Karel Allegaert

Karel Allegaert

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Karel Allegaert

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Severity of asphyxia is a covariate of phenobarbital clearance in newborns undergoing hypothermia.

J Matern Fetal Neonatal Med 2019 Jul 5;32(14):2302-2309. Epub 2018 Feb 5.

c Intensive Care and Department of Pediatric Surgery , Erasmus MC, Sophia Children's Hospital , Rotterdam , The Netherlands.

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http://dx.doi.org/10.1080/14767058.2018.1432039DOI Listing
July 2019

Morphine treatment for neonatal abstinence syndrome: huge dosing variability underscores the need for a better clinical study design.

Minerva Pediatr 2019 Jun 3;71(3):263-286. Epub 2017 Mar 3.

Intensive Care and Department of Pediatric Surgery, Erasmus University Medical Center - Sophia, Rotterdam, the Netherlands.

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http://dx.doi.org/10.23736/S0026-4946.17.04928-3DOI Listing
June 2019

Neonates are not just little children and need more finesse in dosing of antibiotics.

Acta Clin Belg 2019 Jun 10;74(3):157-163. Epub 2018 May 10.

a Intensive Care and Department of Pediatric Surgery , Erasmus MC - Sophia Children's Hospital , Rotterdam , The Netherlands.

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http://dx.doi.org/10.1080/17843286.2018.1473094DOI Listing
June 2019

Maturational changes in vancomycin protein binding affect vancomycin dosing in neonates.

Br J Clin Pharmacol 2019 May 4;85(5):865-867. Epub 2019 Mar 4.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/bcp.13899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475736PMC
May 2019

Local pulmonary drug delivery in the preterm rabbit: feasibility and efficacy of daily intratracheal injections.

Am J Physiol Lung Cell Mol Physiol 2019 Apr 24;316(4):L589-L597. Epub 2019 Jan 24.

Department of Development and Regeneration, Cluster Woman and Child, KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1152/ajplung.00255.2018DOI Listing
April 2019

Research on medication use in the neonatal intensive care unit.

Expert Rev Clin Pharmacol 2019 Apr 20;12(4):343-353. Epub 2019 Feb 20.

c Division of Clinical Pharmacology, Department of Pediatrics , Children's National Health System , Washington , DC , USA.

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http://dx.doi.org/10.1080/17512433.2019.1580569DOI Listing
April 2019

Actual body weight-based vancomycin dosing in neonates.

J Chemother 2019 Apr 14:1-6. Epub 2019 Apr 14.

b Department of Pharmacology , General University Hospital, 1st Faculty of Medicine Charles University in Prague , Czech Republic , Prague , Czech Republic.

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2019.1
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http://dx.doi.org/10.1080/1120009X.2019.1599574DOI Listing
April 2019

Beliefs about medicines and information needs among pregnant women visiting a tertiary hospital in Belgium.

Eur J Clin Pharmacol 2019 Mar 4. Epub 2019 Mar 4.

Department of Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Pharmacotherapy, KU Leuven, Herestraat 49, Box 521, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00228-019-02653-wDOI Listing
March 2019

Narcotic-Sparing Approaches and the Shift Toward Paracetamol in Neonatal Intensive Care.

Handb Exp Pharmacol 2019 Mar 17. Epub 2019 Mar 17.

Intensive Care, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/164_2019_207DOI Listing
March 2019

Characterization of Esophageal Motility in Infants with Congenital Diaphragmatic Hernia using High Resolution Manometry.

J Pediatr Gastroenterol Nutr 2019 Mar 5. Epub 2019 Mar 5.

Department of Neurosciences, Experimental Oto-Rhino-Laryngology, Deglutology, KU Leuven, Belgium.

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http://dx.doi.org/10.1097/MPG.0000000000002325DOI Listing
March 2019

Clinical Pharmacokinetic Studies in Pregnant Women and the Relevance of Pharmacometric Tools.

Curr Pharm Des 2019 03 20. Epub 2019 Mar 20.

Organ Systems, KU Leuven, Department of Development and Regeneration, Leuven. Belgium.

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http://dx.doi.org/10.2174/1381612825666190320135137DOI Listing
March 2019

Impact of Disease on Amikacin Pharmacokinetics and Dosing in Children.

Ther Drug Monit 2019 02;41(1):44-52

Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.

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http://dx.doi.org/10.1097/FTD.0000000000000568DOI Listing
February 2019

Rational Use of Antibiotics in Neonates: Still in Search of Tailored Tools.

Healthcare (Basel) 2019 Feb 16;7(1). Epub 2019 Feb 16.

Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

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http://dx.doi.org/10.3390/healthcare7010028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473895PMC
February 2019

Pregnancy affects the pharmacokinetics of sildenafil and its metabolite in the rabbit.

Xenobiotica 2019 Jan 10;49(1):98-105. Epub 2018 Jan 10.

a Cluster Woman and Child, Department of Development and Regeneration, Biomedical Sciences, KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1080/00498254.2017.1422217DOI Listing
January 2019

How often do we perform painful and stressful procedures in the paediatric intensive care unit? A prospective observational study.

Aust Crit Care 2019 Jan 17;32(1):4-10. Epub 2018 May 17.

Intensive Care and Department of Pediatric Surgery, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands; Division of Neonatology, Department of Pediatrics, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.aucc.2018.04.003DOI Listing
January 2019

Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis.

Br J Clin Pharmacol 2019 Jan 25;85(1):245-251. Epub 2018 Oct 25.

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

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http://doi.wiley.com/10.1111/bcp.13778
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http://dx.doi.org/10.1111/bcp.13778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303200PMC
January 2019

Tramadol, breast feeding and safety in the newborn.

Arch Dis Child 2018 Dec 29;103(12):1110-1113. Epub 2018 Mar 29.

Intensive Care and Department of Pediatric Surgery and Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1136/archdischild-2017-313786DOI Listing
December 2018

Simulation-based suggestions to improve ibuprofen dosing for patent ductus arteriosus in preterm newborns.

Eur J Clin Pharmacol 2018 Dec 28;74(12):1585-1591. Epub 2018 Jul 28.

Department of Pediatrics, Division of Neonatology, Erasmus University Medical Center - Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00228-018-2529-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244763PMC
December 2018

Sildenafil crosses the placenta at therapeutic levels in a dually perfused human cotyledon model.

Am J Obstet Gynecol 2018 Dec 5;219(6):619.e1-619.e10. Epub 2018 Sep 5.

Cluster Woman and Child, the Department of Development and Regeneration, Biomedical Sciences, KU Leuven, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Institute of Women's Health, Institute of Child Health, University College London, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029378183072
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http://dx.doi.org/10.1016/j.ajog.2018.08.041DOI Listing
December 2018

The use of PBPK modeling across the pediatric age range using propofol as a case.

J Pharmacokinet Pharmacodyn 2018 Dec 8;45(6):765-785. Epub 2018 Oct 8.

Laboratory of Medical Biochemistry and Clinical Analysis, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

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http://link.springer.com/10.1007/s10928-018-9607-8
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http://dx.doi.org/10.1007/s10928-018-9607-8DOI Listing
December 2018

Physiologically based pharmacokinetic (PBPK) modeling and simulation in neonatal drug development: how clinicians can contribute.

Expert Opin Drug Metab Toxicol 2018 Dec 17:1-10. Epub 2018 Dec 17.

b Department of Development and Regeneration , KU Leuven , Leuven , Belgium.

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https://www.tandfonline.com/doi/full/10.1080/17425255.2019.1
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http://dx.doi.org/10.1080/17425255.2019.1558205DOI Listing
December 2018

Cerebral autoregulation and activity after propofol for endotracheal intubation in preterm neonates.

Pediatr Res 2018 11 10;84(5):719-725. Epub 2018 Sep 10.

Department of Neonatology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41390-018-0160-3DOI Listing
November 2018

Developmental Pharmacology - Special Issues During Childhood and Adolescence.

Authors:
Karel Allegaert

Drug Res (Stuttg) 2018 Nov 19;68(S 01):S10-S11. Epub 2018 Nov 19.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1055/a-0731-6913DOI Listing
November 2018

Risk factors for spontaneous localized intestinal perforation in the preterm infant.

J Matern Fetal Neonatal Med 2018 Oct 16;31(19):2617-2623. Epub 2017 Jul 16.

f Department of Abdominal Surgery , Universitaire Ziekenhuizen Leuven , Leuven , Belgium.

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https://www.tandfonline.com/doi/full/10.1080/14767058.2017.1
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http://dx.doi.org/10.1080/14767058.2017.1350161DOI Listing
October 2018

Developmental Changes in Pharmacokinetics and Pharmacodynamics.

J Clin Pharmacol 2018 Oct;58 Suppl 10:S10-S25

Arkansas Children's Research Institute, Little Rock, AR, USA.

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http://doi.wiley.com/10.1002/jcph.1284
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http://dx.doi.org/10.1002/jcph.1284DOI Listing
October 2018

Inactive matrix Gla protein is a novel circulating biomarker predicting retinal arteriolar narrowing in humans.

Sci Rep 2018 Oct 10;8(1):15088. Epub 2018 Oct 10.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41598-018-33257-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180139PMC
October 2018

Rational Use of Medicines in Neonates: Current Observations, Areas for Research and Perspectives.

Authors:
Karel Allegaert

Healthcare (Basel) 2018 Sep 14;6(3). Epub 2018 Sep 14.

Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Doctor Molenwaterplein 40, 3015 GD Rotterdam, The Netherlands.

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http://dx.doi.org/10.3390/healthcare6030115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165407PMC
September 2018

Factors impacting unbound vancomycin concentrations in neonates and young infants.

Eur J Clin Microbiol Infect Dis 2018 Aug 16;37(8):1503-1510. Epub 2018 May 16.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s10096-018-3277-8DOI Listing
August 2018

Earlier achievement of full enteral feeding in extremely low birth weight neonates is not associated with growth improvement in the first 2 years of life.

Eur J Pediatr 2018 Aug 30;177(8):1247-1254. Epub 2018 May 30.

Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00431-018-3178-yDOI Listing
August 2018

Excipients in Neonatal Medicinal Products: Never Prescribed, Commonly Administered.

Pharmaceut Med 2018 10;32(4):251-258. Epub 2018 Aug 10.

2Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40290-018-0243-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105181PMC
August 2018

Clinical Outcome for Congenital Diaphragmatic Hernia at the Age of 1 Year in the Era of Fetal Intervention.

Neonatology 2017 2;112(4):365-371. Epub 2017 Sep 2.

Paediatrics (Paediatric Pulmonology),, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1159/000479145DOI Listing
July 2018

Desphospho-uncarboxylated matrix Gla protein is a novel circulating biomarker predicting deterioration of renal function in the general population.

Nephrol Dial Transplant 2018 Jul;33(7):1122-1128

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1093/ndt/gfx258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030862PMC
July 2018

Acetaminophen in the Neonatal Intensive Care Unit: Shotgun Approach or Silver Bullet.

J Pediatr 2018 07 28;198:10-11. Epub 2018 Mar 28.

Intensive Care and Department of Pediatric Surgery; Erasmus Medical Center-Sophia Children's Hospital; Rotterdam, the Netherlands; Department of Development and Regeneration; KU Leuven; Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jpeds.2018.02.046DOI Listing
July 2018

Paracetamol/Acetaminophen During Pregnancy Induces Prenatal Ductus Arteriosus Closure.

Pediatrics 2018 07 7;142(1). Epub 2018 Jun 7.

Departments of Neonatology and

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http://dx.doi.org/10.1542/peds.2017-4021DOI Listing
July 2018

Paracetamol in Older People: Towards Evidence-Based Dosing?

Drugs Aging 2018 07;35(7):603-624

Department of Geriatrics, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1007/s40266-018-0559-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061299PMC
July 2018

Neonatal factors predictive for respiratory and gastro-intestinal morbidity after esophageal atresia repair.

Pediatr Neonatol 2018 Jul 21. Epub 2018 Jul 21.

Neurogastroenterology and Motility, Gastroenterology, University Hospitals Leuven, Leuven, Belgium; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium; Department of Neurosciences, Experimental ORL, KU Leuven, Belgium.

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http://dx.doi.org/10.1016/j.pedneo.2018.07.003DOI Listing
July 2018

Antenatal management of congenital diaphragmatic hernia today and tomorrow.

Minerva Pediatr 2018 Jun 23;70(3):270-280. Epub 2018 Feb 23.

Academic Department of Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, KU Leuven, Leuven, Belgium -

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http://dx.doi.org/10.23736/S0026-4946.18.05186-1DOI Listing
June 2018

Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for .

Clin Epigenetics 2017 3;9:107. Epub 2017 Oct 3.

Department of Neurosciences, Genetic Research About Stress and Psychiatry (GRASP), KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/s13148-017-0408-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627482PMC
May 2018

In Vitro Adsorption of Analgosedative Drugs in New Extracorporeal Membrane Oxygenation Circuits.

Pediatr Crit Care Med 2018 05;19(5):e251-e258

Intensive Care and Department of Pediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/PCC.0000000000001484DOI Listing
May 2018

Drug evaluation studies in neonates: how to overcome the current limitations.

Expert Rev Clin Pharmacol 2018 Apr 14;11(4):387-396. Epub 2018 Mar 14.

b Intensive Care and Department of Pediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , the Netherlands.

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http://dx.doi.org/10.1080/17512433.2018.1439378DOI Listing
April 2018

Pharmacokinetic considerations for pediatric patients receiving analgesia in the intensive care unit; targeting postoperative, ECMO and hypothermia patients.

Expert Opin Drug Metab Toxicol 2018 Apr 11;14(4):417-428. Epub 2018 Apr 11.

a Intensive Care and Department of Pediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , The Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/17425255.2018.1
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http://dx.doi.org/10.1080/17425255.2018.1461836DOI Listing
April 2018

The risk of nephrolithiasis is causally related to inactive matrix Gla protein, a marker of vitamin K status: a Mendelian randomization study in a Flemish population.

Nephrol Dial Transplant 2018 03;33(3):514-522

Studies Coordinating Centre, Research Unit of Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1093/ndt/gfx014DOI Listing
March 2018

Ibuprofen exposure in early neonatal life does not affect renal function in young adolescence.

Arch Dis Child Fetal Neonatal Ed 2018 Mar 14;103(2):F107-F111. Epub 2017 Jun 14.

KU Leuven Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1136/archdischild-2017-312922DOI Listing
March 2018

Reproducibility of Retinal Microvascular Traits Decoded by the Singapore I Vessel Assessment Software Across the Human Age Range.

Am J Hypertens 2018 Mar;31(4):438-449

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium.

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http://dx.doi.org/10.1093/ajh/hpx202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861549PMC
March 2018

Drug metabolism in early infancy: opioids as an illustration.

Expert Opin Drug Metab Toxicol 2018 Mar 30;14(3):287-301. Epub 2018 Jan 30.

a Intensive Care and Department of Paediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , The Netherlands.

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http://dx.doi.org/10.1080/17425255.2018.1432595DOI Listing
March 2018

Association between cognition and the retinal microvasculature in 11-year old children born preterm or at term.

Early Hum Dev 2018 03 3;118:1-7. Epub 2018 Feb 3.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Siciences, University of Leuven, Leuven, Belgium; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.earlhumdev.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885985PMC
March 2018

Conventional and Ambulatory Blood Pressure as Predictors of Diastolic Left Ventricular Function in a Flemish Population.

J Am Heart Assoc 2018 Feb 8;7(4). Epub 2018 Feb 8.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium

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http://dx.doi.org/10.1161/JAHA.117.007868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850199PMC
February 2018

Relation Between EEG Activity and Brain Oxygenation in Preterm Neonates.

Adv Exp Med Biol 2017 ;977:133-139

Department of Electrical Engineering, STADIUS-ESAT, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/978-3-319-55231-6_18DOI Listing
January 2018

Perspectives in Neonatal Pharmacology: Drug Discovery, Knowledge Integration and Structured Prioritization.

Curr Pharm Des 2018 ;24(41):4839-4841

Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.

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http://dx.doi.org/10.2174/138161282441190320125910DOI Listing
January 2018

N-terminal B-type natriuretic peptide urinary concentrations and retinopathy of prematurity.

Pediatr Res 2017 Dec 16;82(6):958-963. Epub 2017 Aug 16.

Newcastle Neonatal Service, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1038/pr.2017.179DOI Listing
December 2017

Amikacin Pharmacokinetics To Optimize Dosing in Neonates with Perinatal Asphyxia Treated with Hypothermia.

Antimicrob Agents Chemother 2017 12 22;61(12). Epub 2017 Nov 22.

Intensive Care, Department of Pediatric Surgery, and Department of Neonatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands

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http://dx.doi.org/10.1128/AAC.01282-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5700363PMC
December 2017

Analysis of renal blood flow and renal volume in normal fetuses and in fetuses with a solitary functioning kidney.

Prenat Diagn 2017 12 21;37(12):1213-1218. Epub 2017 Nov 21.

Department of Obstetrics and Gynecology, KU Leuven, Belgium.

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http://dx.doi.org/10.1002/pd.5167DOI Listing
December 2017

Current and future antenatal management of isolated congenital diaphragmatic hernia.

Semin Fetal Neonatal Med 2017 12 21;22(6):383-390. Epub 2017 Nov 21.

Academic Department of Development and Regeneration, Clinical Specialties Research Groups, Biomedical Sciences; Clinical Department of Obstetrics and Gynaecology, KU Leuven, Leuven, Belgium; Institute for Women's Health and Institute of Child Health, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.siny.2017.11.002DOI Listing
December 2017

Changes in Oxygenation Levels Precede Changes in Amplitude of the EEG in Premature Infants.

Adv Exp Med Biol 2016 ;923:143-149

Department of Electrical Engineering (ESAT), STADIUS, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/978-3-319-38810-6_19DOI Listing
November 2017

Evidence-based drug treatment for special patient populations through model-based approaches.

Eur J Pharm Sci 2017 Nov 11;109S:S22-S26. Epub 2017 May 11.

Leiden Academic Center for Drug Research, Systems Pharmacology Cluster, Division of Pharmacology, Leiden University, Leiden, The Netherlands; Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, The Netherlands.

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http://dx.doi.org/10.1016/j.ejps.2017.05.022DOI Listing
November 2017

Non-maturational covariates for dynamic systems pharmacology models in neonates, infants, and children: Filling the gaps beyond developmental pharmacology.

Eur J Pharm Sci 2017 Nov 12;109S:S27-S31. Epub 2017 May 12.

Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands; Division of Clinical Pharmacology, Children's National Health System, Washington, DC, USA; Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.ejps.2017.05.023DOI Listing
November 2017

Better medicines for neonates: Improving medicine development, testing, and prescribing.

Authors:
Karel Allegaert

Early Hum Dev 2017 11 9;114:22-25. Epub 2017 Sep 9.

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands; Neonatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.. Electronic address:

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http://dx.doi.org/10.1016/j.earlhumdev.2017.09.007DOI Listing
November 2017

Pre- and Postnatal Development of the Eye: A Species Comparison.

Birth Defects Res 2017 Nov 22;109(19):1540-1567. Epub 2017 Sep 22.

Intensive Care and Department of Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/bdr2.1100DOI Listing
November 2017

Biomarkers of propofol metabolism in neonates: the quest beyond ontogeny.

Biomark Med 2017 11 23;11(11):933-936. Epub 2017 Oct 23.

Department of Development & Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.2217/bmm-2017-0184DOI Listing
November 2017

Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg/kg intravenous acetaminophen in very-preterm infants.

Pediatr Res 2017 Oct 21;82(4):678-684. Epub 2017 Jun 21.

Department of Pediatrics, Division of Neonatology, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/pr.2017.129DOI Listing
October 2017

Sleep related breathing disorders and indications for polysomnography in preterm infants.

Early Hum Dev 2017 10 12;113:114-119. Epub 2017 Jul 12.

Department of Pediatric Surgery, Erasmus University Medical Center - Sophia, Rotterdam, The Netherlands; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.earlhumdev.2017.07.005DOI Listing
October 2017

Perinatal and neonatal use of paracetamol for pain relief.

Semin Fetal Neonatal Med 2017 10 15;22(5):308-313. Epub 2017 Jul 15.

Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands; Division of Clinical Pharmacology, Department of Pediatrics, Children's National Health System, Washington DC, USA; Division of Paediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.siny.2017.07.006DOI Listing
October 2017

Continuous Intravenous Acetaminophen for Analgesia: First, Back to the Drawing Table?

J Clin Pharmacol 2017 10 24;57(10):1353-1354. Epub 2017 Jul 24.

Erasmus MC-Sophia Children's Hospital, Intensive Care and Department of Paediatric Surgery, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/jcph.965DOI Listing
October 2017

Enrollment of Neonates in More Than One Clinical Trial.

Clin Ther 2017 Oct 4;39(10):1959-1969. Epub 2017 Oct 4.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.clinthera.2017.09.006DOI Listing
October 2017

Body weight, gender and pregnancy affect enantiomer-specific ketorolac pharmacokinetics.

Br J Clin Pharmacol 2017 Sep 14;83(9):1966-1975. Epub 2017 May 14.

Department of Development and Regeneration, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/bcp.13311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555864PMC
September 2017

Clinically relevant discordances identified after tertiary reassessment of fetuses with isolated congenital diaphragmatic hernia.

Prenat Diagn 2017 Sep 25;37(9):883-888. Epub 2017 Jul 25.

Division of Woman and Child, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/pd.5060DOI Listing
September 2017

Esophageal Atresia: Future Directions for Research on the Digestive Tract.

Eur J Pediatr Surg 2017 Aug 17;27(4):306-312. Epub 2016 Aug 17.

Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1055/s-0036-1587330DOI Listing
August 2017

Neonatal Abstinence Syndrome: Update on Diagnostic and Therapeutic Strategies.

Pharmacotherapy 2017 Jul 2;37(7):814-823. Epub 2017 Jul 2.

NICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1002/phar.1954DOI Listing
July 2017

What is the dose of intravenous paracetamol for pain relief in neonates?

Arch Dis Child 2017 07 26;102(7):649-650. Epub 2017 May 26.

Intensive Care and Department of Paediatric Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1136/archdischild-2017-312870DOI Listing
July 2017

Inter-Subject Variability in OCT1 Activity in 27 Batches of Cryopreserved Human Hepatocytes and Association with OCT1 mRNA Expression and Genotype.

Pharm Res 2017 06 31;34(6):1309-1319. Epub 2017 Mar 31.

Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Campus Gasthuisberg O&N II Herestraat 49 Box 921, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s11095-017-2148-9DOI Listing
June 2017

Pharmacological sedation management in the paediatric intensive care unit.

J Pharm Pharmacol 2017 May 21;69(5):498-513. Epub 2016 Aug 21.

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/jphp.12630DOI Listing
May 2017

Drug-induced renal injury in neonates: challenges in clinical practice and perspectives in drug development.

Expert Opin Drug Metab Toxicol 2017 May 13;13(5):555-565. Epub 2017 Feb 13.

a Department of Medical and Surgical Sciences , University of Bologna , Bologna , Italy.

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http://dx.doi.org/10.1080/17425255.2017.1290081DOI Listing
May 2017

Safety, dosing, and pharmaceutical quality for studies that evaluate medicinal products (including biological products) in neonates.

Pediatr Res 2017 May 3;81(5):692-711. Epub 2016 Nov 3.

Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1038/pr.2016.221DOI Listing
May 2017

Fetal and neonatal rats paracetamol dosage and the perinatal human setting: Lost in translation?

Pharmacol Rep 2017 04 29;69(2):371-372. Epub 2016 Oct 29.

Erasmus MC Sophia Children's Hospital, Intensive Care and Department of Paediatric Surgery, Rotterdam, The Netherlands; Department of Development and Regeneration KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.pharep.2016.10.017DOI Listing
April 2017

Simplified Thresholds for Pediatric (Pre)hypertension: One Approach to Improve Recognition and Outcome.

Hypertension 2017 04 21;69(4):587-588. Epub 2017 Feb 21.

From the KU Leuven Department of Development and Regeneration, University of Leuven, Belgium (K.A., E.L.); Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands (K.A.); and Department of Pediatrics, University Hospitals Leuven, Belgium (E.L.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08883DOI Listing
April 2017

Does Extremely Low Birth Weight Predispose to Low-Renin Hypertension?

Hypertension 2017 03 23;69(3):443-449. Epub 2017 Jan 23.

Departments of Pediatrics and Neonatology (A.R., E.L.) and Laboratory Medicine (J.C., S.P.), University Hospitals Leuven, Belgium; KU Leuven Department of Development and Regeneration (A.R., E.L., K.A.) and Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences (Z.-Y.Z., N.C., F.-F.W., L.J., T.K., J.A.S.), University of Leuven, Belgium; Department of Sociology, Vrije Universiteit Brussel, Belgium (T.P. v.T.); R&D Group VitaK, Maastricht University, The Netherlands (J.A.S.); and Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center Sophia Children's Hospital, Rotterdam, The Netherlands (K.A.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08643DOI Listing
March 2017

The amikacin research program: a stepwise approach to validate dosing regimens in neonates.

Expert Opin Drug Metab Toxicol 2017 Feb 21;13(2):157-166. Epub 2016 Sep 21.

d Intensive Care and Department of Surgery , Erasmus MC Sophia Children's Hospital , Rotterdam , The Netherlands.

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http://dx.doi.org/10.1080/17425255.2017.1234606DOI Listing
February 2017

Enantiomer-specific ketorolac pharmacokinetics in young women, including pregnancy and postpartum period.

Bosn J Basic Med Sci 2017 Feb 21;17(1):54-60. Epub 2017 Feb 21.

Center for Clinical Pharmacology, KU Leuven and University Hospitals Leuven, Leuven, Belgium; Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

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http://dx.doi.org/10.17305/bjbms.2016.1515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341779PMC
February 2017

Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates.

Biomed Res Int 2016 21;2016:1974972. Epub 2016 Aug 21.

Department of Development and Regeneration, KU Leuven, 3000 Leuven, Belgium; Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital, 3000 CB Rotterdam, Netherlands.

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http://dx.doi.org/10.1155/2016/1974972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011197PMC
January 2017

Paracetamol and morphine for infant and neonatal pain; still a long way to go?

Expert Rev Clin Pharmacol 2017 Jan 9;10(1):111-126. Epub 2016 Nov 9.

a Intensive Care and department of Pediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , the Netherlands.

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http://dx.doi.org/10.1080/17512433.2017.1254040DOI Listing
January 2017

Harmonized Use of Frequently Prescribed Medicines in Preterm Neonates: Mission Impossible?

J Pediatr 2017 01 4;180:13-14. Epub 2016 Nov 4.

Intensive Care and Department of Pediatric Surgery Erasmus Medical Center-Sophia Children's Hospital Rotterdam, the Netherlands; Department of Development and Regeneration KU Leuven Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jpeds.2016.10.050DOI Listing
January 2017

Editorial: Neonatal Clinical Pharmacology: A Rapidly Maturing Discipline.

Curr Pharm Des 2017 ;23(38):5767-5768

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.

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http://dx.doi.org/10.2174/138161282338180209180957DOI Listing
January 2017

Developmental Pharmacokinetics in Neonates: Maturational Changes and Beyond.

Curr Pharm Des 2017 ;23(38):5769-5778

Division of Clinical Pharmacology, Children's National Health System, Washington, DC, United States.

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http://dx.doi.org/10.2174/1381612823666170926121124DOI Listing
January 2017

Adverse drug events in pediatric intensive care are common, but improvement strategies exist and are effective.

Authors:
Karel Allegaert

Rev Paul Pediatr 2016 Dec 4;34(4):393-394. Epub 2016 Aug 4.

Intensive Care and Department of Surgery, Erasmus MC-Sophia Children's Hospital, Roterdã, Países Baixos; Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Bélgica. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S010305821630057
Publisher Site
http://dx.doi.org/10.1016/j.rpped.2016.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5176055PMC
December 2016

Propofol Dose-Finding to Reach Optimal Effect for (Semi-)Elective Intubation in Neonates.

J Pediatr 2016 12 2;179:54-60.e9. Epub 2016 Sep 2.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Intensive Care and Department of Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jpeds.2016.07.049DOI Listing
December 2016

Erratum to: A Mechanism to Explain Ototoxicity in Neonates Exposed to Bumetanide: Lessons to Help Improve Future Product Development in Neonates.

Paediatr Drugs 2016 Dec;18(6):475

Intensive Care and Department of Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40272-016-0195-zDOI Listing
December 2016

Catch-Up Growth in Former Preterm Neonates: No Time to Waste.

Nutrients 2016 Dec 17;8(12). Epub 2016 Dec 17.

Department of Development and Regeneration, KU Leuven, Leuven B-3000, Belgium.

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http://dx.doi.org/10.3390/nu8120817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188471PMC
December 2016

Acetaminophen to Prevent Symptomatic Patent Ductus Arteriosus: Another Drug Bites the Dust?

J Pediatr 2016 10 19;177:7-9. Epub 2016 Jul 19.

Intensive Care and Department of Pediatric Surgery Erasmus Medical Center-Sophia Children's Hospital Rotterdam, The Netherlands; Department of Development and Regeneration KU Leuven Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jpeds.2016.06.034DOI Listing
October 2016

A Mechanism to Explain Ototoxicity in Neonates Exposed to Bumetamide: Lessons to Help Improve Future Product Development in Neonates.

Paediatr Drugs 2016 Oct;18(5):331-3

Intensive Care and Department of Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40272-016-0190-4DOI Listing
October 2016

Intravenous paracetamol and intraocular pressure reduction: mannitol may also be involved.

Authors:
Karel Allegaert

Clin Ophthalmol 2016 15;10:1775-1777. Epub 2016 Sep 15.

Intensive Care, Department of Surgery, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Development and Regeneration, KU Leuven, Belgium.

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http://dx.doi.org/10.2147/OPTH.S118752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028100PMC
September 2016