Publications by authors named "Karen H Vousden"

100Publications

Dietary Approaches to Cancer Therapy.

Cancer Cell 2020 06 14;37(6):767-785. Epub 2020 May 14.

The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.04.005DOI Listing
June 2020

p53, cancer and the immune response.

J Cell Sci 2020 03 6;133(5). Epub 2020 Mar 6.

The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK

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http://dx.doi.org/10.1242/jcs.237453DOI Listing
March 2020

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer.

Cancer Cell 2020 02 23;37(2):168-182.e4. Epub 2020 Jan 23.

The Francis Crick Institute, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008247PMC
February 2020

Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization.

Cell Metab 2019 10 22;30(4):720-734.e5. Epub 2019 Aug 22.

The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863392PMC
October 2019

Taking up the reins of power: metabolic functions of p53.

J Mol Cell Biol 2019 07;11(7):610-614

The Francis Crick Institute, London NW1 1AT, UK.

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http://dx.doi.org/10.1093/jmcb/mjz065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736434PMC
July 2019

Brexit negotiations: what is next for science?

Authors:
Karen H Vousden

EMBO Rep 2019 04 15;20(4). Epub 2019 Mar 15.

Cancer Research UK.

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http://dx.doi.org/10.15252/embr.201948026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446190PMC
April 2019

Use of CN-Serine or CN-Methionine for Studying Methylation Dynamics in Cancer Cell Metabolism and Epigenetics.

Methods Mol Biol 2019 ;1928:55-67

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1007/978-1-4939-9027-6_4DOI Listing
June 2019

p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant.

Cancer Metab 2018 3;6:18. Epub 2018 Dec 3.

2Francis Crick Institute, 1 Midland Road, London, NW1 1AT UK.

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http://dx.doi.org/10.1186/s40170-018-0191-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276204PMC
December 2018

Direct Estimation of Metabolic Flux by Heavy Isotope Labeling Simultaneous with Pathway Inhibition: Metabolic Flux Inhibition Assay.

Methods Mol Biol 2019 ;1862:109-119

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1007/978-1-4939-8769-6_8DOI Listing
June 2019

Control of metabolism by p53 - Cancer and beyond.

Biochim Biophys Acta Rev Cancer 2018 08 5;1870(1):32-42. Epub 2018 Jun 5.

The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102416PMC
August 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis.

Proc Natl Acad Sci U S A 2017 12 21;114(50):13254-13259. Epub 2017 Nov 21.

Institute of Cell Biology and Neurobiology, National Research Council of Italy (CNR), 00015 Monterotondo (Rome), Italy;

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http://dx.doi.org/10.1073/pnas.1711777114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740608PMC
December 2017

One carbon, many roads.

Cell Death Differ 2017 02 6;24(2):193-194. Epub 2017 Jan 6.

CRUK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/cdd.2016.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299721PMC
February 2017

The Quid Pro Quo of the Tumor/Stromal Interaction.

Cell Metab 2016 11;24(5):645-646

CRUK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.10.017DOI Listing
November 2016

Serine and one-carbon metabolism in cancer.

Nat Rev Cancer 2016 10 16;16(10):650-62. Epub 2016 Sep 16.

Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/nrc.2016.81DOI Listing
October 2016

Location, location, location.

Science 2016 09;353(6304):1095-6

Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1126/science.aai7629DOI Listing
September 2016

Regulation of Cellular Metabolism and Hypoxia by p53.

Cold Spring Harb Perspect Med 2016 07 1;6(7). Epub 2016 Jul 1.

CRUK-Beatson Institute, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a026146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930918PMC
July 2016

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells.

Mol Cell 2016 Jan 7;61(2):210-21. Epub 2016 Jan 7.

Cancer Research UK Beatson Institute, Switchback Road, Glasgow, G61 1BD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728077PMC
January 2016

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine.

Genes Dev 2016 Jan 17;30(1):52-63. Epub 2015 Dec 17.

Cancer Research UK Beatson Institute, Glasgow, G61 1BD, United Kingdom.

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http://dx.doi.org/10.1101/gad.271130.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701978PMC
January 2016

PHD1 regulates p53-mediated colorectal cancer chemoresistance.

EMBO Mol Med 2015 Oct;7(10):1350-65

Lab of Molecular Oncology and Angiogenesis, Department of Oncology, KU Leuven, Leuven, Belgium Lab of Molecular Oncology and Angiogenesis, Vesalius Research Center, VIB, Leuven, Belgium

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http://dx.doi.org/10.15252/emmm.201505492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604688PMC
October 2015

p53 in survival, death and metabolic health: a lifeguard with a licence to kill.

Nat Rev Mol Cell Biol 2015 Jul;16(7):393-405

Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/nrm4007DOI Listing
July 2015

Hitting cancers' weak spots: vulnerabilities imposed by p53 mutation.

Trends Cell Biol 2015 Aug 7;25(8):486-95. Epub 2015 May 7.

Cancer Research UK Beatson Institute, Glasgow, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2015.04.001DOI Listing
August 2015

Ubiquitin-specific peptidase 42 (USP42) functions to deubiquitylate histones and regulate transcriptional activity.

J Biol Chem 2014 Dec 21;289(50):34862-70. Epub 2014 Oct 21.

From the Cancer Research UK Beatson Institute, Glasgow G61 1BD, Scotland, United Kingdom

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http://dx.doi.org/10.1074/jbc.M114.589267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263885PMC
December 2014

Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense.

Oncotarget 2014 Sep;5(17):7722-33

Department of Ecological and Biological Sciences, University of Tuscia, Largo dell'Università, snc, Viterbo, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202156PMC
http://dx.doi.org/10.18632/oncotarget.2300DOI Listing
September 2014

Localization of NADPH production: a wheel within a wheel.

Mol Cell 2014 Jul;55(2):158-60

Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.07.001DOI Listing
July 2014

Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.

Cell Rep 2014 May 10;7(4):1248-58. Epub 2014 May 10.

Cancer Research UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247140034
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http://dx.doi.org/10.1016/j.celrep.2014.04.045DOI Listing
May 2014

Mutant p53 in cancer: new functions and therapeutic opportunities.

Cancer Cell 2014 Mar;25(3):304-17

CR-UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970583PMC
March 2014

TIGAR, TIGAR, burning bright.

Cancer Metab 2014 Jan 3;2(1). Epub 2014 Jan 3.

Cancer Research-UK Beatson Institute, Switchback Road, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1186/2049-3002-2-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892023PMC
January 2014

Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype.

J Biol Chem 2014 Jan 12;289(1):122-32. Epub 2013 Nov 12.

From the Cancer Research UK Beatson Institute, Glasgow G61 1BD, Scotland, United Kingdom and.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879536PMC
http://dx.doi.org/10.1074/jbc.M113.502138DOI Listing
January 2014

iRFP is a sensitive marker for cell number and tumor growth in high-throughput systems.

Cell Cycle 2014 31;13(2):220-6. Epub 2013 Oct 31.

Cancer Research UK Beatson Institute; Glasgow, UK.

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http://dx.doi.org/10.4161/cc.26985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906239PMC
November 2014

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.

Bioorg Med Chem 2013 Nov 25;21(22):6868-77. Epub 2013 Sep 25.

School of Pharmacy & Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.

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http://dx.doi.org/10.1016/j.bmc.2013.09.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898830PMC
November 2013

Metabolic regulation by p53 family members.

Cell Metab 2013 Nov 15;18(5):617-33. Epub 2013 Aug 15.

The CR-UK Beatson Institute, Glasgow G61 1BD, Scotland, UK.

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http://dx.doi.org/10.1016/j.cmet.2013.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824073PMC
November 2013

The role of ubiquitin modification in the regulation of p53.

Biochim Biophys Acta 2014 Jan 3;1843(1):137-49. Epub 2013 Jun 3.

Cancer Research-UK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1016/j.bbamcr.2013.05.022DOI Listing
January 2014

p53 mutations in cancer.

Nat Cell Biol 2013 Jan;15(1):2-8

The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.

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http://www.nature.com/articles/ncb2641
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http://dx.doi.org/10.1038/ncb2641DOI Listing
January 2013

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

Nature 2013 Jan 16;493(7433):542-6. Epub 2012 Dec 16.

The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/nature11743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485472PMC
January 2013

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death.

Proc Natl Acad Sci U S A 2012 Dec 26;109(50):20491-6. Epub 2012 Nov 26.

The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1206530109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528527PMC
December 2012

Serine is a natural ligand and allosteric activator of pyruvate kinase M2.

Nature 2012 Nov 14;491(7424):458-462. Epub 2012 Oct 14.

Cancer Research UK, The Beatson Institute for Cancer Research, Switchback Road, Glasgow, G61 1BD, Scotland, United Kingdom.

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http://dx.doi.org/10.1038/nature11540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894725PMC
November 2012

Tumor suppression by p53: fall of the triumvirate?

Cell 2012 Jun;149(6):1183-5

The Beatson Institute for Cancer Research, Glasgow, UK.

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http://dx.doi.org/10.1016/j.cell.2012.05.024DOI Listing
June 2012

Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability.

FEBS Lett 2012 Jul 31;586(16):2225-31. Epub 2012 May 31.

Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.

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http://dx.doi.org/10.1016/j.febslet.2012.05.034DOI Listing
July 2012

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.

EMBO Rep 2012 Jun 29;13(7):638-44. Epub 2012 Jun 29.

Quantitative Proteomics Group, Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.

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http://dx.doi.org/10.1038/embor.2012.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388785PMC
June 2012

Small molecules that bind the Mdm2 RING stabilize and activate p53.

Carcinogenesis 2012 Apr 2;33(4):791-8. Epub 2012 Feb 2.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1093/carcin/bgs092DOI Listing
April 2012

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.

Nat Struct Mol Biol 2012 Jan 22;19(2):184-92. Epub 2012 Jan 22.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD, United Kingdom.

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http://dx.doi.org/10.1038/nsmb.2231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880865PMC
January 2012

Regulation of p53 stability and function by the deubiquitinating enzyme USP42.

EMBO J 2011 Nov 15;30(24):4921-30. Epub 2011 Nov 15.

The Beatson Institute for Cancer Research, Glasgow, UK.

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http://dx.doi.org/10.1038/emboj.2011.419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243628PMC
November 2011

An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence.

EMBO J 2012 Jan 8;31(2):471-80. Epub 2011 Nov 8.

The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK.

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http://dx.doi.org/10.1038/emboj.2011.402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261561PMC
January 2012

MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity.

Cell Cycle 2011 Sep 15;10(18):3176-88. Epub 2011 Sep 15.

The Beatson Institute for Cancer Research; Glasgow, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218624PMC
http://dx.doi.org/10.4161/cc.10.18.17436DOI Listing
September 2011

Metabolic regulation by p53.

J Mol Med (Berl) 2011 Mar 23;89(3):237-45. Epub 2011 Feb 23.

The Beatson Institute for Cancer Research, Glasgow, UK.

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http://dx.doi.org/10.1007/s00109-011-0735-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043245PMC
March 2011

p53 and its mutants in tumor cell migration and invasion.

J Cell Biol 2011 Jan;192(2):209-18

Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland, UK.

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http://dx.doi.org/10.1083/jcb.201009059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172183PMC
January 2011

Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.

Genes Dev 2010 Nov;24(21):2430-9

The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1101/gad.1954310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964753PMC
November 2010

p53, ROS and senescence in the control of aging.

Aging (Albany NY) 2010 Aug;2(8):471-4

The Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954038PMC
http://dx.doi.org/10.18632/aging.100189DOI Listing
August 2010

Regulation of the p53 pathway by ubiquitin and related proteins.

Int J Biochem Cell Biol 2010 Oct 17;42(10):1618-21. Epub 2010 Jun 17.

The Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1016/j.biocel.2010.06.011DOI Listing
October 2010

p53 regulation of metabolic pathways.

Cold Spring Harb Perspect Biol 2010 Apr 2;2(4):a001040. Epub 2009 Dec 2.

The Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a001040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845207PMC
April 2010

Alternative fuel--another role for p53 in the regulation of metabolism.

Authors:
Karen H Vousden

Proc Natl Acad Sci U S A 2010 Apr 14;107(16):7117-8. Epub 2010 Apr 14.

The Beatson Institute for Cancer Research, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1002656107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867698PMC
April 2010

p53 and Mdm2: an auld alliance.

Cell Cycle 2010 Mar 1;9(5):865-6. Epub 2010 Mar 1.

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March 2010

p53-mediated induction of Noxa and p53AIP1 requires NFkappaB.

Cell Cycle 2010 Mar 7;9(5):947-52. Epub 2010 Mar 7.

Tumor Cell Death Laboratory, Beatson Institute for Cancer Research, Glasgow, UK.

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http://dx.doi.org/10.4161/cc.9.5.10872DOI Listing
March 2010

Partners in death: a role for p73 and NF-kB in promoting apoptosis.

Authors:
Karen H Vousden

Aging (Albany NY) 2009 Mar 28;1(3):275-7. Epub 2009 Mar 28.

The Beatson Institute for Cancer Research, Garscube Estate, Glasgow G611BD, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806010PMC
http://dx.doi.org/10.18632/aging.100033DOI Listing
March 2009

The role of p53 in glucose metabolism.

Curr Opin Cell Biol 2010 Apr 12;22(2):186-91. Epub 2010 Jan 12.

The Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1016/j.ceb.2009.12.006DOI Listing
April 2010

p53 and metabolism.

Nat Rev Cancer 2009 Oct 17;9(10):691-700. Epub 2009 Sep 17.

The Beatson Institute for Cancer Research, Garscube Estate, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/nrc2715DOI Listing
October 2009

Modulation of intracellular ROS levels by TIGAR controls autophagy.

EMBO J 2009 Oct 27;28(19):3015-26. Epub 2009 Aug 27.

The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1038/emboj.2009.242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736014PMC
October 2009

Functions of p53 in metabolism and invasion.

Authors:
Karen H Vousden

Biochem Soc Trans 2009 Jun;37(Pt 3):511-7

The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1042/BST0370511DOI Listing
June 2009

Blinded by the Light: The Growing Complexity of p53.

Cell 2009 May;137(3):413-31

The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK.

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http://dx.doi.org/10.1016/j.cell.2009.04.037DOI Listing
May 2009

Modifications of p53: competing for the lysines.

Curr Opin Genet Dev 2009 Feb;19(1):18-24

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1016/j.gde.2008.11.010DOI Listing
February 2009

p53-Ubl fusions as models of ubiquitination, sumoylation and neddylation of p53.

Cell Cycle 2008 Aug 9;7(16):2519-28. Epub 2008 Aug 9.

The Beatson Institute for Cancer Research, United Kingdom.

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http://dx.doi.org/10.4161/cc.7.16.6422DOI Listing
August 2008

A role for Numb in p53 stabilization.

Genome Biol 2008 9;9(5):221. Epub 2008 May 9.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, UK.

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http://dx.doi.org/10.1186/gb-2008-9-5-221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441455PMC
July 2008

Lucifer's labyrinth--ten years of path finding in cell death.

Mol Cell 2007 Dec;28(5):746-54

The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK.

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http://dx.doi.org/10.1016/j.molcel.2007.11.016DOI Listing
December 2007

Contribution of membrane localization to the apoptotic activity of PUMA.

Apoptosis 2008 Jan;13(1):87-95

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1007/s10495-007-0140-2DOI Listing
January 2008

Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.

Cancer Res 2007 Oct;67(19):9472-81

Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0568DOI Listing
October 2007

Ubiquitination and degradation of mutant p53.

Mol Cell Biol 2007 Dec 1;27(23):8284-95. Epub 2007 Oct 1.

The Beatson Institute for Cancer Research, Switchback Rd., Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1128/MCB.00050-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169174PMC
December 2007

p73 supports cellular growth through c-Jun-dependent AP-1 transactivation.

Nat Cell Biol 2007 Jun 13;9(6):698-705. Epub 2007 May 13.

Laboratory of Molecular Carcinogenesis, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore.

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http://dx.doi.org/10.1038/ncb1598DOI Listing
June 2007

p53: new roles in metabolism.

Trends Cell Biol 2007 Jun 3;17(6):286-91. Epub 2007 May 3.

The Beatson Institute for Cancer Research, Glasgow, UK.

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http://dx.doi.org/10.1016/j.tcb.2007.04.004DOI Listing
June 2007

p53 in health and disease.

Nat Rev Mol Cell Biol 2007 Apr;8(4):275-83

Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/nrm2147DOI Listing
April 2007

C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.

Nat Cell Biol 2007 Apr 18;9(4):428-35. Epub 2007 Mar 18.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/ncb1562DOI Listing
April 2007

A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo.

J Clin Invest 2007 Apr 8;117(4):1008-18. Epub 2007 Mar 8.

Tumour Cell Death Laboratory, Beatson Institute for Cancer Research, Glasgow, United Kingdom.

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http://dx.doi.org/10.1172/JCI28920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810568PMC
April 2007

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX.

EMBO J 2007 Jan 14;26(1):102-12. Epub 2006 Dec 14.

The Beatson Institute for Cancer Research, Glasgow, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782374PMC
January 2007

Outcomes of p53 activation--spoilt for choice.

Authors:
Karen H Vousden

J Cell Sci 2006 Dec;119(Pt 24):5015-20

Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1242/jcs.03293DOI Listing
December 2006

Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells.

Bioorg Med Chem 2007 Jan 12;15(1):77-86. Epub 2006 Oct 12.

WestCHEM, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1016/j.bmc.2006.10.011DOI Listing
January 2007

Savior and slayer: the two faces of p53.

Nat Med 2005 Dec;11(12):1278-9

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http://dx.doi.org/10.1038/nm1205-1278DOI Listing
December 2005

Apoptosis. p53 and PUMA: a deadly duo.

Authors:
Karen H Vousden

Science 2005 Sep;309(5741):1685-6

Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glagsow G61 1BD, UK.

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http://dx.doi.org/10.1126/science.1118232DOI Listing
September 2005

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells.

Cancer Cell 2005 Jun;7(6):547-59

Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute at Frederick, NIH, 1050 Boyles Street, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.04.029DOI Listing
June 2005

Complicating the complexity of p53.

Carcinogenesis 2005 Aug 11;26(8):1317-22. Epub 2005 May 11.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://academic.oup.com/carcin/article/26/8/1317/2390920/Com
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http://dx.doi.org/10.1093/carcin/bgi122DOI Listing
August 2005

HDM2 phosphorylation by MAPKAP kinase 2.

Oncogene 2005 Mar;24(12):1965-72

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1038/sj.onc.1208389DOI Listing
March 2005

The ubiquitin-protein ligase Itch regulates p73 stability.

EMBO J 2005 Feb 27;24(4):836-48. Epub 2005 Jan 27.

Department of Biology, University of Rome Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1038/sj.emboj.7600444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549609PMC
February 2005