Karen E Knudsen

Karen E Knudsen

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Karen E Knudsen

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Introduction to the 2019 Philadelphia Prostate Cancer Consensus Program: 'Implementation of Genetic Testing for Inherited Prostate Cancer'.

Can J Urol 2019 Oct;26(5S2):1-4

Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia, Pennsylvania, USA.

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October 2019

The AR-DNA repair axis: insights into prostate cancer aggressiveness.

Authors:
Karen E Knudsen

Can J Urol 2019 Oct;26(5S2):22-23

Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia, Pennsylvania, USA.

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October 2019

Expanding Role of Germline DNA Repair Alterations in Prostate Cancer Risk and Early Onset.

Eur Urol 2019 Sep 15;76(3):338-339. Epub 2019 Mar 15.

Departments of Radiation Oncology, Urology, and Medicine and Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.eururo.2019.03.005DOI Listing
September 2019

SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors.

Sci Adv 2019 Sep 18;5(9):eaax6352. Epub 2019 Sep 18.

Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1126/sciadv.aax6352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750908PMC
September 2019

Cancer and the Circadian Clock.

Cancer Res 2019 Aug 12;79(15):3806-3814. Epub 2019 Jul 12.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-19-0566DOI Listing
August 2019

Novel RB1-Loss Transcriptomic Signature Is Associated with Poor Clinical Outcomes across Cancer Types.

Clin Cancer Res 2019 Jul 22;25(14):4290-4299. Epub 2019 Apr 22.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0404DOI Listing
July 2019

DNA Damage Response in Prostate Cancer.

Cold Spring Harb Perspect Med 2019 01 2;9(1). Epub 2019 Jan 2.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania,19107.

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http://dx.doi.org/10.1101/cshperspect.a030486DOI Listing
January 2019

Counterpoint-Prostate Cancer Genomic Analysis: Routine or Research Only?

Oncology (Williston Park) 2018 12;32(12):607, 630-2

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December 2018

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.

Proc Natl Acad Sci U S A 2018 10 17;115(40):E9298-E9307. Epub 2018 Sep 17.

Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107;

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http://dx.doi.org/10.1073/pnas.1807704115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176615PMC
October 2018

Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import.

Cell 2018 08 9;174(5):1200-1215.e20. Epub 2018 Aug 9.

Cancer Biology Department, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA; Medical Oncology Department, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA; Pathology Department, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150493PMC
August 2018

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

Cell 2018 07 19;174(3):758-769.e9. Epub 2018 Jul 19.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco (UCSF), San Francisco, CA, USA; Division of Hematology and Oncology, Department of Medicine, UCSF, San Francisco, CA, USA; Department of Radiation Oncology, UCSF, San Francisco, CA, USA; Department of Urology, UCSF, San Francisco, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425931PMC
July 2018

Targeting Androgen Receptor and DNA Repair in Metastatic Castration-Resistant Prostate Cancer: Results From NCI 9012.

J Clin Oncol 2018 04 20;36(10):991-999. Epub 2017 Dec 20.

Maha Hussain, Robert H. Lurie Comprehensive Cancer Center, Northwestern University; Walter M. Stadler, University of Chicago, Chicago; Daniel H. Shevrin, NorthShore University Health System, Evanston, IL; Maha Hussain, Stephanie Daignault-Newton, Lakshmi P. Kunju, Javed Siddiqui, Yi-Mi Wu, Dan Robinson, Robert J. Lonigro, Xuhong Cao, Scott A. Tomlins, Rohit Mehra, David C. Smith, Megan V. Caram, and Arul M. Chinnaiyan, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; Przemyslaw W. Twardowski, City of Hope Cancer Center, Duarte; Felix Y. Feng, University of California San Francisco, San Francisco, CA; Costantine Albany, Simon Cancer Center, Indiana University, Indianapolis, IN; Mark N. Stein, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ; Kathleen A. Cooney, University of Utah, Salt Lake City, UT; Bruce Montgomery, University of Washington, Seattle, WA; Emmanuel S. Antonarakis, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Paul G. Corn, University of Texas MD Anderson Cancer Center, Houston, TX; Young E. Whang, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC; and Karen E. Knudsen, Thomas Jefferson University, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.2017.75.7310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075827PMC
April 2018

Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017.

J Clin Oncol 2018 02 13;36(4):414-424. Epub 2017 Dec 13.

Veda N. Giri, Karen E. Knudsen, William K. Kelly, Robert B. Den, Adam P. Dicker, Jean Hoffman-Censits, Mark D. Hurwitz, Colette Hyatt, Grace Lu-Yao, Mark J. Mann, James R. Mark, Peter A. McCue, Ronald E. Myers, Stephen C. Peiper, Edouard J. Trabulsi, and Leonard G. Gomella, Jefferson Sidney Kimmel Cancer Center; Justin E. Bekelman, University of Pennsylvania Perelman School of Medicine; S. Bruce Malkowicz, University of Pennsylvania; Elias Obeid and Robert Uzzo, Fox Chase Cancer Center; Gordon F. Schwartz, Foundation for Breast and Prostate Health, Philadelphia; Mark S. Shahin, Hanjani Institute for Gynecologic Oncology, Abington Hospital-Jefferson Health, Abington, PA; Wassim Abida, Philip Kantoff, and Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mitchell C. Benson, Columbia University, New York, NY; Gerald L. Andriole, Washington University School of Medicine, St Louis, MO; Chris H. Bangma, Erasmus Medical Center, Rotterdam, the Netherlands; Amie Blanco, and Matthew Cooperberg, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco; Christopher J. Kane, University of California San Diego, San Diego; Howard Sandler, Cedars-Sinai Medical Center, Los Angeles; Howard R. Soule, Prostate Cancer Foundation, Santa Monica, CA; Arthur Burnett, William B. Isaacs, Christian P. Pavlovich, and Patrick C. Walsh, Johns Hopkins Medical Institutions, Baltimore; Peter A. Pinto and Carol J. Weil, National Cancer Institute, Bethesda, MD; William J. Catalona and Edward Schaeffer, Northwestern University Feinberg School of Medicine; Scott Eggener, Sarah M. Nielsen, and Donald J. Vander Griend, University of Chicago, Chicago, IL; Kathleen A. Cooney, University of Utah School of Medicine, Salt Lake City, UT; David E. Crawford, University of Colorado, Aurora; Lawrence I. Karsh, The Urology Center of Colorado, Denver; Wendy Poage, Prostate Conditions Education Council, Elizabeth, CO; Neil Fleshner, University of Toronto Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Matthew L. Freedman, Kevin R. Loughlin, and Timothy R. Rebbeck, Dana Farber Cancer Institute, and Harvard TH Chan School of Public Health, Boston, MA; Freddie C. Hamdy, University of Oxford, Oxford, England; R. Jeffrey Karnes, Mayo Clinic, Rochester, MN; Eric A. Klein, Cleveland Clinic, Cleveland; Robert Pilarski, The Ohio State University, Columbus, OH; Daniel W. Lin, University of Washington, Seattle, WA; Martin M. Miner, Brown University, Providence, RI; Todd Morgan and Scott A. Tomlins, University of Michigan, Ann Arbor; Matt T. Rosenberg, Mid-Michigan Health Center, Jackson, MI; Judd W. Moul, Duke University, Duke Cancer Institute, Durham, NC; David F. Penson, Vanderbilt University Medical Center, Nashville, TN; Daniel Petrylak and Brian Shuch, Yale University, New Haven, CT; Curtis A. Pettaway, The University of Texas MD Anderson Cancer Center, Houston; Ganesh V. Raj, University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Oliver Sartor, Tulane University Medical School, New Orleans, LA; Neal D. Shore, Atlantic Urology Clinics/Carolina Urologic Research Center, Myrtle Beach, SC; and Richard Wender, American Cancer Society, Atlanta, GA.

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http://dx.doi.org/10.1200/JCO.2017.74.1173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075860PMC
February 2018

PARP Inhibitors in Prostate Cancer.

Curr Treat Options Oncol 2017 06;18(6):37

Departments of Medical Oncology, The Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s11864-017-0480-2DOI Listing
June 2017

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.

Cell Rep 2017 06;19(10):2045-2059

Centre for Molecular Medicine Norway, Nordic European Molecular Biology Laboratory Partnership, Forskningsparken, University of Oslo, 21 0349 Oslo, Norway; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital, 0424 Oslo, Norway; PCUK Movember Centre of Excellence, CCRCB, Queen's University, Belfast BT7 1NN, Northern Ireland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675034PMC
June 2017

Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer.

Cancer Res 2017 05 24;77(9):2439-2452. Epub 2017 Feb 24.

Department of Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462524PMC
May 2017

Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle.

Cancer Cell 2017 04;31(4):471-473

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA; The Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709809PMC
April 2017

There and Back Again: The Middle Earth of DNA Repair.

Authors:
Karen E Knudsen

Mol Cancer Res 2016 10;14(10):895-897

Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1541-7786.MCR-16-0298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223289PMC
October 2016

Linking DNA Damage and Hormone Signaling Pathways in Cancer.

Trends Endocrinol Metab 2016 Apr 1;27(4):216-225. Epub 2016 Mar 1.

Sidney Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th St Philadelphia, PA 19107, USA; Department of Cancer Biology, Thomas Jefferson University, 233 S 10th St Philadelphia, PA 19107, USA; Department of Urology, Thomas Jefferson University, 233 S 10th St Philadelphia, PA 19107, USA; Department of Radiation Oncology, Thomas Jefferson University, 233 S 10th St Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808434PMC
April 2016

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer.

N Engl J Med 2015 Oct;373(18):1697-708

From the Institute of Cancer Research (J.M., S.C., S.S., S.M., H.M., R.P.-L., D.N.R., A.O., N.T., G.B., N.P., P.F., A.G., I.F., C.P., G.S., D.B., J.G., Z.Z., C.T.W., R.F., R.R., B.E., G.F., D. Roda, W.Y., R.B., H.P., R.A., A.S., R.E., G.A., C.J.L., A.A., E.H., J.S.B.), the Royal Marsden NHS Foundation Trust (J.M., S.S., R.P.-L., A.O., N.T., D.B., Z.Z., R.F., D. Roda, R.E., G.A., J.S.B.), and University College London Hospital (U.M.), London, Queen's University, Belfast (S.J.), University of Leeds, Leeds (C.R.), Churchill Hospital, Oxford (A.P.), University of Liverpool, Liverpool (S.H.), Beatson West of Scotland Cancer Centre, Glasgow (R.J.), and Christie Hospital, Manchester (T.E.) - all in the United Kingdom; the University of Michigan, Ann Arbor (D. Robinson, Y.-M.W., X.C., L.P.K., F.Y.F., A.M.C.); Weill Cornell Medical College, New York (M.A.R.); and Thomas Jefferson University, Philadelphia (K.E.K.).

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http://dx.doi.org/10.1056/NEJMoa1506859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228595PMC
October 2015

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.

Cancer Cell 2015 Jul;28(1):97-113

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531387PMC
July 2015

Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function.

Mol Cell 2015 Jun;58(6):925-34

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487541PMC
June 2015

Consequence of the tumor-associated conversion to cyclin D1b.

EMBO Mol Med 2015 May;7(5):628-47

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Department of Urology, Thomas Jefferson University, Philadelphia, PA, USA Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, USA

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http://dx.doi.org/10.15252/emmm.201404242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492821PMC
May 2015

Cell-cycle-dependent regulation of androgen receptor function.

Endocr Relat Cancer 2015 Apr 17;22(2):249-64. Epub 2015 Feb 17.

Department of MicrobiologyImmunology, and Cancer Biology, University of Virginia, Jordan Hall Room 2-16, 1300 Jefferson Park Avenue, PO Box 800734, Charlottesville, Virginia 22908, USASidney Kimmel Cancer CenterThomas Jefferson University, Philadelphia, Pennsylvania, USACancer Center MemberUniversity of Virginia, Charlottesville, Virginia, USA Department of MicrobiologyImmunology, and Cancer Biology, University of Virginia, Jordan Hall Room 2-16, 1300 Jefferson Park Avenue, PO Box 800734, Charlottesville, Virginia 22908, USASidney Kimmel Cancer CenterThomas Jefferson University, Philadelphia, Pennsylvania, USACancer Center MemberUniversity of Virginia, Charlottesville, Virginia, USA

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http://dx.doi.org/10.1530/ERC-14-0549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382102PMC
April 2015

Models of neuroendocrine prostate cancer.

Endocr Relat Cancer 2015 Feb 27;22(1):R33-49. Epub 2014 Oct 27.

Department of Cancer BiologyKimmel Cancer CenterDepartments of UrologyRadiation OncologyThomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA Department of Cancer BiologyKimmel Cancer CenterDepartments of UrologyRadiation OncologyThomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA Department of Cancer BiologyKimmel Cancer CenterDepartments of UrologyRadiation OncologyThomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA Department of Cancer BiologyKimmel Cancer CenterDepartments of UrologyRadiation OncologyThomas Jefferson University, 233 South 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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http://dx.doi.org/10.1530/ERC-14-0393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481630PMC
February 2015

Novel actions of next-generation taxanes benefit advanced stages of prostate cancer.

Clin Cancer Res 2015 Feb;21(4):795-807

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania. Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania. Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania. Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania. Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333741PMC
February 2015

Hormone whodunit: clues for solving the case of intratumor androgen production.

Authors:
Karen E Knudsen

Clin Cancer Res 2014 Nov 18;20(21):5343-5. Epub 2014 Aug 18.

Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania. Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania. Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania. Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216738PMC
November 2014

The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc.

Neoplasia 2014 Nov 20;16(11):900-8. Epub 2014 Nov 20.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI, USA ; Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI, USA ; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/j.neo.2014.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240923PMC
November 2014

Fusing transcriptomics to progressive prostate cancer.

Am J Pathol 2014 Oct 14;184(10):2608-10. Epub 2014 Aug 14.

Division of Surgical Research, Department of Surgery, The Jefferson Pancreas, Biliary, and Related Cancer Center, Sidney Kimmel Medical College, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.08.001DOI Listing
October 2014

Beyond DNA repair: DNA-PK function in cancer.

Cancer Discov 2014 Oct 28;4(10):1126-39. Epub 2014 Aug 28.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania. Department of Urology, Thomas Jefferson University, Philadelphia, Pennsylvania. Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania. Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184981PMC
October 2014

AR function in promoting metastatic prostate cancer.

Cancer Metastasis Rev 2014 Sep;33(2-3):399-411

Department of Cancer Biology, Thomas Jefferson University, 233 10th St., BLSB 1008, Philadelphia, PA, 19107, USA,

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http://dx.doi.org/10.1007/s10555-013-9471-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452946PMC
September 2014

Transcriptional roles of PARP1 in cancer.

Mol Cancer Res 2014 Aug 10;12(8):1069-80. Epub 2014 Jun 10.

Kimmel Cancer Center, Departments of Cancer Biology, Urology, and Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134958PMC
August 2014

AMPed up to treat prostate cancer: novel AMPK activators emerge for cancer therapy.

EMBO Mol Med 2014 04 20;6(4):439-41. Epub 2014 Feb 20.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1002/emmm.201303737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992071PMC
April 2014

Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells.

Mol Endocrinol 2014 Apr 25;28(4):442-57. Epub 2014 Feb 25.

Departments of Medicine and Pharmacology (G.E.D., T.P.K., A.R.D., C.R.H., C.H.D., C.A.L.), Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455; and Departments of Cancer Biology, Urology, and Radiation Oncology (M.J.S., K.E.K.), Kimmel Cancer Center Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

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http://dx.doi.org/10.1210/me.2013-1196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968407PMC
April 2014

Practical guide to the use of radium 223 dichloride.

Can J Urol 2014 Apr;21(2 Supp 1):70-6

Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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April 2014

PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer.

Cancer Res 2014 Mar 28;74(6):1651-60. Epub 2014 Jan 28.

Authors' Affiliations: Michigan Center for Translational Pathology; Departments of Pathology, Radiation Oncology, Internal Medicine, Pharmacology, and Urology; Comprehensive Cancer Center; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan; Department of Genitourinary Medical Oncology, MD Anderson Cancer Center, Houston, Texas; Department of Urology, Institute of Prostate Cancer and LeFrak Center For Robotic Surgery; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College and New York Presbyterian Hospitals, New York, New York; Departments of Cancer Biology, Urology, and Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania; and Centre for Integrative Biology, University of Trento, Trento, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009928PMC
March 2014

Targeting PARP-1 allosteric regulation offers therapeutic potential against cancer.

Cancer Res 2014 Jan 4;74(1):31-7. Epub 2013 Nov 4.

Authors' Affiliations: Departments of Biochemistry and Molecular Biology and Surgery, Division of Surgical Research, The Jefferson Pancreas, Biliary, and Related Cancer Center; and Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-13-1701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903668PMC
January 2014

USP22 regulates oncogenic signaling pathways to drive lethal cancer progression.

Cancer Res 2014 Jan 6;74(1):272-86. Epub 2013 Nov 6.

Authors' Affiliations: Departments of Cancer Biology, Urology, Radiation Oncology, Pathology, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania; Sidney Kimmel Comprehensive Cancer Center; Department of Pathology, Johns Hopkins University, Baltimore, Maryland; and Institute of Biomedical Technology, University of Tampere and Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947329PMC
January 2014

A hormone-DNA repair circuit governs the response to genotoxic insult.

Cancer Discov 2013 Nov 11;3(11):1254-71. Epub 2013 Sep 11.

Departments of 1Cancer Biology, 2Urology, and 3Radiation Oncology, and 4Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania; 5Michigan Center for Translational Pathology, 6Department of Radiation Oncology, and 7Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823813PMC
November 2013

IGF2 revs the steroidogenesis engine.

Endocr Relat Cancer 2013 Oct 19;20(5):C19-21. Epub 2013 Aug 19.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1530/ERC-13-0243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091777PMC
October 2013

Ex vivo culture of human prostate tissue and drug development.

Nat Rev Urol 2013 Aug 11;10(8):483-7. Epub 2013 Jun 11.

Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, University of Adelaide, SA 5000, Australia.

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http://dx.doi.org/10.1038/nrurol.2013.126DOI Listing
August 2013

The epigenetic modifier ubiquitin-specific protease 22 (USP22) regulates embryonic stem cell differentiation via transcriptional repression of sex-determining region Y-box 2 (SOX2).

J Biol Chem 2013 Aug 12;288(33):24234-46. Epub 2013 Jun 12.

Department of Cancer Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M113.469783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745368PMC
August 2013

Molecular pathogenesis and progression of prostate cancer.

Semin Oncol 2013 Jun;40(3):244-58

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2013.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727396PMC
June 2013

Aberrant BAF57 signaling facilitates prometastatic phenotypes.

Clin Cancer Res 2013 May 14;19(10):2657-67. Epub 2013 Mar 14.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655134PMC
May 2013

The role of tumor suppressor dysregulation in prostate cancer progression.

Curr Drug Targets 2013 Apr;14(4):460-71

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.2174/1389450111314040007DOI Listing
April 2013

Middlegame theory, cancer style: a message from the editor-in-chief.

Authors:
Karen E Knudsen

Mol Cancer Res 2013 Jan;11(1):3-4

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http://dx.doi.org/10.1158/1541-7786.MCR-12-0683DOI Listing
January 2013

Cyclin D1 goes metabolic: dual functions of cyclin D1 in regulating lipogenesis.

Authors:
Karen E Knudsen

Cell Cycle 2012 Oct 5;11(19):3533-4. Epub 2012 Sep 5.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.4161/cc.22039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478301PMC
October 2012

The AR dependent cell cycle: mechanisms and cancer relevance.

Mol Cell Endocrinol 2012 Apr 12;352(1-2):34-45. Epub 2011 Jul 12.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.mce.2011.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641823PMC
April 2012

Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression.

Cancer Res 2012 Mar 18;72(5):1248-59. Epub 2012 Jan 18.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-0943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294022PMC
March 2012

mTOR is a selective effector of the radiation therapy response in androgen receptor-positive prostate cancer.

Endocr Relat Cancer 2012 Feb 9;19(1):1-12. Epub 2012 Jan 9.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1530/ERC-11-0072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253653PMC
February 2012

Postprostatectomy radiation therapy: an evidence-based review.

Future Oncol 2011 Dec;7(12):1429-40

Department of Radiation Oncology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

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https://www.futuremedicine.com/doi/10.2217/fon.11.120
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December 2011

Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate.

Int J Biochem Cell Biol 2011 Sep 12;43(9):1318-29. Epub 2011 May 12.

Kimmel Cancer Center, Department of Stem Cell Biology & Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.biocel.2011.04.019DOI Listing
September 2011

FOXA1: master of steroid receptor function in cancer.

EMBO J 2011 Sep 20;30(19):3885-94. Epub 2011 Sep 20.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/emboj.2011.340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209791PMC
September 2011

The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments.

Cell Cycle 2011 Aug 1;10(15):2497-503. Epub 2011 Aug 1.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685613PMC
http://dx.doi.org/10.4161/cc.10.15.16776DOI Listing
August 2011

Time to stratify? The retinoblastoma protein in castrate-resistant prostate cancer.

Nat Rev Urol 2011 Aug 2;8(10):562-8. Epub 2011 Aug 2.

Department of Genitourinary Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/nrurol.2011.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641817PMC
August 2011

Outsmarting androgen receptor: creative approaches for targeting aberrant androgen signaling in advanced prostate cancer.

Expert Rev Endocrinol Metab 2011 May;6(3):483-493

Kimmel Cancer Center, Thomas Jefferson University, 233 10th Street, BLSB 1008, Philadelphia, PA 19107, USA.

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http://www.tandfonline.com/doi/full/10.1586/eem.11.33
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http://dx.doi.org/10.1586/eem.11.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289283PMC
May 2011

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer.

Trends Endocrinol Metab 2010 May 6;21(5):315-24. Epub 2010 Feb 6.

Kimmel Cancer Center, Department of Cancer Biology and Department of Urology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.tem.2010.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862880PMC
May 2010

Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition.

Endocrinology 2010 Mar 10;151(3):896-908. Epub 2010 Feb 10.

Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, Miami, Florida 33136, USA.

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http://dx.doi.org/10.1210/en.2009-1116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840684PMC
March 2010

Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis.

Mol Cell Biol 2009 Dec 5;29(23):6170-81. Epub 2009 Oct 5.

Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1128/MCB.00825-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786694PMC
December 2009

Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancer.

Cancer Res 2009 Nov 20;69(21):8223-30. Epub 2009 Oct 20.

Department of Pathology and Laboratory and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272668PMC
November 2009

Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer.

Clin Cancer Res 2009 Aug 28;15(15):4792-8. Epub 2009 Jul 28.

Departments of Cancer Biology, Urology, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842118PMC
August 2009

Tailoring to RB: tumour suppressor status and therapeutic response.

Nat Rev Cancer 2008 09;8(9):714-24

Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1038/nrc2401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914856PMC
September 2008