Publications by authors named "Karen Nygard"

18Publications

Inhibition of decidual IGF-1 signaling in response to hypoxia and leucine deprivation is mediated by mTOR and AAR pathways and increased IGFBP-1 phosphorylation.

Mol Cell Endocrinol 2020 07 5;512:110865. Epub 2020 Jun 5.

Department of Pediatrics, University of Western Ontario, London, ON, Canada; Department of Biochemistry, University of Western Ontario, London, ON, Canada; Children's Health Research Institute, London, ON, Canada. Electronic address:

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July 2020

Maternal Undernourishment in Guinea Pigs Leads to Fetal Growth Restriction with Increased Hypoxic Cells and Oxidative Stress in the Brain.

Dev Neurosci 2019 21;41(5-6):290-299. Epub 2020 Apr 21.

Department of Obstetrics and Gynecology, University of Western Ontario, London, Ontario, Canada,

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April 2020

Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with increased brain apoptosis.

Pediatr Res 2019 01 12;85(1):105-112. Epub 2018 Nov 12.

Departments of Obstetrics and Gynecology, Physiology and Pharmacology, Pediatrics, and Pathology, Children's Health Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada.

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January 2019

IUGR Is Associated With Marked Hyperphosphorylation of Decidual and Maternal Plasma IGFBP-1.

J Clin Endocrinol Metab 2019 02;104(2):408-422

Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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February 2019

Co-Localization of Insulin-Like Growth Factor Binding Protein-1, Casein Kinase-2β, and Mechanistic Target of Rapamycin in Human Hepatocellular Carcinoma Cells as Demonstrated by Dual Immunofluorescence and in Situ Proximity Ligation Assay.

Am J Pathol 2018 01 14;188(1):111-124. Epub 2017 Oct 14.

Department of Biochemistry, University of Western Ontario, London, Ontario, Canada; Department of Pediatrics, University of Western Ontario, London, Ontario, Canada; Children's Health Research Institute, London, Ontario, Canada. Electronic address:

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January 2018

Impact of ventilation-induced lung injury on the structure and function of lamellar bodies.

Am J Physiol Lung Cell Mol Physiol 2017 Sep 25;313(3):L524-L533. Epub 2017 May 25.

Lawson Health Research Institute, Western University, London Ontario, Canada;

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September 2017

Exposure of decidualized HIESC to low oxygen tension and leucine deprivation results in increased IGFBP-1 phosphorylation and reduced IGF-I bioactivity.

Mol Cell Endocrinol 2017 09 21;452:1-14. Epub 2017 Apr 21.

Children's Health Research Institute, University of Western Ontario, London, Ontario, Canada; Department of Biochemistry, University of Western Ontario, London, Ontario, Canada; Department of Pediatrics, University of Western Ontario, London, Ontario, Canada. Electronic address:

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September 2017

Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with evidence for chronic hypoxia.

Pediatr Res 2017 07 24;82(1):141-147. Epub 2017 May 24.

Department of Obstetrics and Gynecology, University of Western Ontario, London, Ontario, Canada.

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July 2017

Location, Location, Location: Appraising the Pleiotropic Function of HMGB1 in Fetal Brain.

J Neuropathol Exp Neurol 2017 04;76(4):332-334

Integrated Microscopy@ Biotron, Western University, London, ON, Canada.

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April 2017

Decorin over-expression by decidual cells in preeclampsia: a potential blood biomarker.

Am J Obstet Gynecol 2016 09 19;215(3):361.e1-361.e15. Epub 2016 Mar 19.

Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada; Department of Oncology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada; Children's Health Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada. Electronic address:

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September 2016

Brain Injury and Inflammatory Response to Umbilical Cord Occlusions Is Limited With Worsening Acidosis in the Near-Term Ovine Fetus.

Reprod Sci 2016 07 23;23(7):858-70. Epub 2015 Dec 23.

Department of Obstetrics and Gynecology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada

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July 2016

Periostin induces fibroblast proliferation and myofibroblast persistence in hypertrophic scarring.

Exp Dermatol 2015 Feb;24(2):120-6

Cell and Molecular Biology Laboratory, Roth|McFarlane Hand and Upper Limb Centre, Western University, London, ON, Canada; Lawson Health Research Institute, Western University, London, ON, Canada; Department of Biochemistry, Western University, London, ON, Canada.

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February 2015

Synaptic development and neuronal myelination are altered with growth restriction in fetal guinea pigs.

Dev Neurosci 2014 26;36(6):465-76. Epub 2014 Sep 26.

Department of Obstetrics and Gynaecology, University of Western Ontario, London, Ont., Canada.

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July 2015

Effects of maternal global nutrient restriction on fetal baboon hepatic insulin-like growth factor system genes and gene products.

Endocrinology 2009 Oct 2;150(10):4634-42. Epub 2009 Jul 2.

Center for Pregnancy and Newborn Research, University of Texas Health Science Center at San Antonio, Texas 78229, USA.

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October 2009

BDNF and TrkB in the preterm and near-term ovine fetal brain and the effect of intermittent umbilical cord occlusion.

Reprod Sci 2008 Nov;15(9):895-905

Department of Obstetrics and Gynaecology, The Children's Health Research Institute, The University of Western Ontario, London, Canada.

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November 2008