
August 2019

Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV.

Antiviral Res 2019 Jul 26;167:110-116. Epub 2019 Apr 26.

Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066, USA; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520-8066, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.antiviral.2019.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554724PMC
July 2019

Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening.

Bioorg Med Chem Lett 2019 Jun 20;29(11):1413-1418. Epub 2019 Mar 20.

Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2019.03.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624847PMC
June 2019

Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes.

Nat Commun 2019 04 23;10(1):1842. Epub 2019 Apr 23.

Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-09693-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478683PMC
April 2019

The neoepitope landscape of breast cancer: implications for immunotherapy.

BMC Cancer 2019 Mar 4;19(1):200. Epub 2019 Mar 4.

School of Life Sciences, Arizona State University, PO Box 874501, Tempe, AZ, 85287-4501, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-019-5402-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399957PMC
March 2019

The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT.

Mol Cancer Res 2019 02 26;17(2):532-543. Epub 2018 Sep 26.

Department of Pharmacology, Yale University, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-18-0429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647014PMC
February 2019

HPV: Immunology lessons from an ancient oncotarget.

Oncotarget 2019 Feb 12;10(13):1269-1270. Epub 2019 Feb 12.

Karen S. Anderson: Biodesign Center for Personalized Diagnostics, Arizona State University, Tempe, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.26606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407686PMC
February 2019

Lost in the crowd: identifying targetable MHC class I neoepitopes for cancer immunotherapy.

Expert Rev Proteomics 2018 12 14;15(12):1065-1077. Epub 2018 Nov 14.

a Center for Personalized Diagnostics, Biodesign Institute , Arizona State University , Tempe , AZ , USA.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14789450.2018.1
Publisher Site
http://dx.doi.org/10.1080/14789450.2018.1545578DOI Listing
December 2018

Eccrine Sweat as a Biofluid for Profiling Immune Biomarkers.

Proteomics Clin Appl 2018 11 28;12(6):e1800010. Epub 2018 Jun 28.

Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, 85281, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prca.201800010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282813PMC
November 2018

A compact, low-cost, quantitative and multiplexed fluorescence detection platform for point-of-care applications.

Biosens Bioelectron 2018 Oct 4;117:153-160. Epub 2018 Apr 4.

School of Electrical, Computer and Energy Engineering at Arizona State University, Suite 334, Goldwater Center, Tempe, AZ 85287, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bios.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095205PMC
October 2018

JAK2 and PD-L1 Amplification Enhance the Dynamic Expression of PD-L1 in Triple-negative Breast Cancer.

Clin Breast Cancer 2018 10 26;18(5):e1205-e1215. Epub 2018 May 26.

Virginia G. Piper Center for Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, AZ; Department of Medicine, Mayo Clinic, Phoenix, AZ. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15268209173078
Publisher Site
http://dx.doi.org/10.1016/j.clbc.2018.05.006DOI Listing
October 2018

DRONE: Direct Tracking of DNA Cytidine Deamination and Other DNA Modifying Activities.

Anal Chem 2018 10 28;90(20):11735-11740. Epub 2018 Sep 28.

Department of Pharmacology , Yale University , 333 Cedar Street SHM B-350 , New Haven , Connecticut 06520 , United States.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acs.analchem.8b01405
Publisher Site
http://dx.doi.org/10.1021/acs.analchem.8b01405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410358PMC
October 2018

Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent.

Chem Commun (Camb) 2018 Jul 19;54(54):7479-7482. Epub 2018 Jun 19.

Department of Chemistry, Wake Forest University, Wake Downtown Campus, Winston-Salem, NC 27101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8cc04251aDOI Listing
July 2018

Serum Immune Profiling for Early Detection of Cervical Disease.

Theranostics 2017 23;7(16):3814-3823. Epub 2017 Aug 23.

Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/thno.21098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667406PMC
June 2018

Activity and fidelity of human DNA polymerase α depend on primer structure.

J Biol Chem 2018 05 19;293(18):6824-6843. Epub 2018 Mar 19.

From the Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA117.001074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936803PMC
May 2018

Pre-diagnostic dynamic HPV16 IgG seropositivity and risk of oropharyngeal cancer: Methodologic issues.

Oral Oncol 2018 05 30;80:93. Epub 2018 Mar 30.

Biodesign Institute, Arizona State University, Tempe Arizona, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2018.02.013DOI Listing
May 2018

From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection.

Proc Natl Acad Sci U S A 2018 01 26;115(4):E802-E811. Epub 2017 Dec 26.

Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1717932115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789948PMC
January 2018

The success of sentinel lymph node biopsy after neoadjuvant therapy: A single institution review.

Am J Surg 2017 Dec 18;214(6):1096-1101. Epub 2017 Sep 18.

Section of Surgical Oncology, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjsurg.2017.08.024DOI Listing
December 2017

Discussion of: "The success of sentinel lymph node biopsy after neoadjuvant therapy: A single institution review".

Am J Surg 2017 12 30;214(6):1102-1103. Epub 2017 Sep 30.

Section of Surgical Oncology, Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjsurg.2017.09.024DOI Listing
December 2017

Autoantibody biomarkers for the detection of serous ovarian cancer.

Gynecol Oncol 2017 07 18;146(1):129-136. Epub 2017 Apr 18.

Virginia G. Piper Center for Personal Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ygyno.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519143PMC
July 2017

Isolation, Detection, and Quantification of Cancer Biomarkers in HPV-Associated Malignancies.

Sci Rep 2017 06 12;7(1):3322. Epub 2017 Jun 12.

Demirci Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Stanford University School of Medicine, Department of Radiology, Canary Center at Stanford for Cancer Early Detection, 3155 Porter Drive, Palo Alto, CA, 94304, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-02672-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468352PMC
June 2017

MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma.

Stem Cell Res 2017 05 5;21:160-166. Epub 2017 May 5.

Division of Otolaryngology, Department of Surgery, Yale School of Medicine, New Haven, CT, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2017.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518784PMC
May 2017

Structural and Preclinical Studies of Computationally Designed Non-Nucleoside Reverse Transcriptase Inhibitors for Treating HIV infection.

Mol Pharmacol 2017 04 6;91(4):383-391. Epub 2017 Feb 6.

Departments of Pharmacology, School of Medicine (S.N.K., A.H.C., K.S.A.), Infectious Diseases/Internal Medicine, School of Medicine (J.B., P.K.), and Chemistry (W.-G.L., W.L.J.), Yale University, New Haven, Connecticut

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.116.107755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363707PMC
April 2017

Understanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR.

Authors:
Karen S Anderson

Protein Eng Des Sel 2017 Mar;30(3):253-261

Departments of Pharmacology and Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8066,USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/protein/gzx004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438133PMC
March 2017

Human Papillomavirus-Associated Oropharyngeal Cancer: Not Just White Men Anymore.

JAMA Oncol 2017 Feb;3(2):161-162

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston3Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoncol.2016.3510DOI Listing
February 2017

Proteomic Monitoring of B Cell Immunity.

Methods Mol Biol 2016 ;1403:131-52

Center for Personalized Diagnostics, School of Life Sciences, The Biodesign Institute, Arizona State University, 876401, Tempe, AZ, 85287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-3387-7_6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558855PMC
December 2016

T-Cell Epitope Discovery for Therapeutic Cancer Vaccines.

Methods Mol Biol 2016 ;1403:779-96

Center for Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-3387-7_45DOI Listing
December 2016

Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents.

ACS Med Chem Lett 2016 Dec 31;7(12):1156-1160. Epub 2016 Oct 31.

Department of Chemistry, Yale University , New Haven, Connecticut 06520-8107, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsmedchemlett.6b00390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151141PMC
December 2016

Crucial considerations for pipelines to validate circulating biomarkers for breast cancer.

Expert Rev Proteomics 2016 4;13(2):201-11. Epub 2016 Jan 4.

a Center for Personalized Diagnostics, Biodesign Institute , Arizona State University , Tempe , AZ , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/14789450.2016.1132170DOI Listing
October 2016

The DNA Polymerase Gamma R953C Mutant Is Associated with Antiretroviral Therapy-Induced Mitochondrial Toxicity.

Antimicrob Agents Chemother 2016 09 22;60(9):5608-11. Epub 2016 Aug 22.

Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut, USA Department of Epidemiology & Public Health, Yale School of Medicine, New Haven, Connecticut, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00976-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997837PMC
September 2016

Proteomic mapping of p53 immunogenicity in pancreatic, ovarian, and breast cancers.

Proteomics Clin Appl 2016 07 17;10(7):720-31. Epub 2016 May 17.

Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prca.201500096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553208PMC
July 2016

Programmable protein arrays for immunoprofiling HPV-associated cancers.

Proteomics 2016 Apr 4;16(8):1215-24. Epub 2016 Apr 4.

Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201500376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549685PMC
April 2016

Insights into the Molecular Mechanism of Polymerization and Nucleoside Reverse Transcriptase Inhibitor Incorporation by Human PrimPol.

Antimicrob Agents Chemother 2016 01 9;60(1):561-9. Epub 2015 Nov 9.

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.02270-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704227PMC
January 2016

Regional recurrence in the era of sentinel lymph node biopsy.

Am J Surg 2015 Dec 28;210(6):1155-60; discussion 1160-1. Epub 2015 Sep 28.

Department of General Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjsurg.2015.09.001DOI Listing
December 2015

Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase.

Bioorg Med Chem Lett 2015 Nov 9;25(21):4824-4827. Epub 2015 Jul 9.

Department of Chemistry, Yale University, New Haven, CT 06520-8107, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2015.06.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607639PMC
November 2015

Plasma Autoantibodies Associated with Basal-like Breast Cancers.

Cancer Epidemiol Biomarkers Prev 2015 Sep 12;24(9):1332-40. Epub 2015 Jun 12.

Biodesign Institute, Arizona State University, Tempe, Arizona.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-15-0047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560641PMC
September 2015

HPV16 antibodies as risk factors for oropharyngeal cancer and their association with tumor HPV and smoking status.

Oral Oncol 2015 Jul 6;51(7):662-7. Epub 2015 May 6.

Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2015.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457560PMC
July 2015

Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ.

Proc Natl Acad Sci U S A 2015 Jul 29;112(28):8596-601. Epub 2015 Jun 29.

Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77555; Sealy Center for Structural Biology, University of Texas Medical Branch, Galveston, TX 77555;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1421733112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507203PMC
July 2015

HPV Serum Antibodies as Predictors of Survival and Disease Progression in Patients with HPV-Positive Squamous Cell Carcinoma of the Oropharynx.

Clin Cancer Res 2015 Jun;21(12):2861-9

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-14-3323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470305PMC
June 2015

Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy.

ACS Chem Biol 2015 May 24;10(5):1319-29. Epub 2015 Feb 24.

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.5b00014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533833PMC
May 2015

Health promotion training in dental and oral health degrees: a scoping review.

J Dent Educ 2015 May;79(5):584-91

Ms. Bracksley-O'Grady is Teaching Fellow, Department of Public and Community Health, La Trobe Rural Health School, La Trobe University, Bendigo, Australia; Dr. Dickson-Swift is Senior Lecturer, Department of Public and Community Health, La Trobe Rural Health School, La Trobe University, Bendigo, Australia; Dr. Anderson is Lecturer, Department of Public and Community Health, La Trobe Rural Health School, La Trobe University, Bendigo, Australia; and Dr. Gussy is Head, Department of Dentistry and Oral Health, La Trobe Rural Health School, La Trobe University, Bendigo, Australia.

View Article

Download full-text PDF

Source
May 2015

Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors.

Mol Cancer Res 2015 Apr 8;13(4):765-74. Epub 2015 Jan 8.

Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-14-0326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398619PMC
April 2015

Structure-based evaluation of non-nucleoside inhibitors with improved potency and solubility that target HIV reverse transcriptase variants.

J Med Chem 2015 Mar 5;58(6):2737-45. Epub 2015 Mar 5.

†Department of Pharmacology, ‡Department of Chemistry, Yale University, New Haven, Connecticut 06520-8066, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm501908aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378236PMC
March 2015

Immunotherapy for the treatment of breast cancer.

Curr Oncol Rep 2015 Feb;17(2)

Department of Medical Oncology, Mayo Clinic Arizona, Scottsdale, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11912-014-0426-9DOI Listing
February 2015

Modelling the effect of early detection of Ebola.

Lancet Infect Dis 2015 Feb 19;15(2):148-9. Epub 2015 Jan 19.

Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1473-3099(14)71084-9DOI Listing
February 2015

Autoantibody signature for the serologic detection of ovarian cancer.

J Proteome Res 2015 Jan 17;14(1):578-86. Epub 2014 Nov 17.

Center for Personalized Diagnostics, Biodesign Institute, Arizona State University , Tempe, Arizona 85287-6401, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/pr500908nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334299PMC
January 2015

Recent findings on the mechanisms involved in tenofovir resistance.

Antivir Chem Chemother 2014 Dec 16;23(6):217-22. Epub 2014 Dec 16.

Department of Pharmacology, School of Medicine, Yale University, New Haven, CT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3851/IMP2628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077986PMC
December 2014

Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers.

ACS Med Chem Lett 2014 Nov 13;5(11):1259-62. Epub 2014 Oct 13.

Department of Chemistry, Yale University , New Haven, Connecticut 06520-8107, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ml5003713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233359PMC
November 2014

Current perspectives on HIV-1 antiretroviral drug resistance.

Viruses 2014 Oct 24;6(10):4095-139. Epub 2014 Oct 24.

Department of Pharmacology, School of Medicine, Yale University, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v6104095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213579PMC
October 2014

Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase.

Bioorg Med Chem Lett 2014 Sep 24;24(17):4158-61. Epub 2014 Jul 24.

Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2014.07.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427026PMC
September 2014

Cellular, histologic, and molecular changes associated with endometriosis and ovarian cancer.

J Minim Invasive Gynecol 2014 Jan-Feb;21(1):55-63. Epub 2013 Aug 17.

Department of Obstetrics and Gynecology, University of the State of São Paulo, São Paulo, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmig.2013.07.021DOI Listing
August 2014

Artificial antigen-presenting cells expressing CD80, CD70, and 4-1BB ligand efficiently expand functional T cells specific to tumor-associated antigens.

Immunobiology 2014 Aug 20;219(8):583-92. Epub 2014 Mar 20.

Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Department of Immunology and Immunotherapy, Kurume University School of Medicine, Kurume, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imbio.2014.03.003DOI Listing
August 2014

Oral human papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners.

J Clin Oncol 2014 Aug 28;32(23):2408-15. Epub 2014 Apr 28.

Gypsyamber D'Souza, Shirani Rajan, and Jennifer Gerber, Johns Hopkins Bloomberg School of Public Health; Sara I. Pai, Johns Hopkins Medical Institutions, Baltimore, MD; Neil D. Gross, Oregon Health and Science University, Portland, OR; Robert Haddad, Dana-Farber Cancer Institute, Boston, MA; Karen S. Anderson, Arizona State University, Tempe, AZ; Maura L. Gillison, Ohio State University Comprehensive Cancer Center, Columbus, OH; and Marshall R. Posner, Icahn School of Medicine at Mount Sinai, New York, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2014.55.1341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263818PMC
August 2014

A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase.

Biochim Biophys Acta 2014 Jul 12;1840(7):2203-11. Epub 2014 Apr 12.

Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03044165140013
Publisher Site
http://dx.doi.org/10.1016/j.bbagen.2014.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061246PMC
July 2014

Structure-based evaluation of C5 derivatives in the catechol diether series targeting HIV-1 reverse transcriptase.

Chem Biol Drug Des 2014 May 14;83(5):541-9. Epub 2014 Mar 14.

Department of Pharmacology, Yale University, 333 Cedar Street, SHM B350, New Haven, CT, 06520-8066, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cbdd.12266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3999282PMC
May 2014

Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase.

Bioorg Med Chem Lett 2014 Feb 31;24(4):1232-5. Epub 2013 Dec 31.

Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2013.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946055PMC
February 2014

Design, Synthesis, and Antiviral Evaluation of Chimeric Inhibitors of HIV Reverse Transcriptase.

ACS Med Chem Lett 2013 Dec 15;4(12):1183-8. Epub 2013 Oct 15.

Department of Pharmacology, School of Medicine, Yale University , New Haven, Connecticut 06520, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ml4002979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027223PMC
December 2013

Picomolar inhibitors of HIV reverse transcriptase featuring bicyclic replacement of a cyanovinylphenyl group.

J Am Chem Soc 2013 Nov 24;135(44):16705-13. Epub 2013 Oct 24.

Department of Chemistry, Yale University , New Haven, Connecticut 06520-8107, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ja408917nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877923PMC
November 2013

Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors.

Bioorg Med Chem Lett 2013 Oct 24;23(19):5426-8. Epub 2013 Jul 24.

Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2013.07.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853131PMC
October 2013

Discovery of potent and selective inhibitors of thymidylate synthase for opportunistic infections.

ACS Med Chem Lett 2013 Oct;4(12):1148-1151

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ml400208vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901304PMC
October 2013

Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation.

Protein Sci 2013 Sep 1;22(9):1161-73. Epub 2013 Aug 1.

Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06510; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06510.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pro.2300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776329PMC
September 2013

Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility.

Bioorg Med Chem Lett 2013 Sep 8;23(18):5213-6. Epub 2013 Jul 8.

Department of Chemistry, Yale University, New Haven, CT 06520-8107, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2013.06.091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759246PMC
September 2013

Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein-protein interaction in TS-DHFR.

Medchemcomm 2013 Sep;4(9)

Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA ; Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA.

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=c3md00141e
Publisher Site
http://dx.doi.org/10.1039/C3MD00141EDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855065PMC
September 2013