Karen Cichowski

Karen Cichowski

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Karen Cichowski

Karen Cichowski

Publications by authors named "Karen Cichowski"

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37Publications

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Tissue-specificity in cancer: The rule, not the exception.

Science 2019 Mar;363(6432):1150-1151

Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aaw3472DOI Listing
March 2019

Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is.

Genes Dev 2018 09 22;32(17-18):1188-1200. Epub 2018 Aug 22.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.315648.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120715PMC
September 2018

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.

Cancer Discov 2016 09 16;6(9):1006-21. Epub 2016 Jun 16.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010480PMC
September 2016

Loss of negative regulators amplifies RAS signaling.

Nat Genet 2015 May;47(5):426-7

Genetics Division at the Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3299DOI Listing
May 2015

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies.

Nature 2014 Oct 13;514(7521):247-51. Epub 2014 Aug 13.

1] Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA [2] Harvard Medical School, Boston, Massachusetts 02115, USA [3] Ludwig Center at Dana-Farber/Harvard Cancer Center, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nature13561
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http://dx.doi.org/10.1038/nature13561DOI Listing
October 2014

Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers.

Cancer Discov 2014 Sep 9;4(9):1062-73. Epub 2014 Jun 9.

Genetics Division, Department of Medicine, Brigham and Women's Hospital; Harvard Medical School; and Ludwig Center at Dana-Farber/Harvard Cancer Center, Boston, Massachusetts

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http://dx.doi.org/10.1158/2159-8290.CD-14-0159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446704PMC
September 2014

Paths of resistance to EGFR inhibitors: is NF enough?

Cancer Discov 2014 May;4(5):519-21

1Genetics Division, Department of Medicine, Brigham and Women's Hospital; 2Harvard Medical School; and 3Ludwig Center at Dana-Farber/Harvard Cancer Center, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0286DOI Listing
May 2014

An expanding role for RAS GTPase activating proteins (RAS GAPs) in cancer.

Adv Biol Regul 2014 May 30;55:1-14. Epub 2014 Apr 30.

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Ludwig Center at Dana-Farber/Harvard Cancer Center, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2014.04.002DOI Listing
May 2014

The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.

Cancer Cell 2013 Sep;24(3):365-78

Genetics Division, Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822334PMC
September 2013

Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras.

Cancer Discov 2013 Aug 9;3(8):880-93. Epub 2013 May 9.

Brigham and Women’s Hospital, 77 Avenue Louis Pasteur, NRB 0458C, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881282PMC
August 2013

Elucidating distinct roles for NF1 in melanomagenesis.

Cancer Discov 2013 Mar 21;3(3):338-49. Epub 2012 Nov 21.

Genetics Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595355PMC
March 2013

SPRED proteins provide a NF-ty link to Ras suppression.

Genes Dev 2012 Jul;26(14):1515-9

Massachusetts General Hospital Center for Cancer Research, Department of Pathology, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.197434.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404379PMC
July 2012

Drug discovery: inhibitors that activate.

Nature 2010 Mar;464(7287):358-9

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http://dx.doi.org/10.1038/464358aDOI Listing
March 2010

Unexpected pieces to the senescence puzzle.

Cell 2008 Jun;133(6):958-61

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115 USA.

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http://dx.doi.org/10.1016/j.cell.2008.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593023PMC
June 2008

TORC1 is essential for NF1-associated malignancies.

Curr Biol 2008 Jan 27;18(1):56-62. Epub 2007 Dec 27.

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Ludwig Center at Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.cub.2007.11.066DOI Listing
January 2008

A negative feedback signaling network underlies oncogene-induced senescence.

Cancer Cell 2006 Dec;10(6):459-72

Genetics Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 458c NRB, 77 Louis Pasteur Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692661PMC
December 2006

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

Proc Natl Acad Sci U S A 2005 Jun 3;102(24):8573-8. Epub 2005 Jun 3.

Genetics Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 458c NRB, 77 Louis Pasteur Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0503224102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142482PMC
June 2005

ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines.

Proc Natl Acad Sci U S A 2005 Mar 24;102(10):3788-93. Epub 2005 Feb 24.

Department of Systems Biology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0409773102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC553328PMC
March 2005

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor.

Genes Dev 2003 Feb;17(4):449-54

Genetics Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1054703
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http://dx.doi.org/10.1101/gad.1054703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC195996PMC
February 2003