Karen L Mackenzie

Karen L Mackenzie

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Karen L Mackenzie

Karen L Mackenzie

Publications by authors named "Karen L Mackenzie"

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Telomerase promotes formation of a telomere protective complex in cancer cells.

Sci Adv 2019 Oct 2;5(10):eaav4409. Epub 2019 Oct 2.

Cell Biology Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia.

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http://dx.doi.org/10.1126/sciadv.aav4409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774720PMC
October 2019

Differentially expressed genes from RNA-Seq and functional enrichment results are affected by the choice of single-end versus paired-end reads and stranded versus non-stranded protocols.

BMC Genomics 2017 05 23;18(1):399. Epub 2017 May 23.

Systems Biology Initiative, School of Biotechnology and Biomolecular Sciences, UNSW Australia, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1186/s12864-017-3797-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442695PMC
May 2017

p21(WAF1) modulates drug-induced apoptosis and cell cycle arrest in B-cell precursor acute lymphoblastic leukemia.

Cell Cycle 2015 ;14(22):3602-12

a Children's Cancer Institute ; Lowy Cancer Research Centre; UNSW Australia ; Sydney , NSW , Australia.

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http://dx.doi.org/10.1080/15384101.2015.1100774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825786PMC
September 2016

New prospects for targeting telomerase beyond the telomere.

Nat Rev Cancer 2016 08 24;16(8):508-24. Epub 2016 Jun 24.

Personalised Medicine Program, Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia.

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http://www.nature.com/articles/nrc.2016.55
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http://dx.doi.org/10.1038/nrc.2016.55DOI Listing
August 2016

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

Cancer Res 2015 Dec 15;75(23):5143-54. Epub 2015 Oct 15.

Children's Cancer Institute Australia, Randwick, Sydney, New South Wales, Australia. School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Randwick, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0423DOI Listing
December 2015

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819002PMC
December 2015

A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells.

Biochem Pharmacol 2014 Mar 13;88(1):36-45. Epub 2014 Jan 13.

Auckland Cancer Society Research Centre, the University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, the University of Auckland, Auckland, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2013.12.019DOI Listing
March 2014

Modeling human endothelial cell transformation in vascular neoplasias.

Dis Model Mech 2013 Sep;6(5):1066-79

Cancer Cell Development Group, Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Randwick, NSW, Australia.

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http://dx.doi.org/10.1242/dmm.012674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759327PMC
September 2013

Assessment and quantification of telomerase enzyme activity.

Methods Mol Biol 2013 ;965:215-31

Cancer Cell Development Group, Children's Cancer Institute Australia, Randwick, Australia.

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http://dx.doi.org/10.1007/978-1-62703-239-1_14DOI Listing
June 2013

Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells.

Angiogenesis 2013 Apr 10;16(2):373-86. Epub 2012 Nov 10.

Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, PO Box 81, Randwick, NSW, 2031, Australia.

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http://dx.doi.org/10.1007/s10456-012-9321-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595478PMC
April 2013

Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16(INK4a) protein and confers resistance to oxidative stress.

J Biol Chem 2013 Apr 28;288(17):12032-41. Epub 2013 Feb 28.

Cancer Cell Development Group, Children's Cancer Institute Australia, Lowy Cancer Research Centre, University of New South Wales, Randwick, New South Wales 2031, Australia.

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http://dx.doi.org/10.1074/jbc.M112.447821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636889PMC
April 2013

Induction of vascular endothelial growth factor secretion by childhood acute lymphoblastic leukemia cells via the FLT-3 signaling pathway.

Mol Cancer Ther 2012 Jan 14;11(1):183-93. Epub 2011 Nov 14.

Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-11
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http://dx.doi.org/10.1158/1535-7163.MCT-11-0503DOI Listing
January 2012

p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia.

J Biol Chem 2011 Oct 7;286(43):37639-50. Epub 2011 Sep 7.

Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1074/jbc.M111.272336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199508PMC
October 2011

Mild hyperoxia limits hTR levels, telomerase activity, and telomere length maintenance in hTERT-transduced bone marrow endothelial cells.

Biochim Biophys Acta 2010 Oct 7;1803(10):1142-53. Epub 2010 Jul 7.

Lowy Cancer Research Centre, University of New South Wales, Randwick, NSW, Australia.

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http://dx.doi.org/10.1016/j.bbamcr.2010.06.010DOI Listing
October 2010

Targeting telomerase in hematologic malignancy.

Future Oncol 2010 May;6(5):769-89

Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, New South Wales, Australia.

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http://dx.doi.org/10.2217/fon.10.42DOI Listing
May 2010

p53 determines multidrug sensitivity of childhood neuroblastoma.

Cancer Res 2007 Nov;67(21):10351-60

Children's Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4345DOI Listing
November 2007

Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53-competent immortal endothelial cells.

Cancer Res 2006 Nov;66(22):10691-700

Children's Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0979DOI Listing
November 2006

FLT-3: a new focus in the understanding of acute leukemia.

Int J Biochem Cell Biol 2005 Jun 26;37(6):1168-72. Epub 2005 Jan 26.

Children's Cancer Institute Australia for Medical Research, PO Box 81, High Street, Randwick, NSW 2031, Australia.

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http://dx.doi.org/10.1016/j.biocel.2004.12.005DOI Listing
June 2005

Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras.

Oncogene 2002 Jun;21(27):4200-11

James Ewing Laboratory of Developmental Haematopoiesis and Department of Human Genetics, Sloan-Kettering Cancer Institute, New York, NY, USA.

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http://www.nature.com/articles/1205425
Publisher Site
http://dx.doi.org/10.1038/sj.onc.1205425DOI Listing
June 2002

Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibroblasts.

Cancer Res 2002 Apr;62(7):2104-14

James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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April 2002

Methotrexate selection of long-term culture initiating cells following transduction of CD34(+) cells with a retrovirus containing a mutated human dihydrofolate reductase gene.

Cancer Gene Ther 2002 Mar;9(3):308-20

Program of Molecular Pharmacology and Experimental Therapeutics, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/sj.cgt.7700443DOI Listing
March 2002

Ex vivo expansion of stem and progenitor cells in co-culture of mobilized peripheral blood CD34+ cells on human endothelium transfected with adenovectors expressing thrombopoietin, c-kit ligand, and Flt-3 ligand.

J Hematother Stem Cell Res 2002 Feb;11(1):127-38

James Ewing Laboratory of Developmental Hematopoiesis, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 101, New York, NY 10021, USA.

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http://dx.doi.org/10.1089/152581602753448595DOI Listing
February 2002

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells.

Blood 2002 Jan;99(1):15-23

Laboratory of Molecular Hematopoiesis, Sloan-Kettering Institute, New York, NY, USA.

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http://dx.doi.org/10.1182/blood.v99.1.15DOI Listing
January 2002