Karen Marder

Karen Marder

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Karen Marder

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Movement disorders rounds: A case of missing pathology in a patient with LRRK2 Parkinson's disease.

Parkinsonism Relat Disord 2019 Nov 9. Epub 2019 Nov 9.

Department of Neurology, Columbia University College of Physicians and Surgeons, Columbia University Medical Center, 710 West 168th Street, New York, NY, 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2019.11.006DOI Listing
November 2019

Disease Progression in Huntington Disease: An Analysis of Multiple Longitudinal Outcomes.

J Huntingtons Dis 2018 ;7(4):337-344

Department of Neurology, Columbia University Medical Center, New York, NY, USA.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JHD-180297DOI Listing
October 2019

Dietary Patterns, Physical Activity, Sleep, and Risk for Dementia and Cognitive Decline.

Curr Nutr Rep 2018 12;7(4):335-345

Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.

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http://link.springer.com/10.1007/s13668-018-0247-9
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http://dx.doi.org/10.1007/s13668-018-0247-9DOI Listing
December 2018

Heritability and genetic variance of dementia with Lewy bodies.

Neurobiol Dis 2019 07 3;127:492-501. Epub 2019 Apr 3.

Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588425PMC
July 2019

The choice not to undergo genetic testing for Huntington disease: Results from the PHAROS study.

Clin Genet 2019 Jul 15;96(1):28-34. Epub 2019 May 15.

Department of Neurology, University of Rochester, Rochester, NY.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.13529
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http://dx.doi.org/10.1111/cge.13529DOI Listing
July 2019

Patient Knowledge and Attitudes towards Genetic Testing in Parkinson's Disease Subjects with Deep Brain Stimulation.

Parkinsons Dis 2019 21;2019:3494609. Epub 2019 Apr 21.

Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1155/2019/3494609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501170PMC
April 2019

A comprehensive screening of copy number variability in dementia with Lewy bodies.

Neurobiol Aging 2019 03 24;75:223.e1-223.e10. Epub 2018 Oct 24.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183038
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541211PMC
March 2019

Time-varying proportional odds model for mega-analysis of clustered event times.

Biostatistics 2019 01;20(1):129-146

Columbia University, Department of Biostatistics, Mailman School of Public Health, New York, NY, USA.

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http://dx.doi.org/10.1093/biostatistics/kxx065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402758PMC
January 2019

Increased yield of full GBA sequencing in Ashkenazi Jews with Parkinson's disease.

Eur J Med Genet 2019 Jan 26;62(1):65-69. Epub 2018 May 26.

Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada; Department of Human Genetics, McGill University, Montréal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejmg.2018.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261782PMC
January 2019

Dietary Patterns, Physical Activity, Sleep, and Risk for Dementia and Cognitive Decline.

Curr Nutr Rep 2018 12;7(4):335-345

Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA.

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http://link.springer.com/10.1007/s13668-018-0247-9
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http://dx.doi.org/10.1007/s13668-018-0247-9DOI Listing
December 2018

Constructing disease onset signatures using multi-dimensional network-structured biomarkers.

Biostatistics 2018 Aug 1. Epub 2018 Aug 1.

Department of Biostatistics, Mailman School of Public Health, Columbia University, 722 W 168th Street, New York, NY, USA.

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http://dx.doi.org/10.1093/biostatistics/kxy037DOI Listing
August 2018

Low-dose Lithium Treatment for Agitation and Psychosis in Alzheimer Disease and Frontotemporal Dementia: A Case Series.

Alzheimer Dis Assoc Disord 2017 Jan-Mar;31(1):73-75

*Department of Neurology and Psychiatry †Taub Institute for Research on Alzheimer's Disease and the Aging Brain ‡Sergievsky Center §Division of Geriatric Psychiatry, New York State Psychiatric Institute ∥Columbia University Medical Center, New York, NY.

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http://dx.doi.org/10.1097/WAD.0000000000000161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322244PMC
June 2018

Statistical modeling of Huntington disease onset.

Handb Clin Neurol 2017 ;144:47-61

Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, United States.

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http://dx.doi.org/10.1016/B978-0-12-801893-4.00004-3DOI Listing
March 2018

Selected health and lifestyle factors, cytosine-adenine-guanine status, and phenoconversion in Huntington's disease.

Mov Disord 2018 03 3;33(3):472-478. Epub 2018 Jan 3.

Department of Neurology, Georgetown University, Washington, D.C., USA.

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http://dx.doi.org/10.1002/mds.27239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986294PMC
March 2018

Clinical and neuropathological features of progressive supranuclear palsy in Leucine rich repeat kinase (LRRK2) G2019S mutation carriers.

Mov Disord 2018 02 9;33(2):335-338. Epub 2017 Nov 9.

Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1002/mds.27225DOI Listing
February 2018

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

Lancet Neurol 2018 01 16;17(1):64-74. Epub 2017 Dec 16.

UK Dementia Research Institute, University College London, London, UK; Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30400-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805394PMC
January 2018

Alzheimer's Disease-Related Dementias Summit 2016: National research priorities.

Neurology 2017 Dec 8;89(23):2381-2391. Epub 2017 Nov 8.

From the National Institute of Neurological Disorders and Stroke (R.A.C., W.J.K., J.T.G., S.J., D.B., M.E., C.S.M., P.A.S., B.-A.S., M.L.S., C.L.T., A.K.G.), Bethesda, MD; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Department of Neurology (S.T.C.), David Geffen School of Medicine, University of California, Los Angeles; The Association for Frontotemporal Degeneration (S.L.-J.D.), Radnor, PA; Department of Neuroscience (D.W.D.), Mayo Clinic, Jacksonville, FL; The Alzheimer's Drug Discovery Foundation (H.F.); Icahn School of Medicine at Mount Sinai (H.F.), New York, NY; Department of Neurology (S.M.G.), Massachusetts General Hospital, Harvard Medical School, Boston; Eli Lilly and Company (M.L.H.), Lilly Research Centre, Erl Wood Manor, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.) and College of Physicians and Surgeons (K.S.M.), Columbia University, New York, NY; National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; Memory and Aging Center, Department of Neurology (W.W.S.), and Department of Pathology (W.W.S.), University of California San Francisco; Lewy Body Dementia Association (A.T.), Lilburn, GA; National Institute of Diabetes and Digestive and Kidney Diseases (S.P.W.), Bethesda, MD; and Knight Alzheimer's Disease Research Center (D.M.H.), Hope Center for Neurological Disorders (D.M.H.), and Department of Neurology (D.M.H.), Washington University in St. Louis, MO.

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http://dx.doi.org/10.1212/WNL.0000000000004717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719928PMC
December 2017

Sex differences in LRRK2 G2019S and idiopathic Parkinson's Disease.

Ann Clin Transl Neurol 2017 11 19;4(11):801-810. Epub 2017 Oct 19.

Department of Neurology Mount Sinai Beth Israel Medical Center New York New York.

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http://dx.doi.org/10.1002/acn3.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682117PMC
November 2017

Estimation of genetic risk function with covariates in the presence of missing genotypes.

Stat Med 2017 Sep 27;36(22):3533-3546. Epub 2017 Jun 27.

Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, U.S.A.

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http://doi.wiley.com/10.1002/sim.7376
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http://dx.doi.org/10.1002/sim.7376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583003PMC
September 2017

Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis.

PLoS One 2017 17;12(2):e0172348. Epub 2017 Feb 17.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172348PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315374PMC
August 2017

A cognitive fMRI study in non-manifesting LRRK2 and GBA carriers.

Brain Struct Funct 2017 04 11;222(3):1207-1218. Epub 2016 Jul 11.

Movement Disorders Unit, Department of Neurology, Tel-Aviv Medical Center, 6 Weizman Street, 64239, Tel-Aviv, Israel.

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http://dx.doi.org/10.1007/s00429-016-1271-4DOI Listing
April 2017

Statistical Approaches to Longitudinal Data Analysis in Neurodegenerative Diseases: Huntington's Disease as a Model.

Curr Neurol Neurosci Rep 2017 02;17(2):14

Department of Neurology, Columbia University, 630 West 168th Street, New York, NY, 10032, USA.

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http://dx.doi.org/10.1007/s11910-017-0723-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633048PMC
February 2017

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

Neurobiol Aging 2017 01 2;49:214.e13-214.e15. Epub 2016 Sep 2.

Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154872PMC
January 2017

A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease.

Neurology 2017 Jan 2;88(2):152-159. Epub 2016 Dec 2.

From Cooper University Healthcare at Rowan University (A.M.), Camden, NJ; University of Rochester (M.M., K.K., E.A.d.B., K.B., P.C.); Weill Cornell Medical Center (F.B.); Columbia Presbyterian Medical Center (K.M.), New York, NY; Johns Hopkins Medical Center (C.R.), Baltimore, MD; Georgetown University (I.S.), Washington, DC; NINDS (P.G.), Bethesda, MD; Hereditary Neurological Disease Center (W.M.M.), Wichita, KS; The Centre for Movement Disorders (M.G.), Toronto, Canada; Indiana University School of Medicine (J.W.), Indianapolis; Colorado Neurological Institute (R.K.), Englewood; University of Tennessee Health Science Center (M.S.L.), Memphis; London Health Sciences Centre (M.J.), Canada; Massachusetts General Hospital (H.D.R.), Boston; Struthers Parkinson's Center (M.N.), Minneapolis, MN; University of Kansas Medical Center (R.M.D.), Kansas City; Rush University Medical Center (K.M.S.), Chicago, IL; University of Texas Southwestern Medical Center (P.O.), Dallas; University of Michigan (K.C.), Ann Arbor; Wake Forest University (F.W.), Winston-Salem, NC; University of Alberta (W.M.), Edmonton, Canada; University of California Davis (V.L.W.), Sacramento; Westmead Hospital (E. McCusker), Westmead, Australia; Baylor College of Medicine (J.J.), Houston, TX; University of Miami Miller School of Medicine (C.S.), FL; University of South Florida (J.S.-R.), Tampa; Duke University (B.S.), Durham, NC; University of Calgary (O.S.), Canada; Emory University School of Medicine (S.A.F.), Atlanta, GA; Albany Medical College (D.S.H., Eric Molho), NY; University of Cincinnati (F.R.), OH; Mayo Clinic Arizona (J.N.C.), Scottsdale; Butler Hospital (J.H.F.), Providence, RI; Washington University (J.S.P.), St. Louis, MO; Feinstein Institute for Medical Research (A.F.), Manhasset, NY; Georgetown University (K.A.), Washington, DC; University of Florida (R.R., N.R.M.), Gainesville; Johns Hopkins University (R.L.M.), Baltimore, MD; University of Nevada School of Medicine (E.S.F.), Reno; University of British Columbia (L.A.R.), Vancouver, Canada; University of Pittsburgh (V.S.), PA; Ohio State University (S.K.), Columbus; The Cooper University Health System (A.C.), Camden, NJ; Idaho Elks Rehabilitation Hospital (L.S.), Boise, ID; University of Iowa (E.E.), Iowa City; North York General Hospital 1 (S.E.), Toronto, Canada; St. Luke's Hospital (N.D.), Allentown, PA; North York General Hospital 2 (W.L.A.F.), University of Toronto, Canada; Washington Regional Medical Center (A.D.), Fayetteville, AR; Beth-Israel Deaconess Medical Center (S.F.), Boston, MA; NJ Neuroscience Institute (P.H.), Edison; University of California Irvine (N.H.); The University of Alabama at Birmingham (L.S.D.); and Massachusetts General Hospital (M.C.), Harvard Medical School, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000003478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224719PMC
January 2017

Elevated GM3 plasma concentration in idiopathic Parkinson's disease: A lipidomic analysis.

PLoS One 2017 17;12(2):e0172348. Epub 2017 Feb 17.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172348PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315374PMC
August 2017

Combined treatment with memantine/es-citalopram for older depressed patients with cognitive impairment: a pilot study.

Int J Geriatr Psychiatry 2016 Jun 11;31(6):648-55. Epub 2015 Nov 11.

Late Life Depression Clinic, The Memory Disorders Center, and The Division of Geriatric Psychiatry, New York State Psychiatric Institute, New York, NY, USA.

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http://dx.doi.org/10.1002/gps.4375DOI Listing
June 2016

variants and glucocerebrosidase activity in Parkinson's disease.

NPJ Parkinsons Dis 2016;2. Epub 2016 Mar 10.

Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada; Montréal Neurological Institute & Hospital, and the Department of Human Genetics, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1038/npjparkd.2016.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838276PMC
March 2016

Milk consumption and the risk of nigral degeneration.

Neurology 2016 Feb 9;86(6):496-7. Epub 2015 Dec 9.

From the Epidemiology Branch (H.C.), National Institute of Environmental Health Sciences, Research Triangle Park, NC; and the Department of Neurology (K.M.), College of Physicians and Surgeons, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY.

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http://dx.doi.org/10.1212/WNL.0000000000002268DOI Listing
February 2016

Hippocampal laminar distribution of tau relates to Alzheimer's disease and age of onset.

J Alzheimers Dis 2015 ;43(1):315-24

Department of Neurology, Columbia University, New York, NY, USA Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.3233/JAD-140279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293261PMC
January 2016

Gene-wise association of variants in four lysosomal storage disorder genes in neuropathologically confirmed Lewy body disease.

PLoS One 2015 1;10(5):e0125204. Epub 2015 May 1.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, United States of America; Gertrude H. Sergievsky Center, Columbia University, New York, New York, United States of America; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, United States of America; Center for Human Genetics, Columbia University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125204PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416714PMC
January 2016

CSF β-Amyloid 1-42 Predicts Progression to Cognitive Impairment in Newly Diagnosed Parkinson Disease.

J Mol Neurosci 2016 Jan 2;58(1):88-92. Epub 2015 Sep 2.

Department of Neurology, Columbia University, 710 W 168th St, New York, NY, 10032, USA.

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http://link.springer.com/10.1007/s12031-015-0647-x
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http://dx.doi.org/10.1007/s12031-015-0647-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738011PMC
January 2016

Intact working memory in non-manifesting LRRK2 carriers--an fMRI study.

Eur J Neurosci 2016 Jan 18;43(1):106-12. Epub 2015 Dec 18.

Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, 64239, Israel.

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http://dx.doi.org/10.1111/ejn.13120DOI Listing
January 2016

Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.

Authors:
Kevin Michael Biglan Ira Shoulson Karl Kieburtz David Oakes Elise Kayson M Aileen Shinaman Hongwei Zhao Megan Romer Anne Young Steven Hersch Jack Penney Karen Marder Jane Paulsen Kimberly Quaid Eric Siemers Caroline Tanner William Mallonee Greg Suter Richard Dubinsky Carolyn Gray Martha Nance Scott Bundlie Dawn Radtke Sandra Kostyk Corrine Baic James Caress Francis Walker Victoria Hunt Christine O'Neill Sylvain Chouinard Stewart Factor Timothy Greenamyre Cathy Wood-Siverio Jody Corey-Bloom David Song Guerry Peavy Carol Moskowitz Melissa Wesson Ali Samii Thomas Bird Hillary Lipe Karen Blindauer Frederick Marshall Carol Zimmerman Jody Goldstein Diana Rosas Peter Novak John Caviness Charles Adler Amy Duffy Vicki Wheelock Teresa Tempkin David Richman Lauren Seeberger Roger Albin Kelvin L Chou Brad Racette Joel S Perlmutter Susan Perlman Yvette Bordelon Wayne Martin Marguerite Wieler Blair Leavitt Lynn Raymond Joji Decolongon Lorne Clarke Joseph Jankovic Christine Hunter Robert A Hauser Juan Sanchez-Ramos Sarah Furtado Oksana Suchowersky Mary Lou Klimek Mark Guttman Rustom Sethna Andrew Feigin Marie Cox Barbara Shannon Alan Percy Leon Dure Madaline Harrison William Johnson Donald Higgins Eric Molho Constance Nickerson Sharon Evans Douglas Hobson Carlos Singer Nestor Galvez-Jimenez Kathleen Shannon Cynthia Comella Christopher Ross Marie H Saint-Hilaire Claudia Testa Adam Rosenblatt Penelope Hogarth William Weiner Peter Como Rajeev Kumar Candace Cotto Julie Stout Alicia Brocht Arthur Watts Shirley Eberly Christine Weaver Tatiana Foroud James Gusella Marcy MacDonald Richard Myers Stanley Fahn Clifford Shults

JAMA Neurol 2016 Jan;73(1):102-10

Department of Neuroscience, University of California, San Diego, La Jolla.

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http://dx.doi.org/10.1001/jamaneurol.2015.2736DOI Listing
January 2016

Motor onset and diagnosis in Huntington disease using the diagnostic confidence level.

J Neurol 2015 Dec 26;262(12):2691-8. Epub 2015 Sep 26.

Department of Psychiatry, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, IA, 52242, USA.

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http://dx.doi.org/10.1007/s00415-015-7900-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666501PMC
December 2015

GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder.

Ann Clin Transl Neurol 2015 Sep 31;2(9):941-5. Epub 2015 Jul 31.

Montreal Neurological Institute, McGill University Montréal, Quebec, Canada ; Department of Human Genetics, McGill University Montréal, Quebec, Canada ; Department of Neurology and Neurosurgery, McGill University Montréal, Quebec, Canada.

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http://dx.doi.org/10.1002/acn3.228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574811PMC
September 2015

Efficient Estimation of Nonparametric Genetic Risk Function with Censored Data.

Biometrika 2015 Sep;102(3):515-532

Department of Biostatistics, CB # 7420, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7420, U.S.A.

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http://dx.doi.org/10.1093/biomet/asv030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581539PMC
September 2015

Age-specific penetrance of LRRK2 G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium.

Neurology 2015 Jul 10;85(1):89-95. Epub 2015 Jun 10.

From the Departments of Neurology (K.M., R.N.A., H.M.-S., M.-X.T.) and Pathology and Cell Biology (L.C.), and Center for Human Genetics (L.C.), College of Physicians and Surgeons, Columbia University; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (K.M., R.N.A., M.-X.T., L.C.) and Department of Biostatistics, Mailman School of Public Health (Y.W., A.L.), Columbia University, New York; The Alan and Barbara Mirken Department of Neurology (D.R., R.S.-P., S.B.), Beth Israel Medical Center, New York, NY; Movement Disorders Unit, Department of Neurology, Tel Aviv Medical Center (A.M., N.G.), Sackler School of Medicine (A.O.U.), and Sagol School for Neurosciences (A.M., N.G.), Tel Aviv University; School of Health Related Professions (A.M.), Ben Gurion University, Beer Sheba, Israel; Departments of Genetics and Genomic Sciences and Neurology (L.O.), Mount Sinai School of Medicine, New York, NY; and Genetics Institute (A.O.U.), Tel Aviv Sourasky Medical Center, Israel.

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http://dx.doi.org/10.1212/WNL.0000000000001708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501942PMC
July 2015

Differential effects of severe vs mild GBA mutations on Parkinson disease.

Neurology 2015 Mar 4;84(9):880-7. Epub 2015 Feb 4.

From The Genetic Institute (Z.G.-O., I.A., A.B.-S., M.G.-W., A.O.-R.) and Movement Disorders Unit, Parkinson Center, and Department of Neurology (A.M., N.G.), Tel Aviv Sourasky Medical Center; The Sackler Faculty of Medicine (N.G., A.O.-U.), Tel Aviv University, Israel; Stroke and Dementia Research Centre (L.L.K.), St. George's, University of London, UK; Columbia University (K.M.), Columbia Presbyterian Medical Center, New York; and Beth Israel Medical Center (S.B.), New York, NY. Z.G.-O. is currently affiliated with the Department of Human Genetics and Montreal Neurological Institute, McGill University, Montreal, Canada.

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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000131
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http://dx.doi.org/10.1212/WNL.0000000000001315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351661PMC
March 2015

PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease.

Neurology 2015 Mar 6;84(10):972-80. Epub 2015 Feb 6.

From the John P. Hussman Institute for Human Genomics (G.W.B., W.K.S., E.R.M., K.N., L.W., D.M.D., M.A.P.-V., J.M.V.) and University of Miami Brain Endowment Bank (D.C.M.), Miller School of Medicine, University of Miami, FL; Departments of Neuroscience (D.W.D., O.A.R.) and Neurology (Z.K.W.), Mayo Clinic Florida, Jacksonville; Department of Pathology & Laboratory Medicine (G.S., J.Q.T., V.M.V.D., H.I.H.), Perelman School of Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania, Philadelphia; Group Health Research Institute (E.B.L.), Seattle, WA; Departments of Psychiatry, and Genetics and Genomic Sciences (J.D.B.), Mount Sinai School of Medicine, New York, NY; Arizona Alzheimer's Consortium (T.G.B.), Phoenix; Sun Health Research Institute (T.G.B.), Sun City, AZ; Division of Neuropathology, Department of Pathology (J.C.T., O.P.), and Department of Neurology and the Solomon H. Snyder Department of Neuroscience (T.M.D.), Johns Hopkins University School of Medicine, Baltimore, MD; Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital and Harvard Medical School, Charlestown, MA; Department of Pathology and Laboratory Medicine, Indiana Alzheimer Disease Center (B.G.), and Department of Medical and Molecular Genetics (T.M.F.), Indiana University School of Medicine, Indianapolis; Departments of Neurology (L.S.H., K.M.) and Psychiatry (K.M.), Gertrude H. Sergievsky Center, and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York; Department of Pathology and Cell Biology (J.P.V.), Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY; The Parkinson's Institute (S.M.G.), Sunnyvale, CA; Departments of Pathology and Laboratory Medicine (Neuropathology) and Neurology (H.V.V.), David Geffen School of Medicine at University of California Los Angeles; Department of Pathology (T.J.M.), University of Washington School of Medicine, Seattle; VA Puget Sound Health Care System (

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http://dx.doi.org/10.1212/WNL.0000000000001332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352096PMC
March 2015

Neuropsychological performance in LRRK2 G2019S carriers with Parkinson's disease.

Parkinsonism Relat Disord 2015 Feb 20;21(2):106-10. Epub 2014 Nov 20.

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1016/j.parkreldis.2014.09.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306614PMC
February 2015

Reorganization of corticostriatal circuits in healthy G2019S LRRK2 carriers.

Neurology 2015 Jan 24;84(4):399-406. Epub 2014 Dec 24.

From the Centre for Cognitive Neuroimaging (R.C.H., I.T.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen; Department of Neurology (R.C.H., B.R.B.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; Movement Disorders Unit, Department of Neurology (A.T., T.G., A.M., N.G.), and Genetic Institute (A.O.-U.), Tel Aviv Sourasky Medical Center; Sackler School of Medicine (A.T., T.G., A.O.-U., N.G.), Tel Aviv University, Israel; Department of Neurology (B.F.L.v.N.), Catharina Hospital, Eindhoven, the Netherlands; Columbia University (K.S.M.), Columbia University Medical Center, New York; and Beth Israel Medical Center (S.B.), New York, NY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336002PMC
January 2015

Variability in interval production is due to timing-dependent deficits in Huntington's disease.

Mov Disord 2014 Oct 22;29(12):1516-22. Epub 2014 Aug 22.

Department of Rehabilitation & Regenerative Medicine (Program in Physical Therapy), and G.H. Sergievsky Center, College of Physicians & Surgeons, Columbia University, New York, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188696PMC
October 2014

Targeted Local Support Vector Machine for Age-Dependent Classification.

J Am Stat Assoc 2014 Sep;109(507):1174-1187

Department of Biostatistics, University of North Carolina at Chapel Hill.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183366PMC
September 2014

Olfactory identification in LRRK2 G2019S mutation carriers: a relevant marker?

Ann Clin Transl Neurol 2014 Sep 30;1(9):670-8. Epub 2014 Sep 30.

Department of Neurology, Mount Sinai Beth Israel Medical Center New York City, New York ; Department of Neurology, Icahn School of Medicine at Mount Sinai New York City, New York.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241794PMC
September 2014

Recommendations of the Alzheimer's disease-related dementias conference.

Neurology 2014 Aug 30;83(9):851-60. Epub 2014 Jul 30.

From the Department of Pathology (T.J.M.), University of Washington, Seattle; National Institute of Neurological Disorders and Stroke (W.J.K., D.B., W.R.G., A.N.K., B.-A.S., M.S., C.L.T., S.P.W., R.A.C.), Bethesda, MD; Neuropathology Lab (D.W.D.), Mayo Clinic, Jacksonville, FL; Department of Epidemiology & Biostatistics (M.M.G.), University of California San Francisco; Hemorrhagic Stroke Research Program (S.M.G.), Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Neurodegenerative Diseases DHT at Eli Lilly and Company (M.L.H.), Lilly Research Center, Windlesham, UK; Department of Neurology (D.S.K.), Mayo Clinic Rochester, MN; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (J.J.M., K.S.M.), Columbia University Medical Center, New York; Columbia University (J.J.M., K.S.M.), College of Physicians and Surgeons, New York, NY; University of California San Francisco Memory and Aging Center (B.L.M., W.W.S.); National Institute on Aging (C.H.P., N.B.S.), Bethesda, MD; and Zilhka Neurogenetic Institute (B.V.Z.), Center for Neurodegeneration and Regeneration and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155046PMC
August 2014

A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers.

Mov Disord 2014 May 30;29(6):823-7. Epub 2014 Jan 30.

Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler School of Medicine, Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel.

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May 2014

Tracking motor impairments in the progression of Huntington's disease.

Mov Disord 2014 Mar 21;29(3):311-9. Epub 2013 Oct 21.

Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA; Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219558PMC
March 2014

Knowledge of and interest in genetic results among Parkinson disease patients and caregivers.

J Genet Couns 2014 Feb 9;23(1):114-20. Epub 2013 Jun 9.

Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808456PMC
February 2014

COMBINING ISOTONIC REGRESSION AND EM ALGORITHM TO PREDICT GENETIC RISK UNDER MONOTONICITY CONSTRAINT.

Ann Appl Stat 2014 ;8(2):1182-1208

Department of Biostatistics, Columbia University, 630 West 168th Street, New York, New York 10032.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231830PMC
January 2014

Learning fast accurate movements requires intact frontostriatal circuits.

Front Hum Neurosci 2013 13;7:752. Epub 2013 Nov 13.

Motor Performance Lab, Department of Neurology, The Neurological Institute, Columbia University New York, NY, USA.

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http://dx.doi.org/10.3389/fnhum.2013.00752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826079PMC
December 2013

Relationship of Mediterranean diet and caloric intake to phenoconversion in Huntington disease.

JAMA Neurol 2013 Nov;70(11):1382-8

Departments of Neurology and Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York3Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, New York.

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http://dx.doi.org/10.1001/jamaneurol.2013.3487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040231PMC
November 2013

Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers.

Cortex 2013 Oct 7;49(9):2501-11. Epub 2013 Jan 7.

Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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October 2013

Fall risk and gait in Parkinson's disease: the role of the LRRK2 G2019S mutation.

Mov Disord 2013 Oct 7;28(12):1683-90. Epub 2013 Oct 7.

Movement Disorders Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; School of Health-Related Professions, Ben Gurion University, Beer Sheba, Israel.

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October 2013

Regional vulnerability in Huntington's disease: fMRI-guided molecular analysis in patients and a mouse model of disease.

Neurobiol Dis 2013 Apr 4;52:84-93. Epub 2012 Dec 4.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.nbd.2012.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435974PMC
April 2013

Views of internists towards uses of PGD.

Reprod Biomed Online 2013 Feb 21;26(2):142-7. Epub 2012 Nov 21.

Columbia University, 1051 Riverside Drive, Mail Unit 15, New York, NY 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565017PMC
February 2013

Lack of association between cancer history and PARKIN genotype: a family based study in PARKIN/Parkinson's families.

Genes Chromosomes Cancer 2012 Dec 24;51(12):1109-13. Epub 2012 Aug 24.

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465486PMC
December 2012

Lower cognitive performance in healthy G2019S LRRK2 mutation carriers.

Neurology 2012 Sep 22;79(10):1027-32. Epub 2012 Aug 22.

Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430708PMC
September 2012