Publications by authors named "Karen Blyth"

97Publications

RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development.

Elife 2020 Oct 7;9. Epub 2020 Oct 7.

Stem Cell Biology, Cancer Research UK Manchester Institute, The University of Manchester, Macclesfield, United Kingdom.

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http://dx.doi.org/10.7554/eLife.60225DOI Listing
October 2020

Polyamine pathway activity promotes cysteine essentiality in cancer cells.

Nat Metab 2020 Oct 3;2(10):1062-1076. Epub 2020 Aug 3.

Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1038/s42255-020-0253-2DOI Listing
October 2020

Somatic base editing to model oncogenic drivers in breast cancer.

Lab Anim (NY) 2020 04;49(4):115-116

CRUK Beatson Institute, Bearsden, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1038/s41684-020-0510-8DOI Listing
April 2020

Follow-up and Clinical Outcomes of Human Immunodeficiency Virus (HIV)-Exposed Infants in A Low-Prevalence Setting in A Multidisciplinary Model of Care in Australia: The Children's HIV Exposure Study 1.

J Pediatric Infect Dis Soc 2020 Feb 18. Epub 2020 Feb 18.

Infectious Diseases Unit, Department of General Medicine, The Royal Children's Hospital Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1093/jpids/piaa010DOI Listing
February 2020

DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation.

iScience 2020 Feb 14;23(2):100838. Epub 2020 Jan 14.

Institute of Cancer Sciences, University of Glasgow, Glasgow, UK; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000804PMC
February 2020

A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells.

Oncogene 2020 Mar 31;39(12):2624-2637. Epub 2020 Jan 31.

Faculty of Biology, Medicine and Health, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1038/s41388-020-1170-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082223PMC
March 2020

RUNX1 Dosage in Development and Cancer.

Mol Cells 2020 Feb;43(2):126-138

Cancer Research UK Stem Cell Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Macclesfield, SK10 4TG, UK.

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http://dx.doi.org/10.14348/molcells.2019.0301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057845PMC
February 2020

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer.

Cancer Cell 2020 02 23;37(2):168-182.e4. Epub 2020 Jan 23.

The Francis Crick Institute, London NW1 1AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008247PMC
February 2020

Author Correction: Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori.

Cancer Gene Ther 2020 Feb;27(1-2):112

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, Glasgow, G12 8TA, UK.

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http://dx.doi.org/10.1038/s41417-019-0086-xDOI Listing
February 2020

Correction: Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori.

Cancer Gene Ther 2018 12;25(11-12):339

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, Glasgow, G12 8TA, UK.

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http://dx.doi.org/10.1038/s41417-018-0047-9DOI Listing
December 2018

Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori.

Cancer Gene Ther 2019 07 13;26(7-8):183-194. Epub 2018 Aug 13.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, Sir Graeme Davies Building, University of Glasgow, Glasgow, G12 8TA, UK.

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http://dx.doi.org/10.1038/s41417-018-0039-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760541PMC
July 2019

RIPK3 promotes adenovirus type 5 activity.

Cell Death Dis 2017 12 13;8(12):3206. Epub 2017 Dec 13.

Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, G61 1QH, UK.

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http://dx.doi.org/10.1038/s41419-017-0110-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870599PMC
December 2017

Runx1 Deficiency Protects Against Adverse Cardiac Remodeling After Myocardial Infarction.

Circulation 2018 01 13;137(1):57-70. Epub 2017 Oct 13.

Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, University Place, UK (C.S.M., W.H., A.B., K.M., F.V., K.N., C.F., A.R., P.B., E.B.E., C.H., S.M.M., G.L.S., M.W.M., S.A.N., C.M.L.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757664PMC
January 2018

Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function.

J Invest Dermatol 2017 10 22;137(10):2197-2207. Epub 2017 Jun 22.

Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK; Sanford Burnham Prebys Medical Discovery Institute, San Diego, California, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X173166
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http://dx.doi.org/10.1016/j.jid.2017.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613751PMC
October 2017

Increased T-cell Infiltration Elicited by Deletion in a -Deficient Mouse Model of Prostate Carcinogenesis.

Cancer Res 2017 06 17;77(12):3158-3168. Epub 2017 May 17.

Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Bearsden, Glasgow, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474317PMC
June 2017

models in breast cancer research: progress, challenges and future directions.

Dis Model Mech 2017 04;10(4):359-371

Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK

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http://dx.doi.org/10.1242/dmm.028274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399571PMC
April 2017

The enigmatic role of RUNX1 in female-related cancers - current knowledge & future perspectives.

FEBS J 2017 08 10;284(15):2345-2362. Epub 2017 Apr 10.

Cancer Research UK Beatson Institute, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1111/febs.14059DOI Listing
August 2017

Runx Genes in Breast Cancer and the Mammary Lineage.

Adv Exp Med Biol 2017 ;962:353-368

Beatson Institute for Cancer Research, Bearsden, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1007/978-981-10-3233-2_22DOI Listing
September 2017

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation.

Cell Rep 2017 01;18(3):647-658

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.12.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5276806PMC
January 2017

CRISPR/Cas9-Mediated Trp53 and Brca2 Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous Carcinoma.

Cancer Res 2016 10 16;76(20):6118-6129. Epub 2016 Aug 16.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom. Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802386PMC
October 2016

SEARCHBreast Workshop Proceedings: 3D Modelling of Breast Cancer.

Altern Lab Anim 2015 Dec;43(6):367-75

Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1177/026119291504300604DOI Listing
December 2015

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine.

Genes Dev 2016 Jan 17;30(1):52-63. Epub 2015 Dec 17.

Cancer Research UK Beatson Institute, Glasgow, G61 1BD, United Kingdom.

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http://dx.doi.org/10.1101/gad.271130.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701978PMC
January 2016

Frequent infection of human cancer xenografts with murine endogenous retroviruses in vivo.

Viruses 2015 Apr 17;7(4):2014-29. Epub 2015 Apr 17.

Molecular Oncology Laboratory, MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Garscube Estate, Bearsden Road, G61 1QH Glasgow, UK.

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http://dx.doi.org/10.3390/v7042014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411688PMC
April 2015

Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death.

Mol Cell 2015 Mar 19;57(5):860-872. Epub 2015 Feb 19.

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352766PMC
March 2015

Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells.

Cancer Metab 2013 Mar 21;1(1):12. Epub 2013 Mar 21.

Cancer Research UK, Beatson Institute for Cancer Research, Switchback Road, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1186/2049-3002-1-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108060PMC
March 2013

iRFP is a sensitive marker for cell number and tumor growth in high-throughput systems.

Cell Cycle 2014 31;13(2):220-6. Epub 2013 Oct 31.

Cancer Research UK Beatson Institute; Glasgow, UK.

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http://dx.doi.org/10.4161/cc.26985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906239PMC
November 2014

Wnt signaling potentiates nevogenesis.

Proc Natl Acad Sci U S A 2013 Oct 16;110(40):16009-14. Epub 2013 Sep 16.

Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1303491110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791768PMC
October 2013

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

Nature 2013 Jan 16;493(7433):542-6. Epub 2012 Dec 16.

The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/nature11743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485472PMC
January 2013

RUNX2 in mammary gland development and breast cancer.

J Cell Physiol 2013 Jun;228(6):1137-42

The Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1002/jcp.24285DOI Listing
June 2013

The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model?

Curr Opin Genet Dev 2012 Feb 7;22(1):28-35. Epub 2012 Mar 7.

The Beatson Institute for Cancer Research, Switchback Road, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1016/j.gde.2012.02.009DOI Listing
February 2012

Runx2 in normal tissues and cancer cells: A developing story.

Blood Cells Mol Dis 2010 Aug 26;45(2):117-23. Epub 2010 Jun 26.

Beatson Institute for Cancer Research, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1016/j.bcmd.2010.05.007DOI Listing
August 2010

Runx1 promotes B-cell survival and lymphoma development.

Blood Cells Mol Dis 2009 Jul-Aug;43(1):12-9. Epub 2009 Mar 9.

Faculty of Veterinary Medicine, Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1016/j.bcmd.2009.01.013DOI Listing
September 2009

Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts.

Cancer Res 2007 Dec;67(23):11263-71

Molecular Oncology Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-3016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562449PMC
December 2007

A rural model of HIV service provision.

Aust Nurs J 2007 Oct;15(4):37

Victorian HIV Consultancy.

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October 2007

Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas.

Cancer Res 2007 Jun;67(11):5126-33

Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, Scotland, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562448PMC
June 2007

Gene therapy: X-SCID transgene leukaemogenicity.

Nature 2006 Sep;443(7109):E5-6; discussion E6-7

Molecular Immunology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK.

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http://dx.doi.org/10.1038/nature05219DOI Listing
September 2006

Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo.

Cancer Res 2006 Feb;66(4):2195-201

Molecular Oncology Laboratory, Institute of Comparative Medicine, Faculty of Veterinary, Medicine, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3558DOI Listing
February 2006

The RUNX genes: gain or loss of function in cancer.

Nat Rev Cancer 2005 May;5(5):376-87

Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, G61 1QH, UK.

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http://www.nature.com/articles/nrc1607
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http://dx.doi.org/10.1038/nrc1607DOI Listing
May 2005

RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53.

Oncogene 2004 Jul;23(32):5476-86

Molecular Oncology Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, Scotland, UK.

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http://dx.doi.org/10.1038/sj.onc.1207729DOI Listing
July 2004

The Runx genes as dominant oncogenes.

Blood Cells Mol Dis 2003 Mar-Apr;30(2):194-200

Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow G61 1QH, UK.

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http://dx.doi.org/10.1016/s1079-9796(03)00031-7DOI Listing
August 2004

Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma.

Cancer Res 2002 Dec;62(24):7181-5

Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, United Kingdom.

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December 2002

Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection.

J Immunol 2002 Sep;169(6):2866-74

Molecular Oncology Laboratory, Institute of Comparative Medicine, University of Glasgow Veterinary School, Glasgow, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.169.6.2866DOI Listing
September 2002