Karel Allegaert

Karel Allegaert

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Karel Allegaert

Publications by authors named "Karel Allegaert"

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Prevalence and characteristics of pregnancy- and lactation-related calls to the National Poison Centre in Belgium: A retrospective analysis of calls from 2012 to 2017.

J Eval Clin Pract 2020 Jun 12;26(3):911-917. Epub 2019 Jul 12.

Department of Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Pharmacotherapy, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/jep.13228DOI Listing
June 2020

Phenobarbital Increases Midazolam Clearance in Neonates Treated with Hypothermia: Do We Really Need to Know?

Neonatology 2019 11;116(2):188-190. Epub 2019 Jun 11.

Department of Pediatric Surgery, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1159/000499742DOI Listing
May 2020

Growth patterns and body composition in former extremely low birth weight (ELBW) neonates until adulthood: a systematic review.

Eur J Pediatr 2020 May 4;179(5):757-771. Epub 2020 Jan 4.

Department of Development and Regeneration, and Department of Pharmaceutical and Pharmacological Sciences Organ Systems, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00431-019-03552-zDOI Listing
May 2020

Pregnancy related pharmacokinetics and antimicrobial prophylaxis during fetal surgery, cefazolin and clindamycin as examples.

Prenat Diagn 2020 May 22. Epub 2020 May 22.

Department of Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/pd.5753DOI Listing
May 2020

Characterization of esophageal motility and esophagogastric junction in preterm infants with bronchopulmonary dysplasia.

Neurogastroenterol Motil 2020 Apr 16:e13849. Epub 2020 Apr 16.

Department of Neurosciences, Experimental ORL, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/nmo.13849DOI Listing
April 2020

The Predictive Value of Glomerular Filtration Rate-Based Scaling of Pediatric Clearance and Doses for Drugs Eliminated by Glomerular Filtration with Varying Protein-Binding Properties.

Clin Pharmacokinet 2020 Apr 21. Epub 2020 Apr 21.

Division of Systems Biomedicine and Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s40262-020-00890-2DOI Listing
April 2020

Arabic-speaking pregnant women with a migration background: A vulnerable target group for prenatal counseling on medicines.

Res Social Adm Pharm 2020 Mar 13;16(3):377-382. Epub 2019 Jun 13.

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.sapharm.2019.06.004DOI Listing
March 2020

Extremely Low Birth Weight Predisposes to Impaired Renal Health: A Pooled Analysis.

Kidney Blood Press Res 2019 19;44(5):897-906. Epub 2019 Sep 19.

Department of Pediatrics, Jagiellonian University Medical College, Cracow, Poland,

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http://dx.doi.org/10.1159/000502715DOI Listing
March 2020

Acetaminophen Use in Pregnant Women and Their Neonates: Safe or Unsafe till Proven Otherwise?

Neonatology 2020 Mar 10:1-3. Epub 2020 Mar 10.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium,

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http://dx.doi.org/10.1159/000506837DOI Listing
March 2020

Outcome reporting in neonates experiencing withdrawal following opioid exposure in pregnancy: a systematic review.

Trials 2020 Mar 12;21(1):262. Epub 2020 Mar 12.

Department of Pediatric and Child Health, University of Manitoba, 405 Chown, 753 McDermot Ave., Winnipeg, MB, R3E0T6, Canada.

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http://dx.doi.org/10.1186/s13063-020-4183-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069160PMC
March 2020

"How can a drug to treat claudication in adults save preterm newborns?"

Eur J Pediatr 2020 Mar 16. Epub 2020 Mar 16.

Department of Pediatrics, Division Neonatology, Erasmus University Medical Center, Rotterdam, Netherlands.

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http://dx.doi.org/10.1007/s00431-020-03631-6DOI Listing
March 2020

Maturation of Esophageal Motility and Esophagogastric Junction in Preterm Infants.

Neonatology 2020 Mar 24:1-9. Epub 2020 Mar 24.

Department of Neurosciences, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1159/000506481DOI Listing
March 2020

Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis.

Int J Environ Res Public Health 2020 03 24;17(6). Epub 2020 Mar 24.

Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.3390/ijerph17062144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142917PMC
March 2020

A Critical Review on the Relevance of Paracetamol for Procedural Pain Management in Neonates.

Authors:
Karel Allegaert

Front Pediatr 2020 18;8:89. Epub 2020 Mar 18.

Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.3389/fped.2020.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093493PMC
March 2020

Clinical Pharmacokinetic Studies in Pregnant Women and the Relevance of Pharmacometric Tools.

Curr Pharm Des 2019 ;25(5):483-495

Organ Systems, KU Leuven, Department of Development and Regeneration, Leuven, Belgium.

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http://dx.doi.org/10.2174/1381612825666190320135137DOI Listing
February 2020

Perinatal Clinical Pharmacology: Optimizing Pharmacotherapy for Pregnant Women, Their Fetuses and Infants.

Curr Pharm Des 2019 ;25(5):467-468

Division of Clinical Pharmacology, Department of Pediatrics, Children's National Health System, Washington, DC, United States.

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http://dx.doi.org/10.2174/138161282504190516090723DOI Listing
February 2020

Medical devices that look like medicines: safety and regulatory concerns for children in Europe.

Arch Dis Child 2020 02 18;105(2):147-154. Epub 2019 Sep 18.

Department of Paediatric Gastroenteroloy, Ghent University Hospital - Ghent University, Gent, Belgium

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http://dx.doi.org/10.1136/archdischild-2018-316391DOI Listing
February 2020

A sensitive liquid chromatography method for analysis of propofol in small volumes of neonatal blood.

J Clin Pharm Ther 2020 Feb 3;45(1):128-133. Epub 2019 Oct 3.

Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/jcpt.13038DOI Listing
February 2020

Pharmacokinetic modeling of intravenous sildenafil in newborns with congenital diaphragmatic hernia.

Eur J Clin Pharmacol 2020 Feb 18;76(2):219-227. Epub 2019 Nov 18.

Department of Pharmacy, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00228-019-02767-1DOI Listing
February 2020

Effect of esophageal length on high-resolution manometry metrics: Extension to the neonatal population.

Neurogastroenterol Motil 2020 02;32(2):e13800

Department of Neurosciences, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/nmo.13800DOI Listing
February 2020

Anatomical and physiological alterations of pregnancy.

J Pharmacokinet Pharmacodyn 2020 Feb 6. Epub 2020 Feb 6.

Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

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http://dx.doi.org/10.1007/s10928-020-09677-1DOI Listing
February 2020

Integration of Placental Transfer in a Fetal-Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus.

Clin Pharmacokinet 2020 Feb 12. Epub 2020 Feb 12.

Pediatric Pharmacology, Pharmacometrics Research Center and University Children's Hospital Basel (UKBB), Basel, Switzerland.

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http://dx.doi.org/10.1007/s40262-020-00861-7DOI Listing
February 2020

Preterm birth impairs postnatal lung development in the neonatal rabbit model.

Respir Res 2020 Feb 21;21(1):59. Epub 2020 Feb 21.

Department of Development and Regeneration, KULeuven, Herestraat 49, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1186/s12931-020-1321-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035772PMC
February 2020

Nonlinear Transfer Entropy to Assess the Neurovascular Coupling in Premature Neonates.

Adv Exp Med Biol 2020 ;1232:11-17

Department of Electrical Engineering (ESAT), STADIUS, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/978-3-030-34461-0_2DOI Listing
January 2020

Simvastatin attenuates lung functional and vascular effects of hyperoxia in preterm rabbits.

Pediatr Res 2019 Dec 9. Epub 2019 Dec 9.

Department of Development and Regeneration, KULeuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41390-019-0711-2DOI Listing
December 2019

Community pharmacists' attitudes, barriers, knowledge and counseling practice with regard to preconception, pregnancy and lactation.

Res Social Adm Pharm 2019 Dec 16. Epub 2019 Dec 16.

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.sapharm.2019.12.010DOI Listing
December 2019

Perspectives in Neonatal Pharmacology: Drug Discovery, Knowledge Integration and Structured Prioritization.

Curr Pharm Des 2018 ;24(41):4839-4841

Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.

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http://dx.doi.org/10.2174/138161282441190320125910DOI Listing
November 2019

Intravenous or Oral Acetaminophen for Analgesia After Cesarean Section: Exposure Drives Pain Relief.

Pain Med 2019 11;20(11):2329-2331

Department of Paediatric Surgery and Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Development and Regeneration, Paediatric Pharmacology and Pharmacometrics Research Center, University Children's Hospital Basel, Basel, Switzerland; Division of Clinical Pharmacology, Children's National Medical Center, Washington, DC; Division of Neonatology, Department of Paediatrics, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1093/pm/pnz136DOI Listing
November 2019

Oral antibiotics for neonatal infections: a systematic review and meta-analysis.

J Antimicrob Chemother 2019 11;74(11):3150-3161

Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/jac/dkz252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814091PMC
November 2019

Rapidly maturing fentanyl clearance in preterm neonates.

Arch Dis Child Fetal Neonatal Ed 2019 Nov 1;104(6):F598-F603. Epub 2019 Feb 1.

Division of Pharmacology, Division Systems Pharmacology and Biomedicine, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1136/archdischild-2018-315920DOI Listing
November 2019

Actual body weight-based vancomycin dosing in neonates.

J Chemother 2019 Oct 14;31(6):307-312. Epub 2019 Apr 14.

Department of Pharmacology, General University Hospital, 1st Faculty of Medicine Charles University in Prague , Czech Republic , Prague , Czech Republic.

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2019.1
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http://dx.doi.org/10.1080/1120009X.2019.1599574DOI Listing
October 2019

Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns: impact of design optimisation.

Eur J Clin Pharmacol 2019 Oct 16;75(10):1393-1404. Epub 2019 Jul 16.

Clinical Pharmacology and Therapeutics, University College London, BMA House, Tavistock Square, London, WC1H 9JP, UK.

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http://link.springer.com/10.1007/s00228-019-02708-y
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http://dx.doi.org/10.1007/s00228-019-02708-yDOI Listing
October 2019

Propofol Formulation Affects Myocardial Function in Newborn Infants.

Pediatr Cardiol 2019 Oct 14;40(7):1536-1542. Epub 2019 Aug 14.

Department of Neonatology, Royal Hospital for Children, Glasgow, UK.

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http://dx.doi.org/10.1007/s00246-019-02182-4DOI Listing
October 2019

A manual propofol infusion regimen for neonates and infants.

Paediatr Anaesth 2019 09 12;29(9):907-914. Epub 2019 Aug 12.

Department of Anaesthesiology, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1111/pan.13706DOI Listing
September 2019

Health products' and substance use among pregnant women visiting a tertiary hospital in Belgium: A cross-sectional study.

Pharmacoepidemiol Drug Saf 2019 09 25;28(9):1231-1238. Epub 2019 Jul 25.

Department of Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Pharmacotherapy, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/pds.4862DOI Listing
September 2019

Pharmacokinetic modelling and Bayesian estimation-assisted decision tools to optimize vancomycin dosage in neonates: only one piece of the puzzle.

Expert Opin Drug Metab Toxicol 2019 Sep 19;15(9):735-749. Epub 2019 Aug 19.

Department of Development and Regeneration, KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1080/17425255.2019.1655540DOI Listing
September 2019

Ontogeny of Phase I Metabolism of Drugs.

J Clin Pharmacol 2019 09;59 Suppl 1:S33-S41

Division of Clinical Pharmacology, Children's National Health System, Washington, DC, USA.

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http://dx.doi.org/10.1002/jcph.1483DOI Listing
September 2019

Drug Disposition and Pharmacotherapy in Neonatal ECMO: From Fragmented Data to Integrated Knowledge.

Front Pediatr 2019 3;7:360. Epub 2019 Sep 3.

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.

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http://dx.doi.org/10.3389/fped.2019.00360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733981PMC
September 2019

Developmental neurobiology as a guide for pharmacological management of pain in neonates.

Semin Fetal Neonatal Med 2019 08 10;24(4):101012. Epub 2019 May 10.

Intensive Care and Department of Paediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.siny.2019.05.004DOI Listing
August 2019

Severity of asphyxia is a covariate of phenobarbital clearance in newborns undergoing hypothermia.

J Matern Fetal Neonatal Med 2019 Jul 5;32(14):2302-2309. Epub 2018 Feb 5.

c Intensive Care and Department of Pediatric Surgery , Erasmus MC, Sophia Children's Hospital , Rotterdam , The Netherlands.

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http://dx.doi.org/10.1080/14767058.2018.1432039DOI Listing
July 2019

Beliefs about medicines and information needs among pregnant women visiting a tertiary hospital in Belgium.

Eur J Clin Pharmacol 2019 Jul 4;75(7):995-1003. Epub 2019 Mar 4.

Department of Pharmaceutical and Pharmacological Sciences, Clinical Pharmacology and Pharmacotherapy, KU Leuven, Herestraat 49, Box 521, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00228-019-02653-wDOI Listing
July 2019

Characterization of Esophageal Motility in Infants With Congenital Diaphragmatic Hernia Using High-resolution Manometry.

J Pediatr Gastroenterol Nutr 2019 07;69(1):32-38

Department of Neurosciences, Experimental Oto-Rhino-Laryngology, Deglutology, KU Leuven.

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http://dx.doi.org/10.1097/MPG.0000000000002325DOI Listing
July 2019

Neonates are not just little children and need more finesse in dosing of antibiotics.

Acta Clin Belg 2019 Jun 10;74(3):157-163. Epub 2018 May 10.

a Intensive Care and Department of Pediatric Surgery , Erasmus MC - Sophia Children's Hospital , Rotterdam , The Netherlands.

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http://dx.doi.org/10.1080/17843286.2018.1473094DOI Listing
June 2019

Neonatal factors predictive for respiratory and gastro-intestinal morbidity after esophageal atresia repair.

Pediatr Neonatol 2019 06 21;60(3):261-269. Epub 2018 Jul 21.

Neurogastroenterology and Motility, Gastroenterology, University Hospitals Leuven, Leuven, Belgium; Department of Clinical and Experimental Medicine, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium; Department of Neurosciences, Experimental ORL, KU Leuven, Belgium.

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http://dx.doi.org/10.1016/j.pedneo.2018.07.003DOI Listing
June 2019

Maturational changes in vancomycin protein binding affect vancomycin dosing in neonates.

Br J Clin Pharmacol 2019 05 4;85(5):865-867. Epub 2019 Mar 4.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/bcp.13899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475736PMC
May 2019

Local pulmonary drug delivery in the preterm rabbit: feasibility and efficacy of daily intratracheal injections.

Am J Physiol Lung Cell Mol Physiol 2019 04 24;316(4):L589-L597. Epub 2019 Jan 24.

Department of Development and Regeneration, Cluster Woman and Child, KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1152/ajplung.00255.2018DOI Listing
April 2019

Research on medication use in the neonatal intensive care unit.

Expert Rev Clin Pharmacol 2019 Apr 20;12(4):343-353. Epub 2019 Feb 20.

c Division of Clinical Pharmacology, Department of Pediatrics , Children's National Health System , Washington , DC , USA.

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http://dx.doi.org/10.1080/17512433.2019.1580569DOI Listing
April 2019

Narcotic-Sparing Approaches and the Shift Toward Paracetamol in Neonatal Intensive Care.

Handb Exp Pharmacol 2019 Mar 17. Epub 2019 Mar 17.

Intensive Care, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/164_2019_207DOI Listing
March 2019

Impact of Disease on Amikacin Pharmacokinetics and Dosing in Children.

Ther Drug Monit 2019 02;41(1):44-52

Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.

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http://dx.doi.org/10.1097/FTD.0000000000000568DOI Listing
February 2019

Rational Use of Antibiotics in Neonates: Still in Search of Tailored Tools.

Healthcare (Basel) 2019 Feb 16;7(1). Epub 2019 Feb 16.

Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

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http://dx.doi.org/10.3390/healthcare7010028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473895PMC
February 2019

Pregnancy affects the pharmacokinetics of sildenafil and its metabolite in the rabbit.

Xenobiotica 2019 Jan 10;49(1):98-105. Epub 2018 Jan 10.

a Cluster Woman and Child, Department of Development and Regeneration, Biomedical Sciences, KU Leuven , Leuven , Belgium.

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http://dx.doi.org/10.1080/00498254.2017.1422217DOI Listing
January 2019

How often do we perform painful and stressful procedures in the paediatric intensive care unit? A prospective observational study.

Aust Crit Care 2019 01 17;32(1):4-10. Epub 2018 May 17.

Intensive Care and Department of Pediatric Surgery, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands; Division of Neonatology, Department of Pediatrics, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.aucc.2018.04.003DOI Listing
January 2019

Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis.

Br J Clin Pharmacol 2019 01 25;85(1):245-251. Epub 2018 Oct 25.

Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

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http://doi.wiley.com/10.1111/bcp.13778
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http://dx.doi.org/10.1111/bcp.13778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303200PMC
January 2019

Physiologically based pharmacokinetic (PBPK) modeling and simulation in neonatal drug development: how clinicians can contribute.

Expert Opin Drug Metab Toxicol 2019 Jan 17;15(1):25-34. Epub 2018 Dec 17.

b Department of Development and Regeneration , KU Leuven , Leuven , Belgium.

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https://www.tandfonline.com/doi/full/10.1080/17425255.2019.1
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http://dx.doi.org/10.1080/17425255.2019.1558205DOI Listing
January 2019

Tramadol, breast feeding and safety in the newborn.

Arch Dis Child 2018 12 29;103(12):1110-1113. Epub 2018 Mar 29.

Intensive Care and Department of Pediatric Surgery and Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1136/archdischild-2017-313786DOI Listing
December 2018

Simulation-based suggestions to improve ibuprofen dosing for patent ductus arteriosus in preterm newborns.

Eur J Clin Pharmacol 2018 Dec 28;74(12):1585-1591. Epub 2018 Jul 28.

Department of Pediatrics, Division of Neonatology, Erasmus University Medical Center - Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00228-018-2529-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244763PMC
December 2018

Sildenafil crosses the placenta at therapeutic levels in a dually perfused human cotyledon model.

Am J Obstet Gynecol 2018 12 5;219(6):619.e1-619.e10. Epub 2018 Sep 5.

Cluster Woman and Child, the Department of Development and Regeneration, Biomedical Sciences, KU Leuven, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium; Institute of Women's Health, Institute of Child Health, University College London, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029378183072
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http://dx.doi.org/10.1016/j.ajog.2018.08.041DOI Listing
December 2018

The use of PBPK modeling across the pediatric age range using propofol as a case.

J Pharmacokinet Pharmacodyn 2018 12 8;45(6):765-785. Epub 2018 Oct 8.

Laboratory of Medical Biochemistry and Clinical Analysis, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

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http://link.springer.com/10.1007/s10928-018-9607-8
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http://dx.doi.org/10.1007/s10928-018-9607-8DOI Listing
December 2018

Cerebral autoregulation and activity after propofol for endotracheal intubation in preterm neonates.

Pediatr Res 2018 11 10;84(5):719-725. Epub 2018 Sep 10.

Department of Neonatology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41390-018-0160-3DOI Listing
November 2018

Developmental Pharmacology - Special Issues During Childhood and Adolescence.

Authors:
Karel Allegaert

Drug Res (Stuttg) 2018 Nov 19;68(S 01):S10-S11. Epub 2018 Nov 19.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1055/a-0731-6913DOI Listing
November 2018

Developmental Changes in Pharmacokinetics and Pharmacodynamics.

J Clin Pharmacol 2018 10;58 Suppl 10:S10-S25

Arkansas Children's Research Institute, Little Rock, AR, USA.

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http://doi.wiley.com/10.1002/jcph.1284
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http://dx.doi.org/10.1002/jcph.1284DOI Listing
October 2018

Inactive matrix Gla protein is a novel circulating biomarker predicting retinal arteriolar narrowing in humans.

Sci Rep 2018 10 10;8(1):15088. Epub 2018 Oct 10.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41598-018-33257-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180139PMC
October 2018

Rational Use of Medicines in Neonates: Current Observations, Areas for Research and Perspectives.

Authors:
Karel Allegaert

Healthcare (Basel) 2018 Sep 14;6(3). Epub 2018 Sep 14.

Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Doctor Molenwaterplein 40, 3015 GD Rotterdam, The Netherlands.

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http://dx.doi.org/10.3390/healthcare6030115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165407PMC
September 2018

Factors impacting unbound vancomycin concentrations in neonates and young infants.

Eur J Clin Microbiol Infect Dis 2018 Aug 16;37(8):1503-1510. Epub 2018 May 16.

Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s10096-018-3277-8DOI Listing
August 2018

Earlier achievement of full enteral feeding in extremely low birth weight neonates is not associated with growth improvement in the first 2 years of life.

Eur J Pediatr 2018 Aug 30;177(8):1247-1254. Epub 2018 May 30.

Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/s00431-018-3178-yDOI Listing
August 2018

Excipients in Neonatal Medicinal Products: Never Prescribed, Commonly Administered.

Pharmaceut Med 2018 10;32(4):251-258. Epub 2018 Aug 10.

2Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40290-018-0243-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105181PMC
August 2018

Acetaminophen in the Neonatal Intensive Care Unit: Shotgun Approach or Silver Bullet.

J Pediatr 2018 07 28;198:10-11. Epub 2018 Mar 28.

Intensive Care and Department of Pediatric Surgery; Erasmus Medical Center-Sophia Children's Hospital; Rotterdam, the Netherlands; Department of Development and Regeneration; KU Leuven; Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jpeds.2018.02.046DOI Listing
July 2018

Paracetamol/Acetaminophen During Pregnancy Induces Prenatal Ductus Arteriosus Closure.

Pediatrics 2018 07 7;142(1). Epub 2018 Jun 7.

Departments of Neonatology and

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http://dx.doi.org/10.1542/peds.2017-4021DOI Listing
July 2018

Paracetamol in Older People: Towards Evidence-Based Dosing?

Drugs Aging 2018 07;35(7):603-624

Department of Geriatrics, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1007/s40266-018-0559-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061299PMC
July 2018

Antenatal management of congenital diaphragmatic hernia today and tomorrow.

Minerva Pediatr 2018 Jun 23;70(3):270-280. Epub 2018 Feb 23.

Academic Department of Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, KU Leuven, Leuven, Belgium -

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http://dx.doi.org/10.23736/S0026-4946.18.05186-1DOI Listing
June 2018

Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for .

Clin Epigenetics 2017 3;9:107. Epub 2017 Oct 3.

Department of Neurosciences, Genetic Research About Stress and Psychiatry (GRASP), KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/s13148-017-0408-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5627482PMC
May 2018

In Vitro Adsorption of Analgosedative Drugs in New Extracorporeal Membrane Oxygenation Circuits.

Pediatr Crit Care Med 2018 05;19(5):e251-e258

Intensive Care and Department of Pediatric Surgery, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/PCC.0000000000001484DOI Listing
May 2018

Drug evaluation studies in neonates: how to overcome the current limitations.

Expert Rev Clin Pharmacol 2018 Apr 14;11(4):387-396. Epub 2018 Mar 14.

b Intensive Care and Department of Pediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , the Netherlands.

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http://dx.doi.org/10.1080/17512433.2018.1439378DOI Listing
April 2018

Pharmacokinetic considerations for pediatric patients receiving analgesia in the intensive care unit; targeting postoperative, ECMO and hypothermia patients.

Expert Opin Drug Metab Toxicol 2018 Apr 11;14(4):417-428. Epub 2018 Apr 11.

a Intensive Care and Department of Pediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , The Netherlands.

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https://www.tandfonline.com/doi/full/10.1080/17425255.2018.1
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http://dx.doi.org/10.1080/17425255.2018.1461836DOI Listing
April 2018

Reproducibility of Retinal Microvascular Traits Decoded by the Singapore I Vessel Assessment Software Across the Human Age Range.

Am J Hypertens 2018 03;31(4):438-449

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium.

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http://dx.doi.org/10.1093/ajh/hpx202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861549PMC
March 2018

Drug metabolism in early infancy: opioids as an illustration.

Expert Opin Drug Metab Toxicol 2018 Mar 30;14(3):287-301. Epub 2018 Jan 30.

a Intensive Care and Department of Paediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , The Netherlands.

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http://dx.doi.org/10.1080/17425255.2018.1432595DOI Listing
March 2018

Association between cognition and the retinal microvasculature in 11-year old children born preterm or at term.

Early Hum Dev 2018 03 3;118:1-7. Epub 2018 Feb 3.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Siciences, University of Leuven, Leuven, Belgium; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.earlhumdev.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885985PMC
March 2018

Conventional and Ambulatory Blood Pressure as Predictors of Diastolic Left Ventricular Function in a Flemish Population.

J Am Heart Assoc 2018 02 8;7(4). Epub 2018 Feb 8.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium

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http://dx.doi.org/10.1161/JAHA.117.007868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850199PMC
February 2018

Analysis of renal blood flow and renal volume in normal fetuses and in fetuses with a solitary functioning kidney.

Prenat Diagn 2017 12 21;37(12):1213-1218. Epub 2017 Nov 21.

Department of Obstetrics and Gynecology, KU Leuven, Belgium.

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http://dx.doi.org/10.1002/pd.5167DOI Listing
December 2017

Current and future antenatal management of isolated congenital diaphragmatic hernia.

Semin Fetal Neonatal Med 2017 12 21;22(6):383-390. Epub 2017 Nov 21.

Academic Department of Development and Regeneration, Clinical Specialties Research Groups, Biomedical Sciences; Clinical Department of Obstetrics and Gynaecology, KU Leuven, Leuven, Belgium; Institute for Women's Health and Institute of Child Health, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.siny.2017.11.002DOI Listing
December 2017

Biomarkers of propofol metabolism in neonates: the quest beyond ontogeny.

Biomark Med 2017 11 23;11(11):933-936. Epub 2017 Oct 23.

Department of Development & Regeneration, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.2217/bmm-2017-0184DOI Listing
November 2017