Karen Posey

Karen Posey

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Karen Posey

Karen Posey

Publications by authors named "Karen Posey"

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Novel mTORC1 Mechanism Suggests Therapeutic Targets for COMPopathies.

Am J Pathol 2019 Jan;189(1):132-146

Department of Pediatrics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas; School of Dentistry, University of Texas Health Science Center, Houston, Texas.

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http://dx.doi.org/10.1016/j.ajpath.2018.09.008DOI Listing
January 2019

Cartilage oligomeric matrix protein: COMPopathies and beyond.

Matrix Biol 2018 10 9;71-72:161-173. Epub 2018 Mar 9.

McGovern Medical School, UTHealth, Department of Pediatrics, United States; UTHealth, School of Dentistry, United States.

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http://dx.doi.org/10.1016/j.matbio.2018.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129439PMC
October 2018

Novel therapeutic interventions for pseudoachondroplasia.

Bone 2017 Sep 21;102:60-68. Epub 2017 Mar 21.

McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, United States; School of Dentistry University of Texas Heath, Houston, TX, United States.

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http://dx.doi.org/10.1016/j.bone.2017.03.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168010PMC
September 2017

Antisense Reduction of Mutant COMP Reduces Growth Plate Chondrocyte Pathology.

Mol Ther 2017 03 3;25(3):705-714. Epub 2017 Feb 3.

Department of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ymthe.2016.12.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363192PMC
March 2017

Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia.

Hum Mol Genet 2015 Jul 9;24(14):3918-28. Epub 2015 Apr 9.

Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USA and Shriners Hospital for Children, Houston, TX, USA.

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http://dx.doi.org/10.1093/hmg/ddv122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476442PMC
July 2015

Pseudoachondroplasia/COMP - translating from the bench to the bedside.

Matrix Biol 2014 Jul 2;37:167-73. Epub 2014 Jun 2.

Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX 77030, USA; Shriners Hospital for Children, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.matbio.2014.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209947PMC
July 2014

Identification of a 3Kbp mechanoresponsive promoter region in the human cartilage oligomeric matrix protein gene.

Tissue Eng Part A 2012 Sep 10;18(17-18):1882-9. Epub 2012 Aug 10.

Department of Orthopaedic Surgery, University of California, Davis School of Medicine, Sacramento, CA 95817, USA.

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http://dx.doi.org/10.1089/ten.TEA.2011.0497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432897PMC
September 2012

D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis.

Am J Pathol 2012 Feb 7;180(2):738-48. Epub 2011 Dec 7.

Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ajpath.2011.10.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349870PMC
February 2012

Thrombospondins and novel TSR-containing proteins, R-spondins, regulate bone formation and remodeling.

Curr Osteoporos Rep 2010 Jun;8(2):68-76

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 311 Hill Pavilion, 380 South University Avenue, Philadelphia, PA, 19104-4539, USA.

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http://dx.doi.org/10.1007/s11914-010-0017-0DOI Listing
June 2010

RNAi reduces expression and intracellular retention of mutant cartilage oligomeric matrix protein.

PLoS One 2010 Apr 22;5(4):e10302. Epub 2010 Apr 22.

Department of Pediatrics, University of Texas Medical School at Houston, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010302PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858657PMC
April 2010

Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen.

Am J Pathol 2008 Jun 8;172(6):1664-74. Epub 2008 May 8.

Department of Pediatrics, University of Texas Medical School, 6431 Fannin, Houston, TX 77030, USA.

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http://dx.doi.org/10.2353/ajpath.2008.071094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408425PMC
June 2008

COMP mutations: domain-dependent relationship between abnormal chondrocyte trafficking and clinical PSACH and MED phenotypes.

J Cell Biochem 2008 Feb;103(3):778-87

Department of Cell Biology and Anatomy, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA.

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http://dx.doi.org/10.1002/jcb.21445DOI Listing
February 2008

Computational identification and functional validation of regulatory motifs in cartilage-expressed genes.

Genome Res 2007 Oct 4;17(10):1438-47. Epub 2007 Sep 4.

Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1101/gr.6224007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1987341PMC
October 2007

In vivo human Cartilage oligomeric matrix protein (COMP) promoter activity.

Matrix Biol 2005 Dec 7;24(8):539-49. Epub 2005 Oct 7.

Department of Pediatrics, University of Texas Medical School at Houston, 6431 Fannin, 77030, USA.

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http://dx.doi.org/10.1016/j.matbio.2005.07.007DOI Listing
December 2005

Evolution of divergent DNA recognition specificities in VDE homing endonucleases from two yeast species.

Nucleic Acids Res 2004 27;32(13):3947-56. Epub 2004 Jul 27.

Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, 2121 W. Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/nar/gkh734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC506816PMC
July 2004

Role of TSP-5/COMP in pseudoachondroplasia.

Int J Biochem Cell Biol 2004 Jun;36(6):1005-12

Department of Pediatrics, Medical School at Houston, University of Texas Health Science Center, 6431 Fannin, Room MSB 3.306, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.biocel.2004.01.011DOI Listing
June 2004

Assessing the plasticity of DNA target site recognition of the PI-SceI homing endonuclease using a bacterial two-hybrid selection system.

J Mol Biol 2003 Dec;334(5):993-1008

Center for Genome Research, Institute of Biosciences and Technology, Texas A & M University System Health Science Center, 2121 W. Holcombe Blvd., Houston, TX 77030, USA.

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December 2003

Insertion of a reversible redox switch into a rare-cutting DNA endonuclease.

Biochemistry 2002 Feb;41(7):2184-90

Center for Genome Research, Institute of Biosciences and Technology, The Texas A&M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, Texas 77030, USA.

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February 2002